-
1
-
-
80155150299
-
The current landscape of locally advanced rectal cancer
-
Aklilu M, Eng C. The current landscape of locally advanced rectal cancer. Nat Rev Clin Oncol. 2011;8(11):649–659.
-
(2011)
Nat Rev Clin Oncol
, vol.8
, Issue.11
, pp. 649-659
-
-
Aklilu, M.1
Eng, C.2
-
2
-
-
84870940346
-
Developmental pathways in colon cancer: Crosstalk between WNT, BMP, Hedgehog and Notch
-
Bertrand FE, Angus CW, Partis WJ, Sigounas G. Developmental pathways in colon cancer: crosstalk between WNT, BMP, Hedgehog and Notch. Cell Cycle. 2012;11(23):4344–4351.
-
(2012)
Cell Cycle
, vol.11
, Issue.23
, pp. 4344-4351
-
-
Bertrand, F.E.1
Angus, C.W.2
Partis, W.J.3
Sigounas, G.4
-
3
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646–674.
-
(2011)
Cell
, vol.144
, Issue.5
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
4
-
-
84879414522
-
The mechanisms of Hedgehog signalling and its roles in development and disease
-
Briscoe J, Thérond PP. The mechanisms of Hedgehog signalling and its roles in development and disease. Nat Rev Mol Cell Biol. 2013;14(7): 416–429.
-
(2013)
Nat Rev Mol Cell Biol
, vol.14
, Issue.7
, pp. 416-429
-
-
Briscoe, J.1
Thérond, P.P.2
-
5
-
-
84862269410
-
Hedgehog pathway and GLI1 isoforms in human cancer
-
Carpenter RL, Lo HW. Hedgehog pathway and GLI1 isoforms in human cancer. Discov Med. 2012;13(69):105–113.
-
(2012)
Discov Med
, vol.13
, Issue.69
, pp. 105-113
-
-
Carpenter, R.L.1
Lo, H.W.2
-
6
-
-
80054022786
-
Gli proteins in development and disease
-
Hui CC, Angers S. Gli proteins in development and disease. Annu Rev Cell Dev Biol. 2011;27:513–537.
-
(2011)
Annu Rev Cell Dev Biol
, vol.27
, pp. 513-537
-
-
Hui, C.C.1
Angers, S.2
-
7
-
-
70349238733
-
Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
-
Von Hoff DD, LoRusso PM, Rudin CM, et al. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med. 2009;361(12):1164–1172.
-
(2009)
N Engl J Med
, vol.361
, Issue.12
, pp. 1164-1172
-
-
Von Hoff, D.D.1
Lorusso, P.M.2
Rudin, C.M.3
-
8
-
-
77649337790
-
Hedgehog beyond medulloblastoma and basal cell carcinoma
-
Teglund S, Toftgård R. Hedgehog beyond medulloblastoma and basal cell carcinoma. Biochim Biophys Acta. 2010;1805(2):181–208.
-
(2010)
Biochim Biophys Acta
, vol.1805
, Issue.2
, pp. 181-208
-
-
Teglund, S.1
Toftgård, R.2
-
9
-
-
77953362373
-
Hedgehog signaling and gastrointestinal cancer
-
Saqui-Salces M, Merchant JL. Hedgehog signaling and gastrointestinal cancer. Biochim Biophys Acta. 2010;1803(7):786–795.
-
(2010)
Biochim Biophys Acta
, vol.1803
, Issue.7
, pp. 786-795
-
-
Saqui-Salces, M.1
Merchant, J.L.2
-
10
-
-
70349244812
-
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449
-
Rudin CM, Hann CL, Laterra J, et al. Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med. 2009; 361(12):1173–1178.
-
(2009)
N Engl J Med
, vol.361
, Issue.12
, pp. 1173-1178
-
-
Rudin, C.M.1
Hann, C.L.2
Laterra, J.3
-
11
-
-
84855888693
-
Hedgehog signaling pathway as a therapeutic target in various types of cancer
-
Onishi H, Katano M. Hedgehog signaling pathway as a therapeutic target in various types of cancer. Cancer Sci. 2011;102(10):1756–1760.
-
(2011)
Cancer Sci
, vol.102
, Issue.10
, pp. 1756-1760
-
-
Onishi, H.1
Katano, M.2
-
12
-
-
84886879974
-
Targeting hedgehog signaling in cancer: Research and clinical developments
-
Xie J, Bartels CM, Barton SW, Gu D. Targeting hedgehog signaling in cancer: research and clinical developments. Onco Targets Ther. 2013;6: 1425–1435.
-
(2013)
Onco Targets Ther
, vol.6
, pp. 1425-1435
-
-
Xie, J.1
Bartels, C.M.2
Barton, S.W.3
Gu, D.4
-
13
-
-
51949085076
-
Hedgehog: Functions and mechanisms
-
Varjosalo M, Taipale J. Hedgehog: functions and mechanisms. Genes Dev. 2008;22(18):2454–2472.
-
(2008)
Genes Dev
, vol.22
, Issue.18
, pp. 2454-2472
-
-
Varjosalo, M.1
Taipale, J.2
-
14
-
-
77952898697
-
Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals
-
Stecca B, Ruiz I Altaba A. Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals. J Mol Cell Biol. 2010;2(2):84–95.
-
(2010)
J Mol Cell Biol
, vol.2
, Issue.2
, pp. 84-95
-
-
Stecca, B.1
Ruiz, I.2
Altaba, A.3
-
15
-
-
34848901657
-
The Gli code: An information nexus regulating cell fate, stemness and cancer
-
Ruiz i Altaba A, Mas C, Stecca B. The Gli code: an information nexus regulating cell fate, stemness and cancer. Trends Cell Biol. 2007;17(9): 438–447.
-
(2007)
Trends Cell Biol
, vol.17
, Issue.9
, pp. 438-447
-
-
Ruiz, I.1
Altaba, A.2
Mas, C.3
Stecca, B.4
-
16
-
-
0010740572
-
In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins
-
Chen GQ, Zhu J, Shi XG, et al. In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins. Blood. 1996;88(3):1052–1061.
-
(1996)
Blood
, vol.88
, Issue.3
, pp. 1052-1061
-
-
Chen, G.Q.1
Zhu, J.2
Shi, X.G.3
-
17
-
-
77955804589
-
Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector
-
Kim J, Lee JJ, Kim J, Gardner D, Beachy PA. Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector. Proc Natl Acad Sci U S A. 2010;107(30):13432–13437.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, Issue.30
, pp. 13432-13437
-
-
Kim, J.1
Lee, J.J.2
Kim, J.3
Gardner, D.4
Beachy, P.A.5
-
18
-
-
84871388295
-
Toward a systems-level understanding of the Hedgehog signaling pathway: Defining the complex, robust, and fragile
-
Tran PV, Lachke SA, Stottmann RW. Toward a systems-level understanding of the Hedgehog signaling pathway: defining the complex, robust, and fragile. Wiley Interdiscip Rev Syst Biol Med. 2013;5(1): 83–100.
-
(2013)
Wiley Interdiscip Rev Syst Biol Med
, vol.5
, Issue.1
, pp. 83-100
-
-
Tran, P.V.1
Lachke, S.A.2
Stottmann, R.W.3
-
19
-
-
79551540949
-
Hedgehog signaling drives cellular survival in human colon carcinoma cells
-
Mazumdar T, DeVecchio J, Shi T, Jones J, Agyeman A, Houghton JA. Hedgehog signaling drives cellular survival in human colon carcinoma cells. Cancer Res. 2011;71(3):1092–1102.
-
(2011)
Cancer Res
, vol.71
, Issue.3
, pp. 1092-1102
-
-
Mazumdar, T.1
Devecchio, J.2
Shi, T.3
Jones, J.4
Agyeman, A.5
Houghton, J.A.6
-
20
-
-
84856058700
-
The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer
-
Mazumdar T, DeVecchio J, Agyeman A, Shi T, Houghton JA. The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer. Oncotarget. 2011;2(8):638–645.
-
(2011)
Oncotarget
, vol.2
, Issue.8
, pp. 638-645
-
-
Mazumdar, T.1
Devecchio, J.2
Agyeman, A.3
Shi, T.4
Houghton, J.A.5
-
21
-
-
69549138464
-
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade
-
Hyman JM, Firestone AJ, Heine VM, et al. Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc Natl Acad Sci U S A. 2009;106(33):14132–14137.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, Issue.33
, pp. 14132-14137
-
-
Hyman, J.M.1
Firestone, A.J.2
Heine, V.M.3
-
22
-
-
34249867843
-
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
-
Lauth M, Bergström A, Shimokawa T, Toftgård R. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci U S A. 2007;104(20):8455–8460.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, Issue.20
, pp. 8455-8460
-
-
Lauth, M.1
Bergström, A.2
Shimokawa, T.3
Toftgård, R.4
-
23
-
-
0037447269
-
Identification of a small molecule inhibitor of the hedgehog signaling pathway: Effects on basal cell carcinoma-like lesions
-
Williams JA, Guicherit OM, Zaharian BI, et al. Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. Proc Natl Acad Sci U S A. 2003;100(8): 4616–4621.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, Issue.8
, pp. 4616-4621
-
-
Williams, J.A.1
Guicherit, O.M.2
Zaharian, B.I.3
-
24
-
-
77952911825
-
Hedgehog signalling in colon cancer and stem cells
-
Gulino A, Ferretti E, De Smaele E. Hedgehog signalling in colon cancer and stem cells. EMBO Mol Med. 2009;1(6–7):300–302.
