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Volumn 73, Issue 7, 2016, Pages 1333-1348

Metabolic changes associated with tumor metastasis, part 1: Tumor pH, glycolysis and the pentose phosphate pathway

Author keywords

Glycolysis; Lactate; Pentose phosphate pathway (PPP); Phosphoglucose isomerase (PGI); Tumor metastasis; Tumor pH

Indexed keywords

GLUCOSE 6 PHOSPHATE ISOMERASE; INTERLEUKIN 8; PENTOSE PHOSPHATE; LACTIC ACID;

EID: 84949521347     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-015-2098-5     Document Type: Review
Times cited : (179)

References (209)
  • 1
    • 33751252276 scopus 로고    scopus 로고
    • Cancer metastasis: Building a framework
    • 1:CAS:528:DC%2BD28Xht1yqs7rL 17110329
    • Gupta GP, Massague J (2006) Cancer metastasis: building a framework. Cell 127:679-695
    • (2006) Cell , vol.127 , pp. 679-695
    • Gupta, G.P.1    Massague, J.2
  • 2
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • 1:CAS:528:DC%2BD3cXks1CktA%3D%3D 10647931
    • Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57-70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 3
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • 1:CAS:528:DC%2BC3MXjsFeqtrk%3D 21376230
    • Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646-674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 4
    • 85006768050 scopus 로고
    • The metabolism of tumors in the body
    • 1:CAS:528:DyaB2sXitlyhuw%3D%3D 19872213 2140820
    • Warburg O, Wind F, Negelein E (1927) The metabolism of tumors in the body. J Gen Physiol 8:519-530
    • (1927) J Gen Physiol , vol.8 , pp. 519-530
    • Warburg, O.1    Wind, F.2    Negelein, E.3
  • 5
    • 77949967131 scopus 로고    scopus 로고
    • Targeting metabolic transformation for cancer therapy
    • 1:CAS:528:DC%2BC3cXjsFWjsL4%3D 20300106
    • Tennant DA, Duran RV, Gottlieb E (2010) Targeting metabolic transformation for cancer therapy. Nat Rev Cancer 10:267-277
    • (2010) Nat Rev Cancer , vol.10 , pp. 267-277
    • Tennant, D.A.1    Duran, R.V.2    Gottlieb, E.3
  • 6
    • 84865976786 scopus 로고    scopus 로고
    • Anticancer targets in the glycolytic metabolism of tumors: A comprehensive review
    • 21904528 3161244
    • Porporato PE, Dhup S, Dadhich RK, Copetti T, Sonveaux P (2011) Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review. Front Pharmacol 2:49
    • (2011) Front Pharmacol , vol.2 , pp. 49
    • Porporato, P.E.1    Dhup, S.2    Dadhich, R.K.3    Copetti, T.4    Sonveaux, P.5
  • 7
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • 1:CAS:528:DC%2BD28XhtlWltLg%3D 16493418
    • Thiery JP, Sleeman JP (2006) Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7:131-142
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 8
    • 84861194016 scopus 로고    scopus 로고
    • EMT as the ultimate survival mechanism of cancer cells
    • 1:CAS:528:DC%2BC38Xnt12kurw%3D 22406545
    • Tiwari N, Gheldof A, Tatari M, Christofori G (2012) EMT as the ultimate survival mechanism of cancer cells. Semin Cancer Biol 22:194-207
    • (2012) Semin Cancer Biol , vol.22 , pp. 194-207
    • Tiwari, N.1    Gheldof, A.2    Tatari, M.3    Christofori, G.4
  • 10
    • 0028057613 scopus 로고
    • Disruption of epithelial cell-matrix interactions induces apoptosis
    • 1:CAS:528:DyaK2cXhtlSrsLo%3D 8106557
    • Frisch SM, Francis H (1994) Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 124:619-626
    • (1994) J Cell Biol , vol.124 , pp. 619-626
    • Frisch, S.M.1    Francis, H.2
  • 11
    • 84887621878 scopus 로고    scopus 로고
    • Anoikis molecular pathways and its role in cancer progression
    • 1:CAS:528:DC%2BC3sXhtFCjurbM 23830918
    • Paoli P, Giannoni E, Chiarugi P (2013) Anoikis molecular pathways and its role in cancer progression. Biochim Biophys Acta 1833:3481-3498
    • (2013) Biochim Biophys Acta , vol.1833 , pp. 3481-3498
    • Paoli, P.1    Giannoni, E.2    Chiarugi, P.3
  • 12
    • 52949139787 scopus 로고    scopus 로고
    • Seeding and propagation of untransformed mouse mammary cells in the lung
    • 1:CAS:528:DC%2BD1cXhtFCrtLrI 18755941 2694414
    • Podsypanina K, Du YC, Jechlinger M, Beverly LJ, Hambardzumyan D, Varmus H (2008) Seeding and propagation of untransformed mouse mammary cells in the lung. Science 321:1841-1844
    • (2008) Science , vol.321 , pp. 1841-1844
    • Podsypanina, K.1    Du, Y.C.2    Jechlinger, M.3    Beverly, L.J.4    Hambardzumyan, D.5    Varmus, H.6
  • 14
    • 73449098612 scopus 로고    scopus 로고
    • Isolation of circulating epithelial and tumor progenitor cells with an invasive phenotype from breast cancer patients
    • 1:CAS:528:DC%2BD1MXhsFGjs7fK 19662651 2795034
    • Lu J, Fan T, Zhao Q, Zeng W, Zaslavsky E, Chen JJ, Frohman MA, Golightly MG, Madajewicz S, Chen WT (2010) Isolation of circulating epithelial and tumor progenitor cells with an invasive phenotype from breast cancer patients. Int J Cancer 126:669-683
    • (2010) Int J Cancer , vol.126 , pp. 669-683
    • Lu, J.1    Fan, T.2    Zhao, Q.3    Zeng, W.4    Zaslavsky, E.5    Chen, J.J.6    Frohman, M.A.7    Golightly, M.G.8    Madajewicz, S.9    Chen, W.T.10
  • 15
    • 84893645443 scopus 로고    scopus 로고
    • Molecular biomarkers of cancer stem/progenitor cells associated with progression, metastases, and treatment resistance of aggressive cancers
    • 1:CAS:528:DC%2BC2cXisVCnsrs%3D 24273063 3977531
    • Mimeault M, Batra SK (2014) Molecular biomarkers of cancer stem/progenitor cells associated with progression, metastases, and treatment resistance of aggressive cancers. Cancer Epidemiol Biomarkers Prev 23:234-254
    • (2014) Cancer Epidemiol Biomarkers Prev , vol.23 , pp. 234-254
    • Mimeault, M.1    Batra, S.K.2
  • 16
    • 84887273608 scopus 로고    scopus 로고
    • Epithelial plasticity: A common theme in embryonic and cancer cells
    • Nieto MA (2013) Epithelial plasticity: a common theme in embryonic and cancer cells. Science 342:1234850
    • (2013) Science , vol.342 , pp. 1234850
    • Ma, N.1
  • 17
    • 79953300698 scopus 로고    scopus 로고
    • The seed and soil hypothesis revisited-The role of tumor-stroma interactions in metastasis to different organs
    • 1:CAS:528:DC%2BC3MXktVSgt7c%3D 21365651 3075088
    • Langley RR, Fidler IJ (2011) The seed and soil hypothesis revisited-the role of tumor-stroma interactions in metastasis to different organs. Int J Cancer 128:2527-2535
    • (2011) Int J Cancer , vol.128 , pp. 2527-2535
    • Langley, R.R.1    Fidler, I.J.2
  • 18
    • 80054686286 scopus 로고    scopus 로고
    • Tumor metastasis: Molecular insights and evolving paradigms
    • 1:CAS:528:DC%2BC3MXhtlaksb3N 22000009 3261217
    • Valastyan S, Weinberg RA (2011) Tumor metastasis: molecular insights and evolving paradigms. Cell 147:275-292
    • (2011) Cell , vol.147 , pp. 275-292
    • Valastyan, S.1    Weinberg, R.A.2
  • 19
    • 84885352426 scopus 로고    scopus 로고
    • Origins of metastatic traits
    • 1:CAS:528:DC%2BC3sXhs1Wks7rP 24135279 3998120
    • Vanharanta S, Massague J (2013) Origins of metastatic traits. Cancer Cell 24:410-421
    • (2013) Cancer Cell , vol.24 , pp. 410-421
    • Vanharanta, S.1    Massague, J.2
  • 20
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
    • 1:CAS:528:DyaK3cXltlSmtQ%3D%3D 2684393
    • Vaupel P, Kallinowski F, Okunieff P (1989) Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 49:6449-6465
    • (1989) Cancer Res , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 21
    • 0025771650 scopus 로고
    • Are cancer cells acidic?
