Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro

Journal of Thoracic and Cardiovascular Surgery

Volumn 147, Issue 1, 2014, Pages 508-516

  You, Min ^a   Varona Santos, Javier ^a   Singh, Samer ^b   Robbins, David J ^b   Savaraj, Niramol ^b   Nguyen, Dao M ^a  

^a UNIVERSITY OF MIAMI   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ARSENIC TRIOXIDE; GANT61; ITRACONAZOLE; PROTEIN GLI; SMALL INTERFERING RNA; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VISMODEGIB;

CELL SURVIVAL; CELL VIABILITY; CONFERENCE PAPER; CONTROLLED STUDY; GENE; GLI1 GENE; HUMAN; HUMAN CELL; IN VITRO STUDY; PLEURA MESOTHELIOMA; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMO GENE;

14; 29; 3-(4,5-DIMETHYLTHIAZOL-2-YL)-2,5-DIPHENYLTETRAZOLIUM BROMIDE; ARSENIC TRIOXIDE; ATO; DRUG CONCENTRATION THAT MEDIATES 50% INHIBITION OF CELL NUMBER OR VIABILITY; EGFR; EPIDERMAL GROWTH FACTOR RECEPTOR; FDA; FOOD AND DRUG ADMINISTRATION; GDC; GDC-0449; HEDGEHOG; HEDGEHOG PATHWAY INHIBITOR; HH; HPI; IC(50); ITRA; ITRACONAZOLE; MALIGNANT PLEURAL MESOTHELIOMA; MESSENGER RNA; MPM; MRNA; MTT; NONTARGET SCRAMBLE CONTROL SIRNA; PATCHED; PCR; PI; POLYMERASE CHAIN REACTION; PROPIDIUM IODIDE; PTCH; REVERSE TRANSCRIPTASE/REVERSE TRANSCRIBED; RT; SINT; SIRNA; SIRNA TARGETING SMO; SISMO; SMALL INTERFERING RNA; SMO; SMOOTHENED;

ANILIDES; ANTINEOPLASTIC AGENTS; APOPTOSIS; ARSENICALS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, NEOPLASTIC; HEDGEHOG PROTEINS; HUMANS; ITRACONAZOLE; LUNG NEOPLASMS; MESOTHELIOMA; MOLECULAR TARGETED THERAPY; OXIDES; PLEURAL NEOPLASMS; PYRIDINES; PYRIMIDINES; RECEPTORS, G-PROTEIN-COUPLED; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 84890547769     PISSN: 00225223     EISSN: 1097685X     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2013.08.035     Document Type: Conference Paper

References (29)

