Correlation of high lactate levels in head and neck tumors with incidence of metastasis

American Journal of Pathology

Volumn 150, Issue 2, 1997, Pages 409-415

  Walenta, Stefan ^b   Salameh, Ahmad ^b   Lyng, Heidi ^a   Evensen, Jan F ^a   Mitze, Margarethe ^b   Rofstad, Einar K ^a   Mueller Klieser, Wolfgang ^b  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE; LACTIC ACID;

ADULT; AGED; ARTICLE; BIOLUMINESCENCE; CLINICAL ARTICLE; CONTROLLED STUDY; DYSPLASIA; FEMALE; HEAD AND NECK TUMOR; HIGH RISK PATIENT; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MALE; METASTASIS POTENTIAL; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; TISSUE LEVEL; TUMOR BIOPSY;

AGED; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; INCIDENCE; LACTATES; MALE; MIDDLE AGED; OSMOLAR CONCENTRATION; TISSUE DISTRIBUTION;

EID: 0031029634     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Muelier-Klieser W, Schaefer C, Walenta S, Rofstad EK, Fenton BM, Sutherland RM: Assessment of tumor energy and oxygenation status by bioluminescence nuclear magnetic resonance spectroscopy and cryospectrophotometry. Cancer Res 1990, 50:1681-1685
2. Walenta S, Dellian M, Goetz AE, Kuhnle GEH, MuelierKlieser W: Pixel-to-pixel correlation between images of absolute ATP concentrations and blood flow in tumours. Br J Cancer 1992, 66:1099-1102
3. Kallinowski F, Schlenger K, Runkel S, Kloes M, Stohrer M, Okunieff P, Vaupel P: Blood flow, metabolism, cellular microenvironment and growth rate of human tumor xenografts. Cancer Res 1989, 49:3759-3764
4. Hirst DG, Hirst VK, Joiner B, Prise V, Shaffi KM: Changes in tumour morphology with alterations in oxygen availability: further evidence for oxygen as a limiting substrate. Br J Cancer 1991, 64:54-58
5. Gatenby RA, Kessler HB, Rosenblum JS, Coia LR, Moldofsky PJ, Hartz WH, Broder GJ: Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. Int J Radiat Oncol Biol Phys 1988, 14:831-838
6. 2 predicts survival in advanced cancer of the uterine cervix. Radiother Oncol 1993, 26:45-50
7. Kroeger M, Walenta S, Rofstad EK, Mueller-Klieser W: Growth rates or radiobiological hypoxia are not correlated with local metabolite content in human melanoma xenografts with similar vascular network, Br J Cancer 1995, 72:912-916
8. Weidner N: Tumor angiogenesis: review of current applications in tumor prognostication, Semin Diagn Pathol 1993, 10:302-313
9. Gasparini G: Quantification of intratumoral vascularisation predicts metastasis in human invasive solid tumours. Oncol Rep 1994, 1:7-12
10. Schwickert G, Walenta S, Sundfor K, Rofstad EK, Mueller-Klieser W: Correlation of high lactate levels in human cervical cancer with incidence of metastasis. Cancer Res 1995, 55:4757-4759
11. Mueller-Klieser W, Walenta S: Geographical mapping of metabolites in biological tissue with quantitative bioluminescence and single photon imaging, Histochem J 1993, 25:407-420
12. Mueller-Klieser W, Walenta S, Paschen W, Kallinowski F, Vaupel P: Metabolic imaging in microregions of tumors and normal tissues with bioluminescence and photon counting. J Natl Cancer Inst 1988, 80:842-848
13. Walenta S, Doetsch J, Mueller-Klieser W: ATP concentrations in multicellular tumor spheroids assessed by single photon imaging and quantitative bioluminescence, Eur J Cell Biol 1990, 52:389-393
14. Kuhnle GEH, Dellian M, Walenta S, Mueller-Klieser W, Goetz AE: Simultaneous high-resolution measurement of adenosine triphosphate levels and blood flow in the hamster amelanotic melanoma A-Mel-3. J Natl Cancer Inst 1992, 84:1642-1647
15. Bourrat-Floeck B, Groebe K, Mueller-Klieser W: Biological response of multicellular EMT6 spheroids to exogenous lactate, Int J Cancer 1991, 47:792-799
16. Brizei DM, Scully SP, Harrelson JM, Layfield LJ, Bean JM, Prosnitz LR, Dewhirst MW: Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res 1996, 56:941-943
17. Young SD, Marshall RS, Hill RP: Hypoxia induces DMA overreplication and enhances metastatic potential of murine tumor cells. Proc Natl Acad Sci USA 1988, 85:9533-9537
18. GraeberTG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe SW, Giaccia AJ: Hypoxia mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 1996, 379:19-20
19. Levy AP, Levy NS, Wegner S, Goldberg MA: Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia, J Biol Chem 1995, 270:13333-13340
20. Weidner N, Carroll PR, Flax J, Blumenfeld W, Folkman J: Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am J Pathol 1993, 143: 401-409
21. Weidner N, Folkman J, Pozza F, Bevilacqua P, Allred EN, Moore DH, Meli S, Gasparini G: Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J Natl Cancer Inst 1992, 84:1875-1887
22. Scheumman GF, Hoang Vu C, Cetin Y, Gimm O, Behrends J, von Wasielewski R, Georgii A, Birchmeier W, von Zur Muhlen A, Dralle H: Clinical significance of E-cadherin as a prognostic marker in thyroid carcinomas. J Clin Endocrinol Metab 1995, 80:2168-2172