    • 1:CAS:528:DyaK38XotFahtw%3D%3D 1911181 1977628
    • Griffiths JR (1991) Are cancer cells acidic? Br J Cancer 64:425-427
    • (1991) Br J Cancer , vol.64 , pp. 425-427
    • Griffiths, J.R.1
  • 22
    • 0029971428 scopus 로고    scopus 로고
    • Cellular pH gradient in tumor versus normal tissue: Potential exploitation for the treatment of cancer
    • 1:CAS:528:DyaK28XhsFGnsL0%3D 8640796
    • Gerweck LE, Seetharaman K (1996) Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer. Cancer Res 56:1194-1198
    • (1996) Cancer Res , vol.56 , pp. 1194-1198
    • Gerweck, L.E.1    Seetharaman, K.2
  • 24
    • 84857716739 scopus 로고    scopus 로고
    • Multiple biological activities of lactic acid in cancer: Influences on tumor growth, angiogenesis and metastasis
    • 1:CAS:528:DC%2BC38XkvVKktbc%3D 22360558
    • Dhup S, Dadhich RK, Porporato PE, Sonveaux P (2012) Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis. Curr Pharm Des 18:1319-1330
    • (2012) Curr Pharm des , vol.18 , pp. 1319-1330
    • Dhup, S.1    Dadhich, R.K.2    Porporato, P.E.3    Sonveaux, P.4
  • 26
    • 0034663601 scopus 로고    scopus 로고
    • The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells
    • 1:CAS:528:DC%2BD3cXmsVejsrc%3D 10926847 1221245
    • Dimmer KS, Friedrich B, Lang F, Deitmer JW, Broer S (2000) The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells. Biochem J 350(Pt 1):219-227
    • (2000) Biochem J , vol.350 , pp. 219-227
    • Dimmer, K.S.1    Friedrich, B.2    Lang, F.3    Deitmer, J.W.4    Broer, S.5
  • 27
    • 33646917296 scopus 로고    scopus 로고
    • The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism
    • 1:CAS:528:DC%2BD28XjtVSkt7Y%3D 16452478
    • Ullah MS, Davies AJ, Halestrap AP (2006) The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. J Biol Chem 281:9030-9037
    • (2006) J Biol Chem , vol.281 , pp. 9030-9037
    • Ullah, M.S.1    Davies, A.J.2    Halestrap, A.P.3
  • 29
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
    • 1:CAS:528:DC%2BD1cXnsFSnsg%3D%3D 18177721
    • DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB (2008) The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 7:11-20
    • (2008) Cell Metab , vol.7 , pp. 11-20
    • DeBerardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 31
    • 84921288028 scopus 로고    scopus 로고
    • Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions
    • 1:CAS:528:DC%2BC2MXhsFyksQ%3D%3D 25554788 4446723
    • Tomasetti C, Vogelstein B (2015) Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science 347:78-81
    • (2015) Science , vol.347 , pp. 78-81
    • Tomasetti, C.1    Vogelstein, B.2
  • 32
    • 0026623304 scopus 로고
    • Clastogenicity of low pH to various cultured mammalian cells
    • 1:STN:280:DyaK38zltVWrsQ%3D%3D 1379335
    • Morita T, Nagaki T, Fukuda I, Okumura K (1992) Clastogenicity of low pH to various cultured mammalian cells. Mutat Res 268:297-305
    • (1992) Mutat Res , vol.268 , pp. 297-305
    • Morita, T.1    Nagaki, T.2    Fukuda, I.3    Okumura, K.4
  • 33
    • 0032565578 scopus 로고    scopus 로고
    • Mutagenesis induced by the tumor microenvironment
    • 1:CAS:528:DyaK1cXks1OnsLc%3D 9685702
    • Yuan J, Glazer PM (1998) Mutagenesis induced by the tumor microenvironment. Mutat Res 400:439-446
    • (1998) Mutat Res , vol.400 , pp. 439-446
    • Yuan, J.1    Glazer, P.M.2
  • 34
    • 0034662615 scopus 로고    scopus 로고
    • Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH
    • 1:CAS:528:DC%2BD3cXmsVaiurY%3D 10969780
    • Yuan J, Narayanan L, Rockwell S, Glazer PM (2000) Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH. Cancer Res 60:4372-4376
    • (2000) Cancer Res , vol.60 , pp. 4372-4376
    • Yuan, J.1    Narayanan, L.2    Rockwell, S.3    Glazer, P.M.4
  • 35
    • 0029989610 scopus 로고    scopus 로고
    • Effect of intracellular acidity and ionomycin on apoptosis in HL-60 cells
    • 1:CAS:528:DyaK28XisFyitbo%3D 8814704
    • Park HJ, Makepeace CM, Lyons JC, Song CW (1996) Effect of intracellular acidity and ionomycin on apoptosis in HL-60 cells. Eur J Cancer 32A:540-546
    • (1996) Eur J Cancer , vol.32 , pp. 540-546
    • Park, H.J.1    Makepeace, C.M.2    Lyons, J.C.3    Song, C.W.4
  • 36
    • 0032788570 scopus 로고    scopus 로고
    • Acidic environment causes apoptosis by increasing caspase activity
    • 1:CAS:528:DyaK1MXlvVaisrw%3D 10471036 2363148
    • Park HJ, Lyons JC, Ohtsubo T, Song CW (1999) Acidic environment causes apoptosis by increasing caspase activity. Br J Cancer 80:1892-1897
    • (1999) Br J Cancer , vol.80 , pp. 1892-1897
    • Park, H.J.1    Lyons, J.C.2    Ohtsubo, T.3    Song, C.W.4
  • 37
    • 0033609365 scopus 로고    scopus 로고
    • An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: Implications for clonal selection during colorectal carcinogenesis
    • 1:CAS:528:DyaK1MXjvVeqsrg%3D 10359525
    • Williams AC, Collard TJ, Paraskeva C (1999) An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis. Oncogene 18:3199-3204
    • (1999) Oncogene , vol.18 , pp. 3199-3204
    • Williams, A.C.1    Collard, T.J.2    Paraskeva, C.3
  • 38
    • 0035071662 scopus 로고    scopus 로고
    • The effects of extracellular pH on immune function
    • 1:CAS:528:DC%2BD3MXivVagurs%3D 11310837
    • Lardner A (2001) The effects of extracellular pH on immune function. J Leukoc Biol 69:522-530
    • (2001) J Leukoc Biol , vol.69 , pp. 522-530
    • Lardner, A.1
  • 39
    • 0034801774 scopus 로고    scopus 로고
    • Biased activation of human T lymphocytes due to low extracellular pH is antagonized by B7/CD28 costimulation
    • 1:CAS:528:DC%2BD3MXntFWjsL0%3D 11536182
    • Bosticardo M, Ariotti S, Losana G, Bernabei P, Forni G, Novelli F (2001) Biased activation of human T lymphocytes due to low extracellular pH is antagonized by B7/CD28 costimulation. Eur J Immunol 31:2829-2838
    • (2001) Eur J Immunol , vol.31 , pp. 2829-2838
    • Bosticardo, M.1    Ariotti, S.2    Losana, G.3    Bernabei, P.4    Forni, G.5    Novelli, F.6
  • 40
    • 82955173044 scopus 로고    scopus 로고
    • Drug resistance and cellular adaptation to tumor acidic pH microenvironment
    • 1:CAS:528:DC%2BC3MXhtlKgsL%2FM 21981633 3230683
    • Wojtkowiak JW, Verduzco D, Schramm KJ, Gillies RJ (2011) Drug resistance and cellular adaptation to tumor acidic pH microenvironment. Mol Pharm 8:2032-2038
    • (2011) Mol Pharm , vol.8 , pp. 2032-2038
    • Wojtkowiak, J.W.1    Verduzco, D.2    Schramm, K.J.3    Gillies, R.J.4
  • 41
    • 45849084652 scopus 로고    scopus 로고
    • An acidic extracellular pH induces Src kinase-dependent loss of beta-catenin from the adherens junction
    • 1:CAS:528:DC%2BD1cXotlCgtbc%3D 18423982
    • Chen KH, Tung PY, Wu JC, Chen Y, Chen PC, Huang SH, Wang SM (2008) An acidic extracellular pH induces Src kinase-dependent loss of beta-catenin from the adherens junction. Cancer Lett 267:37-48
    • (2008) Cancer Lett , vol.267 , pp. 37-48
    • Chen, K.H.1    Tung, P.Y.2    Wu, J.C.3    Chen, Y.4    Chen, P.C.5    Huang, S.H.6    Wang, S.M.7
  • 42
    • 84875204528 scopus 로고    scopus 로고
    • SLC9/NHE gene family, a plasma membrane and organellar family of Na(+)/H(+) exchangers
    • 1:CAS:528:DC%2BC3sXksVyqtro%3D 23506868 3724465
    • Donowitz M, Ming TC, Fuster D (2013) SLC9/NHE gene family, a plasma membrane and organellar family of Na(+)/H(+) exchangers. Mol Aspects Med 34:236-251
    • (2013) Mol Aspects Med , vol.34 , pp. 236-251
    • Donowitz, M.1    Ming, T.C.2    Fuster, D.3
  • 43
    • 84899774937 scopus 로고    scopus 로고
    • Carbonic anhydrase IX: Regulation and role in cancer
    • 1:CAS:528:DC%2BC2MXovVagsLg%3D 24146381
    • Benej M, Pastorekova S, Pastorek J (2014) Carbonic anhydrase IX: regulation and role in cancer. Subcell Biochem 75:199-219
    • (2014) Subcell Biochem , vol.75 , pp. 199-219
    • Benej, M.1    Pastorekova, S.2    Pastorek, J.3
  • 44
    • 0036356519 scopus 로고    scopus 로고
    • How pH regulates a pH regulator: A regulatory hot spot in the N-terminal cytoplasmic domain of the AE2 anion exchanger
    • 1:CAS:528:DC%2BD38XlsV2rtLk%3D 12139398
    • Alper SL, Chernova MN, Stewart AK (2002) How pH regulates a pH regulator: a regulatory hot spot in the N-terminal cytoplasmic domain of the AE2 anion exchanger. Cell Biochem Biophys 36:123-136
    • (2002) Cell Biochem Biophys , vol.36 , pp. 123-136
    • Alper, S.L.1    Chernova, M.N.2    Stewart, A.K.3
  • 45
    • 0034061827 scopus 로고    scopus 로고
    • Polarization of Na(+)/H(+) and Cl(-)/HCO (3)(-) exchangers in migrating renal epithelial cells
    • 1:CAS:528:DC%2BD3cXjtl2hu7Y%3D 10779317 2217220
    • Klein M, Seeger P, Schuricht B, Alper SL, Schwab A (2000) Polarization of Na(+)/H(+) and Cl(-)/HCO (3)(-) exchangers in migrating renal epithelial cells. J Gen Physiol 115:599-608
    • (2000) J Gen Physiol , vol.115 , pp. 599-608
    • Klein, M.1    Seeger, P.2    Schuricht, B.3    Alper, S.L.4    Schwab, A.5
  • 46
    • 0033739497 scopus 로고    scopus 로고
    • Regulation of the formation of tumor cell pseudopodia by the Na(+)/H(+) exchanger NHE1
    • 1:CAS:528:DC%2BD3cXosVKgtbg%3D 11017880
    • Lagana A, Vadnais J, Le PU, Nguyen TN, Laprade R, Nabi IR, Noel J (2000) Regulation of the formation of tumor cell pseudopodia by the Na(+)/H(+) exchanger NHE1. J Cell Sci 113(Pt 20):3649-3662
    • (2000) J Cell Sci , vol.113 , pp. 3649-3662
    • Lagana, A.1    Vadnais, J.2    Le, P.U.3    Nguyen, T.N.4    Laprade, R.5    Nabi, I.R.6    Noel, J.7
  • 48
    • 0037164808 scopus 로고    scopus 로고
    • Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1
    • 1:CAS:528:DC%2BD3sXjt1em 12486114 2173980
    • Denker SP, Barber DL (2002) Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1. J Cell Biol 159:1087-1096
    • (2002) J Cell Biol , vol.159 , pp. 1087-1096
    • Denker, S.P.1    Barber, D.L.2
  • 49
    • 23844449323 scopus 로고    scopus 로고
    • Migration of human melanoma cells depends on extracellular pH and Na+/H+ exchange
    • 1:CAS:528:DC%2BD2MXps1Omsbg%3D 15946960 1474168
    • Stock C, Gassner B, Hauck CR, Arnold H, Mally S, Eble JA, Dieterich P, Schwab A (2005) Migration of human melanoma cells depends on extracellular pH and Na+/H+ exchange. J Physiol 567:225-238
    • (2005) J Physiol , vol.567 , pp. 225-238
    • Stock, C.1    Gassner, B.2    Hauck, C.R.3    Arnold, H.4    Mally, S.5    Eble, J.A.6    Dieterich, P.7    Schwab, A.8
  • 50
    • 84893639632 scopus 로고    scopus 로고
    • Acidic priming enhances metastatic potential of cancer cells
    • 1:CAS:528:DC%2BC2cXis1ahsLs%3D 24531759
    • Riemann A, Schneider B, Gundel D, Stock C, Thews O, Gekle M (2014) Acidic priming enhances metastatic potential of cancer cells. Pflugers Arch 466:2127-2138
    • (2014) Pflugers Arch , vol.466 , pp. 2127-2138
    • Riemann, A.1    Schneider, B.2    Gundel, D.3    Stock, C.4    Thews, O.5    Gekle, M.6
  • 51
    • 0034058373 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase is involved in the tumor-specific activation of human breast cancer cell Na(+)/H(+) exchange, motility, and invasion induced by serum deprivation
    • 1:CAS:528:DC%2BD3cXhsFKks7g%3D 10681510
    • Reshkin SJ, Bellizzi A, Albarani V, Guerra L, Tommasino M, Paradiso A, Casavola V (2000) Phosphoinositide 3-kinase is involved in the tumor-specific activation of human breast cancer cell Na(+)/H(+) exchange, motility, and invasion induced by serum deprivation. J Biol Chem 275:5361-5369
    • (2000) J Biol Chem , vol.275 , pp. 5361-5369
    • Reshkin, S.J.1    Bellizzi, A.2    Albarani, V.3    Guerra, L.4    Tommasino, M.5    Paradiso, A.6    Casavola, V.7
  • 52
    • 36649014657 scopus 로고    scopus 로고
    • PH dependence of melanoma cell migration: Protons extruded by NHE1 dominate protons of the bulk solution
    • 17916606 2230576
    • Stuwe L, Muller M, Fabian A, Waning J, Mally S, Noel J, Schwab A, Stock C (2007) pH dependence of melanoma cell migration: protons extruded by NHE1 dominate protons of the bulk solution. J Physiol 585:351-360
    • (2007) J Physiol , vol.585 , pp. 351-360
    • Stuwe, L.1    Muller, M.2    Fabian, A.3    Waning, J.4    Mally, S.5    Noel, J.6    Schwab, A.7    Stock, C.8
  • 53
    • 79953138420 scopus 로고    scopus 로고
    • Carbonic anhydrase IX (CA9) modulates tumor-associated cell migration and invasion
    • 1:CAS:528:DC%2BC3MXls1OisLo%3D 21363891
    • Shin HJ, Rho SB, Jung DC, Han IO, Oh ES, Kim JY (2011) Carbonic anhydrase IX (CA9) modulates tumor-associated cell migration and invasion. J Cell Sci 124:1077-1087
    • (2011) J Cell Sci , vol.124 , pp. 1077-1087
    • Shin, H.J.1    Rho, S.B.2    Jung, D.C.3    Han, I.O.4    Oh, E.S.5    Kim, J.Y.6
  • 54
    • 0025061478 scopus 로고
    • Susceptibility of the cartilage collagens types II, IX and XI to degradation by the cysteine proteinases, cathepsins B and L
    • 1:CAS:528:DyaK3cXlsFSjt7s%3D 2387401
    • Maciewicz RA, Wotton SF, Etherington DJ, Duance VC (1990) Susceptibility of the cartilage collagens types II, IX and XI to degradation by the cysteine proteinases, cathepsins B and L. FEBS Lett 269:189-193
    • (1990) FEBS Lett , vol.269 , pp. 189-193
    • Maciewicz, R.A.1    Wotton, S.F.2    Etherington, D.J.3    Duance, V.C.4
  • 55
    • 0026575258 scopus 로고
    • Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumour tissues
    • 1:CAS:528:DyaK38Xht1Gqsr8%3D 1540143 1130919
    • Buck MR, Karustis DG, Day NA, Honn KV, Sloane BF (1992) Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumour tissues. Biochem J 282(Pt 1):273-278
    • (1992) Biochem J , vol.282 , pp. 273-278
    • Buck, M.R.1    Karustis, D.G.2    Day, N.A.3    Honn, K.V.4    Sloane, B.F.5
  • 56
    • 0343548835 scopus 로고
    • Ha-ras oncogene induction of invasion and metastasis is associated with the activation and redistribution of protease(s) in rat-kidney cells
    • 1:CAS:528:DyaK3sXht1Wqur8%3D 21584614
    • Ostad M, Weiss R, Droller M, Liu B (1992) Ha-ras oncogene induction of invasion and metastasis is associated with the activation and redistribution of protease(s) in rat-kidney cells. Int J Oncol 1:765-771
    • (1992) Int J Oncol , vol.1 , pp. 765-771
    • Ostad, M.1    Weiss, R.2    Droller, M.3    Liu, B.4
  • 57
    • 0027179188 scopus 로고
    • Effects of membrane-associated cathepsin B on the activation of receptor-bound prourokinase and subsequent invasion of reconstituted basement membranes
    • 1:CAS:528:DyaK3sXmtVSktro%3D 8329457
    • Kobayashi H, Moniwa N, Sugimura M, Shinohara H, Ohi H, Terao T (1993) Effects of membrane-associated cathepsin B on the activation of receptor-bound prourokinase and subsequent invasion of reconstituted basement membranes. Biochim Biophys Acta 1178:55-62
    • (1993) Biochim Biophys Acta , vol.1178 , pp. 55-62
    • Kobayashi, H.1    Moniwa, N.2    Sugimura, M.3    Shinohara, H.4    Ohi, H.5    Terao, T.6
  • 58
    • 0028618307 scopus 로고
    • Pericellular pH affects distribution and secretion of cathepsin B in malignant cells
    • 1:CAS:528:DyaK2MXislalsLg%3D 7987851
    • Rozhin J, Sameni M, Ziegler G, Sloane BF (1994) Pericellular pH affects distribution and secretion of cathepsin B in malignant cells. Cancer Res 54:6517-6525
    • (1994) Cancer Res , vol.54 , pp. 6517-6525
    • Rozhin, J.1    Sameni, M.2    Ziegler, G.3    Sloane, B.F.4
  • 59
    • 3042692979 scopus 로고    scopus 로고
    • CD44 interaction with Na + -H + exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion
    • 1:CAS:528:DC%2BD2cXkvFGnsrY%3D 15090545
    • Bourguignon LY, Singleton PA, Diedrich F, Stern R, Gilad E (2004) CD44 interaction with Na + -H + exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion. J Biol Chem 279:26991-27007
    • (2004) J Biol Chem , vol.279 , pp. 26991-27007
    • Bourguignon, L.Y.1    Singleton, P.A.2    Diedrich, F.3    Stern, R.4    Gilad, E.5
  • 60
    • 33746149756 scopus 로고    scopus 로고
    • Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice
    • 1:CAS:528:DC%2BD28XmsVamu74%3D 16818644
    • Rofstad EK, Mathiesen B, Kindem K, Galappathi K (2006) Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice. Cancer Res 66:6699-6707
    • (2006) Cancer Res , vol.66 , pp. 6699-6707
    • Rofstad, E.K.1    Mathiesen, B.2    Kindem, K.3    Galappathi, K.4
  • 61
    • 0345791482 scopus 로고    scopus 로고
    • Extracellular acidification alters lysosomal trafficking in human breast cancer cells
    • 1:CAS:528:DC%2BD2cXht1WgtrY%3D 14965446 1502575
    • Glunde K, Guggino SE, Solaiyappan M, Pathak AP, Ichikawa Y, Bhujwalla ZM (2003) Extracellular acidification alters lysosomal trafficking in human breast cancer cells. Neoplasia 5:533-545
    • (2003) Neoplasia , vol.5 , pp. 533-545
    • Glunde, K.1    Guggino, S.E.2    Solaiyappan, M.3    Pathak, A.P.4    Ichikawa, Y.5    Bhujwalla, Z.M.6
  • 62
    • 65749092298 scopus 로고    scopus 로고
    • Na+/H+ exchangers and RhoA regulate acidic extracellular pH-induced lysosome trafficking in prostate cancer cells
    • 1:CAS:528:DC%2BD1MXntFGlt7o%3D 19302267
    • Steffan JJ, Snider JL, Skalli O, Welbourne T, Cardelli JA (2009) Na+/H+ exchangers and RhoA regulate acidic extracellular pH-induced lysosome trafficking in prostate cancer cells. Traffic 10:737-753
    • (2009) Traffic , vol.10 , pp. 737-753
    • Steffan, J.J.1    Snider, J.L.2    Skalli, O.3    Welbourne, T.4    Cardelli, J.A.5
  • 63
    • 77951165622 scopus 로고    scopus 로고
    • HGF-induced invasion by prostate tumor cells requires anterograde lysosome trafficking and activity of Na + -H + exchangers
    • 1:CAS:528:DC%2BC3cXmsF2qsL0%3D 20215403 2844323
    • Steffan JJ, Williams BC, Welbourne T, Cardelli JA (2010) HGF-induced invasion by prostate tumor cells requires anterograde lysosome trafficking and activity of Na + -H + exchangers. J Cell Sci 123:1151-1159
    • (2010) J Cell Sci , vol.123 , pp. 1151-1159
    • Steffan, J.J.1    Williams, B.C.2    Welbourne, T.3    Cardelli, J.A.4
  • 65
    • 0023784140 scopus 로고
    • In vitro degradation of extracellular matrix with Mr 52,000 cathepsin D secreted by breast cancer cells
    • 1:CAS:528:DyaL1cXkslWhu78%3D 3378211
    • Briozzo P, Morisset M, Capony F, Rougeot C, Rochefort H (1988) In vitro degradation of extracellular matrix with Mr 52,000 cathepsin D secreted by breast cancer cells. Cancer Res 48:3688-3692
    • (1988) Cancer Res , vol.48 , pp. 3688-3692
    • Briozzo, P.1    Morisset, M.2    Capony, F.3    Rougeot, C.4    Rochefort, H.5
  • 66
    • 0024331466 scopus 로고
    • Activity and deletion analysis of recombinant human cathepsin L expressed in Escherichia coli
    • 1:CAS:528:DyaL1MXmtFSjt7Y%3D 2684978
    • Smith SM, Gottesman MM (1989) Activity and deletion analysis of recombinant human cathepsin L expressed in Escherichia coli. J Biol Chem 264:20487-20495
    • (1989) J Biol Chem , vol.264 , pp. 20487-20495
    • Smith, S.M.1    Gottesman, M.M.2
  • 67
    • 0026664252 scopus 로고
    • Rat procathepsin B. Proteolytic processing to the mature form in vitro
    • 1:CAS:528:DyaK38XltVOhurk%3D 1639824
