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Volumn 2, Issue 12, 2012, Pages

The VEGF pathway in cancer and disease: Responses, resistance, and the path forward

Author keywords

[No Author keywords available]

Indexed keywords

AFLIBERCEPT; ANGIOGENESIS INHIBITOR; AXITINIB; BEVACIZUMAB; CAPECITABINE; CEDIRANIB; FLUOROURACIL; FOLINIC ACID; HUMV833; INTERFERON; JNJ 26483327; MIDOSTAURIN; MOTESANIB; OXALIPLATIN; PACLITAXEL; PAZOPANIB; PEGAPTANIB; PEGAPTANIB APTAMER; RANIBIZUMAB; SEMAXANIB; SORAFENIB; SUNITINIB; TANDUTINIB; TELATINIB; TRAP EYE; UNCLASSIFIED DRUG; VANDETANIB; VASCULOTROPIN; VASCULOTROPIN A; VASCULOTROPIN B; VASCULOTROPIN C; VASCULOTROPIN D; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VATALANIB; CYTOKINE;

EID: 84877296919     PISSN: None     EISSN: 21571422     Source Type: Journal    
DOI: 10.1101/cshperspect.a006593     Document Type: Article
Times cited : (180)

References (195)
  • 1
    • 11244349115 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) inhibition by small molecules
    • Ahmed SI, Thomas AL, Steward WP. 2004. Vascular endothelial growth factor (VEGF) inhibition by small molecules. J Chemother 16: 59-63.
    • (2004) J Chemother , vol.16 , pp. 59-63
    • Ahmed, S.I.1    Thomas, A.L.2    Steward, W.P.3
  • 2
    • 67650742630 scopus 로고    scopus 로고
    • Role of endothelial progenitors and other bone marrow-derived cells in the development of the tumor vasculature
    • Ahn GO, Brown JM. 2009. Role of endothelial progenitors and other bone marrow-derived cells in the development of the tumor vasculature. Angiogenesis 12: 159-164.
    • (2009) Angiogenesis , vol.12 , pp. 159-164
    • Ahn, G.O.1    Brown, J.M.2
  • 4
    • 74549205168 scopus 로고    scopus 로고
    • Vandetanib, designed to inhibit VEGFR2 and EGFR signaling, had no clinical activity as monotherapy for recurrent ovarian cancer and no detectable modulation of VEGFR2
    • Annunziata CM, Walker AJ, Minasian L, Yu M, Kotz H, Wood BJ, Calvo K, Choyke P, Kimm D, Steinberg SM, et al. 2010. Vandetanib, designed to inhibit VEGFR2 and EGFR signaling, had no clinical activity as monotherapy for recurrent ovarian cancer and no detectable modulation of VEGFR2. Clin Cancer Res 16: 664-672.
    • (2010) Clin Cancer Res , vol.16 , pp. 664-672
    • Annunziata, C.M.1    Walker, A.J.2    Minasian, L.3    Yu, M.4    Kotz, H.5    Wood, B.J.6    Calvo, K.7    Choyke, P.8    Kimm, D.9    Steinberg, S.M.10
  • 5
    • 34548262708 scopus 로고    scopus 로고
    • Pegaptanib 1-year systemic safety results from a safety-pharmacokinetic trial in patients with neovascular age-related macular degeneration
    • Apte RS, Modi M, Masonson H, Patel M, Whitfield L, Adamis AP. 2007. Pegaptanib 1-year systemic safety results from a safety-pharmacokinetic trial in patients with neovascular age-related macular degeneration. Ophthalmology 114: 1702-1712.
    • (2007) Ophthalmology , vol.114 , pp. 1702-1712
    • Apte, R.S.1    Modi, M.2    Masonson, H.3    Patel, M.4    Whitfield, L.5    Adamis, A.P.6
  • 6
    • 34948844052 scopus 로고    scopus 로고
    • Phase II study of vandetanib or placebo in small-cell lung cancer patients after complete or partial response to induction chemotherapy with or without radiation therapy: National Cancer Institute of Canada Clinical Trials Group Study BR. 20
    • Arnold AM, Seymour L, Smylie M, Ding K, Ung Y, Findlay B, Lee CW, Djurfeldt M, Whitehead M, Ellis P, et al. 2007. Phase II study of vandetanib or placebo in small-cell lung cancer patients after complete or partial response to induction chemotherapy with or without radiation therapy: National Cancer Institute of Canada Clinical Trials Group Study BR. 20. J Clin Oncol 25: 4278-4284.
    • (2007) J Clin Oncol , vol.25 , pp. 4278-4284
    • Arnold, A.M.1    Seymour, L.2    Smylie, M.3    Ding, K.4    Ung, Y.5    Findlay, B.6    Lee, C.W.7    Djurfeldt, M.8    Whitehead, M.9    Ellis, P.10
  • 7
    • 77954200948 scopus 로고    scopus 로고
    • Posterior reversible encephalopathy syndrome after intravitreal bevacizumab injection in patient with choroidal neovascular membrane secondary to age-related maculopathy
    • Artunay O, Yuzbasioglu E, Rasier R, Sengul A, Bahcecioglu H. 2010. Posterior reversible encephalopathy syndrome after intravitreal bevacizumab injection in patient with choroidal neovascular membrane secondary to age-related maculopathy. J Ocul Pharmacol Ther 26: 301-303.
    • (2010) J Ocul Pharmacol Ther , vol.26 , pp. 301-303
    • Artunay, O.1    Yuzbasioglu, E.2    Rasier, R.3    Sengul, A.4    Bahcecioglu, H.5
  • 8
    • 77951667987 scopus 로고    scopus 로고
    • Mechanisms of resistance to antiangiogenesis therapy
    • Azam F, Mehta S, Harris AL. 2010. Mechanisms of resistance to antiangiogenesis therapy. Eur J Cancer 46: 1323-1332.
    • (2010) Eur J Cancer , vol.46 , pp. 1323-1332
    • Azam, F.1    Mehta, S.2    Harris, A.L.3
  • 9
    • 33751413349 scopus 로고    scopus 로고
    • A review of the latest clinical compounds to inhibit VEGF in pathological angiogenesis
    • Baka S, Clamp AR, Jayson GC. 2006. A review of the latest clinical compounds to inhibit VEGF in pathological angiogenesis. Expert Opin Ther Targets 10: 867-876.
    • (2006) Expert Opin Ther Targets , vol.10 , pp. 867-876
    • Baka, S.1    Clamp, A.R.2    Jayson, G.C.3
  • 10
    • 19544361854 scopus 로고    scopus 로고
    • Bi-directional interactions of prostate cancer cells and bone marrow endothelial cells in three-dimensional culture
    • Barrett JM, Mangold KA, Jilling T, Kaul KL. 2005. Bi-directional interactions of prostate cancer cells and bone marrow endothelial cells in three-dimensional culture. Prostate 64: 75-82.
    • (2005) Prostate , vol.64 , pp. 75-82
    • Barrett, J.M.1    Mangold, K.A.2    Jilling, T.3    Kaul, K.L.4
  • 13
    • 0028788710 scopus 로고
    • Vascular endothelial growth factor (VEGF) mRNA expression in human tumor models of different histologies
    • Berger DP, Herbstritt L, Dengler WA, Marme D, Mertelsmann R, Fiebig HH. 1995. Vascular endothelial growth factor (VEGF) mRNA expression in human tumor models of different histologies. Ann Oncol 6: 817-825.
    • (1995) Ann Oncol , vol.6 , pp. 817-825
    • Berger, D.P.1    Herbstritt, L.2    Dengler, W.A.3    Marme, D.4    Mertelsmann, R.5    Fiebig, H.H.6
  • 14
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G, Hanahan D. 2008. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 8: 592-603.
    • (2008) Nat Rev Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 16
    • 77955123488 scopus 로고    scopus 로고
    • A phase I study of Vandetanib in combination with vinorelbine/cisplatin or gemcitabine/cisplatin as first-line treatment for advanced non-small cell lung cancer
    • Blackhall FH, O'Brien M, Schmid P, Nicolson M, Taylor P, Milenkova T, Kennedy SJ, Thatcher N. 2010. A phase I study of Vandetanib in combination with vinorelbine/cisplatin or gemcitabine/cisplatin as first-line treatment for advanced non-small cell lung cancer. J Thorac Oncol 5: 1285-1288.
    • (2010) J Thorac Oncol , vol.5 , pp. 1285-1288
    • Blackhall, F.H.1    O'Brien, M.2    Schmid, P.3    Nicolson, M.4    Taylor, P.5    Milenkova, T.6    Kennedy, S.J.7    Thatcher, N.8
  • 17
    • 0031469819 scopus 로고    scopus 로고
    • Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance [see comments]
    • Boehm T, Folkman J, Browder T, O'Reilly MS. 1997. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance [see comments]. Nature 390: 404-407.