-
(2009)
EMBO Mol Med
, vol.1
, Issue.6-7
, pp. 300-302
-
-
Gulino, A.1
Ferretti, E.2
De Smaele, E.3
-
25
-
-
34347253037
-
Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells
-
Ji Z, Mei FC, Xie J, Cheng X. Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells. J Biol Chem. 2007;282(19): 14048–14055.
-
(2007)
J Biol Chem
, vol.282
, Issue.19
, pp. 14048-14055
-
-
Ji, Z.1
Mei, F.C.2
Xie, J.3
Cheng, X.4
-
26
-
-
67651111632
-
Co-activation of hedgehog and AKT pathways promote tumorigenesis in zebrafish
-
Ju B, Spitsbergen J, Eden CJ, Taylor MR, Chen W. Co-activation of hedgehog and AKT pathways promote tumorigenesis in zebrafish. Mol Cancer. 2009;8:40.
-
(2009)
Mol Cancer
, vol.8
, pp. 40
-
-
Ju, B.1
Spitsbergen, J.2
Eden, C.J.3
Taylor, M.R.4
Chen, W.5
-
27
-
-
68249135293
-
Inhibition of p70S6K2 down-regulates Hedgehog/GLI pathway in non-small cell lung cancer cell lines
-
Mizuarai S, Kawagishi A, Kotani H. Inhibition of p70S6K2 down-regulates Hedgehog/GLI pathway in non-small cell lung cancer cell lines. Mol Cancer. 2009;8:44.
-
(2009)
Mol Cancer
, vol.8
, pp. 44
-
-
Mizuarai, S.1
Kawagishi, A.2
Kotani, H.3
-
28
-
-
33645220566
-
Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling
-
Riobo NA, Lu K, Ai X, Haines GM, Emerson CP Jr. Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling. Proc Nat Acad Sci U S A. 2006;103(12):4505–4510.
-
(2006)
Proc Nat Acad Sci U S A
, vol.103
, Issue.12
, pp. 4505-4510
-
-
Riobo, N.A.1
Lu, K.2
Ai, X.3
Haines, G.M.4
Emerson, C.P.5
-
29
-
-
84872827424
-
Overlapping activities of TGF-β and Hedgehog signaling in cancer: Therapeutic targets for cancer treatment
-
Perrot CY, Javelaud D, Mauviel A. Overlapping activities of TGF-β and Hedgehog signaling in cancer: therapeutic targets for cancer treatment. Pharmacol Ther. 2013;137(2):183–199.
-
(2013)
Pharmacol Ther
, vol.137
, Issue.2
, pp. 183-199
-
-
Perrot, C.Y.1
Javelaud, D.2
Mauviel, A.3
-
30
-
-
60549104260
-
Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway
-
Schnidar H, Eberl M, Klingler S, et al. Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway. Cancer Res. 2009;69(4):1284–1292.
-
(2009)
Cancer Res
, vol.69
, Issue.4
, pp. 1284-1292
-
-
Schnidar, H.1
Eberl, M.2
Klingler, S.3
-
31
-
-
34347226348
-
Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways
-
Stecca B, Mas C, Clement V, et al. Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways. Proc Natl Acad Sci U S A. 2007;104(14):5895–5900.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, Issue.14
, pp. 5895-5900
-
-
Stecca, B.1
Mas, C.2
Clement, V.3
-
32
-
-
68849105590
-
Regulation of the hedgehog signaling by the mitogen-activated protein kinase cascade in gastric cancer
-
Seto M, Ohta M, Asaoka Y, et al. Regulation of the hedgehog signaling by the mitogen-activated protein kinase cascade in gastric cancer. Mol Carcinog. 2009;48(8):703–712.
-
(2009)
Mol Carcinog
, vol.48
, Issue.8
, pp. 703-712
-
-
Seto, M.1
Ohta, M.2
Asaoka, Y.3
|