Endogenous glucose production is inhibited by the adipose-derived protein Acrp30

Journal of Clinical Investigation

Volumn 108, Issue 12, 2001, Pages 1875-1881

  Combs, Terry P ^a   Berg, Anders H ^a   Obici, Silvana ^b,c   Scherer, Philipp E ^a,c   Rossetti, Luciano ^a,b,c  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b Department of Medicine ^*  (United States)

^c Diabetes Research and Training Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLUCOSE 6 PHOSPHATE; GLYCOGEN; MESSENGER RNA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PROTEIN ACRP30; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ADIPOSE TISSUE CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GLUCONEOGENESIS; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOGEN SYNTHESIS; GLYCOLYSIS; HYPERINSULINEMIA; HYPOGLYCEMIA; MALE; MOUSE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0035663963     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI14120     Document Type: Article

References (38)

1. Role of fatty acids in the pathogenesis of insulin resist ance and NIDDM
2. Obesity and insulin resistance
3. Generalized lipodysccophy, congenital and acquired (lipoatrophy)
4. Lipoatrophy revisited
5. PPAR gamma and the treatment of insulin resistance
6. Mechanisms of fatty acid-induced inhibition of glucose uptake
7. Central role of the adipocyte in the metabolic syndrome
8. The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog
9. Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance
10. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
11. A novel serum protein similar to Clq, produced exclusively in adipocytes
12. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients
13. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
14. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity
15. Genomic structure and mutations in adiposespecific gene, adiponectin
16. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
17. AdipoQ is a novel adipose specific gene dysregulated in obesity
18. Genomewide search for type 2 diabetes-susceptibility genes in French whites: Evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome q21-q24
19. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys
20. Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia
21. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
22. Quantitation of hepatic glucose fluxes and pathways of hepatic glycogen synthesis in conscious mice
23. Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene
24. Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele
25. Relative contribution of glycogen synthesis and glycolysis to insulin-mediated glucose uptake. A dose response euglycemic clamp study in normal and diabetic rats
26. Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. Implications for the pathophysiology of fasting hyperglycemia in diabetes
27. Loss of hepatic autoregulation after carbohydrate overfeeding in normal man
28. Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding
29. Role of the glucosamine pathway in fat-induced insulin resistance
30. Intracerebroventricular leptin regulates hepatic but not peripheral glucose fluxes
31. Effects of leptin on insulin sensitivity in normal rats
32. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
33. In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: Overlapping but distinct pathways from insulin
34. Protection from obesity-induced insulin resistance in mice lacking TNF alpha function
35. The hormone resistin links obesity to diabetes
36. Troglitazone action is independent of adipose tissue
37. Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones
38. Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice