Targeted inhibition of hedgehog signaling by cyclopamine prodrugs for advanced prostate cancer

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 6, 2008, Pages 2764-2768

  Kumar, Srinivas K ^a   Roy, Indrajit ^b   Anchoori, Ravi K ^a   Fazli, Sarah ^a   Maitra, Anirban ^a   Beachy, Philip A ^c   Khan, Saeed R ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

Cyclopamine; Hedgehog signaling; Peptides; Prodrug; PSA

Indexed keywords

AMINE; CYCLOPAMINE; MU HSSKLQ CYCLOPAMINE; MU SSKYQ CYCLOPAMINE; PROSTATE SPECIFIC ANTIGEN; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

ADVANCED CANCER; ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; MODULATION; PROSTATE CANCER;

AMINO ACID SEQUENCE; ANIMALS; DRUG DELIVERY SYSTEMS; DRUG DESIGN; HEDGEHOG PROTEINS; HYDROLYSIS; KINETICS; MALE; MICE; OLIGOPEPTIDES; PRODRUGS; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; VERATRUM ALKALOIDS;

ERINACEIDAE;

EID: 41249085384     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.01.012     Document Type: Article

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