    • (1997) Nature , vol.390 , pp. 404-407
    • Boehm, T.1    Folkman, J.2    Browder, T.3    O'Reilly, M.S.4
  • 18
    • 77951879926 scopus 로고    scopus 로고
    • Antiangiogenic drugs in oncology: A focus on drug safety and the elderly-A mini-review
    • Boehm S, Rothermundt C, Hess D, Joerger M. 2010. Antiangiogenic drugs in oncology: A focus on drug safety and the elderly-A mini-review. Gerontology 56: 303-309.
    • (2010) Gerontology , vol.56 , pp. 303-309
    • Boehm, S.1    Rothermundt, C.2    Hess, D.3    Joerger, M.4
  • 19
    • 69249222585 scopus 로고    scopus 로고
    • A Phase IIIb study to evaluate the safety of ranibizumab in subjects with neovascular age-related macular degeneration
    • Boyer DS, Heier JS, Brown DM, Francom SF, Ianchulev T, Rubio RG. 2009. A Phase IIIb study to evaluate the safety of ranibizumab in subjects with neovascular age-related macular degeneration. Ophthalmology 116: 1731-1739.
    • (2009) Ophthalmology , vol.116 , pp. 1731-1739
    • Boyer, D.S.1    Heier, J.S.2    Brown, D.M.3    Francom, S.F.4    Ianchulev, T.5    Rubio, R.G.6
  • 21
    • 38949162167 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled phase II trial of maintenance sunitinib versus placebo after chemotherapy for patients with advanced urothelial carcinoma: Scientific rationale and study design
    • Bradley DA, Dunn R, Nanus D, Stadler W, Dreicer R, Rosenberg J, Smith DC, Hussain M. 2007. Randomized, double-blind, placebo-controlled phase II trial of maintenance sunitinib versus placebo after chemotherapy for patients with advanced urothelial carcinoma: Scientific rationale and study design. Clin Genitourin Cancer 5: 460-463.
    • (2007) Clin Genitourin Cancer , vol.5 , pp. 460-463
    • Bradley, D.A.1    Dunn, R.2    Nanus, D.3    Stadler, W.4    Dreicer, R.5    Rosenberg, J.6    Smith, D.C.7    Hussain, M.8
  • 22
    • 72449155176 scopus 로고    scopus 로고
    • EORTC study 26041-22041: Phase I/II study on concomitant and adjuvant temozolomide (TMZ) and radiotherapy (RT) with PTK787/ZK222584 (PTK/ZK) in newly diagnosed glioblastoma
    • Brandes AA, Stupp R, Hau P, Lacombe D, Gorlia T, Tosoni A, Mirimanoff RO, KrosJM, van den Bent MJ. 2010. EORTC study 26041-22041: Phase I/II study on concomitant and adjuvant temozolomide (TMZ) and radiotherapy (RT) with PTK787/ZK222584 (PTK/ZK) in newly diagnosed glioblastoma. Eur J Cancer 46: 348-354.
    • (2010) Eur J Cancer , vol.46 , pp. 348-354
    • Brandes, A.A.1    Stupp, R.2    Hau, P.3    Lacombe, D.4    Gorlia, T.5    Tosoni, A.6    Mirimanoff, R.O.7    Kros, J.M.8    van den Bent, M.J.9
  • 23
    • 58449085584 scopus 로고    scopus 로고
    • Improved vision-related function after ranibizumab vs photodynamic therapy: A randomized clinical trial
    • Bressler NM, Chang TS, Fine JT, Dolan CM, Ward J. 2009. Improved vision-related function after ranibizumab vs photodynamic therapy: A randomized clinical trial. Arch Ophthalmol 127: 13-21.
    • (2009) Arch Ophthalmol , vol.127 , pp. 13-21
    • Bressler, N.M.1    Chang, T.S.2    Fine, J.T.3    Dolan, C.M.4    Ward, J.5
  • 25
    • 57949094834 scopus 로고    scopus 로고
    • Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: Two-year results of the ANCHOR study
    • Brown DM, Michels M, Kaiser PK, Heier JS, Sy JP, Ianchulev T. 2009. Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: Two-year results of the ANCHOR study. Ophthalmology 116: 57-65.
    • (2009) Ophthalmology , vol.116 , pp. 57-65
    • Brown, D.M.1    Michels, M.2    Kaiser, P.K.3    Heier, J.S.4    Sy, J.P.5    Ianchulev, T.6
  • 26
    • 67651227774 scopus 로고    scopus 로고
    • Targeted therapies: Bevacizumab and interferon-α in metastatic renal-cell carcinoma
    • Bukowski RM. 2009. Targeted therapies: Bevacizumab and interferon-α in metastatic renal-cell carcinoma. Nat Rev Clin Oncol 6: 253-254.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 253-254
    • Bukowski, R.M.1
  • 27
    • 36849019301 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: A Gynecologic Oncology Group Study
    • Burger RA, Sill MW, Monk BJ, Greer BE, Sorosky JI. 2007. Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: A Gynecologic Oncology Group Study. J Clin Oncol 25: 5165-5171.
    • (2007) J Clin Oncol , vol.25 , pp. 5165-5171
    • Burger, R.A.1    Sill, M.W.2    Monk, B.J.3    Greer, B.E.4    Sorosky, J.I.5
  • 28
    • 42949148257 scopus 로고    scopus 로고
    • Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane
    • Burstein HJ, Elias AD, Rugo HS, Cobleigh MA, Wolff AC, Eisenberg PD, Lehman M, Adams BJ, Bello CL, DePrimo SE, et al. 2008. Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane. J Clin Oncol 26: 1810-1816.
    • (2008) J Clin Oncol , vol.26 , pp. 1810-1816
    • Burstein, H.J.1    Elias, A.D.2    Rugo, H.S.3    Cobleigh, M.A.4    Wolff, A.C.5    Eisenberg, P.D.6    Lehman, M.7    Adams, B.J.8    Bello, C.L.9    DePrimo, S.E.10
  • 29
    • 77952891051 scopus 로고    scopus 로고
    • Ranibizumab for macular edema following branch retinal vein occlusion: Six-month primary end point results of a phase III study
    • Campochiaro PA, Heier JS, Feiner L, Gray S, Saroj N, Rundle AC, Murahashi WY, Rubio RG. 2010. Ranibizumab for macular edema following branch retinal vein occlusion: Six-month primary end point results of a phase III study. Ophthalmology 117: 1102-1112.
    • (2010) Ophthalmology , vol.117 , pp. 1102-1112
    • Campochiaro, P.A.1    Heier, J.S.2    Feiner, L.3    Gray, S.4    Saroj, N.5    Rundle, A.C.6    Murahashi, W.Y.7    Rubio, R.G.8
  • 30
    • 63849261238 scopus 로고    scopus 로고
    • Tumor angiogenesis and molecular targets for therapy
    • Cao Y. 2009. Tumor angiogenesis and molecular targets for therapy. Front Biosci 14: 3962-3973.
    • (2009) Front Biosci , vol.14 , pp. 3962-3973
    • Cao, Y.1
  • 31
    • 60549112008 scopus 로고    scopus 로고
    • Antiangiogenic therapy for metastatic breast cancer: Current status and future directions
    • Chan A. 2009. Antiangiogenic therapy for metastatic breast cancer: Current status and future directions. Drugs 69: 167-181.
    • (2009) Drugs , vol.69 , pp. 167-181
    • Chan, A.1
  • 32
    • 44649151405 scopus 로고    scopus 로고
    • Axitinib, a novel anti-angiogenic drug with promising activity in various solid tumors
    • Choueiri TK. 2008. Axitinib, a novel anti-angiogenic drug with promising activity in various solid tumors. Curr Opin Investig Drugs 9: 658-671.
    • (2008) Curr Opin Investig Drugs , vol.9 , pp. 658-671
    • Choueiri, T.K.1
  • 33
    • 65549162660 scopus 로고    scopus 로고
    • Antivascular endothelial growth factor therapy for neovascular age-related macular degeneration
    • Ciulla TA, Rosenfeld PJ. 2009. Antivascular endothelial growth factor therapy for neovascular age-related macular degeneration. Curr Opin Ophthalmol 20: 158-165.
    • (2009) Curr Opin Ophthalmol , vol.20 , pp. 158-165
    • Ciulla, T.A.1    Rosenfeld, P.J.2
  • 35
    • 75449088610 scopus 로고    scopus 로고
    • FDA drug approval summary: Bevacizumab (Avastin) as treatment of recurrent glioblastoma multiforme
    • Cohen MH, Shen YL, Keegan P, Pazdur R. 2009b. FDA drug approval summary: Bevacizumab (Avastin) as treatment of recurrent glioblastoma multiforme. Oncologist 14: 1131-1138.