1. R.M. Flores, H.I. Pass, V.E. Seshan, J. Dycoco, M. Zakowski, and M. Carbone Extrapleural pneumonectomy versus pleurectomy/decortication in the surgical management of malignant pleural mesothelioma: results in 663 patients J Thorac Cardiovasc Surg 135 2008 620 626 6.e1-3
2. N.J. Vogelzang, J.J. Rusthoven, J. Symanowski, C. Denham, E. Kaukel, and P. Ruffie Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma J Clin Oncol 21 2003 2636 2644
3. J.N. Jakobsen, and J.B. Sorensen Review on clinical trials of targeted treatments in malignant mesothelioma Cancer Chemother Pharmacol 68 2011 1 15
4. D.J. Robbins, D.L. Fei, and N.A. Riobo The Hedgehog signal transduction network Sci Signal 5 2012 re6
5. N.H. Heintz, Y.M. Janssen-Heininger, and B.T. Mossman Asbestos, lung cancers, and mesotheliomas: from molecular approaches to targeting tumor survival pathways Am J Respir Cell Mol Biol 42 2010 133 139
6. C.C. Hui, and S. Angers Gli proteins in development and disease Annu Rev Cell Dev Biol 27 2011 513 537
7. D.D. Von Hoff, P.M. LoRusso, C.M. Rudin, J.C. Reddy, R.L. Yauch, and R. Tibes Inhibition of the hedgehog pathway in advanced basal-cell carcinoma N Engl J Med 361 2009 1164 1172
8. M. Axelson, K. Liu, X. Jiang, K. He, J. Wang, and H. Zhao U.S. Food and Drug Administration approval: vismodegib for recurrent, locally advanced, or metastatic basal cell carcinoma Clin Cancer Res 19 2013 2289 2293
9. J. Kim, J.Y. Tang, R. Gong, J. Kim, J.J. Lee, and K.V. Clemons Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth Cancer Cell 17 2010 388 399
10. S.J. Scales, and F.J. de Sauvage Mechanisms of Hedgehog pathway activation in cancer and implications for therapy Trends Pharmacol Sci 30 2009 303 312
11. M. Wickstrom, C. Dyberg, T. Shimokawa, J. Milosevic, N. Baryawno, and O.M. Fuskevag Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo Int J Cancer 132 2013 1516 1524
12. T. Mazumdar, J. Devecchio, A. Agyeman, T. Shi, and J.A. Houghton Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells Cancer Res 71 2011 5904 5914
13. E.M. Beauchamp, L. Ringer, G. Bulut, K.P. Sajwan, M.D. Hall, and Y.C. Lee Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway J Clin Invest 121 2011 148 160
14. J. Kim, J.J. Lee, J. Kim, D. Gardner, and P.A. Beachy Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector Proc Natl Acad Sci U S A 107 2010 13432 13437
15. R. Tokhunts, S. Singh, T. Chu, G. D'Angelo, V. Baubet, and J.A. Goetz The full-length unprocessed hedgehog protein is an active signaling molecule J Biol Chem 285 2010 2562 2568
16. C.K. Lee, C. Brown, R.J. Gralla, V. Hirsh, S. Thongprasert, and C.M. Tsai Impact of EGFR inhibitor in non-small cell lung cancer on progression-free and overall survival: a meta-analysis J Natl Cancer Inst 105 2013 595 605
17. M.E. Dodge, and L. Lum Drugging the cancer stem cell compartment: lessons learned from the hedgehog and Wnt signal transduction pathways Annu Rev Pharmacol Toxicol 51 2011 289 310
18. M.R. Garcia Campelo, G. Alonso Curbera, G. Aparicio Gallego, E. Grande Pulido, and L.M. Anton Aparicio Stem cell and lung cancer development: blaming the Wnt, Hh and Notch signalling pathway Clin Transl Oncol 13 2011 77 83
19. M. Pasca di Magliano, and M. Hebrok Hedgehog signalling in cancer formation and maintenance Nat Rev Cancer 3 2003 903 911
20. J.M. Ng, and T. Curran The Hedgehog's tale: developing strategies for targeting cancer Nat Rev Cancer 11 2011 493 501
21. D.L. Fei, A. Sanchez-Mejias, Z. Wang, C. Flaveny, J. Long, and S. Singh Hedgehog signaling regulates bladder cancer growth and tumorigenicity Cancer Res 72 2012 4449 4458
22. S. Singh, Z. Wang, D. Liang Fei, K.E. Black, J.A. Goetz, and R. Tokhunts Hedgehog-producing cancer cells respond to and require autocrine Hedgehog activity Cancer Res 71 2011 4454 4463
23. J. Rodriguez-Blanco, N.S. Schilling, R. Tokhunts, C. Giambelli, J. Long, and D. Liang Fei The Hedgehog processing pathway is required for NSCLC growth and survival Oncogene 32 2013 2335 2345
24. B.A. Nacev, P. Grassi, A. Dell, S.M. Haslam, and J.O. Liu The antifungal drug itraconazole inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells J Biol Chem 286 2011 44045 44056
25. C.M. Rudin, J.R. Brahmer, R.A. Juergens, C.L. Hann, D.S. Ettinger, and R. Sebree Phase 2 study of pemetrexed and itraconazole as second-line therapy for metastatic nonsquamous non-small-cell lung cancer J Thorac Oncol 8 2013 619 623
26. E.S. Antonarakis, E.I. Heath, D.C. Smith, D. Rathkopf, A.L. Blackford, and D.C. Danila Repurposing itraconazole as a treatment for advanced prostate cancer: a noncomparative randomized phase II trial in men with metastatic castration-resistant prostate cancer Oncologist 18 2013 163 173
27. Y. Shi, U. Moura, I. Opitz, A. Soltermann, H. Rehrauer, and S. Thies Role of Hedgehog signaling in malignant pleural mesothelioma Clin Cancer Res 18 2012 4646 4656
28. R. Eguchi, Y. Fujimori, H. Takeda, C. Tabata, T. Ohta, and K. Kuribayashi Arsenic trioxide induces apoptosis through JNK and ERK in human mesothelioma cells J Cell Physiol 226 2011 762 768
29. H.M. Pettersson, A. Pietras, M. Munksgaard Persson, J. Karlsson, L. Johansson, and M.C. Shoshan Arsenic trioxide is highly cytotoxic to small cell lung carcinoma cells Mol Cancer Ther 8 2009 160 170