Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Sonveaux, Pierre ^a,b   Copetti, Tamara ^a   de Saedeleer, Christophe J ^a   Végran, Frédérique ^a   Verrax, Julien ^a   Kennedy, Kelly M ^b   Moon, Eui Jung ^b   Dhup, Suveera ^a   Danhier, Pierre ^a   Frérart, Françoise ^a   Gallez, Bernard ^a   Ribeiro, Anthony ^b   Michiels, Carine ^c   Dewhirst, Mark W ^b   Feron, Olivier ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF NAMUR   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; HYPOXIA INDUCIBLE FACTOR 1; LACTIC ACID; MONOCARBOXYLATE TRANSPORTER 1; VASCULOTROPIN RECEPTOR 2; COTRANSPORTER; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 13; LUCIFERASE; MONOCARBOXYLATE TRANSPORT PROTEIN 1; MONOCARBOXYLATE TRANSPORTER; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CELL TRANSPORT; CONTROLLED STUDY; CYTOSKELETON; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; TUMOR VASCULARIZATION; ANALYSIS OF VARIANCE; ANIMAL; CELL MOTION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; NEOPLASM; NEOVASCULARIZATION (PATHOLOGY); NUCLEAR MAGNETIC RESONANCE; PHYSIOLOGY; POLYMERASE CHAIN REACTION; RNA INTERFERENCE; VASCULARIZATION; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; CELL MOVEMENT; ENDOTHELIAL CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLAST GROWTH FACTORS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; IMMUNOHISTOCHEMISTRY; LACTIC ACID; LUCIFERASES; MICE; MONOCARBOXYLIC ACID TRANSPORTERS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, SMALL INTERFERING; SYMPORTERS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84858120137     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033418     Document Type: Article

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