Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia

Journal of Clinical Endocrinology and Metabolism

Volumn 86, Issue 5, 2001, Pages 1930-1935

  Weyer, Christian ^a   Funahashi, Tohru ^b   Tanaka, Sachiyo ^b   Hotta, Kikuko ^b   Matsuzawa, Yuji ^b   Pratley, Richard E ^a   Tataranni, P Antonio ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; INSULIN; PROTEIN; UNCLASSIFIED DRUG;

ADULT; AMERICAN INDIAN; ARTICLE; BODY COMPOSITION; BODY FAT; CAUCASIAN; CORRELATION FUNCTION; DUAL ENERGY X RAY ABSORPTIOMETRY; ETHNIC DIFFERENCE; FEMALE; HUMAN; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

EID: 0034999667     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.86.5.7463     Document Type: Article

References (31)

1. Pratley RE, Weyer C, Bogardus C. 2000 Metabolic abnormalities in the development of noninsulin-dependent diabetes mellitus. In: LeRoith D, Taylor SI, Olefsky JM, eds. Diabetes mellitus, ed 2. Philadelphia: Lippincot-Raven Publishers; 548-557.
2. NHLBI Obesity Education Initiative Expert Panel on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults. 1998 Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: the evidence report. Obes Res. 6(Suppl 2):71S-82S.
3. Funahashi T, Nakamura T, Shimomura I, et al. 1999 Role of adipocytokines on the pathogenesis of atherosclerosis in visceral obesity. Int Med. 38:202-206.
4. Matsuzawa Y, Funahashi T, Nakamura T. 1999 Molecular mechanism of metabolic syndrome X: contribution of adipocyte-derived bioactive substances. Ann NY Acad Sci. 892:146-154.
5. Boden G. 1997 Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes. 46:3-10.
6. Hotamisligil GS, Spiegelman BM. 1994 Tumor-necrosis factor α: a key component of the obesity-diabetes link. Diabetes. 43:1271-1278.
7. Hotamisligil GS, Murray DL, Choy LN, Spiegelman BM. 1994 Tumor necrosis factor-α inhibits signaling from the insulin receptor. Proc Natl Acad Sci USA. 91:4854-4858.
8. Alessi MC, Peiretti F, Morange P, Henry M, Nalbone G, Juhan-Vague I. 1997 Production of plasminogen activator inhibitor 1 by human adipose tissue: possible line between visceral fat accumulation and vascular disease. Diabetes. 46:860-867.
9. Yudkin JS, Kumari M, Humphries SE, Mohammed-Ali V. 2000 Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis. 148:209-214.
10. Hanson K, Pratley RE. 2000 Interleukin-6 is associated with insulin resistance independently of obesity (abstract). Diabetes. 49(Suppl 1):A297.
11. Weyer C, Tataranni PA, Pratley RE. 2000 Insulin action and insulinemia are closely related to the fasting complement C3, but not acylation-stimulating protein concentration. Diabetes Care. 23:779-785.
12. Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. 1996 cDNA cloning and expression of a novel adipose-specific collagen-like factor, apM1 (adipose most abundant gene transcript 1). Biochem Biophys Res Commun. 221:286-289.
13. Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. 1995 A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem. 270:26746-26749.
14. Hu E, Liang P, Spiegelman BM. 1996 AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem. 18:10697-10703.
15. Takahashi M, Arita Y, Yamagata K, et al. 2000 Genomic structure and mutations in adipose-specific gene, adiponectin. Int J Obes. 24:861-868.
16. Shapiro L, Scherer PE. 1998 The crystal structure of a complement-1q family protein suggests art evolutionary link to tumor necrosis factor. Curr Biol. 12:335-338.
17. Okamoto Y, Arita Y, Nishida M, et al. 2000 An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls. Horm Metab Res. 32:47-50.
18. Ouchi N, Kihara S, Arita Y, et al. 1999 Novel modulator of endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation. 100:2473-2476.
19. Ouchi N, Kihara S, Arita Y, et al. 2000 Adiponectin, an adipocyte-derived plasma protein, inhibits NF-κB signalling through a cAMP-dependent pathway. Circulation. 102:1296-1301.
20. Yokota T, Oritani K, Takahashi I, et al. 2000 Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the function of macrophages. Blood. 96:1723-1732.
21. Statnick MA, Beavers LS, Conner LJ, et al. 2000 Decreased expression of apM1 in omental and subcutaneous adipose tissue of humans with type 2 diabetes. Int J Reprod Diabetes Res. 1:51-58.
22. Arita Y, Kihara S, Ouchi N, et al. 1999 Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Comm. 257:79-83.
23. Hotta K, Funahashi T, Arita Y, et al. 2000 Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vase Biol. 20:1595-1599.
24. Knowler WC, Pettitt DJ, Saad MF, Bennett PH. 1990 Diabetes mellitus in the Pima Indians: incidence risk factors and pathogenesis. Diab Metab Rev. 6:1-27.
25. Lillioja S, Nyomba BL, Saad MF, et al. 1991 Exaggerated early insulin release and insulin resistance in a diabetes-prone population: a metabolic comparison of Pima Indians and Caucasians. J Clin Endocrinol Metab. 73:866-876.
26. Ingelfinger JA, Bennett PH, Liebow IM, Miller M. 1976 Coronary heart disease in the Pima Indians: electrocardiographic findings and post-mortem evidence of myocardial infarction in a population with a high prevalence of diabetes mellitus. Diabetes. 25:561-565.
27. Weyer C, Bogardus C, Mott D, Pratley RE. 1999 The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest. 104:787-794.
28. Weyer C, Hanson R, Tataranni PA, Bogardus C, Pratley RE. 2000 A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia. Diabetes. 49:2094-2101.
29. Tataranni PA, Ravussin E. 1995 Use of dual-energy x-ray absorptiometry in obese individuals. Am J Clin Nutr. 62:730-734.
30. World Health Organization. 1985 Diabetes mellitus: report of a WHO study group. World Health Organization Technical Report Series 17:45-51.
31. Kissebah AH, Sonnenberg GE, Myklebust J, et al. 2000 Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proc Natl Acad Sci USA 97:14478-14483.