-
2
-
-
34247646461
-
Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis
-
Morton JP, Mongeau ME, Klimstra DS, Morris JP, Lee YC, Kawaguchi Y et al. Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis. Proc Natl Acad Sci USA 2007; 104: 5103-5108.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 5103-5108
-
-
Morton, J.P.1
Mongeau, M.E.2
Klimstra, D.S.3
Morris, J.P.4
Lee, Y.C.5
Kawaguchi, Y.6
-
3
-
-
57049089995
-
Hedgehog signaling in development and cancer
-
Jiang J, Hui CC. Hedgehog signaling in development and cancer. Dev Cell 2008; 15: 801-812.
-
(2008)
Dev Cell
, vol.15
, pp. 801-812
-
-
Jiang, J.1
Hui, C.C.2
-
4
-
-
63149124772
-
Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
-
Tian H, Callahan CA, DuPree KJ, Darbonne WC, Ahn CP, Scales SJ et al. Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc Natl Acad Sci USA 2009; 106: 4254-4259.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 4254-4259
-
-
Tian, H.1
Callahan, C.A.2
Dupree, K.J.3
Darbonne, W.C.4
Ahn, C.P.5
Scales, S.J.6
-
5
-
-
52149119128
-
A paracrine requirement for hedgehog signalling in cancer
-
Yauch RL, Gould SE, Scales SJ, Tang T, Tian H, Ahn CP et al. A paracrine requirement for hedgehog signalling in cancer. Nature 2008; 455: 406-410.
-
(2008)
Nature
, vol.455
, pp. 406-410
-
-
Yauch, R.L.1
Gould, S.E.2
Scales, S.J.3
Tang, T.4
Tian, H.5
Ahn, C.P.6
-
6
-
-
58149506283
-
GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation
-
Nolan-Stevaux O, Lau J, Truitt ML, Chu GC, Hebrok M, Fernandez-Zapico ME et al. GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes Dev 2009; 23: 24-36.
-
(2009)
Genes Dev
, vol.23
, pp. 24-36
-
-
Nolan-Stevaux, O.1
Lau, J.2
Truitt, M.L.3
Chu, G.C.4
Hebrok, M.5
Fernandez-Zapico, M.E.6
-
7
-
-
33847052127
-
Identification of pancreatic cancer stem cells
-
Li C, Heidt DG, Dalerba P, Burant CF, Zhang L, Adsay V et al. Identification of pancreatic cancer stem cells. Cancer Res 2007; 67: 1030-1037.
-
(2007)
Cancer Res
, vol.67
, pp. 1030-1037
-
-
Li, C.1
Heidt, D.G.2
Dalerba, P.3
Burant, C.F.4
Zhang, L.5
Adsay, V.6
-
8
-
-
2942738996
-
The Hedgehog response network: Sensors, switches, and routers
-
Lum L, Beachy PA. The Hedgehog response network: sensors, switches, and routers. Science 2004; 304: 1755-1759.
-
(2004)
Science
, vol.304
, pp. 1755-1759
-
-
Lum, L.1
Beachy, P.A.2
-
9
-
-
2942742564
-
Novel lipid modifications of secreted protein signals
-
Mann RK, Beachy PA. Novel lipid modifications of secreted protein signals. Annu Rev Biochem 2004; 73: 891-923.
-
(2004)
Annu Rev Biochem
, vol.73
, pp. 891-923
-
-
Mann, R.K.1
Beachy, P.A.2
-
10
-
-
51949097274
-
Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog
-
Buglino JA, Resh MD. Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog. J Biol Chem 2008; 283: 22076-22088.
-
(2008)
J Biol Chem
, vol.283
, pp. 22076-22088
-
-
Buglino, J.A.1
Resh, M.D.2
-
11
-
-
27644441955
-
Differential range and activity of various forms of the Hedgehog protein
-
Dawber RJ, Hebbes S, Herpers B, Docquier F, van den Heuvel M. Differential range and activity of various forms of the Hedgehog protein. BMC Dev Biol 2005; 5: 21.
-
(2005)
BMC Dev Biol
, vol.5
, pp. 21
-
-
Dawber, R.J.1
Hebbes, S.2
Herpers, B.3
Docquier, F.4
Van Den Heuvel, M.5
-
12
-
-
1842853184
-
Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates
-
Chen MH, Li YJ, Kawakami T, Xu SM, Chuang PT. Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev 2004; 18: 641-659.