    • Rowan AD, Mason P, Mach L, Mort JS (1992) Rat procathepsin B. Proteolytic processing to the mature form in vitro. J Biol Chem 267:15993-15999
    • (1992) J Biol Chem , vol.267 , pp. 15993-15999
    • Rowan, A.D.1    Mason, P.2    Mach, L.3    Mort, J.S.4
  • 68
    • 0030151647 scopus 로고    scopus 로고
    • Slow induction of gelatinase B mRNA by acidic culture conditions in mouse metastatic melanoma cells
    • 1:CAS:528:DyaK28XkvFeksb4%3D 8688855
    • Kato Y, Ozono S, Shuin T, Miyazaki K (1996) Slow induction of gelatinase B mRNA by acidic culture conditions in mouse metastatic melanoma cells. Cell Biol Int 20:375-377
    • (1996) Cell Biol Int , vol.20 , pp. 375-377
    • Kato, Y.1    Ozono, S.2    Shuin, T.3    Miyazaki, K.4
  • 69
    • 20144378365 scopus 로고    scopus 로고
    • Acidic extracellular pH induces matrix metalloproteinase-9 expression in mouse metastatic melanoma cells through the phospholipase D-mitogen-activated protein kinase signaling
    • 1:CAS:528:DC%2BD2MXisVOqtbo%3D 15657063
    • Kato Y, Lambert CA, Colige AC, Mineur P, Noel A, Frankenne F, Foidart JM, Baba M, Hata R, Miyazaki K, Tsukuda M (2005) Acidic extracellular pH induces matrix metalloproteinase-9 expression in mouse metastatic melanoma cells through the phospholipase D-mitogen-activated protein kinase signaling. J Biol Chem 280:10938-10944
    • (2005) J Biol Chem , vol.280 , pp. 10938-10944
    • Kato, Y.1    Lambert, C.A.2    Colige, A.C.3    Mineur, P.4    Noel, A.5    Frankenne, F.6    Foidart, J.M.7    Baba, M.8    Hata, R.9    Miyazaki, K.10    Tsukuda, M.11
  • 70
    • 34249790593 scopus 로고    scopus 로고
    • Acidic extracellular pH increases calcium influx-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase-9 expression in mouse metastatic melanoma
    • 1:CAS:528:DC%2BD2sXntlKntbo%3D 17540003
    • Kato Y, Ozawa S, Tsukuda M, Kubota E, Miyazaki K, St Pierre Y, Hata R (2007) Acidic extracellular pH increases calcium influx-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase-9 expression in mouse metastatic melanoma. FEBS J 274:3171-3183
    • (2007) FEBS J , vol.274 , pp. 3171-3183
    • Kato, Y.1    Ozawa, S.2    Tsukuda, M.3    Kubota, E.4    Miyazaki, K.5    St Pierre, Y.6    Hata, R.7
  • 72
    • 0030873998 scopus 로고    scopus 로고
    • An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells
    • 1:CAS:528:DyaK2sXls1ektLw%3D 9247250
    • Jang A, Hill RP (1997) An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells. Clin Exp Metastasis 15:469-483
    • (1997) Clin Exp Metastasis , vol.15 , pp. 469-483
    • Jang, A.1    Hill, R.P.2
  • 73
    • 79960103892 scopus 로고    scopus 로고
    • NHE1 mediates MDA-MB-231 cells invasion through the regulation of MT1-MMP
    • 1:CAS:528:DC%2BC3MXos1ykt70%3D 21669197
    • Lin Y, Chang G, Wang J, Jin W, Wang L, Li H, Ma L, Li Q, Pang T (2011) NHE1 mediates MDA-MB-231 cells invasion through the regulation of MT1-MMP. Exp Cell Res 317:2031-2040
    • (2011) Exp Cell Res , vol.317 , pp. 2031-2040
    • Lin, Y.1    Chang, G.2    Wang, J.3    Jin, W.4    Wang, L.5    Li, H.6    Ma, L.7    Li, Q.8    Pang, T.9
  • 74
    • 84855310010 scopus 로고    scopus 로고
    • NHE1 mediates migration and invasion of HeLa cells via regulating the expression and localization of MT1-MMP
    • 1:CAS:528:DC%2BC38XnvVCl 21997166
    • Lin Y, Wang J, Jin W, Wang L, Li H, Ma L, Li Q, Pang T (2012) NHE1 mediates migration and invasion of HeLa cells via regulating the expression and localization of MT1-MMP. Cell Biochem Funct 30:41-46
    • (2012) Cell Biochem Funct , vol.30 , pp. 41-46
    • Lin, Y.1    Wang, J.2    Jin, W.3    Wang, L.4    Li, H.5    Ma, L.6    Li, Q.7    Pang, T.8
  • 75
    • 0020570408 scopus 로고
    • Heparan sulfate degradation: Relation to tumor invasive and metastatic properties of mouse B16 melanoma sublines
    • 1:CAS:528:DyaL3sXktVeltLw%3D 6220468
    • Nakajima M, Irimura T, Di FD, Di FN, Nicolson GL (1983) Heparan sulfate degradation: relation to tumor invasive and metastatic properties of mouse B16 melanoma sublines. Science 220:611-613
    • (1983) Science , vol.220 , pp. 611-613
    • Nakajima, M.1    Irimura, T.2    Di, F.D.3    Di, F.N.4    Nicolson, G.L.5
  • 76
    • 0021354360 scopus 로고
    • Metastatic melanoma cell heparanase. Characterization of heparan sulfate degradation fragments produced by B16 melanoma endoglucuronidase
    • 1:CAS:528:DyaL2cXhslSmtLk%3D 6698965
    • Nakajima M, Irimura T, Di FN, Nicolson GL (1984) Metastatic melanoma cell heparanase. Characterization of heparan sulfate degradation fragments produced by B16 melanoma endoglucuronidase. J Biol Chem 259:2283-2290
    • (1984) J Biol Chem , vol.259 , pp. 2283-2290
    • Nakajima, M.1    Irimura, T.2    Di, F.N.3    Nicolson, G.L.4
  • 77
    • 0031059664 scopus 로고    scopus 로고
    • Exposure to hypoxia, glucose starvation and acidosis: Effect on invasive capacity of murine tumor cells and correlation with cathepsin (L + B) secretion
    • 1:CAS:528:DyaK2sXhs1Oktr4%3D 9009102
    • Cuvier C, Jang A, Hill RP (1997) Exposure to hypoxia, glucose starvation and acidosis: effect on invasive capacity of murine tumor cells and correlation with cathepsin (L + B) secretion. Clin Exp Metastasis 15:19-25
    • (1997) Clin Exp Metastasis , vol.15 , pp. 19-25
    • Cuvier, C.1    Jang, A.2    Hill, R.P.3
  • 79
    • 0025771024 scopus 로고
    • Glucose starvation and acidosis: Effect on experimental metastatic potential, DNA content and MTX resistance of murine tumour cells
    • 1:CAS:528:DyaK38XhtVentL8%3D 1911214 1977701
    • Schlappack OK, Zimmermann A, Hill RP (1991) Glucose starvation and acidosis: effect on experimental metastatic potential, DNA content and MTX resistance of murine tumour cells. Br J Cancer 64:663-670
    • (1991) Br J Cancer , vol.64 , pp. 663-670
    • Schlappack, O.K.1    Zimmermann, A.2    Hill, R.P.3
  • 81
    • 2642530312 scopus 로고    scopus 로고
    • Effects of tumour acidification with glucose + MIBG on the spontaneous metastatic potential of two murine cell lines
    • 1:STN:280:DC%2BD2czgsFWgug%3D%3D 15150590 2409743
    • Kalliomaki T, Hill RP (2004) Effects of tumour acidification with glucose + MIBG on the spontaneous metastatic potential of two murine cell lines. Br J Cancer 90:1842-1849
    • (2004) Br J Cancer , vol.90 , pp. 1842-1849
    • Kalliomaki, T.1    Hill, R.P.2
  • 84
    • 0032712997 scopus 로고    scopus 로고
    • Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic
    • 1:CAS:528:DyaK1MXotV2gt7c%3D 10589791
    • Shi Q, Abbruzzese JL, Huang S, Fidler IJ, Xiong Q, Xie K (1999) Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic. Clin Cancer Res 5:3711-3721
    • (1999) Clin Cancer Res , vol.5 , pp. 3711-3721
    • Shi, Q.1    Abbruzzese, J.L.2    Huang, S.3    Fidler, I.J.4    Xiong, Q.5    Xie, K.6
  • 85
    • 0033661527 scopus 로고    scopus 로고
    • Regulation of interleukin-8 expression by cellular pH in human pancreatic adenocarcinoma cells
    • 1:CAS:528:DC%2BD3cXosl2juro%3D 11096460
    • Shi Q, Le X, Wang B, Xiong Q, Abbruzzese JL, Xie K (2000) Regulation of interleukin-8 expression by cellular pH in human pancreatic adenocarcinoma cells. J Interferon Cytokine Res 20:1023-1028
    • (2000) J Interferon Cytokine Res , vol.20 , pp. 1023-1028
    • Shi, Q.1    Le, X.2    Wang, B.3    Xiong, Q.4    Abbruzzese, J.L.5    Xie, K.6
  • 86
    • 0034662635 scopus 로고    scopus 로고
    • Acidic pH-induced elevation in interleukin 8 expression by human ovarian carcinoma cells
    • 1:CAS:528:DC%2BD3cXmsVahsLw%3D 10969814
    • Xu L, Fidler IJ (2000) Acidic pH-induced elevation in interleukin 8 expression by human ovarian carcinoma cells. Cancer Res 60:4610-4616
    • (2000) Cancer Res , vol.60 , pp. 4610-4616
    • Xu, L.1    Fidler, I.J.2
  • 87
    • 0035927544 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells
    • 1:CAS:528:DC%2BD3MXltVKnsbw%3D 11439338
    • Shi Q, Le X, Wang B, Abbruzzese JL, Xiong Q, He Y, Xie K (2001) Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells. Oncogene 20:3751-3756
    • (2001) Oncogene , vol.20 , pp. 3751-3756
    • Shi, Q.1    Le, X.2    Wang, B.3    Abbruzzese, J.L.4    Xiong, Q.5    He, Y.6    Xie, K.7
  • 88
    • 0035881307 scopus 로고    scopus 로고
    • Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo
    • 1:CAS:528:DC%2BD3MXmt12ktrc%3D 11507045
    • Fukumura D, Xu L, Chen Y, Gohongi T, Seed B, Jain RK (2001) Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo. Cancer Res 61:6020-6024
    • (2001) Cancer Res , vol.61 , pp. 6020-6024
    • Fukumura, D.1    Xu, L.2    Chen, Y.3    Gohongi, T.4    Seed, B.5    Jain, R.K.6
  • 89
    • 0037192802 scopus 로고    scopus 로고
    • Acidic extracellular pH induces vascular endothelial growth factor (VEGF) in human glioblastoma cells via ERK1/2 MAPK signaling pathway: Mechanism of low pH-induced VEGF
    • 1:CAS:528:DC%2BD38Xis1KgsLk%3D 11741977
    • Xu L, Fukumura D, Jain RK (2002) Acidic extracellular pH induces vascular endothelial growth factor (VEGF) in human glioblastoma cells via ERK1/2 MAPK signaling pathway: mechanism of low pH-induced VEGF. J Biol Chem 277:11368-11374
    • (2002) J Biol Chem , vol.277 , pp. 11368-11374
    • Xu, L.1    Fukumura, D.2    Jain, R.K.3
  • 90
    • 0029010434 scopus 로고
    • Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor
    • 1:CAS:528:DyaK2MXmsFOnsrs%3D 7673356
    • Roberts WG, Palade GE (1995) Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. J Cell Sci 108(Pt 6):2369-2379
    • (1995) J Cell Sci , vol.108 , pp. 2369-2379
    • Roberts, W.G.1    Palade, G.E.2
  • 91