    • (2009) Oncologist , vol.14 , pp. 1131-1138
    • Cohen, M.H.1    Shen, Y.L.2    Keegan, P.3    Pazdur, R.4
  • 38
    • 45449098532 scopus 로고    scopus 로고
    • The evolving role of vascular endothelial growth factor inhibitors in the treatment of neovascular age-related macular degeneration
    • Dadgostar H, Waheed N. 2008. The evolving role of vascular endothelial growth factor inhibitors in the treatment of neovascular age-related macular degeneration. Eye (Lond) 22: 761-767.
    • (2008) Eye (Lond) , vol.22 , pp. 761-767
    • Dadgostar, H.1    Waheed, N.2
  • 40
    • 59649110012 scopus 로고    scopus 로고
    • Transcriptional control of endothelial cell development
    • De Val S, Black BL. 2009. Transcriptional control of endothelial cell development. Dev Cell 16: 180-195.
    • (2009) Dev Cell , vol.16 , pp. 180-195
    • De Val, S.1    Black, B.L.2
  • 45
    • 27944442568 scopus 로고    scopus 로고
    • Angiogenesis: Update 2005
    • Dvorak HF. 2005. Angiogenesis: Update 2005. J Thromb Haemost 3: 1835-1842.
    • (2005) J Thromb Haemost , vol.3 , pp. 1835-1842
    • Dvorak, H.F.1
  • 47
    • 70249129087 scopus 로고    scopus 로고
    • Phase I dose escalation study of telatinib, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2 and 3, platelet-derived growth factor receptor β, and c-Kit, in patients with advanced or metastatic solid tumors
    • Eskens FA, Steeghs N, Verweij J, Bloem JL, Christensen O, van Doorn L, Ouwerkerk J, de Jonge MJ, Nortier JW, Kraetzschmar J, et al. 2009. Phase I dose escalation study of telatinib, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2 and 3, platelet-derived growth factor receptor β, and c-Kit, in patients with advanced or metastatic solid tumors. J Clin Oncol 27: 4169-4176.
    • (2009) J Clin Oncol , vol.27 , pp. 4169-4176
    • Eskens, F.A.1    Steeghs, N.2    Verweij, J.3    Bloem, J.L.4    Christensen, O.5    van Doorn, L.6    Ouwerkerk, J.7    de Jonge, M.J.8    Nortier, J.W.9    Kraetzschmar, J.10
  • 49
    • 34548316976 scopus 로고    scopus 로고
    • Molecular basis for sunitinib efficacy and future clinical development
    • Faivre S, Demetri G, Sargent W, Raymond E. 2007. Molecular basis for sunitinib efficacy and future clinical development. Nat Rev Drug Discov 6: 734-745.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 734-745
    • Faivre, S.1    Demetri, G.2    Sargent, W.3    Raymond, E.4
  • 50
    • 0024384470 scopus 로고
    • Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
    • Ferrara N, Henzel WJ. 1989. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 161: 851-858.
    • (1989) Biochem Biophys Res Commun , vol.161 , pp. 851-858
    • Ferrara, N.1    Henzel, W.J.2
  • 51
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. 2003. The biology of VEGF and its receptors. Nat Med 9: 669-676.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 53
    • 19944431093 scopus 로고    scopus 로고
    • A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease
    • Fiedler W, Serve H, Dohner H, Schwittay M, Ottmann OG, O'Farrell AM, Bello CL, Allred R, Manning WC, Cherrington JM, et al. 2005. A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease. Blood 105: 986-993.
    • (2005) Blood , vol.105 , pp. 986-993
    • Fiedler, W.1    Serve, H.2    Dohner, H.3    Schwittay, M.4    Ottmann, O.G.5    O'Farrell, A.M.6    Bello, C.L.7    Allred, R.8    Manning, W.C.9    Cherrington, J.M.10
  • 55
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. 1971. Tumor angiogenesis: Therapeutic implications. N Engl J Med 285: 1182-1186.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 56
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman J. 1995. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1: 27-31.
    • (1995) Nat Med , vol.1 , pp. 27-31
    • Folkman, J.1
  • 61
    • 78649978359 scopus 로고    scopus 로고
    • Safety of bevacizumab in patients with advanced cancer: A meta-analysis of randomized controlled trials
    • Geiger-Gritsch S, Stollenwerk B, Miksad R, Guba B, Wild C, Siebert U. 2010. Safety of bevacizumab in patients with advanced cancer: A meta-analysis of randomized controlled trials. Oncologist 15: 1179-1191.
    • (2010) Oncologist , vol.15 , pp. 1179-1191
    • Geiger-Gritsch, S.1    Stollenwerk, B.2    Miksad, R.3    Guba, B.4    Wild, C.5    Siebert, U.6
  • 63
    • 0345270394 scopus 로고    scopus 로고
    • Phase II study of SU5416-a small-molecule, vascular endothelial growth factor tyrosine-kinase receptor inhibitor-in patients with refractory myeloproliferative diseases
    • Giles FJ, Cooper MA, Silverman L, Karp JE, Lancet JE, Zangari M, Shami PJ, KhanKD, Hannah AL, Cherrington JM, et al. 2003a. Phase II study of SU5416-a small-molecule, vascular endothelial growth factor tyrosine-kinase receptor inhibitor-in patients with refractory myeloproliferative diseases. Cancer 97: 1920-1928.
    • (2003) Cancer , vol.97 , pp. 1920-1928
    • Giles, F.J.1    Cooper, M.A.2    Silverman, L.3    Karp, J.E.4    Lancet, J.E.5    Zangari, M.6    Shami, P.J.7    Khan, K.D.8    Hannah, A.L.9    Cherrington, J.M.10
  • 64
  • 65
    • 34249826968 scopus 로고    scopus 로고
    • PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor of vascular endothelial growth factor (VEGF), has modest activity in myelofibrosis with myeloid metaplasia
    • Giles FJ, List AF, Carroll M, Cortes JE, Valickas J, Chen BL, Masson E, Jacques C, Laurent D, Albitar M, et al. 2007. PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor of vascular endothelial growth factor (VEGF), has modest activity in myelofibrosis with myeloid metaplasia. Leuk Res 31: 891-897.
    • (2007) Leuk Res , vol.31 , pp. 891-897
    • Giles, F.J.1    List, A.F.2    Carroll, M.3    Cortes, J.E.4    Valickas, J.5    Chen, B.L.6    Masson, E.7    Jacques, C.8    Laurent, D.9    Albitar, M.10
  • 67
    • 70450175957 scopus 로고    scopus 로고
    • Targeting angiogenesis: Progress with anti-VEGF treatment with large molecules
    • Grothey A, Galanis E. 2009. Targeting angiogenesis: Progress with anti-VEGF treatment with large molecules. Nat Rev Clin Oncol 6: 507-518.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 507-518
    • Grothey, A.1    Galanis, E.2
  • 68
    • 28444434771 scopus 로고    scopus 로고
    • Regulatory aspects of drug approval for macular degeneration
    • Gryziewicz L. 2005. Regulatory aspects of drug approval for macular degeneration. Adv Drug Deliv Rev 57: 2092-2098.
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 2092-2098
    • Gryziewicz, L.1
  • 70
    • 33645014406 scopus 로고    scopus 로고
    • Review of the effects of anti-angiogenic compounds on the epiphyseal growth plate
    • Hall AP, Westwood FR, Wadsworth PF. 2006. Review of the effects of anti-angiogenic compounds on the epiphyseal growth plate. Toxicol Pathol 34: 131-147.
    • (2006) Toxicol Pathol , vol.34 , pp. 131-147
    • Hall, A.P.1    Westwood, F.R.2    Wadsworth, P.F.3
  • 71
    • 66149121478 scopus 로고    scopus 로고
    • Risk of gastrointestinal perforation in patients with cancer treated with bevacizumab: A meta-analysis
    • Hapani S, Chu D, Wu S. 2009. Risk of gastrointestinal perforation in patients with cancer treated with bevacizumab: A meta-analysis. Lancet Oncol 10: 559-568.
    • (2009) Lancet Oncol , vol.10 , pp. 559-568
    • Hapani, S.1    Chu, D.2    Wu, S.3
  • 72
    • 78049382933 scopus 로고    scopus 로고
    • Increased risk of serious hemorrhage with bevacizumab in cancer patients: A meta-analysis
    • Hapani S, Sher A, Chu D, Wu S. 2010. Increased risk of serious hemorrhage with bevacizumab in cancer patients: A meta-analysis. Oncology 79: 27-38.
