Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 98, Issue 9, 2001, Pages 5187-5192

  Zabolotny, Janice M ^a   Kim, Young Bum ^a   Peroni, Odile D ^a   Kim, Jason K ^b   Pani, Michael A ^a   Boss, Olivier ^a   Klaman, Lori D ^a   Kamatkar, Shubhangi ^a   Shulman, Gerald I ^b   Kahn, Barbara B ^a,c   Neel, Benjamin G ^a,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^d HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; LEUKOCYTE ANTIGEN; PHOSPHOTYROSINE; PROTEIN TYROSINE PHOSPHATASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; CONTROLLED STUDY; DEPHOSPHORYLATION; ENZYME ACTIVITY; GENE OVEREXPRESSION; INSULIN RESISTANCE; MOUSE; NONHUMAN; OBESITY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BLOOD GLUCOSE; BODY COMPOSITION; CREATINE KINASE; CREATINE KINASE, MM FORM; FATTY ACIDS, NONESTERIFIED; HUMANS; INSULIN; INSULIN RESISTANCE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISOENZYMES; MICE; MICE, TRANSGENIC; MUSCLES; ORGAN SPECIFICITY; PHOSPHORYLATION; PHOSPHOTYROSINE; PROMOTER REGIONS (GENETICS); PROTEIN-TYROSINE-PHOSPHATASE; RECOMBINANT FUSION PROTEINS; SHP1 PROTEIN TYROSINE PHOSPHATASE; SIGNAL TRANSDUCTION;

ANIMALIA; MUS MUSCULUS; RODENTIA;

EID: 0035942161     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.071050398     Document Type: Article

References (42)