  • 92
    • 0026446859 scopus 로고
    • Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells
    • 1:CAS:528:DyaK3sXhs12msA%3D%3D 1447317
    • Unemori EN, Ferrara N, Bauer EA, Amento EP (1992) Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. J Cell Physiol 153:557-562
    • (1992) J Cell Physiol , vol.153 , pp. 557-562
    • Unemori, E.N.1    Ferrara, N.2    Bauer, E.A.3    Amento, E.P.4
  • 93
  • 94
    • 0032960519 scopus 로고    scopus 로고
    • Role of interleukin-8 in tumor growth and metastasis of human melanoma
    • 1:CAS:528:DyaK1MXnvVyjtQ%3D%3D 9873223
    • Bar-Eli M (1999) Role of interleukin-8 in tumor growth and metastasis of human melanoma. Pathobiology 67:12-18
    • (1999) Pathobiology , vol.67 , pp. 12-18
    • Bar-Eli, M.1
  • 95
    • 79952808077 scopus 로고    scopus 로고
    • Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis
    • 1:CAS:528:DC%2BC3MXislagsb0%3D 21361354
    • Pacchiano F, Carta F, McDonald PC, Lou Y, Vullo D, Scozzafava A, Dedhar S, Supuran CT (2011) Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis. J Med Chem 54:1896-1902
    • (2011) J Med Chem , vol.54 , pp. 1896-1902
    • Pacchiano, F.1    Carta, F.2    McDonald, P.C.3    Lou, Y.4    Vullo, D.5    Scozzafava, A.6    Dedhar, S.7    Supuran, C.T.8
  • 102
    • 0025740495 scopus 로고
    • Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor
    • 1:CAS:528:DyaK38XhsVCjtLY%3D 1649192
    • Watanabe H, Carmi P, Hogan V, Raz T, Silletti S, Nabi IR, Raz A (1991) Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor. J Biol Chem 266:13442-13448
    • (1991) J Biol Chem , vol.266 , pp. 13442-13448
    • Watanabe, H.1    Carmi, P.2    Hogan, V.3    Raz, T.4    Silletti, S.5    Nabi, I.R.6    Raz, A.7
  • 103
    • 0029986708 scopus 로고    scopus 로고
    • Autocrine motility factor signals integrin-mediated metastatic melanoma cell adhesion and invasion
    • 1:CAS:528:DyaK28XitlyksLk%3D 8620512
    • Timar J, Trikha M, Szekeres K, Bazaz R, Tovari J, Silletti S, Raz A, Honn KV (1996) Autocrine motility factor signals integrin-mediated metastatic melanoma cell adhesion and invasion. Cancer Res 56:1902-1908
    • (1996) Cancer Res , vol.56 , pp. 1902-1908
    • Timar, J.1    Trikha, M.2    Szekeres, K.3    Bazaz, R.4    Tovari, J.5    Silletti, S.6    Raz, A.7    Honn, K.V.8
  • 106
    • 9344260855 scopus 로고    scopus 로고
    • Autocrine motility factor signaling enhances pancreatic cancer metastasis
    • 1:CAS:528:DC%2BD2cXhtVanurrO 15570012
    • Tsutsumi S, Yanagawa T, Shimura T, Kuwano H, Raz A (2004) Autocrine motility factor signaling enhances pancreatic cancer metastasis. Clin Cancer Res 10:7775-7784
    • (2004) Clin Cancer Res , vol.10 , pp. 7775-7784
    • Tsutsumi, S.1    Yanagawa, T.2    Shimura, T.3    Kuwano, H.4    Raz, A.5
  • 107
    • 2342560617 scopus 로고    scopus 로고
    • Overexpression of autocrine motility factor in metastatic tumor cells: Possible association with augmented expression of KIF3A and GDI-beta
    • 1:CAS:528:DC%2BD2cXmtF2it78%3D 14968121
    • Yanagawa T, Watanabe H, Takeuchi T, Fujimoto S, Kurihara H, Takagishi K (2004) Overexpression of autocrine motility factor in metastatic tumor cells: possible association with augmented expression of KIF3A and GDI-beta. Lab Invest 84:513-522
    • (2004) Lab Invest , vol.84 , pp. 513-522
    • Yanagawa, T.1    Watanabe, H.2    Takeuchi, T.3    Fujimoto, S.4    Kurihara, H.5    Takagishi, K.6
  • 108
    • 24644488689 scopus 로고    scopus 로고
    • Regulation of phosphoglucose isomerase/autocrine motility factor expression by hypoxia
    • 1:CAS:528:DC%2BD2MXpvFSltrY%3D 16126909
    • Funasaka T, Yanagawa T, Hogan V, Raz A (2005) Regulation of phosphoglucose isomerase/autocrine motility factor expression by hypoxia. FASEB J 19:1422-1430
    • (2005) FASEB J , vol.19 , pp. 1422-1430
    • Funasaka, T.1    Yanagawa, T.2    Hogan, V.3    Raz, A.4
  • 110
    • 0037224507 scopus 로고    scopus 로고
    • Overexpression of the autocrine motility factor/phosphoglucose isomerase induces transformation and survival of NIH-3T3 fibroblasts
    • 1:CAS:528:DC%2BD3sXjvFKntw%3D%3D 12517804
    • Tsutsumi S, Hogan V, Nabi IR, Raz A (2003) Overexpression of the autocrine motility factor/phosphoglucose isomerase induces transformation and survival of NIH-3T3 fibroblasts. Cancer Res 63:242-249
    • (2003) Cancer Res , vol.63 , pp. 242-249
    • Tsutsumi, S.1    Hogan, V.2    Nabi, I.R.3    Raz, A.4
  • 111
    • 84899517033 scopus 로고    scopus 로고
    • Autocrine motility factor modulates EGF-mediated invasion signaling
    • 1:CAS:528:DC%2BC2cXmtVOmsbY%3D 24576828 4091754
    • Kho DH, Zhang T, Balan V, Wang Y, Ha SW, Xie Y, Raz A (2014) Autocrine motility factor modulates EGF-mediated invasion signaling. Cancer Res 74:2229-2237
    • (2014) Cancer Res , vol.74 , pp. 2229-2237
    • Kho, D.H.1    Zhang, T.2    Balan, V.3    Wang, Y.4    Ha, S.W.5    Xie, Y.6    Raz, A.7
  • 112
    • 0036682378 scopus 로고    scopus 로고
    • Activation of small GTPase Rho is required for autocrine motility factor signaling
    • 1:CAS:528:DC%2BD38XlvFeksr0%3D 12154059
    • Tsutsumi S, Gupta SK, Hogan V, Collard JG, Raz A (2002) Activation of small GTPase Rho is required for autocrine motility factor signaling. Cancer Res 62:4484-4490
    • (2002) Cancer Res , vol.62 , pp. 4484-4490
    • Tsutsumi, S.1    Gupta, S.K.2    Hogan, V.3    Collard, J.G.4    Raz, A.5
  • 113
    • 67650463104 scopus 로고    scopus 로고
    • Phosphoglucose isomerase/autocrine motility factor mediates epithelial and mesenchymal phenotype conversions in breast cancer
    • 1:CAS:528:DC%2BD1MXnvFWqu7s%3D 19531650 2875197
    • Funasaka T, Hogan V, Raz A (2009) Phosphoglucose isomerase/autocrine motility factor mediates epithelial and mesenchymal phenotype conversions in breast cancer. Cancer Res 69:5349-5356
    • (2009) Cancer Res , vol.69 , pp. 5349-5356
    • Funasaka, T.1    Hogan, V.2    Raz, A.3
  • 114
    • 79955497173 scopus 로고    scopus 로고
    • Phosphoglucose isomerase/autocrine motility factor mediates epithelial-mesenchymal transition regulated by miR-200 in breast cancer cells
    • 1:CAS:528:DC%2BC3MXltlGhurg%3D 21389093 3085607
    • Ahmad A, Aboukameel A, Kong D, Wang Z, Sethi S, Chen W, Sarkar FH, Raz A (2011) Phosphoglucose isomerase/autocrine motility factor mediates epithelial-mesenchymal transition regulated by miR-200 in breast cancer cells. Cancer Res 71:3400-3409
    • (2011) Cancer Res , vol.71 , pp. 3400-3409
    • Ahmad, A.1    Aboukameel, A.2    Kong, D.3    Wang, Z.4    Sethi, S.5    Chen, W.6    Sarkar, F.H.7    Raz, A.8
  • 115
    • 0034816920 scopus 로고    scopus 로고
    • Tumor autocrine motility factor is an angiogenic factor hat stimulates endothelial cell motility
    • 1:CAS:528:DC%2BD3MXksVKjsbg%3D 11414699
    • Funasaka T, Haga A, Raz A, Nagase H (2001) Tumor autocrine motility factor is an angiogenic factor hat stimulates endothelial cell motility. Biochem Biophys Res Commun 284:1116-1125
    • (2001) Biochem Biophys Res Commun , vol.284 , pp. 1116-1125
    • Funasaka, T.1    Haga, A.2    Raz, A.3    Nagase, H.4
  • 116
    • 0037144363 scopus 로고    scopus 로고
    • Autocrine motility factor secreted by tumor cells upregulates vascular endothelial growth factor receptor (Flt-1) expression in endothelial cells
    • 1:CAS:528:DC%2BD38XmvVeqs7Y%3D 12209971
    • Funasaka T, Haga A, Raz A, Nagase H (2002) Autocrine motility factor secreted by tumor cells upregulates vascular endothelial growth factor receptor (Flt-1) expression in endothelial cells. Int J Cancer 101:217-223
    • (2002) Int J Cancer , vol.101 , pp. 217-223
    • Funasaka, T.1    Haga, A.2    Raz, A.3    Nagase, H.4
  • 117
    • 0036296172 scopus 로고    scopus 로고
    • Tumor autocrine motility factor induces hyperpermeability of endothelial and mesothelial cells leading to accumulation of ascites fluid
    • 1:CAS:528:DC%2BD38XksVGitL8%3D 12054583
    • Funasaka T, Haga A, Raz A, Nagase H (2002) Tumor autocrine motility factor induces hyperpermeability of endothelial and mesothelial cells leading to accumulation of ascites fluid. Biochem Biophys Res Commun 293:192-200
    • (2002) Biochem Biophys Res Commun , vol.293 , pp. 192-200
    • Funasaka, T.1    Haga, A.2    Raz, A.3    Nagase, H.4
  • 118
    • 0026321067 scopus 로고
    • Serum phosphohexose isomerase activities in patients with colorectal cancer
    • 1:STN:280:DyaK387ovVSqtQ%3D%3D 1798910
    • Filella X, Molina R, Jo J, Mas E, Ballesta AM (1991) Serum phosphohexose isomerase activities in patients with colorectal cancer. Tumour Biol 12:360-367
    • (1991) Tumour Biol , vol.12 , pp. 360-367
    • Filella, X.1    Molina, R.2    Jo, J.3    Mas, E.4    Ballesta, A.M.5
  • 119
    • 0027978023 scopus 로고
    • Expression of autocrine motility factor receptor in colorectal cancer as a predictor for disease recurrence
    • 1:STN:280:DyaK2czmtlKnug%3D%3D 8082090
    • Nakamori S, Watanabe H, Kameyama M, Imaoka S, Furukawa H, Ishikawa O, Sasaki Y, Kabuto T, Raz A (1994) Expression of autocrine motility factor receptor in colorectal cancer as a predictor for disease recurrence. Cancer 74:1855-1862
    • (1994) Cancer , vol.74 , pp. 1855-1862
    • Nakamori, S.1    Watanabe, H.2    Kameyama, M.3    Imaoka, S.4    Furukawa, H.5    Ishikawa, O.6    Sasaki, Y.7    Kabuto, T.8    Raz, A.9
  • 121
    • 0031880489 scopus 로고    scopus 로고
    • Autocrine motility factor in pulmonary adenocarcinomas: Results of an immunohistochemical study
    • 1:CAS:528:DyaK1cXmtVOrtbY%3D 9701729