    • (2010) Oncology , vol.79 , pp. 27-38
    • Hapani, S.1    Sher, A.2    Chu, D.3    Wu, S.4
  • 73
    • 0038143145 scopus 로고    scopus 로고
    • Vasculogenic mimicry and tumour-cell plasticity: Lessons from melanoma
    • Hendrix MJ, Seftor EA, Hess AR, Seftor RE. 2003. Vasculogenic mimicry and tumour-cell plasticity: Lessons from melanoma. Nat Rev Cancer 3: 411-421.
    • (2003) Nat Rev Cancer , vol.3 , pp. 411-421
    • Hendrix, M.J.1    Seftor, E.A.2    Hess, A.R.3    Seftor, R.E.4
  • 74
    • 77954035012 scopus 로고    scopus 로고
    • Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): A double-blind, randomised, phase 3 trial
    • Herbst RS, Sun Y, Eberhardt WE, Germonpre P, Saijo N, Zhou C, Wang J, Li L, Kabbinavar F, Ichinose Y, et al. 2010. Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): A double-blind, randomised, phase 3 trial. Lancet Oncol 11: 619-626.
    • (2010) Lancet Oncol , vol.11 , pp. 619-626
    • Herbst, R.S.1    Sun, Y.2    Eberhardt, W.E.3    Germonpre, P.4    Saijo, N.5    Zhou, C.6    Wang, J.7    Li, L.8    Kabbinavar, F.9    Ichinose, Y.10
  • 79
    • 34447108810 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Biology and therapeutic applications
    • Ho QT, Kuo CJ. 2007. Vascular endothelial growth factor: Biology and therapeutic applications. Int J Biochem Cell Biol 39: 1349-1357.
    • (2007) Int J Biochem Cell Biol , vol.39 , pp. 1349-1357
    • Ho, Q.T.1    Kuo, C.J.2
  • 80
    • 33645148035 scopus 로고    scopus 로고
    • A Phase I study of escalating doses of the tyrosine kinase inhibitor semaxanib (SU5416) in combination with irinotecan in patients with advanced colorectal carcinoma
    • Hoff PM, Wolff RA, Bogaard K, Waldrum S, Abbruzzese JL. 2006. A Phase I study of escalating doses of the tyrosine kinase inhibitor semaxanib (SU5416) in combination with irinotecan in patients with advanced colorectal carcinoma. Jpn J Clin Oncol 36: 100-103.
    • (2006) Jpn J Clin Oncol , vol.36 , pp. 100-103
    • Hoff, P.M.1    Wolff, R.A.2    Bogaard, K.3    Waldrum, S.4    Abbruzzese, J.L.5
  • 82
    • 66249113517 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled phase II study of vandetanib plus docetaxel/prednisolone in patients with hormone-refractory prostate cancer
    • Horti J, Widmark A, Stenzl A, Federico MH, Abratt RP, Sanders N, Pover GM, Bodrogi I. 2009. A randomized, double-blind, placebo-controlled phase II study of vandetanib plus docetaxel/prednisolone in patients with hormone-refractory prostate cancer. Cancer Biother Radiopharm 24: 175-180.
    • (2009) Cancer Biother Radiopharm , vol.24 , pp. 175-180
    • Horti, J.1    Widmark, A.2    Stenzl, A.3    Federico, M.H.4    Abratt, R.P.5    Sanders, N.6    Pover, G.M.7    Bodrogi, I.8
  • 85
    • 78149492402 scopus 로고    scopus 로고
    • Phase II trial of pazopanib (GW786034), an oral multi-targeted angiogenesis inhibitor, for adults with recurrent glioblastoma (North American Brain Tumor Consortium Study 06-02)
    • Iwamoto FM, Lamborn KR, Robins HI, Mehta MP, Chang SM, Butowski NA, Deangelis LM, Abrey LE, Zhang WT, Prados MD, et al. 2010. Phase II trial of pazopanib (GW786034), an oral multi-targeted angiogenesis inhibitor, for adults with recurrent glioblastoma (North American Brain Tumor Consortium Study 06-02). Neuro Oncol 12: 855-861.
    • (2010) Neuro Oncol , vol.12 , pp. 855-861
    • Iwamoto, F.M.1    Lamborn, K.R.2    Robins, H.I.3    Mehta, M.P.4    Chang, S.M.5    Butowski, N.A.6    Deangelis, L.M.7    Abrey, L.E.8    Zhang, W.T.9    Prados, M.D.10
  • 86
    • 34447635695 scopus 로고    scopus 로고
    • Angiogenesis inhibitor therapies: Focus on kidney toxicity and hypertension
    • Izzedine H, Rixe O, Billemont B, Baumelou A, Deray G. 2007. Angiogenesis inhibitor therapies: Focus on kidney toxicity and hypertension. Am J Kidney Dis 50: 203-218.
    • (2007) Am J Kidney Dis , vol.50 , pp. 203-218
    • Izzedine, H.1    Rixe, O.2    Billemont, B.3    Baumelou, A.4    Deray, G.5
  • 88
    • 30944446883 scopus 로고    scopus 로고
    • Lessons from phase III clinical trials on anti-VEGF therapy for cancer
    • Jain RK, Duda DG, Clark JW, Loeffler JS. 2006. Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat Clin Pract Oncol 3: 24-40.
    • (2006) Nat Clin Pract Oncol , vol.3 , pp. 24-40
    • Jain, R.K.1    Duda, D.G.2    Clark, J.W.3    Loeffler, J.S.4
  • 91
    • 34748844162 scopus 로고    scopus 로고
    • Angiographic and optical coherence tomographic results of the MARINA study of ranibizumab in neovascular age-related macular degeneration
    • Kaiser PK, Blodi BA, Shapiro H, Acharya NR. 2007a. Angiographic and optical coherence tomographic results of the MARINA study of ranibizumab in neovascular age-related macular degeneration. Ophthalmology 114: 1868-1875.
    • (2007) Ophthalmology , vol.114 , pp. 1868-1875
    • Kaiser, P.K.1    Blodi, B.A.2    Shapiro, H.3    Acharya, N.R.4
  • 92
    • 36249002808 scopus 로고    scopus 로고
    • Ranibizumab for predominantly classic neovascular age-related macular degeneration: Subgroup analysis of first-year ANCHOR results
    • Kaiser PK, Brown DM, Zhang K, Hudson HL, Holz FG, Shapiro H, Schneider S, Acharya NR. 2007b. Ranibizumab for predominantly classic neovascular age-related macular degeneration: subgroup analysis of first-year ANCHOR results. Am J Ophthalmol 144: 850-857.
    • (2007) Am J Ophthalmol , vol.144 , pp. 850-857
    • Kaiser, P.K.1    Brown, D.M.2    Zhang, K.3    Hudson, H.L.4    Holz, F.G.5    Shapiro, H.6    Schneider, S.7    Acharya, N.R.8
  • 94
    • 58449120765 scopus 로고    scopus 로고
    • New insights in vascular development: Vasculogenesis and endothelial progenitor cells
    • Kassmeyer S, Plendl J, Custodis P, Bahramsoltani M. 2009. New insights in vascular development: Vasculogenesis and endothelial progenitor cells. Anat Histol Embryol 38: 1-11.
    • (2009) Anat Histol Embryol , vol.38 , pp. 1-11
    • Kassmeyer, S.1    Plendl, J.2    Custodis, P.3    Bahramsoltani, M.4
  • 96
    • 59449108256 scopus 로고    scopus 로고
    • Phase I study of SU5416, a small molecule inhibitor of the vascular endothelial growth factor receptor (VEGFR) in refractory pediatric central nervous system tumors
    • Kieran MW, Supko JG, Wallace D, Fruscio R, Poussaint TY, Phillips P, Pollack I, Packer R, Boyett JM, Blaney S, et al. 2009. Phase I study of SU5416, a small molecule inhibitor of the vascular endothelial growth factor receptor (VEGFR) in refractory pediatric central nervous system tumors. Pediatr Blood Cancer 52: 169-176.
    • (2009) Pediatr Blood Cancer , vol.52 , pp. 169-176
    • Kieran, M.W.1    Supko, J.G.2    Wallace, D.3    Fruscio, R.4    Poussaint, T.Y.5    Phillips, P.6    Pollack, I.7    Packer, R.8    Boyett, J.M.9    Blaney, S.10
  • 98
    • 44149110127 scopus 로고    scopus 로고
    • Identification of human liver cytochrome P450 isoforms involved in autoinduced metabolism of the antiangiogenic agent (Z)-5-[(1, 2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2, 4-dimethyl-1H-pyrro le-3-propanoic acid (TSU-68)
    • Kitamura R, Asanoma H, Nagayama S, Otagiri M. 2008. Identification of human liver cytochrome P450 isoforms involved in autoinduced metabolism of the antiangiogenic agent (Z)-5-[(1, 2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2, 4-dimethyl-1H-pyrro le-3-propanoic acid (TSU-68). Drug Metab Dispos 36: 1003-1009.
