The hedgehog response network: Sensors, switches, and routers

Science

Volumn 304, Issue 5678, 2004, Pages 1755-1759

  Lum, Lawrence ^a   Beachy, Philip A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELL MEMBRANES; GROWTH KINETICS; PATHOLOGY; PROTEINS; TUMORS;

CELL DIFFERENTIATION; TRANSCRIPTION FACTORS;

BIOTECHNOLOGY;

KINESIN; MEMBRANE PROTEIN; PROTEIN SMOOTHENED; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CI; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

BIOLOGY;

CARCINOGENESIS; CELL DIFFERENTIATION; CELL GROWTH; CYTOPLASM; EMBRYO PATTERN FORMATION; HOMEOSTASIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REVIEW; SENSOR; SIGNAL TRANSDUCTION; TUMOR GROWTH;

ANIMALS; CELL NUCLEUS; CYTOPLASM; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; HEDGEHOG PROTEINS; KINESIN; MAMMALS; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; PHOSPHORYLATION; PROTEIN TRANSPORT; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

ERINACEIDAE;

EID: 2942738996     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1098020     Document Type: Review

References (67)

1. T. M. Jessell, Nat. Rev. Genet. 1, 20 (2000).
2. Y. Zhang, D. Kalderon, Nature 410, 599 (2001).
3. J. Taipale, P. A. Beachy, Nature 411, 349 (2001).
4. T. Reya, S. J. Morrison, M. F. Clarke, I. L. Weissman, Nature 414, 105 (2001).
5. R. Machold et al., Neuron 39, 937 (2003).
6. K. Lai, B. K. Kaspar, F. H. Gage, D. V. Schaffer, Nat. Neurosci. 6, 21 (2003).
7. D. M. Berman et al., Nature 425, 846 (2003).
8. S. P. Thayer et al., Nature 425, 851 (2003).
9. D. N. Watkins et al., Nature 422, 313 (2003).
10. R. K. Mann, P. A. Beachy, Annu. Rev. Biochem. 73, 891 (2004).
11. R. Burke et al., Cell 99, 803 (1999).
12. T. Caspary et al., Curr. Biol. 12, 1628 (2002).
13. T. Kawakami et al., Development 129, 5753 (2002).
14. Y. Ma et al., Cell 111, 63 (2002).
15. C. Han, T. Y. Belenkaya, B. Wang, X. Lin, Development 131, 601 (2004).
16. V. Marigo, R. A. Davey, Y. Zuo, J. M. Cunningham, C. J. Tabin, Nature 384, 176 (1996).
17. D. M. Stone et al., Nature 384, 129 (1996).
18. N. Fuse et al., Proc. Natl. Acad. Sci. U.S.A. 96, 10992 (1999).
19. J. Taipale, M. K. Cooper, T. Maiti, P. A. Beachy, Nature 418, 892 (2002).
20. P. Aza-Blanc, F. A. Ramirez-Weber, M. P. Laget, C. Schwartz, T. B. Kornberg, Cell 89, 1043 (1997).
21. H. Akimaru et al., Nature 386, 735 (1997).
22. C. H. Chen et al., Cell 98, 305 (1999).
23. Q. T. Wang, R. A. Holmgren, Development 127, 3131 (2000).
24. N. Methot, K. Basler, Cell 96, 819 (1999).
25. N. Methot, K. Basler, Development 128, 733 (2001).
26. Y. Chen, N. Gallaher, R. H. Goodman, S. M. Smolik, Proc. Natl. Acad. Sci. U.S.A. 95, 2349 (1998).
27. M. A. Price, D. Kalderon, Cell 108, 823 (2002).
28. J. Jia et al., Nature 416, 548 (2002).
29. L. Lum et al., Science 299, 2039 (2003).
