Leptin regulation of the immune response and the immunodeficiency of malnutrition

FASEB Journal

Volumn 15, Issue 14, 2001, Pages 2565-2571

  Faggioni, R ^a   Feingold, K R ^a   Grunfeld, C ^a  

^a AMGEN INC   (United States)

Author keywords

Lymphocytes; Macrophages; Pleiotropic molecule; Starvation

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; CYTOKINE; CYTOKINE RECEPTOR; GLYCOPROTEIN GP 130; INTERLEUKIN 11; INTERLEUKIN 6; LEPTIN; LEUKEMIA INHIBITORY FACTOR;

CELLULAR IMMUNITY; CYTOKINE PRODUCTION; HUMAN; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNITY; INFECTION; INFLAMMATION; LYMPHOCYTE; MACROPHAGE; MALNUTRITION; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN SECONDARY STRUCTURE; REGULATORY MECHANISM; REVIEW; STARVATION; TH1 CELL;

ANIMALS; HUMANS; IMMUNITY; IMMUNOLOGIC DEFICIENCY SYNDROMES; LEPTIN; NUTRITION DISORDERS; OBESITY;

EID: 0035195887     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.01-0431rev     Document Type: Review

References (90)

1. Positional cloning of the mouse obese gene and its human homologue
2. Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice
3. Identification and expression cloning of a leptin receptor, OB-R
4. Abnormal splicing of the leptin receptor in diabetic mice
5. Congenital leptin deficiency is associated with severe early-onset obesity in humans
6. Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
7. Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
8. Weight-reducing effects of the plasma protein encoded by the obese gene
9. Effects of the obese gene product on body weight regulation in ob/ob mice
10. Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
11. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
12. Effects of recombinant leptin therapy in a child with congenital leptin deficiency
13. Transgenic mice overexpressing leptin accumulate adipose tissue mass at an older, but not younger, age
14. Role of leptin in the neuroendocrine response to fasting
15. Expression of ob mRNA and its encoded protein in rodents
16. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
17. Clinical review 94: What's in a name? In search of leptin's physiologic role
18. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice
19. Leptin enhances wound re-epithelialization and constitutes a direct function of leptin in skin repair
20. Systemically and topically administered leptin both accelerate wound healing in diabetic ob/ob mice
21. Leptin and bone: Does the brain control bone biology?
22. Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass
23. Detective STAT signaling by the leptin receptor in diabetic mice
24. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice
25. Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells
26. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
27. Expression of leptin receptor in lung: Leptin as a growth factor
28. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
29. Human leptin enhances activation and proliferation of human circulating T lymphocytes
30. Leptin regulates proinflammatory immune responses
31. Biological action of leptin as an angiogenic factor
32. Crystal structure of the obese protein leptin-E100
33. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors
34. Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction
35. Expression and function of leptin receptor isoforms in myeloid leukemia and myelodysplastic syndromes: Proliferative and anti-apoptotic activities
36. Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor
37. Divergent signaling capacities of the long and short isoforms of the leptin receptor
38. Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting
39. Modulation of circulating leptin levels by its soluble receptor
40. Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors
41. OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily
42. Soluble leptin receptor represents the main leptin binding activity in human blood
43. The role of SOCS-3 in leptin signaling and leptin resistance
44. Acute-phase proteins and other systemic responses to inflammation
45. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. A role for leptin in the anorexia of infection
46. Multiple cytokines and acute inflammation raise mouse leptin levels: Potential role in inflammatory anorexia
47. IL-1 beta mediates leptin induction during inflammation
48. Systemic administration of lipopolysaccharide increases plasma leptin levels: Blockade by soluble interleukin-1 receptor
49. Increased leptin expression in mice with bacterial peritonitis is partially regulated by tumor necrosis factor alpha
50. Elevated serum leptin concentrations induced by experimental acute inflammation
51. LPS-induced anorexia in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice
52. Leptin causes body weight loss in the absence of in vivo activities typical of cytokines of the IL-6 family
53. Leptin produces anorexia and weight loss without inducing an acute phase response or protein wasting
54. Leptin deficiency enhances sensitivity to endotoxin-induced lethality
55. Leptin is and endogenous protective protein against the toxicity exerted by tumor necrosis factor
56. Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis
57. Leptindeficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: Role of tumor necrosis factor alpha and IL-18
58. Phenotypic abnormalities in macrophages from leptin-deficient, obese mice
59. Altered hepatic lymphocyte subpopulations in obesity-related murine fatty livers: Potential mechanism for sensitization to liver damage
60. Leptin: A potential regulator of polymorphonuclear neutrophil bactericidal action?
61. Leptin directly induces the secretion of interleukin 1 receptor antagonist in human monocytes
62. Interleukin 1 alpha increases serum leptin concentrations in humans
63. Tumor necrosis factor increases serum leptin levels in humans
64. Circulating leptin during experimental endotoxemia in humans
65. The co-ordinated cytokine/hormone response to acute injury incorporates leptin
66. Serum leptin levels in the acquired immunodeficiency syndrome
67. Leptin serum levels are not correlated with disease activity in patients with rheumatoid arthritis
68. Serum leptin in children and young adults with inflammatory bowel disease
69. Serum leptin concentrations and their relation to metabolic abnormalities in human sepsis
70. Leptin and interleukin-6 in sepsis
71. Plasma leptin levels are increased in survivors of acute sepsis: Associated loss of diurnal rhythm, in cortisol and leptin secretion
72. Relationship of plasma leptin to plasma cytokines and human survival in sepsis and septic shock
73. Human leptin deficiency caused by a missense mutation: Multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects
74. Elevated plasma leptin concentrations in early stages of experimental intestinal inflammation in rats
75. Leptin deficient (ob/ob) mice are resistant to experimental colitis: Role of Th1 cytokines
76. Nutrition, immunity and infection: From basic knowledge of dietary manipulation of immune responses to practical application of ameliorating suffering and improving survival
77. Seminars in medicine of the Beth Israel Deaconess Medical Center. Neuroendocrine responses to starvation and weight loss
78. Cell-mediated immunity in nutritional imbalance
79. Effects of protein calorie malnutrition on tuberculosis in mice
80. Cell-mediated immunity in anorexia nervosa
81. A longitudinal hormonal profile of the genetically obese mouse
82. Reduced leptin levels in starvation increase susceptibility to endotoxic shock
83. A regulatory, loop between the hypothalamo-pituitary-adrenal (HPA) axis and circulating leptin: A physiological role of ACTH
84. Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function
85. Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress
86. Generalized lipodystrophy, congenital and acquired (lipoatrophy)
87. Congenital lipodystrophy with defective leucocyte function
88. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
89. Fat distribution and metabolic changes in patients with HIV infection
90. Alteration of tumor necrosis factor-alpha T-cell homeostasis following potent antiretroviral therapy: Contribution to the development of human immunodeficiency virus-associated lipodystrophy syndrome