    • (2008) Drug Metab Dispos , vol.36 , pp. 1003-1009
    • Kitamura, R.1    Asanoma, H.2    Nagayama, S.3    Otagiri, M.4
  • 99
    • 41749097667 scopus 로고    scopus 로고
    • A randomized, double-blind, phase IIa dose-finding study of Vandetanib (ZD6474) in Japanese patients with non-small cell lung cancer
    • Kiura K, Nakagawa K, Shinkai T, Eguchi K, Ohe Y, Yamamoto N, Tsuboi M, YokotaS, Seto T, Jiang H, et al. 2008. A randomized, double-blind, phase IIa dose-finding study of Vandetanib (ZD6474) in Japanese patients with non-small cell lung cancer. J Thorac Oncol 3: 386-393.
    • (2008) J Thorac Oncol , vol.3 , pp. 386-393
    • Kiura, K.1    Nakagawa, K.2    Shinkai, T.3    Eguchi, K.4    Ohe, Y.5    Yamamoto, N.6    Tsuboi, M.7    Yokota, S.8    Seto, T.9    Jiang, H.10
  • 100
    • 0036933684 scopus 로고    scopus 로고
    • The role of neuropilin in vascular and tumor biology
    • Klagsbrun M, Takashima S, Mamluk R. 2002. The role of neuropilin in vascular and tumor biology. Adv Exp Med Biol 515: 33-48.
    • (2002) Adv Exp Med Biol , vol.515 , pp. 33-48
    • Klagsbrun, M.1    Takashima, S.2    Mamluk, R.3
  • 102
    • 63849092341 scopus 로고    scopus 로고
    • Sunitinib treatment for patients with clear-cell metastatic renal cell carcinoma: Clinical outcomes and plasma angiogenesis markers
    • doi: 10. 1186/1471-2407-9-82
    • Kontovinis LF, Papazisis KT, Touplikioti P, Andreadis C, Mouratidou D, KortsarisAH. 2009. Sunitinib treatment for patients with clear-cell metastatic renal cell carcinoma: Clinical outcomes and plasma angiogenesis markers. BMC Cancer 9: 82. doi: 10. 1186/1471-2407-9-82.
    • (2009) BMC Cancer , vol.9 , pp. 82
    • Kontovinis, L.F.1    Papazisis, K.T.2    Touplikioti, P.3    Andreadis, C.4    Mouratidou, D.5    Kortsaris, A.H.6
  • 103
    • 33749337234 scopus 로고    scopus 로고
    • Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia
    • Kornblau SM, Womble M, Qiu YH, Jackson CE, Chen W, Konopleva M, Estey EH, Andreeff M. 2006. Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia. Blood 108: 2358-2365.
    • (2006) Blood , vol.108 , pp. 2358-2365
    • Kornblau, S.M.1    Womble, M.2    Qiu, Y.H.3    Jackson, C.E.4    Chen, W.5    Konopleva, M.6    Estey, E.H.7    Andreeff, M.8
  • 104
    • 36749080289 scopus 로고    scopus 로고
    • Ranibizumab for the treatment of neovascular age-related macular degeneration: A review
    • Kourlas H, Abrams P. 2007. Ranibizumab for the treatment of neovascular age-related macular degeneration: a review. Clin Ther 29: 1850-1861.
    • (2007) Clin Ther , vol.29 , pp. 1850-1861
    • Kourlas, H.1    Abrams, P.2
  • 105
    • 33747644424 scopus 로고    scopus 로고
    • A phase II study of ZD6474 (Zactima), a selective inhibitor of VEGFR and EGFR tyrosine kinase in patients with relapsed multiple myeloma-NCIC CTG IND. 145
    • Kovacs MJ, Reece DE, Marcellus D, Meyer RM, Mathews S, Dong RP, Eisenhauer E. 2006. A phase II study of ZD6474 (Zactima), a selective inhibitor of VEGFR and EGFR tyrosine kinase in patients with relapsed multiple myeloma-NCIC CTG IND. 145. Invest New Drugs 24: 529-535.
    • (2006) Invest New Drugs , vol.24 , pp. 529-535
    • Kovacs, M.J.1    Reece, D.E.2    Marcellus, D.3    Meyer, R.M.4    Mathews, S.5    Dong, R.P.6    Eisenhauer, E.7
  • 106
    • 33749028188 scopus 로고    scopus 로고
    • Vascular endothelial growth factor signaling pathways: Therapeutic perspective
    • Kowanetz M, Ferrara N. 2006. Vascular endothelial growth factor signaling pathways: Therapeutic perspective. Clin Cancer Res 12: 5018-5022.
    • (2006) Clin Cancer Res , vol.12 , pp. 5018-5022
    • Kowanetz, M.1    Ferrara, N.2
  • 107
    • 0038327794 scopus 로고    scopus 로고
    • Efficacy and toxicity of the angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma
    • Kuenen BC, Tabernero J, Baselga J, Cavalli F, Pfanner E, Conte PF, Seeber S, Madhusudan S, Deplanque G, Huisman H, et al. 2003. Efficacy and toxicity of the angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma. Clin Cancer Res 9: 1648-1655.
    • (2003) Clin Cancer Res , vol.9 , pp. 1648-1655
    • Kuenen, B.C.1    Tabernero, J.2    Baselga, J.3    Cavalli, F.4    Pfanner, E.5    Conte, P.F.6    Seeber, S.7    Madhusudan, S.8    Deplanque, G.9    Huisman, H.10
  • 111
    • 76749097152 scopus 로고    scopus 로고
    • Phase 1 study of combination treatment with PTK 787/ZK 222584 and cetuximab for patients with advanced solid tumors: Safety, pharmacokinetics, pharmacodynamics analysis
    • Langenberg MH, Witteveen PO, Lankheet NA, Roodhart JM, Rosing H, van den Heuvel IJ, Beijnen JH, Voest EE. 2010. Phase 1 study of combination treatment with PTK 787/ZK 222584 and cetuximab for patients with advanced solid tumors: Safety, pharmacokinetics, pharmacodynamics analysis. Neoplasia 12: 206-213.
    • (2010) Neoplasia , vol.12 , pp. 206-213
    • Langenberg, M.H.1    Witteveen, P.O.2    Lankheet, N.A.3    Roodhart, J.M.4    Rosing, H.5    van den Heuvel, I.J.6    Beijnen, J.H.7    Voest, E.E.8
  • 112
    • 10744225601 scopus 로고    scopus 로고
    • SU5416 plus interferon α in advanced renal cell carcinoma: A phase II California Cancer Consortium Study with biological and imaging correlates of angiogenesis inhibition
    • Lara PN, Quinn DI, Margolin K, Meyers FJ, Longmate J, Frankel P, Mack PC, TurrellC, Valk P, Rao J, et al. 2003. SU5416 plus interferon α in advanced renal cell carcinoma: A phase II California Cancer Consortium Study with biological and imaging correlates of angiogenesis inhibition. Clin Cancer Res 9: 4772-4781.
    • (2003) Clin Cancer Res , vol.9 , pp. 4772-4781
    • Lara, P.N.1    Quinn, D.I.2    Margolin, K.3    Meyers, F.J.4    Longmate, J.5    Frankel, P.6    McK, P.C.7    Turrell, C.8    Valk, P.9    Rao, J.10
  • 113
    • 4444353257 scopus 로고    scopus 로고
    • Tumor progression: The effects of thrombospondin-1 and-2
    • Lawler J, Detmar M. 2004. Tumor progression: The effects of thrombospondin-1 and-2. Int J Biochem Cell Biol 36: 1038-1045.
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 1038-1045
    • Lawler, J.1    Detmar, M.2
  • 114
    • 32044467693 scopus 로고    scopus 로고
    • Phase II data with ZD6474, a small-molecule kinase inhibitor of epidermal growth factor receptor and vascular endothelial growth factor receptor, in previously treated advanced non-small-cell lung cancer
    • Lee D. 2005. Phase II data with ZD6474, a small-molecule kinase inhibitor of epidermal growth factor receptor and vascular endothelial growth factor receptor, in previously treated advanced non-small-cell lung cancer. Clin Lung Cancer 7: 89-91.