    • Takanami I, Takeuchi K, Naruke M, Kodaira S, Tanaka F, Watanabe H, Raz A (1998) Autocrine motility factor in pulmonary adenocarcinomas: results of an immunohistochemical study. Tumour Biol 19:384-389
    • (1998) Tumour Biol , vol.19 , pp. 384-389
    • Takanami, I.1    Takeuchi, K.2    Naruke, M.3    Kodaira, S.4    Tanaka, F.5    Watanabe, H.6    Raz, A.7
  • 123
    • 0025701432 scopus 로고
    • Glycolysis as primary energy source in tumor cell chemotaxis
    • 1:CAS:528:DyaK3MXitVCksro%3D 2174462
    • Beckner ME, Stracke ML, Liotta LA, Schiffmann E (1990) Glycolysis as primary energy source in tumor cell chemotaxis. J Natl Cancer Inst 82:1836-1840
    • (1990) J Natl Cancer Inst , vol.82 , pp. 1836-1840
    • Beckner, M.E.1    Stracke, M.L.2    Liotta, L.A.3    Schiffmann, E.4
  • 125
    • 84873822732 scopus 로고    scopus 로고
    • Influence of cell detachment on the respiration rate of tumor and endothelial cells
    • 1:CAS:528:DC%2BC3sXis1akt7Y%3D 23382841 3559693
    • Danhier P, Copetti T, De PG, Leveque P, Feron O, Jordan BF, Sonveaux P, Gallez B (2013) Influence of cell detachment on the respiration rate of tumor and endothelial cells. PLoS One 8:e53324
    • (2013) PLoS One , vol.8 , pp. e53324
    • Danhier, P.1    Copetti, T.2    De, P.G.3    Leveque, P.4    Feron, O.5    Jordan, B.F.6    Sonveaux, P.7    Gallez, B.8
  • 126
    • 84926646150 scopus 로고    scopus 로고
    • Common responses of tumors and wounds to hypoxia
    • 1:CAS:528:DC%2BC2MXlsleitrw%3D 25815847
    • Payen VL, Brisson L, Dewhirst MW, Sonveaux P (2015) Common responses of tumors and wounds to hypoxia. Cancer J 21:75-87
    • (2015) Cancer J , vol.21 , pp. 75-87
    • Payen, V.L.1    Brisson, L.2    Dewhirst, M.W.3    Sonveaux, P.4
  • 127
    • 84855444042 scopus 로고    scopus 로고
    • The monocarboxylate transporter family-Structure and functional characterization
    • 1:CAS:528:DC%2BC3MXhsFeitrnI 22131303
    • Halestrap AP (2012) The monocarboxylate transporter family-Structure and functional characterization. IUBMB Life 64:1-9
    • (2012) IUBMB Life , vol.64 , pp. 1-9
    • Halestrap, A.P.1
  • 128
    • 37449034854 scopus 로고    scopus 로고
    • Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
    • 1:CAS:528:DC%2BD1cXisVOjtQ%3D%3D 18032601 2148292
    • DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, Thompson CB (2007) Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci USA 104:19345-19350
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 19345-19350
    • DeBerardinis, R.J.1    Mancuso, A.2    Daikhin, E.3    Nissim, I.4    Yudkoff, M.5    Wehrli, S.6    Thompson, C.B.7
  • 129
    • 3242798360 scopus 로고    scopus 로고
    • Lactate in solid malignant tumors: Potential basis of a metabolic classification in clinical oncology
    • 1:CAS:528:DC%2BD2cXlslWltbY%3D 15279558
    • Walenta S, Schroeder T, Mueller-Klieser W (2004) Lactate in solid malignant tumors: potential basis of a metabolic classification in clinical oncology. Curr Med Chem 11:2195-2204
    • (2004) Curr Med Chem , vol.11 , pp. 2195-2204
    • Walenta, S.1    Schroeder, T.2    Mueller-Klieser, W.3
  • 130
    • 47249118348 scopus 로고    scopus 로고
    • Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway
    • 1:CAS:528:DC%2BD1cXmtVantLg%3D 18490716
    • Shime H, Yabu M, Akazawa T, Kodama K, Matsumoto M, Seya T, Inoue N (2008) Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway. J Immunol 180:7175-7183
    • (2008) J Immunol , vol.180 , pp. 7175-7183
    • Shime, H.1    Yabu, M.2    Akazawa, T.3    Kodama, K.4    Matsumoto, M.5    Seya, T.6    Inoue, N.7
  • 131
    • 78650359602 scopus 로고    scopus 로고
    • IL-23-dependent and -independent enhancement pathways of IL-17A production by lactic acid
    • 1:CAS:528:DC%2BC3cXhsFyltL7P 21131367
    • Yabu M, Shime H, Hara H, Saito T, Matsumoto M, Seya T, Akazawa T, Inoue N (2011) IL-23-dependent and -independent enhancement pathways of IL-17A production by lactic acid. Int Immunol 23:29-41
    • (2011) Int Immunol , vol.23 , pp. 29-41
    • Yabu, M.1    Shime, H.2    Hara, H.3    Saito, T.4    Matsumoto, M.5    Seya, T.6    Akazawa, T.7    Inoue, N.8
  • 135
    • 79960029992 scopus 로고    scopus 로고
    • Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release
    • 1:CAS:528:DC%2BC3MXpvVegsbg%3D 21617859
    • Goetze K, Walenta S, Ksiazkiewicz M, Kunz-Schughart LA, Mueller-Klieser W (2011) Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release. Int J Oncol 39:453-463
    • (2011) Int J Oncol , vol.39 , pp. 453-463
    • Goetze, K.1    Walenta, S.2    Ksiazkiewicz, M.3    Kunz-Schughart, L.A.4    Mueller-Klieser, W.5
  • 136
    • 77149174857 scopus 로고    scopus 로고
    • Manipulation of glycolysis in malignant tumors: Fantasy or therapy?
    • 1:CAS:528:DC%2BC3cXhsVSmtrs%3D 19941476
    • Sattler UG, Hirschhaeusera F, Mueller-Klieser WF (2010) Manipulation of glycolysis in malignant tumors: fantasy or therapy? Curr Med Chem 17:96-108
    • (2010) Curr Med Chem , vol.17 , pp. 96-108
    • Sattler, U.G.1    Hirschhaeusera, F.2    Mueller-Klieser, W.F.3
  • 137
    • 0031029634 scopus 로고    scopus 로고
    • Correlation of high lactate levels in head and neck tumors with incidence of metastasis
    • 1:CAS:528:DyaK2sXhtlSgs7s%3D 9033256 1858285
    • Walenta S, Salameh A, Lyng H, Evensen JF, Mitze M, Rofstad EK, Mueller-Klieser W (1997) Correlation of high lactate levels in head and neck tumors with incidence of metastasis. Am J Pathol 150:409-415
    • (1997) Am J Pathol , vol.150 , pp. 409-415
    • Walenta, S.1    Salameh, A.2    Lyng, H.3    Evensen, J.F.4    Mitze, M.5    Rofstad, E.K.6    Mueller-Klieser, W.7
  • 140
    • 0028784650 scopus 로고
    • Correlation of high lactate levels in human cervical cancer with incidence of metastasis
    • 1:CAS:528:DyaK2MXptFKitLc%3D 7585499
    • Schwickert G, Walenta S, Sundfor K, Rofstad EK, Mueller-Klieser W (1995) Correlation of high lactate levels in human cervical cancer with incidence of metastasis. Cancer Res 55:4757-4759
    • (1995) Cancer Res , vol.55 , pp. 4757-4759
    • Schwickert, G.1    Walenta, S.2    Sundfor, K.3    Rofstad, E.K.4    Mueller-Klieser, W.5
  • 141
    • 0034652620 scopus 로고    scopus 로고
    • High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers
    • 1:CAS:528:DC%2BD3cXhs1Shsrk%3D 10706105
    • Walenta S, Wetterling M, Lehrke M, Schwickert G, Sundfor K, Rofstad EK, Mueller-Klieser W (2000) High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res 60:916-921
    • (2000) Cancer Res , vol.60 , pp. 916-921
    • Walenta, S.1    Wetterling, M.2    Lehrke, M.3    Schwickert, G.4    Sundfor, K.5    Rofstad, E.K.6    Mueller-Klieser, W.7
  • 142
    • 0036347515 scopus 로고    scopus 로고
    • Lactate stimulates fibroblast expression of hyaluronan and CD44: The Warburg effect revisited
    • 1:CAS:528:DC%2BD38XjtFyisrk%3D 11978005
    • Stern R, Shuster S, Neudecker BA, Formby B (2002) Lactate stimulates fibroblast expression of hyaluronan and CD44: the Warburg effect revisited. Exp Cell Res 276:24-31
    • (2002) Exp Cell Res , vol.276 , pp. 24-31
    • Stern, R.1    Shuster, S.2    Neudecker, B.A.3    Formby, B.4
  • 146
    • 0037189542 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis
    • 1:CAS:528:DC%2BD38XltF2nsr4%3D 11943784
    • Lu H, Forbes RA, Verma A (2002) Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. J Biol Chem 277:23111-23115
    • (2002) J Biol Chem , vol.277 , pp. 23111-23115
    • Lu, H.1    Forbes, R.A.2    Verma, A.3
  • 147
    • 29644442625 scopus 로고    scopus 로고
    • Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1
    • 1:CAS:528:DC%2BD2MXhtlajsrnN 16223732
    • Lu H, Dalgard CL, Mohyeldin A, McFate T, Tait AS, Verma A (2005) Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1. J Biol Chem 280:41928-41939
    • (2005) J Biol Chem , vol.280 , pp. 41928-41939
    • Lu, H.1    Dalgard, C.L.2    Mohyeldin, A.3    McFate, T.4    Tait, A.S.5    Verma, A.6
  • 148
    • 79953329777 scopus 로고    scopus 로고
    • Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-kappaB/IL-8 pathway that drives tumor angiogenesis
    • 1:CAS:528:DC%2BC3MXktVOjtLg%3D 21300765
    • Vegran F, Boidot R, Michiels C, Sonveaux P, Feron O (2011) Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-kappaB/IL-8 pathway that drives tumor angiogenesis. Cancer Res 71:2550-2560
    • (2011) Cancer Res , vol.71 , pp. 2550-2560
    • Vegran, F.1    Boidot, R.2    Michiels, C.3    Sonveaux, P.4    Feron, O.5
  • 149
  • 150
    • 84875053754 scopus 로고    scopus 로고
    • Lactate stimulates angiogenesis and accelerates the healing of superficial and ischemic wounds in mice
    • 1:CAS:528:DC%2BC38Xhs12jsLfL 22660894
    • Porporato PE, Payen VL, De Saedeleer CJ, Preat V, Thissen JP, Feron O, Sonveaux P (2012) Lactate stimulates angiogenesis and accelerates the healing of superficial and ischemic wounds in mice. Angiogenesis 15:581-592
    • (2012) Angiogenesis , vol.15 , pp. 581-592
    • Porporato, P.E.1    Payen, V.L.2    De Saedeleer, C.J.3    Preat, V.4    Thissen, J.P.5    Feron, O.6    Sonveaux, P.7
  • 152
    • 84859377387 scopus 로고    scopus 로고
    • Lactate-induced IL-8 pathway in endothelial cells-response
    • 1:CAS:528:DC%2BC38XkvVelt7c%3D
    • Vegran F, Seront E, Sonveaux P, Feron O (2012) Lactate-induced IL-8 pathway in endothelial cells-response. Cancer Res 72:1903-1904
    • (2012) Cancer Res , vol.72 , pp. 1903-1904
    • Vegran, F.1    Seront, E.2    Sonveaux, P.3    Feron, O.4
  • 153
    • 0034541196 scopus 로고    scopus 로고
    • Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor kappaB
    • 1:CAS:528:DC%2BD3cXosl2isLo%3D 11118032
    • Andela VB, Schwarz EM, Puzas JE, O'Keefe RJ, Rosier RN (2000) Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor kappaB. Cancer Res 60:6557-6562
    • (2000) Cancer Res , vol.60 , pp. 6557-6562
    • Andela, V.B.1    Schwarz, E.M.2    Puzas, J.E.3    O'Keefe, R.J.4    Rosier, R.N.5
  • 154
    • 78650373860 scopus 로고    scopus 로고
    • Hypoxia and hypoxia-inducible factors: Master regulators of metastasis
    • 1:CAS:528:DC%2BC3cXhsFOjsbfJ 20962028 3005023
    • Lu X, Kang Y (2010) Hypoxia and hypoxia-inducible factors: master regulators of metastasis. Clin Cancer Res 16:5928-5935
    • (2010) Clin Cancer Res , vol.16 , pp. 5928-5935
    • Lu, X.1    Kang, Y.2
  • 156
    • 34249293335 scopus 로고    scopus 로고
    • Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231
    • 1:CAS:528:DC%2BD2sXltVyrs74%3D 17483329
    • Gallagher SM, Castorino JJ, Wang D, Philp NJ (2007) Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231. Cancer Res 67:4182-4189
    • (2007) Cancer Res , vol.67 , pp. 4182-4189
    • Gallagher, S.M.1    Castorino, J.J.2    Wang, D.3    Philp, N.J.4
  • 159
    • 84887607569 scopus 로고    scopus 로고
    • Downregulation of MCT1 inhibits tumor growth, metastasis and enhances chemotherapeutic efficacy in osteosarcoma through regulation of the NF-kappaB pathway
    • 1:CAS:528:DC%2BC3sXhsFenur3M 24012639
    • Zhao Z, Wu MS, Zou C, Tang Q, Lu J, Liu D, Wu Y, Yin J, Xie X, Shen J, Kang T, Wang J (2014) Downregulation of MCT1 inhibits tumor growth, metastasis and enhances chemotherapeutic efficacy in osteosarcoma through regulation of the NF-kappaB pathway. Cancer Lett 342:150-158
    • (2014) Cancer Lett , vol.342 , pp. 150-158
    • Zhao, Z.1    Wu, M.S.2    Zou, C.3    Tang, Q.4    Lu, J.5    Liu, D.6    Wu, Y.7    Yin, J.8    Xie, X.9    Shen, J.10    Kang, T.11    Wang, J.12
  • 160
    • 79960320020 scopus 로고    scopus 로고
    • Lysyl oxidase-like-1 enhances lung metastasis when lactate accumulation and monocarboxylate transporter expression are involved
    • 1:CAS:528:DC%2BC3MXhtFSrsLvK 22866136 3408044
    • Lee GH, Kim DS, Chung MJ, Chae SW, Kim HR, Chae HJ (2011) Lysyl oxidase-like-1 enhances lung metastasis when lactate accumulation and monocarboxylate transporter expression are involved. Oncol Lett 2:831-838
    • (2011) Oncol Lett , vol.2 , pp. 831-838
    • Lee, G.H.1    Kim, D.S.2    Chung, M.J.3    Chae, S.W.4    Kim, H.R.5    Chae, H.J.6
  • 161
    • 84855370259 scopus 로고    scopus 로고
    • Prognostic significance of monocarboxylate transporter 4 expression in patients with colorectal cancer
    • 22969839 3438655
    • Nakayama Y, Torigoe T, Inoue Y, Minagawa N, Izumi H, Kohno K, Yamaguchi K (2012) Prognostic significance of monocarboxylate transporter 4 expression in patients with colorectal cancer. Exp Ther Med 3:25-30
    • (2012) Exp Ther Med , vol.3 , pp. 25-30
    • Nakayama, Y.1    Torigoe, T.2    Inoue, Y.3    Minagawa, N.4    Izumi, H.5    Kohno, K.6    Yamaguchi, K.7
  • 163
    • 0036605095 scopus 로고    scopus 로고
    • Basigin (CD147) is expressed on melanoma cells and induces tumor cell invasion by stimulating production of matrix metalloproteinases by fibroblasts
    • 1:CAS:528:DC%2BD38XjsFansL4%3D 11992541
    • Kanekura T, Chen X, Kanzaki T (2002) Basigin (CD147) is expressed on melanoma cells and induces tumor cell invasion by stimulating production of matrix metalloproteinases by fibroblasts. Int J Cancer 99:520-528
    • (2002) Int J Cancer , vol.99 , pp. 520-528
    • Kanekura, T.1    Chen, X.2    Kanzaki, T.3
  • 164
    • 84860760655 scopus 로고    scopus 로고
    • CD147 silencing via RNA interference reduces tumor cell invasion, metastasis and increases chemosensitivity in pancreatic cancer cells
    • 1:CAS:528:DC%2BC38XnvFekur8%3D 22427101
    • Pan Y, He B, Song G, Bao Q, Tang Z, Tian F, Wang S (2012) CD147 silencing via RNA interference reduces tumor cell invasion, metastasis and increases chemosensitivity in pancreatic cancer cells. Oncol Rep 27:2003-2009
    • (2012) Oncol Rep , vol.27 , pp. 2003-2009
    • Pan, Y.1    He, B.2    Song, G.3    Bao, Q.4    Tang, Z.5    Tian, F.6    Wang, S.7
  • 165
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • 1:CAS:528:DC%2BD1MXmtVKlsbg%3D 19460998 2849637
    • Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324:1029-1033
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 167
    • 84898924956 scopus 로고    scopus 로고
    • Identification and validation of dysregulated metabolic pathways in metastatic renal cell carcinoma
    • 1:CAS:528:DC%2BC2cXltlyrt74%3D 24136743
    • White NM, Newsted DW, Masui O, Romaschin AD, Siu KW, Yousef GM (2014) Identification and validation of dysregulated metabolic pathways in metastatic renal cell carcinoma. Tumour Biol 35:1833-1846
    • (2014) Tumour Biol , vol.35 , pp. 1833-1846
    • White, N.M.1    Newsted, D.W.2    Masui, O.3    Romaschin, A.D.4    Siu, K.W.5    Yousef, G.M.6
  • 168
    • 0027388949 scopus 로고
    • Studies with glycolysis-deficient cells suggest that production of lactic acid is not the only cause of tumor acidity
    • 1:CAS:528:DyaK3sXht1ajs7Y%3D 8430084 45824
    • Newell K, Franchi A, Pouyssegur J, Tannock I (1993) Studies with glycolysis-deficient cells suggest that production of lactic acid is not the only cause of tumor acidity. Proc Natl Acad Sci USA 90:1127-1131
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 1127-1131
    • Newell, K.1    Franchi, A.2    Pouyssegur, J.3    Tannock, I.4
  • 169
    • 0031748828 scopus 로고    scopus 로고
    • The contribution of lactic acid to acidification of tumours: Studies of variant cells lacking lactate dehydrogenase
    • 1:CAS:528:DyaK1cXktVCmsL0%3D 9667639 2150353
    • Yamagata M, Hasuda K, Stamato T, Tannock IF (1998) The contribution of lactic acid to acidification of tumours: studies of variant cells lacking lactate dehydrogenase. Br J Cancer 77:1726-1731
    • (1998) Br J Cancer , vol.77 , pp. 1726-1731
    • Yamagata, M.1    Hasuda, K.2    Stamato, T.3    Tannock, I.F.4
  • 170
    • 0036554644 scopus 로고    scopus 로고
    • Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism
    • 1:CAS:528:DC%2BD38XjsF2ltb4%3D 11948144
    • Helmlinger G, Sckell A, Dellian M, Forbes NS, Jain RK (2002) Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism. Clin Cancer Res 8:1284-1291
    • (2002) Clin Cancer Res , vol.8 , pp. 1284-1291
    • Helmlinger, G.1    Sckell, A.2    Dellian, M.3    Forbes, N.S.4    Jain, R.K.5
  • 171
    • 76049104247 scopus 로고    scopus 로고
    • TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alpha stabilization
    • 1:CAS:528:DC%2BC3cXhs1aqsrg%3D 20103683 2824550
    • Sun W, Liu Y, Glazer CA, Shao C, Bhan S, Demokan S, Zhao M, Rudek MA, Ha PK, Califano JA (2010) TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alpha stabilization. Clin Cancer Res 16:857-866
    • (2010) Clin Cancer Res , vol.16 , pp. 857-866
    • Sun, W.1    Liu, Y.2    Glazer, C.A.3    Shao, C.4    Bhan, S.5    Demokan, S.6    Zhao, M.7    Rudek, M.A.8    Ha, P.K.9    Califano, J.A.10
  • 172
    • 0028834278 scopus 로고
    • Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress
    • 1:CAS:528:DyaK2MXps1Kmsbk%3D 7489710 394630
    • Pandolfi PP, Sonati F, Rivi R, Mason P, Grosveld F, Luzzatto L (1995) Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress. EMBO J 14:5209-5215
    • (1995) EMBO J , vol.14 , pp. 5209-5215
    • Pandolfi, P.P.1    Sonati, F.2    Rivi, R.3    Mason, P.4    Grosveld, F.5    Luzzatto, L.6
  • 175
    • 23044500915 scopus 로고    scopus 로고
    • Pyruvate kinase type M2 and its role in tumor growth and spreading
    • 1:CAS:528:DC%2BD2MXmvVKntbw%3D 15908230
    • Mazurek S, Boschek CB, Hugo F, Eigenbrodt E (2005) Pyruvate kinase type M2 and its role in tumor growth and spreading. Semin Cancer Biol 15:300-308
    • (2005) Semin Cancer Biol , vol.15 , pp. 300-308
    • Mazurek, S.1    Boschek, C.B.2    Hugo, F.3    Eigenbrodt, E.4
  • 177
    • 75149150660 scopus 로고    scopus 로고
    • HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
    • 1:CAS:528:DC%2BD1MXhsFGjsLfO 20010808 2950088
    • David CJ, Chen M, Assanah M, Canoll P, Manley JL (2010) HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer. Nature 463:364-368
    • (2010) Nature , vol.463 , pp. 364-368
    • David, C.J.1    Chen, M.2    Assanah, M.3    Canoll, P.4    Manley, J.L.5
  • 178
    • 79958103961 scopus 로고    scopus 로고
    • Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells
    • 1:CAS:528:DC%2BC3MXntV2msbY%3D 20156581
    • Mazurek S (2011) Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells. Int J Biochem Cell Biol 43:969-980
    • (2011) Int J Biochem Cell Biol , vol.43 , pp. 969-980
    • Mazurek, S.1
  • 181
    • 79952280229 scopus 로고    scopus 로고
    • P53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
    • 1:CAS:528:DC%2BC3MXisFKntrs%3D 21336310 3110666
    • Jiang P, Du W, Wang X, Mancuso A, Gao X, Wu M, Yang X (2011) p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nat Cell Biol 13:310-316
    • (2011) Nat Cell Biol , vol.13 , pp. 310-316
    • Jiang, P.1    Du, W.2    Wang, X.3    Mancuso, A.4    Gao, X.5    Wu, M.6    Yang, X.7
  • 182
    • 84940435170 scopus 로고    scopus 로고
    • Malic enzyme 1 induces epithelial-mesenchymal transition and indicates poor prognosis in hepatocellular carcinoma
    • 1:CAS:528:DC%2BC2MXktFegtr8%3D 25753478
