Discovery of PF-04449913, a potent and orally bioavailable inhibitor of smoothened

ACS Medicinal Chemistry Letters

Volumn 3, Issue 2, 2012, Pages 106-111

  Munchhof, Michael J ^a   Li, Qifang ^b   Shavnya, Andrei ^b   Borzillo, Gary V ^b   Boyden, Tracey L ^b   Jones, Christopher S ^c   Lagreca, Susan D ^d   Martinez Alsina, Luis ^b   Patel, Nandini ^b   Pelletier, Kathleen ^b   Reiter, Larry A ^e   Robbins, Michael D ^f   Tkalcevic, George T ^b  

^a Michael J Munchhof LLC   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^c INC Research ^*  (United States)

^d SYNEOS HEALTH   (United States)

^e ReiterMedChem   (United States)

^f BRISTOL MYERS SQUIBB   (United States)

Author keywords

Hedgehog signaling pathway; PF 04449913; Smoothened

Indexed keywords

1 [2 (1H BENZO[D]IMIDAZOL 2 YL) 1 METHYLPIPERIDIN 4 YL] 3 (4 CYANOPHENYL)UREA; ANTINEOPLASTIC AGENT; PF 04449913; SMOOTHENED PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CHIRAL CHROMATOGRAPHY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; IN VITRO STUDY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ERINACEIDAE;

EID: 84863172647     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml2002423     Document Type: Article

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