    • (2005) Clin Lung Cancer , vol.7 , pp. 89-91
    • Lee, D.1
  • 115
    • 0028080215 scopus 로고
    • Cytokine networks in solid human tumors: Regulation of angiogenesis
    • Leek RD, Harris AL, Lewis CE. 1994. Cytokine networks in solid human tumors: Regulation of angiogenesis. J Leukoc Biol 56: 423-435.
    • (1994) J Leukoc Biol , vol.56 , pp. 423-435
    • Leek, R.D.1    Harris, A.L.2    Lewis, C.E.3
  • 116
    • 67651242368 scopus 로고    scopus 로고
    • Current status of cediranib: The rapid development of a novel anti-angiogenic therapy
    • Lindsay CR, MacPherson IR, Cassidy J. 2009. Current status of cediranib: The rapid development of a novel anti-angiogenic therapy. Future Oncol 5: 421-432.
    • (2009) Future Oncol , vol.5 , pp. 421-432
    • Lindsay, C.R.1    McPherson, I.R.2    Cassidy, J.3
  • 118
    • 63749125392 scopus 로고    scopus 로고
    • VEGFs and receptors involved in angiogenesis versus lymphangiogenesis
    • Lohela M, Bry M, Tammela T, Alitalo K. 2009. VEGFs and receptors involved in angiogenesis versus lymphangiogenesis. Curr Opin Cell Biol 21: 154-165.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 154-165
    • Lohela, M.1    Bry, M.2    Tammela, T.3    Alitalo, K.4
  • 119
    • 34247849335 scopus 로고    scopus 로고
    • Target practice: Lessons from phase III trials with bevacizumab and vatalanib in the treatment of advanced colorectal cancer
    • Los M, Roodhart JM, Voest EE. 2007. Target practice: Lessons from phase III trials with bevacizumab and vatalanib in the treatment of advanced colorectal cancer. Oncologist 12: 443-450.
    • (2007) Oncologist , vol.12 , pp. 443-450
    • Los, M.1    Roodhart, J.M.2    Voest, E.E.3
  • 120
    • 77955293298 scopus 로고    scopus 로고
    • Report of a multicenter phase II trial testing a combination of biweekly bevacizumab and daily erlotinib in patients with unresectable biliary cancer: A phase II Consortium study
    • Lubner SJ, Mahoney MR, Kolesar JL, Loconte NK, Kim GP, Pitot HC, Philip PA, PicusJ, Yong WP, Horvath L, et al. 2010. Report of a multicenter phase II trial testing a combination of biweekly bevacizumab and daily erlotinib in patients with unresectable biliary cancer: A phase II Consortium study. J Clin Oncol 28: 3491-3497.
    • (2010) J Clin Oncol , vol.28 , pp. 3491-3497
    • Lubner, S.J.1    Mahoney, M.R.2    Kolesar, J.L.3    Loconte, N.K.4    Kim, G.P.5    Pitot, H.C.6    Philip, P.A.7    Picus, J.8    Yong, W.P.9    Horvath, L.10
  • 123
    • 70449428715 scopus 로고    scopus 로고
    • Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models
    • Maione F, Molla F, Meda C, Latini R, Zentilin L, Giacca M, Seano G, Serini G, Bussolino F, Giraudo E. 2009. Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models. J Clin Invest 119: 3356-3372.
    • (2009) J Clin Invest , vol.119 , pp. 3356-3372
    • Maione, F.1    Molla, F.2    Meda, C.3    Latini, R.4    Zentilin, L.5    Giacca, M.6    Seano, G.7    Serini, G.8    Bussolino, F.9    Giraudo, E.10
  • 124
  • 125
    • 0033549556 scopus 로고    scopus 로고
    • Neuropilin-1 mediates collapsin-1/semaphorin III inhibition of endothelial cell motility: Functional competition of collapsin-1 and vascular endothelial growth factor-165
    • Miao HQ, Soker S, Feiner L, Alonso JL, Raper JA, Klagsbrun M. 1999. Neuropilin-1 mediates collapsin-1/semaphorin III inhibition of endothelial cell motility: Functional competition of collapsin-1 and vascular endothelial growth factor-165. J Cell Biol 146: 233-242.
    • (1999) J Cell Biol , vol.146 , pp. 233-242
    • Miao, H.Q.1    Soker, S.2    Feiner, L.3    Alonso, J.L.4    Raper, J.A.5    Klagsbrun, M.6
  • 126
    • 64649096230 scopus 로고    scopus 로고
    • Open-label phase I trial of vandetanib in combination with mFOLFOX6 in patients with advanced colorectal cancer
    • Michael M, Gibbs P, Smith R, Godwood A, Oliver S, Tebbutt N. 2009. Open-label phase I trial of vandetanib in combination with mFOLFOX6 in patients with advanced colorectal cancer. Invest New Drugs 27: 253-261.
    • (2009) Invest New Drugs , vol.27 , pp. 253-261
    • Michael, M.1    Gibbs, P.2    Smith, R.3    Godwood, A.4    Oliver, S.5    Tebbutt, N.6
  • 127
    • 67649200247 scopus 로고    scopus 로고
    • Anti-VEGF therapies for malignant glioma: Treatment effects and escape mechanisms
    • Miletic H, Niclou SP, Johansson M, Bjerkvig R. 2009. Anti-VEGF therapies for malignant glioma: Treatment effects and escape mechanisms. Expert Opin Ther Targets 13: 455-468.
    • (2009) Expert Opin Ther Targets , vol.13 , pp. 455-468
    • Miletic, H.1    Niclou, S.P.2    Johansson, M.3    Bjerkvig, R.4
  • 129
    • 18244387980 scopus 로고    scopus 로고
    • A multicenter phase II trial of ZD6474, a vascular endothelial growth factor receptor-2 and epidermal growth factor receptor tyrosine kinase inhibitor, in patients with previously treated metastatic breast cancer
    • Miller KD, Trigo JM, Wheeler C, Barge A, Rowbottom J, Sledge G, Baselga J. 2005b. A multicenter phase II trial of ZD6474, a vascular endothelial growth factor receptor-2 and epidermal growth factor receptor tyrosine kinase inhibitor, in patients with previously treated metastatic breast cancer. Clin Cancer Res 11: 3369-3376.
    • (2005) Clin Cancer Res , vol.11 , pp. 3369-3376
    • Miller, K.D.1    Trigo, J.M.2    Wheeler, C.3    Barge, A.4    Rowbottom, J.5    Sledge, G.6    Baselga, J.7
  • 131
    • 70249114110 scopus 로고    scopus 로고
    • Targeting renal cell carcinoma
    • Motzer RJ, Molina AM. 2009. Targeting renal cell carcinoma. J Clin Oncol 27: 3274-3276.
    • (2009) J Clin Oncol , vol.27 , pp. 3274-3276
    • Motzer, R.J.1    Molina, A.M.2
  • 132
    • 33644833910 scopus 로고    scopus 로고
    • Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
    • Motzer RJ, Michaelson MD, Redman BG, Hudes GR, Wilding G, Figlin RA, GinsbergMS, Kim ST, Baum CM, DePrimo SE, et al. 2006. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 24: 16-24.
    • (2006) J Clin Oncol , vol.24 , pp. 16-24
    • Motzer, R.J.1    Michaelson, M.D.2    Redman, B.G.3    Hudes, G.R.4    Wilding, G.5    Figlin, R.A.6    Ginsberg, M.S.7    Kim, S.T.8    Baum, C.M.9    DePrimo, S.E.10
  • 134
    • 20444473802 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of PTK/ZK, a multiple VEGF receptor inhibitor, in patients with liver metastases from solid tumours
    • Mross K, Drevs J, Muller M, Medinger M, Marme D, Hennig J, Morgan B, LebwohlD, Masson E, Ho YY, et al. 2005. Phase I clinical and pharmacokinetic study of PTK/ZK, a multiple VEGF receptor inhibitor, in patients with liver metastases from solid tumours. Eur J Cancer 41: 1291-1299.
    • (2005) Eur J Cancer , vol.41 , pp. 1291-1299
    • Mross, K.1    Drevs, J.2    Muller, M.3    Medinger, M.4    Marme, D.5    Hennig, J.6    Morgan, B.7    Lebwohl, D.8    Masson, E.9    Ho, Y.Y.10
  • 135
    • 41949092558 scopus 로고    scopus 로고
    • Fibroblast growth factor regulation of neovascularization
    • Murakami M, Simons M. 2008. Fibroblast growth factor regulation of neovascularization. Curr Opin Hematol 15: 215-220.