    • Wen D, Liu D, Tang J, Dong L, Liu Y, Tao Z, Wan J, Gao D, Wang L, Sun H, Fan J, Wu W (2015) Malic enzyme 1 induces epithelial-mesenchymal transition and indicates poor prognosis in hepatocellular carcinoma. Tumour Biol 36:6211-6221
    • (2015) Tumour Biol , vol.36 , pp. 6211-6221
    • Wen, D.1    Liu, D.2    Tang, J.3    Dong, L.4    Liu, Y.5    Tao, Z.6    Wan, J.7    Gao, D.8    Wang, L.9    Sun, H.10    Fan, J.11    Wu, W.12
  • 183
    • 84902332213 scopus 로고    scopus 로고
    • Quantitative flux analysis reveals folate-dependent NADPH production
    • 1:CAS:528:DC%2BC2cXps1WmtLc%3D 24805240 4104482
    • Fan J, Ye J, Kamphorst JJ, Shlomi T, Thompson CB, Rabinowitz JD (2014) Quantitative flux analysis reveals folate-dependent NADPH production. Nature 510:298-302
    • (2014) Nature , vol.510 , pp. 298-302
    • Fan, J.1    Ye, J.2    Kamphorst, J.J.3    Shlomi, T.4    Thompson, C.B.5    Rabinowitz, J.D.6
  • 184
    • 84884287630 scopus 로고    scopus 로고
    • 6-Phosphogluconate dehydrogenase regulates tumor cell migration in vitro by regulating receptor tyrosine kinase c-Met
    • 1:CAS:528:DC%2BC3sXhtl2qtL3O 23973484
    • Chan B, VanderLaan PA, Sukhatme VP (2013) 6-Phosphogluconate dehydrogenase regulates tumor cell migration in vitro by regulating receptor tyrosine kinase c-Met. Biochem Biophys Res Commun 439:247-251
    • (2013) Biochem Biophys Res Commun , vol.439 , pp. 247-251
    • Chan, B.1    VanderLaan, P.A.2    Sukhatme, V.P.3
  • 186
    • 21244460340 scopus 로고    scopus 로고
    • Mutations in the transketolase-like gene TKTL1: Clinical implications for neurodegenerative diseases, diabetes and cancer
    • 1:CAS:528:DC%2BD2MXmtFyms78%3D 15991799
    • Coy JF, Dressler D, Wilde J, Schubert P (2005) Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer. Clin Lab 51:257-273
    • (2005) Clin Lab , vol.51 , pp. 257-273
    • Coy, J.F.1    Dressler, D.2    Wilde, J.3    Schubert, P.4
  • 188
    • 34247592022 scopus 로고    scopus 로고
    • The TKTL1 gene influences total transketolase activity and cell proliferation in human colon cancer LoVo cells
    • 1:CAS:528:DC%2BD2sXis1anurs%3D 17351395
    • Hu LH, Yang JH, Zhang DT, Zhang S, Wang L, Cai PC, Zheng JF, Huang JS (2007) The TKTL1 gene influences total transketolase activity and cell proliferation in human colon cancer LoVo cells. Anticancer Drugs 18:427-433
    • (2007) Anticancer Drugs , vol.18 , pp. 427-433
    • Hu, L.H.1    Yang, J.H.2    Zhang, D.T.3    Zhang, S.4    Wang, L.5    Cai, P.C.6    Zheng, J.F.7    Huang, J.S.8
  • 189
    • 34249905885 scopus 로고    scopus 로고
    • Gene silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cells
    • 1:CAS:528:DC%2BD2sXmtlWhsL4%3D 17321041
    • Zhang S, Yang JH, Guo CK, Cai PC (2007) Gene silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cells. Cancer Lett 253:108-114
    • (2007) Cancer Lett , vol.253 , pp. 108-114
    • Zhang, S.1    Yang, J.H.2    Guo, C.K.3    Cai, P.C.4
  • 190
    • 42549156713 scopus 로고    scopus 로고
    • Metastasis is promoted by a bioenergetic switch: New targets for progressive renal cell cancer
    • 1:CAS:528:DC%2BD1cXltlaitbk%3D 18302154
    • Langbein S, Frederiks WM, Zur HA, Popa J, Lehmann J, Weiss C, Alken P, Coy JF (2008) Metastasis is promoted by a bioenergetic switch: new targets for progressive renal cell cancer. Int J Cancer 122:2422-2428
    • (2008) Int J Cancer , vol.122 , pp. 2422-2428
    • Langbein, S.1    Frederiks, W.M.2    Zur, H.A.3    Popa, J.4    Lehmann, J.5    Weiss, C.6    Alken, P.7    Coy, J.F.8
  • 191
  • 192
    • 52049110833 scopus 로고    scopus 로고
    • Increased expression of transketolase-like-1 in papillary thyroid carcinomas smaller than 1.5 cm in diameter is associated with lymph-node metastases
    • 18615628
    • Zerilli M, Amato MC, Martorana A, Cabibi D, Coy JF, Cappello F, Pompei G, Russo A, Giordano C, Rodolico V (2008) Increased expression of transketolase-like-1 in papillary thyroid carcinomas smaller than 1.5 cm in diameter is associated with lymph-node metastases. Cancer 113:936-944
    • (2008) Cancer , vol.113 , pp. 936-944
    • Zerilli, M.1    Amato, M.C.2    Martorana, A.3    Cabibi, D.4    Coy, J.F.5    Cappello, F.6    Pompei, G.7    Russo, A.8    Giordano, C.9    Rodolico, V.10
  • 193
    • 80053206983 scopus 로고    scopus 로고
    • Transketolase-like 1 expression is modulated during colorectal cancer progression and metastasis formation
    • 1:CAS:528:DC%2BC3MXhtlCjsrzL 21980427 3181277
    • Diaz-Moralli S, Tarrado-Castellarnau M, Alenda C, Castells A, Cascante M (2011) Transketolase-like 1 expression is modulated during colorectal cancer progression and metastasis formation. PLoS One 6:e25323
    • (2011) PLoS One , vol.6 , pp. e25323
    • Diaz-Moralli, S.1    Tarrado-Castellarnau, M.2    Alenda, C.3    Castells, A.4    Cascante, M.5
  • 194
    • 77954162688 scopus 로고    scopus 로고
    • Glucose metabolism of malignant cells is not regulated by transketolase-like (TKTL)-1
    • 1:CAS:528:DC%2BC3cXhtVamsrzN 20596653
    • Mayer A, Von WA, Vaupel P (2010) Glucose metabolism of malignant cells is not regulated by transketolase-like (TKTL)-1. Int J Oncol 37:265-271
    • (2010) Int J Oncol , vol.37 , pp. 265-271
    • Mayer, A.1    Von, W.A.2    Vaupel, P.3
  • 195
    • 84934440529 scopus 로고    scopus 로고
    • Evidence against a major role for TKTL-1 in hypoxic and normoxic cancer cells
    • 1:CAS:528:DC%2BC3MXhtVyntrvO 21445778
    • Mayer A, Von WA, Vaupel P (2011) Evidence against a major role for TKTL-1 in hypoxic and normoxic cancer cells. Adv Exp Med Biol 701:123-128
    • (2011) Adv Exp Med Biol , vol.701 , pp. 123-128
    • Mayer, A.1    Von, W.A.2    Vaupel, P.3
  • 198
    • 84902658757 scopus 로고    scopus 로고
    • Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux
    • 1:CAS:528:DC%2BC2cXpt1Kqu7w%3D 24672058
    • Draoui N, Schicke O, Seront E, Bouzin C, Sonveaux P, Riant O, Feron O (2014) Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux. Mol Cancer Ther 13:1410-1418
    • (2014) Mol Cancer Ther , vol.13 , pp. 1410-1418
    • Draoui, N.1    Schicke, O.2    Seront, E.3    Bouzin, C.4    Sonveaux, P.5    Riant, O.6    Feron, O.7
  • 199
    • 67349275453 scopus 로고    scopus 로고
    • Metabolic acidosis and the importance of balanced equations
    • 1:CAS:528:DC%2BD1MXltleqtb0%3D
    • Lane AN, Fan TWM, Higashi RM (2009) Metabolic acidosis and the importance of balanced equations. Metabolomics 5:163-165
    • (2009) Metabolomics , vol.5 , pp. 163-165
    • Lane, A.N.1    Fan, T.W.M.2    Higashi, R.M.3
  • 200
    • 84923169480 scopus 로고    scopus 로고
    • Targeting carbonic anhydrase IX with small organic ligands
    • 1:CAS:528:DC%2BC2MXjtlWisbc%3D 25721398
    • Wichert M, Krall N (2015) Targeting carbonic anhydrase IX with small organic ligands. Curr Opin Chem Biol 26:48-54
    • (2015) Curr Opin Chem Biol , vol.26 , pp. 48-54
    • Wichert, M.1    Krall, N.2
  • 201
    • 84901983377 scopus 로고    scopus 로고
    • PH-sensitive nano-systems for drug delivery in cancer therapy
    • 1:CAS:528:DC%2BC3sXhvF2rtrvO 24309541
    • Liu J, Huang Y, Kumar A, Tan A, Jin S, Mozhi A, Liang XJ (2014) pH-sensitive nano-systems for drug delivery in cancer therapy. Biotechnol Adv 32:693-710
    • (2014) Biotechnol Adv , vol.32 , pp. 693-710
    • Liu, J.1    Huang, Y.2    Kumar, A.3    Tan, A.4    Jin, S.5    Mozhi, A.6    Liang, X.J.7
  • 202
    • 84898929476 scopus 로고    scopus 로고
    • PH-sensitive polymeric nanoparticles for tumor-targeting doxorubicin delivery: Concept and recent advances
    • 1:CAS:528:DC%2BC2cXmsVelu7Y%3D
    • Meng F, Zhong Y, Cheng R, Deng C, Zhong Z (2014) pH-sensitive polymeric nanoparticles for tumor-targeting doxorubicin delivery: concept and recent advances. Nanomedicine (Lond) 9:487-499
    • (2014) Nanomedicine (Lond) , vol.9 , pp. 487-499
    • Meng, F.1    Zhong, Y.2    Cheng, R.3    Deng, C.4    Zhong, Z.5
  • 203
    • 33947520506 scopus 로고    scopus 로고
    • Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: Possible links between cell metabolism and stabilization of HIF
    • 1:CAS:528:DC%2BD2sXhsFKgsrY%3D 17182618
    • Koivunen P, Hirsila M, Remes AM, Hassinen IE, Kivirikko KI, Myllyharju J (2007) Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF. J Biol Chem 282:4524-4532
    • (2007) J Biol Chem , vol.282 , pp. 4524-4532
    • Koivunen, P.1    Hirsila, M.2    Remes, A.M.3    Hassinen, I.E.4    Kivirikko, K.I.5    Myllyharju, J.6
  • 204
    • 84862632865 scopus 로고    scopus 로고
    • Inhibition of alpha-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
    • 1:CAS:528:DC%2BC38XhtVegs7zM 22677546 3387660
    • Xiao M, Yang H, Xu W, Ma S, Lin H, Zhu H, Liu L, Liu Y, Yang C, Xu Y, Zhao S, Ye D, Xiong Y, Guan KL (2012) Inhibition of alpha-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev 26:1326-1338
    • (2012) Genes Dev , vol.26 , pp. 1326-1338
    • Xiao, M.1    Yang, H.2    Xu, W.3    Ma, S.4    Lin, H.5    Zhu, H.6    Liu, L.7    Liu, Y.8    Yang, C.9    Xu, Y.10    Zhao, S.11    Ye, D.12    Xiong, Y.13    Guan, K.L.14
  • 209
    • 84937468857 scopus 로고    scopus 로고
    • How do glycolytic enzymes favour cancer cell proliferation by nonmetabolic functions?
    • 1:CAS:528:DC%2BC2cXhs1GmsbnE 25263450
    • Lincet H, Icard P (2015) How do glycolytic enzymes favour cancer cell proliferation by nonmetabolic functions? Oncogene 34:3751-3759
    • (2015) Oncogene , vol.34 , pp. 3751-3759
    • Lincet, H.1    Icard, P.2


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