30. N. A. Theodosiou, S. Zhang, W. Y. Wang, T. Xu, Development 125, 3411 (1998).
31. J. Jiang, G. Struhl, Nature 391, 493 (1998).
32. D. J. Robbins et al., Cell 90, 225 (1997).
33. J. C. Sisson, K. S. Ho, K. Suyama, M. P. Scott, Cell 90, 235 (1997).
34. L. Lum et al., Mol. Cell 12, 1261 (2003).
35. J. E. Hooper, Development 130, 3951 (2003).
36. J. Jia, C. Tong, J. Jiang, Genes Dev. 17, 2709 (2003).
37. J. Alcedo, Y. Zou, M. Noll, Mol. Cell 6, 457 (2000).
38. N. Denef, D. Neubuser, L. Perez, S. M. Cohen, Cell 102, 521 (2000).
39. S. K. Ogden et al., Curr. Biol. 13, 1998 (2003).
40. L. Ruel, R. Rodriguez, A. Gallet, L. Lavenant-Staccini, P. P. Therond. Nat. Cell Biol. 5, 907 (2003).
41. G. Wang, K. Amanai, B. Wang, J. Jiang, Genes Dev. 14, 2893 (2000).
42. N. Methot, K. Basler, Development 127, 4001 (2000).
43. M. A. Lefers, Q. T. Wang, R. A. Holmgren, Dev. Biol. 236, 411 (2001).
44. T. Preat, Genetics 132, 725 (1992).
45. S. C. Desbordes, B. Sanson, Development 130, 6245 (2003).
46. L. Lum, P. A. Beachy, unpublished data.
47. P. P. Therond, J. D. Knight, T. B. Kornberg, J. M. Bishop, Proc. Natl. Acad. Sci. U.S.A. 93, 4224 (1996).
48. Q. T. Wang, R. A. Holmgren, Development 126, 5097 (1999).
49. J. Taipale et al., Nature 406, 1005 (2000).
50. A. J. Zhu, L. Zheng, K. Suyama, M. P. Scott, Genes Dev. 17, 1240 (2003).
51. R. V. Pearse, 2nd, L. S. Collier, M. P. Scott, C. J. Tabin, Dev. Biol. 212, 323 (1999).
52. S. Y. Cheng, J. M. Bishop. Proc. Natl. Acad. Sci. U.S.A. 99, 5442 (2002).
53. F. Charron, E. Stein, J. Jeong, A. P. McMahon, M. Tessier-Lavigne, Cell 113, 11 (2003).
54. M. T. Veeman, J. D. Axelrod, R. T. Moon, Dev. Cell 5, 367 (2003).
55. D. Kalderon, Trends Cell Biol. 12, 523 (2002).
56. R. Nusse, Development 130, 5297 (2003).
57. X. He, M. Semenov, K. Tamai, X. Zeng, Development 131, 1663 (2004).
58. K. Tamai et al., Mol. Cell 13, 149 (2004).
59. Y. Litingtung, C. Chiang, Nat. Neurosci. 3, 979 (2000).
60. H. L. Park et al., Development 127, 1593 (2000).
61. M. Murone et al., Nat. Cell Biol. 2, 310 (2000).
62. C. Wolff, S. Roy, P. W. Ingham, Curr. Biol. 13, 1169 (2003).
63. O. V. Bulgakov, J. T. Eggenschwiler, D. H. Hong, K. V. Anderson, T. Li, Development 131, 2149 (2004).
64. Y. Chen, R. H. Goodman, S. M. Smolik, Mol. Cell. Biol. 20, 1616 (2000).
65. G. Wang, J. Jiang, Dev. Biol. 268, 493 (2004).
66. C. H. Chen, D. V. Kessler, P. A. Beachy, unpublished data.
67. We would like to thank members of the Beachy lab and J. Taipale for critical comments on this manuscript. We apologize to the authors of original work not cited. Because of editorial limits on references, we were largely limited to citing review articles and more recent original articles. P.A.B. is an investigator of the Howard Hughes Medical Institute. This work was supported by a grant from the NIH.