    • (2008) Curr Opin Hematol , vol.15 , pp. 215-220
    • Murakami, M.1    Simons, M.2
  • 139
    • 27144531036 scopus 로고    scopus 로고
    • A Phase I study of the angiogenesis inhibitor SU5416 (semaxanib) in solid tumours, incorporating dynamic contrast MR pharmacodynamic end points
    • O'Donnell A, Padhani A, Hayes C, Kakkar AJ, Leach M, Trigo JM, Scurr M, RaynaudF, Phillips S, Aherne W, et al. 2005. A Phase I study of the angiogenesis inhibitor SU5416 (semaxanib) in solid tumours, incorporating dynamic contrast MR pharmacodynamic end points. Br J Cancer 93: 876-883.
    • (2005) Br J Cancer , vol.93 , pp. 876-883
    • O'Donnell, A.1    Padhani, A.2    Hayes, C.3    Kakkar, A.J.4    Leach, M.5    Trigo, J.M.6    Scurr, M.7    Raynaud, F.8    Phillips, S.9    Aherne, W.10
  • 140
    • 2442584575 scopus 로고    scopus 로고
    • Effects of SU5416, a small molecule tyrosine kinase receptor inhibitor, on FLT3 expression and phosphorylation in patients with refractory acute myeloid leukemia
    • O'Farrell AM, Yuen HA, Smolich B, Hannah AL, Louie SG, Hong W, Stopeck AT, Silverman LR, Lancet JE, Karp JE, et al. 2004. Effects of SU5416, a small molecule tyrosine kinase receptor inhibitor, on FLT3 expression and phosphorylation in patients with refractory acute myeloid leukemia. Leuk Res 28: 679-689.
    • (2004) Leuk Res , vol.28 , pp. 679-689
    • O'Farrell, A.M.1    Yuen, H.A.2    Smolich, B.3    Hannah, A.L.4    Louie, S.G.5    Hong, W.6    Stopeck, A.T.7    Silverman, L.R.8    Lancet, J.E.9    Karp, J.E.10
  • 141
  • 143
    • 35348984015 scopus 로고    scopus 로고
    • Hypertension secondary to anti-angiogenic therapy: Experience with bevacizumab
    • Pande A, Lombardo J, Spangenthal E, Javle M. 2007. Hypertension secondary to anti-angiogenic therapy: Experience with bevacizumab. Anticancer Res 27: 3465-3470.
    • (2007) Anticancer Res , vol.27 , pp. 3465-3470
    • Pande, A.1    Lombardo, J.2    Spangenthal, E.3    Javle, M.4
  • 144
    • 55649114212 scopus 로고    scopus 로고
    • A randomised, double-masked phase III/IV study of the efficacy and safety of Avastin® (Bevacizumab) intravitreal injections compared to standard therapy in subjects with choroidal neovascularisation secondary to age-related macular degeneration: Clinical trial design
    • doi: 10. 1186/1745-6215-9-56
    • Patel PJ, Bunce C, Tufail A. 2008. A randomised, double-masked phase III/IV study of the efficacy and safety of Avastin® (Bevacizumab) intravitreal injections compared to standard therapy in subjects with choroidal neovascularisation secondary to age-related macular degeneration: Clinical trial design. Trials 9: 56. doi: 10. 1186/1745-6215-9-56.
    • (2008) Trials , vol.9 , pp. 56
    • Patel, P.J.1    Bunce, C.2    Tufail, A.3
  • 146
    • 77949647348 scopus 로고    scopus 로고
    • Targeted therapies for pancreatic cancer
    • Philip PA. 2008. Targeted therapies for pancreatic cancer. Gastrointest Cancer Res 2: S16-S19.
    • (2008) Gastrointest Cancer Res , vol.2
    • Philip, P.A.1
  • 147
    • 79960295130 scopus 로고    scopus 로고
    • Sunitinib in pretreated advanced non-small-cell lung carcinoma: A primary result from Asian population
    • Ping G, Hui-Min W, Wei-Min W, Bao-Hui H. 2010. Sunitinib in pretreated advanced non-small-cell lung carcinoma: A primary result from Asian population. Med Oncol 28: 578-583.
    • (2010) Med Oncol , vol.28 , pp. 578-583
    • Ping, G.1    Hui-Min, W.2    Wei-Min, W.3    Bao-Hui, H.4
  • 148
    • 38749133681 scopus 로고    scopus 로고
    • Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma and various other solid tumors
    • Polyzos A. 2008. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma and various other solid tumors. J Steroid Biochem Mol Biol 108: 261-266.
    • (2008) J Steroid Biochem Mol Biol , vol.108 , pp. 261-266
    • Polyzos, A.1
  • 149
    • 67249141051 scopus 로고    scopus 로고
    • Sorafenib tosylate in advanced kidney cancer: Past, present and future
    • Porta C, Paglino C, Imarisio I, Ferraris E. 2009. Sorafenib tosylate in advanced kidney cancer: Past, present and future. Anticancer Drugs 20: 409-415.
    • (2009) Anticancer Drugs , vol.20 , pp. 409-415
    • Porta, C.1    Paglino, C.2    Imarisio, I.3    Ferraris, E.4
  • 150
  • 151
    • 61649113720 scopus 로고    scopus 로고
    • Endogenous inhibitors of angiogenesis: A historical review
    • Ribatti D. 2009. Endogenous inhibitors of angiogenesis: A historical review. Leuk Res 33: 638-644.
    • (2009) Leuk Res , vol.33 , pp. 638-644
    • Ribatti, D.1
  • 152
    • 67650762620 scopus 로고    scopus 로고
    • Morphological and molecular aspects of physiological vascular morphogenesis
    • Ribatti D, Nico B, Crivellato E. 2009. Morphological and molecular aspects of physiological vascular morphogenesis. Angiogenesis 12: 101-111.
    • (2009) Angiogenesis , vol.12 , pp. 101-111
    • Ribatti, D.1    Nico, B.2    Crivellato, E.3
  • 155
    • 77954478933 scopus 로고    scopus 로고
    • Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer
    • Robinson BG, Paz-Ares L, Krebs A, Vasselli J, Haddad R. 2010a. Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer. J Clin Endocrinol Metab 95: 2664-2671.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2664-2671
    • Robinson, B.G.1    Paz-Ares, L.2    Krebs, A.3    Vasselli, J.4    Haddad, R.5
  • 156
  • 157
    • 33744482540 scopus 로고    scopus 로고
    • Phase 1 study of PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor, for the treatment of acute myeloid leukemia and myelodysplastic syndrome
    • Roboz GJ, Giles FJ, List AF, Cortes JE, Carlin R, Kowalski M, Bilic S, Masson E, Rosamilia M, Schuster MW, et al. 2006. Phase 1 study of PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor, for the treatment of acute myeloid leukemia and myelodysplastic syndrome. Leukemia 20: 952-957.
    • (2006) Leukemia , vol.20 , pp. 952-957
    • Roboz, G.J.1    Giles, F.J.2    List, A.F.3    Cortes, J.E.4    Carlin, R.5    Kowalski, M.6    Bilic, S.7    Masson, E.8    Rosamilia, M.9    Schuster, M.W.10
  • 160
    • 50849120002 scopus 로고    scopus 로고
    • VEGF receptor protein-tyrosine kinases: Structure and regulation
    • Roskoski R Jr. 2008. VEGF receptor protein-tyrosine kinases: Structure and regulation. Biochem Biophys Res Commun 375: 287-291.
    • (2008) Biochem Biophys Res Commun , vol.375 , pp. 287-291
    • Roskoski Jr., R.1
  • 162
    • 77958614178 scopus 로고    scopus 로고
    • Anatomical benefit from ranibizumab treatment of predominantly classic neovascular age-related macular degeneration in the 2-year anchor study
    • Sadda SR, Stoller G, Boyer DS, Blodi BA, Shapiro H, Ianchulev T. 2010. Anatomical benefit from ranibizumab treatment of predominantly classic neovascular age-related macular degeneration in the 2-year anchor study. Retina 30: 1390-1399.
    • (2010) Retina , vol.30 , pp. 1390-1399
    • Sadda, S.R.1    Stoller, G.2    Boyer, D.S.3    Blodi, B.A.4    Shapiro, H.5    Ianchulev, T.6
  • 165
    • 68149172828 scopus 로고    scopus 로고
    • Vandetanib with FOLFIRI in patients with advanced colorectal adenocarcinoma: Results from an open-label, multicentre Phase I study
    • Saunders MP, Wilson R, Peeters M, Smith R, Godwood A, Oliver S, Van Cutsem E. 2009. Vandetanib with FOLFIRI in patients with advanced colorectal adenocarcinoma: Results from an open-label, multicentre Phase I study. Cancer Chemother Pharmacol 64: 665-672.
