Context-dependent signal integration by the GLI code: The oncogenic load, pathways, modifiers and implications for cancer therapy

Seminars in Cell and Developmental Biology

Volumn 33, Issue , 2014, Pages 93-104

  Aberger, Fritz ^a   Ruiz i Altaba, Ariel ^b  

^a UNIVERSITY OF SALZBURG   (Austria)

^b UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

Cancer; Development; GLI transcription factors; Hedgehog GLI signaling; Oncogenes; Signal transduction; Signaling integration; Stem cells

Indexed keywords

EPIDERMAL GROWTH FACTOR; SONIC HEDGEHOG PROTEIN; T CELL FACTOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GLI; TRANSCRIPTION FACTOR GLI1; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; GLI1 PROTEIN, HUMAN;

BASAL CELL CARCINOMA; BINDING AFFINITY; CANCER THERAPY; CARCINOGENESIS; COLON CANCER; DEVELOPMENT; DNA BINDING; HOMEOSTASIS; HUMAN; NONHUMAN; ONCOGENE; PROTEIN INTERACTION; PROTEIN PROCESSING; PROTO ONCOGENE; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; CARCINOMA, BASAL CELL; COLONIC NEOPLASMS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULARLY TARGETED THERAPY; PHYSIOLOGY;

ERINACEIDAE;

ANIMALS; CARCINOGENESIS; CARCINOMA, BASAL CELL; COLONIC NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEDGEHOG PROTEINS; HUMANS; MOLECULAR TARGETED THERAPY; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84905586280     PISSN: 10849521     EISSN: 10963634     Source Type: Journal    
DOI: 10.1016/j.semcdb.2014.05.003     Document Type: Review

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