-
(2004)
Genes Dev
, vol.18
, pp. 641-659
-
-
Chen, M.H.1
Li, Y.J.2
Kawakami, T.3
Xu, S.M.4
Chuang, P.T.5
-
13
-
-
84875424307
-
Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling
-
Petrova E, Rios-Esteves J, Ouerfelli O, Glickman JF, Resh MD. Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling. Nat Chem Biol 2013; 9: 247-249.
-
(2013)
Nat Chem Biol
, vol.9
, pp. 247-249
-
-
Petrova, E.1
Rios-Esteves, J.2
Ouerfelli, O.3
Glickman, J.F.4
Resh, M.D.5
-
14
-
-
0242270878
-
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
-
Thayer SP, di Magliano MP, Heiser PW, Nielsen CM, Roberts DJ, Lauwers GY et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 2003; 425: 851-856.
-
(2003)
Nature
, vol.425
, pp. 851-856
-
-
Thayer, S.P.1
Di Magliano, M.P.2
Heiser, P.W.3
Nielsen, C.M.4
Roberts, D.J.5
Lauwers, G.Y.6
-
15
-
-
4644250693
-
Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway
-
Wu X, Walker J, Zhang J, Ding S, Schultz PG. Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. Chem Biol 2004; 11: 1229-1238.
-
(2004)
Chem Biol
, vol.11
, pp. 1229-1238
-
-
Wu, X.1
Walker, J.2
Zhang, J.3
Ding, S.4
Schultz, P.G.5
-
16
-
-
0242268525
-
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
-
Berman DM, Karhadkar SS, Maitra A, Montes De Oca R, Gerstenblith MR, Briggs K et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 2003; 425: 846-851.
-
(2003)
Nature
, vol.425
, pp. 846-851
-
-
Berman, D.M.1
Karhadkar, S.S.2
Maitra, A.3
Montes De Oca, R.4
Gerstenblith, M.R.5
Briggs, K.6
-
17
-
-
77956292749
-
Discovery of NVP-LDE225, a potent and selective smoothened antagonist
-
Pan S, Wu X, Jiang J, Gao W, Wan Y, Cheng D et al. Discovery of NVP-LDE225, a potent and selective smoothened antagonist. ACS Medicinal Chemistry Letters 2010; 1: 130-134.
-
(2010)
ACS Medicinal Chemistry Letters
, vol.1
, pp. 130-134
-
-
Pan, S.1
Wu, X.2
Jiang, J.3
Gao, W.4
Wan, Y.5
Cheng, D.6
-
18
-
-
33751549095
-
Targeting the Hedgehog pathway in cancer
-
Rubin LL, de Sauvage FJ. Targeting the Hedgehog pathway in cancer. Nat Rev Drug Discov 2006; 5: 1026-1033.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 1026-1033
-
-
Rubin, L.L.1
De Sauvage, F.J.2
-
19
-
-
67149143399
-
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 2009; 324: 1457-1461.
-
(2009)
Science
, vol.324
, pp. 1457-1461
-
-
Olive, K.P.1
Jacobetz, M.A.2
Davidson, C.J.3
Gopinathan, A.4
McIntyre, D.5
Honess, D.6
-
20
-
-
79960340656
-
Topical treatment of Basal cell carcinomas in nevoid Basal cell carcinoma syndrome with a smoothened inhibitor
-
Skvara H, Kalthoff F, Meingassner JG, Wolff-Winiski B, Aschauer H, Kelleher JF et al. Topical treatment of Basal cell carcinomas in nevoid Basal cell carcinoma syndrome with a smoothened inhibitor. J Invest Dermatol 2011; 131: 1735-1744.
-
(2011)
J Invest Dermatol
, vol.131
, pp. 1735-1744
-
-
Skvara, H.1
Kalthoff, F.2
Meingassner, J.G.3
Wolff-Winiski, B.4
Aschauer, H.5
Kelleher, J.F.6
-
21
-
-
84871114929
-
Identification of N-terminal residues of Sonic Hedgehog important for palmitoylation by Hedgehog acyltransferase
-
Hardy RY, Resh MD. Identification of N-terminal residues of Sonic Hedgehog important for palmitoylation by Hedgehog acyltransferase. J Biol Chem 2012; 287: 42881-42889.