    • (2009) Cancer Chemother Pharmacol , vol.64 , pp. 665-672
    • Saunders, M.P.1    Wilson, R.2    Peeters, M.3    Smith, R.4    Godwood, A.5    Oliver, S.6    Van Cutsem, E.7
  • 167
    • 35648932996 scopus 로고    scopus 로고
    • Vasculogenesis, angiogenesis, and arteriogenesis: Mechanisms of blood vessel formation and remodeling
    • Semenza GL. 2007. Vasculogenesis, angiogenesis, and arteriogenesis: Mechanisms of blood vessel formation and remodeling. J Cell Biochem 102: 840-847.
    • (2007) J Cell Biochem , vol.102 , pp. 840-847
    • Semenza, G.L.1
  • 168
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF. 1983. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219: 983-985.
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3    Perruzzi, C.A.4    Harvey, V.S.5    Dvorak, H.F.6
  • 169
    • 62749091032 scopus 로고    scopus 로고
    • A phase I trial of PTK787/ZK222584 in combination with pemetrexed and cisplatin in patients with advanced solid tumors
    • Sharma S, Freeman B, Turner J, Symanowski J, Manno P, Berg W, Vogelzang N. 2009. A phase I trial of PTK787/ZK222584 in combination with pemetrexed and cisplatin in patients with advanced solid tumors. Invest New Drugs 27: 63-65.
    • (2009) Invest New Drugs , vol.27 , pp. 63-65
    • Sharma, S.1    Freeman, B.2    Turner, J.3    Symanowski, J.4    Manno, P.5    Berg, W.6    Vogelzang, N.7
  • 170
    • 84856535087 scopus 로고    scopus 로고
    • A phase II study of tandutinib (MLN518), a selective inhibitor of type III tyrosine receptor kinases, in patients with metastatic renal cell carcinoma
    • doi: 10. 1007/s10637-010-9516-1
    • Shepard DR, Cooney MM, Elson P, Bukowski RM, Dreicer R, Rini BI, Garcia JA. 2010. A phase II study of tandutinib (MLN518), a selective inhibitor of type III tyrosine receptor kinases, in patients with metastatic renal cell carcinoma. Invest New Drugs doi: 10. 1007/s10637-010-9516-1.
    • (2010) Invest New Drugs
    • Shepard, D.R.1    Cooney, M.M.2    Elson, P.3    Bukowski, R.M.4    Dreicer, R.5    Rini, B.I.6    Garcia, J.A.7
  • 172
    • 57349179851 scopus 로고    scopus 로고
    • Pazopanib, a VEGF receptor tyrosine kinase inhibitor for cancer therapy
    • Sloan B, Scheinfeld NS. 2008. Pazopanib, a VEGF receptor tyrosine kinase inhibitor for cancer therapy. Curr Opin Investig Drugs 9: 1324-1335.
    • (2008) Curr Opin Investig Drugs , vol.9 , pp. 1324-1335
    • Sloan, B.1    Scheinfeld, N.S.2
  • 176
    • 75649152090 scopus 로고    scopus 로고
    • FDA drug approval summary: Bevacizumab plus interferon for advanced renal cell carcinoma
    • Summers J, Cohen MH, Keegan P, Pazdur R. 2010. FDA drug approval summary: Bevacizumab plus interferon for advanced renal cell carcinoma. Oncologist 15: 104-111.
    • (2010) Oncologist , vol.15 , pp. 104-111
    • Summers, J.1    Cohen, M.H.2    Keegan, P.3    Pazdur, R.4
  • 177
    • 34147130694 scopus 로고    scopus 로고
    • The role of VEGF and EGFR inhibition: Implications for combining anti-VEGF and anti-EGFR agents
    • Tabernero J. 2007. The role of VEGF and EGFR inhibition: Implications for combining anti-VEGF and anti-EGFR agents. Mol Cancer Res 5: 203-220.
    • (2007) Mol Cancer Res , vol.5 , pp. 203-220
    • Tabernero, J.1
  • 179
    • 23044432756 scopus 로고    scopus 로고
    • Phase I study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of PTK787/ZK 222584 administered twice daily in patients with advanced cancer
    • Thomas AL, Morgan B, Horsfield MA, Higginson A, Kay A, Lee L, Masson E, Puccio-Pick M, Laurent D, Steward WP. 2005. Phase I study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of PTK787/ZK 222584 administered twice daily in patients with advanced cancer. J Clin Oncol 23: 4162-4171.
    • (2005) J Clin Oncol , vol.23 , pp. 4162-4171
    • Thomas, A.L.1    Morgan, B.2    Horsfield, M.A.3    Higginson, A.4    Kay, A.5    Lee, L.6    Masson, E.7    Puccio-Pick, M.8    Laurent, D.9    Steward, W.P.10
  • 180
    • 79959831637 scopus 로고    scopus 로고
    • Correlation of MRI sequences to assess progressive glioblastoma multiforme treated with bevacizumab
    • Thompson EM, Dosa E, Kraemer DF, Neuwelt EA. 2010. Correlation of MRI sequences to assess progressive glioblastoma multiforme treated with bevacizumab. J Neurooncol 103: 353-360.
    • (2010) J Neurooncol , vol.103 , pp. 353-360
    • Thompson, E.M.1    Dosa, E.2    Kraemer, D.F.3    Neuwelt, E.A.4
  • 181
    • 48049113069 scopus 로고    scopus 로고
    • Antiangiogenic drugs and tyrosine kinases
    • Timar J, Dome B. 2008. Antiangiogenic drugs and tyrosine kinases. Anticancer Agents Med Chem 8: 462-469.
    • (2008) Anticancer Agents Med Chem , vol.8 , pp. 462-469
    • Timar, J.1    Dome, B.2
  • 182
    • 0347286792 scopus 로고    scopus 로고
    • Resistance to anti-VEGF agents
    • Ton NC, Jayson GC. 2004. Resistance to anti-VEGF agents. Curr Pharm Des 10: 51-64.
    • (2004) Curr Pharm Des , vol.10 , pp. 51-64
    • Ton, N.C.1    Jayson, G.C.2
  • 184
    • 77958465052 scopus 로고    scopus 로고
    • Bevacizumab: Current updates in treatment
    • Van Meter ME, Kim ES. 2010. Bevacizumab: Current updates in treatment. Curr Opin Oncol 22: 586-591.
    • (2010) Curr Opin Oncol , vol.22 , pp. 586-591
    • Van Meter, M.E.1    Kim, E.S.2
  • 190
    • 3843051508 scopus 로고    scopus 로고
    • Molecular targets for anti-angiogenic therapy
    • Wary KK. 2004. Molecular targets for anti-angiogenic therapy. Curr Opin Mol Ther 6: 54-70.
    • (2004) Curr Opin Mol Ther , vol.6 , pp. 54-70
    • Wary, K.K.1
  • 193
    • 33646078924 scopus 로고    scopus 로고
    • Therapeutic potential of cytokine and chemokine antagonists in cancer therapy
    • Yan L, Anderson GM, DeWitte M, Nakada MT. 2006. Therapeutic potential of cytokine and chemokine antagonists in cancer therapy. Eur J Cancer 42: 793-802.
    • (2006) Eur J Cancer , vol.42 , pp. 793-802
    • Yan, L.1    Anderson, G.M.2    DeWitte, M.3    Nakada, M.T.4
  • 194
    • 33847421319 scopus 로고    scopus 로고
    • Vascular endothelial growth factors: Biology and current status of clinical applications in cardiovascular medicine
    • Yla-Herttuala S, Rissanen TT, Vajanto I, Hartikainen J. 2007. Vascular endothelial growth factors: Biology and current status of clinical applications in cardiovascular medicine. J Am Coll Cardiol 49: 1015-1026.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 1015-1026
    • Yla-Herttuala, S.1    Rissanen, T.T.2    Vajanto, I.3    Hartikainen, J.4
  • 195
    • 1642453748 scopus 로고    scopus 로고
    • Phase II study of SU5416, a small molecule vascular endothelial growth factor tyrosine kinase receptor inhibitor, in patients with refractory multiple myeloma
    • Zangari M, Anaissie E, Stopeck A, Morimoto A, Tan N, Lancet J, Cooper M, Hannah A, Garcia-Manero G, Faderl S, et al. 2004. Phase II study of SU5416, a small molecule vascular endothelial growth factor tyrosine kinase receptor inhibitor, in patients with refractory multiple myeloma. Clin Cancer Res 10: 88-95.
    • (2004) Clin Cancer Res , vol.10 , pp. 88-95
    • Zangari, M.1    Anaissie, E.2    Stopeck, A.3    Morimoto, A.4    Tan, N.5    Lancet, J.6    Cooper, M.7    Hannah, A.8    Garcia-Manero, G.9    Faderl, S.10


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