MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor

FASEB Journal

Volumn 29, Issue 5, 2015, Pages 1817-1829

  Hoch, Lucile ^a   Faure, Helene ^a   Roudaut, Hermine ^a   Schoenfelder, Angele ^b   Mann, Andre ^b   Girard, Nicolas ^b   Bihannic, Laure ^a   Ayrault, Olivier ^a   Petricci, Elena ^c   Taddei, Maurizio ^c   Rognan, Didier ^b   Ruat, Martial ^a  

^a CNRS   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c UNIVERSITY OF SIENA   (Italy)

Author keywords

Antagonist; Medulloblastoma; Molecular modeling; Stem cell

Indexed keywords

MRT 92; PROTEIN INHIBITOR; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TALADEGIB; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; G PROTEIN COUPLED RECEPTOR; GUANIDINE DERIVATIVE; MOLECULAR LIBRARY; MRT-92; PROTEIN BINDING; SMO PROTEIN, HUMAN;

ARTICLE; BINDING SITE; CELL PROLIFERATION; DRUG MECHANISM; DRUG STRUCTURE; EUKARYOTIC FLAGELLUM; GENETIC MANIPULATION; MEDULLOBLASTOMA; MOLECULAR DOCKING; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; WNT SIGNALING PATHWAY; ADULT; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL MEMBRANE; CEREBELLAR NEOPLASMS; DRUG EFFECTS; DRUG RESISTANCE; ENZYME IMMUNOASSAY; GENETICS; HUMAN; METABOLISM; MOLECULAR LIBRARY; MOUSE; MUTATION; PATHOLOGY; PHARMACOLOGY; PROTEIN CONFORMATION; WESTERN BLOTTING;

ERINACEIDAE; RODENTIA;

ADULT; ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; BLOTTING, WESTERN; CELL MEMBRANE; CELL PROLIFERATION; CELLS, CULTURED; CEREBELLAR NEOPLASMS; DRUG RESISTANCE, NEOPLASM; GUANIDINES; HEDGEHOG PROTEINS; HUMANS; IMMUNOENZYME TECHNIQUES; MEDULLOBLASTOMA; MICE; MOLECULAR DOCKING SIMULATION; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES;

EID: 84932607395     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-267849     Document Type: Article

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