-
(2012)
J Biol Chem
, vol.287
, pp. 42881-42889
-
-
Hardy, R.Y.1
Resh, M.D.2
-
22
-
-
31744439979
-
Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion
-
Miura GI, Buglino J, Alvarado D, Lemmon MA, Resh MD, Treisman JE. Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion. Dev Cell 2006; 10: 167-176.
-
(2006)
Dev Cell
, vol.10
, pp. 167-176
-
-
Miura, G.I.1
Buglino, J.2
Alvarado, D.3
Lemmon, M.A.4
Resh, M.D.5
Treisman, J.E.6
-
23
-
-
77955420936
-
Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer
-
Barakat MT, Humke EW, Scott MP. Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer. Trends Mol Med 2010; 16: 337-348.
-
(2010)
Trends Mol Med
, vol.16
, pp. 337-348
-
-
Barakat, M.T.1
Humke, E.W.2
Scott, M.P.3
-
24
-
-
77950647110
-
Small-molecule inhibitors of the hedgehog signaling pathway as cancer therapeutics
-
Peukert S, Miller-Moslin K. Small-molecule inhibitors of the hedgehog signaling pathway as cancer therapeutics. ChemMedChem 2010; 5: 500-512.
-
(2010)
Chem Med Chem
, vol.5
, pp. 500-512
-
-
Peukert, S.1
Miller-Moslin, K.2
-
25
-
-
79960935826
-
Hedgehog fights back: Mechanisms of acquired resistance against Smoothened antagonists
-
Metcalfe C, de Sauvage FJ. Hedgehog fights back: mechanisms of acquired resistance against Smoothened antagonists. Cancer Res 2011; 71: 5057-5061.
-
(2011)
Cancer Res
, vol.71
, pp. 5057-5061
-
-
Metcalfe, C.1
De Sauvage, F.J.2
-
26
-
-
84877583655
-
The Hedgehog processing pathway is required for NSCLC growth and survival
-
Rodriguez-Blanco J, Schilling NS, Tokhunts R, Giambelli C, Long J, Liang Fei D et al. The Hedgehog processing pathway is required for NSCLC growth and survival. Oncogene 2013; 32: 2335-2345.
-
(2013)
Oncogene
, vol.32
, pp. 2335-2345
-
-
Rodriguez-Blanco, J.1
Schilling, N.S.2
Tokhunts, R.3
Giambelli, C.4
Long, J.5
Liang Fei, D.6
-
27
-
-
0035940498
-
Sonic hedgehog restricts adhesion and migration of neural crest cells independently of the Patched-Smoothened-Gli signaling pathway
-
Testaz S, Jarov A, Williams KP, Ling LE, Koteliansky VE, Fournier-Thibault C et al. Sonic hedgehog restricts adhesion and migration of neural crest cells independently of the Patched-Smoothened-Gli signaling pathway. Proc Natl Acad Sci USA 2001; 98: 12521-12526.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 12521-12526
-
-
Testaz, S.1
Jarov, A.2
Williams, K.P.3
Ling, L.E.4
Koteliansky, V.E.5
Fournier-Thibault, C.6
-
28
-
-
77951932085
-
Hedgehog proteins activate proangiogenic responses in endothelial cells through non-canonical signaling pathways
-
Chinchilla P, Xiao L, Kazanietz MG, Riobo NA. Hedgehog proteins activate proangiogenic responses in endothelial cells through non-canonical signaling pathways. Cell Cycle 2010; 9: 570-579.
-
(2010)
Cell Cycle
, vol.9
, pp. 570-579
-
-
Chinchilla, P.1
Xiao, L.2
Kazanietz, M.G.3
Riobo, N.A.4
-
29
-
-
77955293319
-
Identification of conserved regions and residues within Hedgehog acyltransferase critical for palmitoylation of Sonic Hedgehog
-
Buglino JA, Resh MD. Identification of conserved regions and residues within Hedgehog acyltransferase critical for palmitoylation of Sonic Hedgehog. PLoS One 2010; 5: e11195.
-
(2010)
PLoS One
, vol.5
, pp. e11195
-
-
Buglino, J.A.1
Resh, M.D.2
|