Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity

International Journal of Cancer

Volumn 129, Issue 1, 2011, Pages 245-255

  Wilhelm, Scott M ^a   Dumas, Jacques ^a,c   Adnane, Lila ^a   Lynch, Mark ^a,d   Carter, Christopher A ^a,e   Schütz, Gunnar ^b   Thierauch, Karl Heinz ^b   Zopf, Dieter ^b  

^a BAYER CORPORATION   (United States)

^b BAYER PHARMA AG   (Germany)

^c ASTRAZENECA   (United Kingdom)

^d OSI Pharmaceuticals   (United States)

^e BRISTOL MYERS SQUIBB   (United States)

Author keywords

angiogenesis; BAY 73 4506; DCE MRI; multikinase inhibitor; regorafenib

Indexed keywords

ANGIOGENESIS INHIBITOR; B RAF KINASE; FIBROBLAST GROWTH FACTOR RECEPTOR 1; PACLITAXEL; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN RET; PROTEIN TYROSINE KINASE; REGORAFENIB; SUNITINIB; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 3; VATALANIB;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL ACTIVITY; CELL PROLIFERATION; COLORECTAL CANCER; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; DRUG TARGETING; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; GLIOBLASTOMA; IN VIVO STUDY; LOW DRUG DOSE; MICROVASCULATURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; TUMOR XENOGRAFT;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; ENZYME INHIBITORS; FEMALE; MAGNETIC RESONANCE IMAGING; MICE; MICE, NUDE; PHENYLUREA COMPOUNDS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PYRIDINES; RATS; RATS, INBRED F344;

EID: 79954499886     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25864     Document Type: Article

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