Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo

International Journal of Cancer

Volumn 132, Issue 7, 2013, Pages 1516-1524

  Wickström, Malin ^a   Dyberg, Cecilia ^a   Shimokawa, Takashi ^b   Milosevic, Jelena ^a   Baryawno, Ninib ^a   Fuskevåg, Ole M ^c   Larsson, Rolf ^d   Kogner, Per ^a   Zaphiropoulos, Peter G ^b   Johnsen, John I ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF TROMSØ   (Norway)

^d UPPSALA UNIVERSITY   (Sweden)

Author keywords

GANT61; GLI; Hedgehog signaling; neuroblastoma

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; CYCLIN D1; CYCLOPAMINE; DOXORUBICIN; GANT 61; IRINOTECAN; MYC PROTEIN; SANT 1; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; UNCLASSIFIED DRUG; VINCRISTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENTIATION; DRUG RESISTANCE; DRUG SENSITIVITY; DRUG TARGETING; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEUROBLASTOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CELL PROLIFERATION; FEMALE; GENE AMPLIFICATION; HEDGEHOG PROTEINS; HUMANS; LUCIFERASES; MICE; MICE, NUDE; NEUROBLASTOMA; NUCLEAR PROTEINS; ONCOGENE PROTEINS; PYRIDINES; PYRIMIDINES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; VERATRUM ALKALOIDS;

EID: 84873082449     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.27820     Document Type: Article

References (33)

1. Brodeur GM,. Neuroblastoma: biological insights into a clinical enigma. Nat Rev Cancer 2003; 3: 203-16.
2. Maris JM,. Recent advances in neuroblastoma. N Engl J Med 2010; 362: 2202-11.
3. Le Douarin NM, Teillet MA, Catala M,. Neurulation in amniote vertebrates: a novel view deduced from the use of quail-chick chimeras. Int J Dev Biol 1998; 42: 909-16.
4. Varjosalo M, Taipale J,. Hedgehog: functions and mechanisms. Genes Dev 2008; 22: 2454-72.
5. Jiang M, Stanke J, Lahti JM,. The connections between neural crest development and neuroblastoma. Curr Top Dev Biol 2011; 94: 77-127.
6. Ng JM, Curran T,. The Hedgehog's tale: developing strategies for targeting cancer. Nat Rev Cancer 2011; 11: 493-501.
7. Pasca di Magliano M, Hebrok M,. Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer 2003; 3: 903-11.
8. Scales SJ, de Sauvage FJ,. Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci 2009; 30: 303-12.
9. Maris JM, Hogarty MD, Bagatell R, et al,. Neuroblastoma. Lancet 2007; 369: 2106-20.
10. Chen JK, Taipale J, Cooper MK, et al,. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev 2002; 16: 2743-8.
11. Frank-Kamenetsky M, Zhang XM, Bottega S, et al,. Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. J Biol 2002; 1: 10.
12. Chen JK, Taipale J, Young KE, et al,. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci USA 2002; 99: 14071-6.
13. Lauth M, Bergstrom A, Shimokawa T, et al,. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci USA 2007; 104: 8455-60.
14. Lauth M, Rohnalter V, Bergstrom A, et al,. Antipsychotic drugs regulate hedgehog signaling by modulation of 7-dehydrocholesterol reductase levels. Mol Pharmacol 2010; 78: 486-96. With Erratum in Mol Pharmacol 2011;79:793.
15. Mao L, Xia YP, Zhou YN, et al,. A critical role of Sonic Hedgehog signaling in maintaining the tumorigenicity of neuroblastoma cells. Cancer Sci 2009; 100: 1848-55.
16. Schiapparelli P, Shahi MH, Enguita-German M, et al,. Inhibition of the sonic hedgehog pathway by cyplopamine reduces the CD133+/CD15+ cell compartment and the in vitro tumorigenic capability of neuroblastoma cells. Cancer Lett 2011; 310: 222-31.
17. Teglund S, Toftgard R,. Hedgehog beyond medulloblastoma and basal cell carcinoma. Biochim Biophys Acta 2010; 1805: 181-208.
18. Grimmer MR, Weiss WA,. Childhood tumors of the nervous system as disorders of normal development. Curr Opin Pediatr 2006; 18: 634-8.
19. Caren H, Kryh H, Nethander M, et al,. High-risk neuroblastoma tumors with 11q-deletion display a poor prognostic, chromosome instability phenotype with later onset. Proc Natl Acad Sci USA 2010; 107: 4323-8.
20. Johnsen JI, Segerstrom L, Orrego A, et al,. Inhibitors of mammalian target of rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo. Oncogene 2008; 27: 2910-22.
21. Lindhagen E, Nygren P, Larsson R,. The fluorometric microculture cytotoxicity assay. Nat Protoc 2008; 3: 1364-9.
22. Baryawno N, Sveinbjornsson B, Eksborg S, et al,. Tumor-growth-promoting cyclooxygenase-2 prostaglandin E2 pathway provides medulloblastoma therapeutic targets. Neuro Oncol 2008; 10: 661-74.
23. Shimokawa T, Tostar U, Lauth M, et al,. Novel human glioma-associated oncogene 1 (GLI1) splice variants reveal distinct mechanisms in the terminal transduction of the hedgehog signal. J Biol Chem 2008; 283: 14345-54.
24. Chou TC, Talalay P,. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 1984; 22: 27-55.
25. Ponthan F, Wickstrom M, Gleissman H, et al,. Celecoxib prevents neuroblastoma tumor development and potentiates the effect of chemotherapeutic drugs in vitro and in vivo. Clin Cancer Res 2007; 13: 1036-44.
26. Mazumdar T, Devecchio J, Agyeman A, et al,. Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells. Cancer Res 2011; 71: 5904-14.
27. Mazumdar T, DeVecchio J, Shi T, et al,. Hedgehog signaling drives cellular survival in human colon carcinoma cells. Cancer Res 2011; 71: 1092-102.
28. Tostar U, Toftgard R, Zaphiropoulos PG, et al,. Reduction of human embryonal rhabdomyosarcoma tumor growth by inhibition of the hedgehog signaling pathway. Genes Cancer 2010; 1: 941-51.
29. Koppen A, Ait-Aissa R, Koster J, et al,. Dickkopf-3 expression is a marker for neuroblastic tumor maturation and is down-regulated by MYCN. Int J Cancer 2008; 122: 1455-64.
30. Hatton BA, Knoepfler PS, Kenney AM, et al,. N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth. Cancer Res 2006; 66: 8655-61.
31. Kessler JD, Hasegawa H, Brun SN, et al,. N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma. Genes Dev 2009; 23: 157-70.
32. Weiss WA, Aldape K, Mohapatra G, et al,. Targeted expression of MYCN causes neuroblastoma in transgenic mice. Embo J 1997; 16: 2985-95.
33. Zhang Y, Laterra J, Pomper MG,. Hedgehog pathway inhibitor HhAntag691 is a potent inhibitor of ABCG2/BCRP and ABCB1/Pgp. Neoplasia 2009; 11: 96-101.