Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted

British Journal of Cancer

Volumn 94, Issue 4, 2006, Pages 578-585

  Langbein, S ^a,g   Zerilli, M ^b   Zur Hausen, A ^c   Staiger, W ^a   Rensch Boschert, K ^d   Lukan, N ^a   Popa, J ^a   Ternullo, M P ^e   Steidler, A ^a   Weiss, C ^a   Grobholz, R ^a   Willeke, F ^a   Alken, P ^a   Stassi, G ^b   Schubert, P ^f   Coy, J F ^d,f  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF PALERMO   (Italy)

^c UNIVERSITY OF FREIBURG   (Germany)

^d TAVARTIS GmbH   (Germany)

^e UNIVERSITY OF PALERMO   (Italy)

^f R Biopharm AG Rhome Ltd Scotland   (Germany)

^g ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Aerobic glycolysis; Pentose phosphate pathway (PPP); Pharmacodiagnostic marker; Transketolase (TKT); Transketolase like 1 (TKTL1); Warburg effect

Indexed keywords

ENZYME; GLUCOSE; LACTIC ACID; OXYGEN; TRANSKETOLASE; TRANSKETOLASE LIKE 2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER INHIBITION; CANCER INVASION; CANCER SURVIVAL; COLON CANCER; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME INHIBITION; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC TRANSCRIPTION; GLYCOLYSIS; HUMAN; HUMAN TISSUE; MALE; METASTASIS; PREDICTION; PRIORITY JOURNAL; UPREGULATION; UROGENITAL TRACT CANCER;

ADENOCARCINOMA; AGED; COLONIC NEOPLASMS; FEMALE; GENE EXPRESSION PROFILING; GLYCOLYSIS; HUMANS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PREDICTIVE VALUE OF TESTS; PROGNOSIS; SURVIVAL ANALYSIS; TRANSKETOLASE; UP-REGULATION; URINARY BLADDER NEOPLASMS;

EID: 33344456073     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6602962     Document Type: Article

References (38)

1. Boros LG, Bassilian S, Lim S, Lee W-NP (2001a) Genistein inhibits nonoxidative ribose synthesis in MIA pancreatic adenocarcinoma cells: a new mechanism of controlling tumour growth. Pancreas 22: 1-7
2. Boros LG, Lapis K, Szende B, Tomoskozi-Farkas R, Balogh A, Boren J, Marin S, Cascante M, Hidvegi M (2001b) Wheat germ extract decreases glucose uptake and RNA ribose formation but increases fatty acid synthesis in MIA pancreatic adenocarcinoma cells. Pancreas 23: 141-147
3. Boros LG, Puigjaner J, Cascante M, Lee W-NP, Brandes JL, