PG545, an angiogenesis and heparanase inhibitor, reduces primary tumor growth and metastasis in experimental pancreatic cancer

Molecular Cancer Therapeutics

Volumn 12, Issue 7, 2013, Pages 1190-1201

  Ostapoff, Katherine T ^a,b   Awasthi, Niranjan ^a,b   Cenik, Bercin Kutluk ^b   Hinz, Stefan ^a,b,c   Dredge, Keith ^d   Schwarz, Roderich E ^a,b   Brekken, Rolf A ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF LÜBECK   (Germany)

^d Progen Pharmaceuticals Limited   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; COLLAGEN; ENZYME INHIBITOR; GEMCITABINE; HEPARANASE INHIBITOR; PG 545; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOACCUMULATION; CANCER CELL CULTURE; CANCER INHIBITION; CANCER MODEL; CAPILLARY DENSITY; COLONY FORMATION; CONTROLLED STUDY; DRUG TARGETING; ENDOTHELIUM CELL; ENZYME INHIBITION; FIBROBLAST; HUMAN; HUMAN CELL; HYPOXIA; METASTASIS INHIBITION; MIGRATION INHIBITION; MITOSIS INHIBITION; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL TIME; TUMOR DIFFERENTIATION;

EID: 84880070907     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-12-1123     Document Type: Article

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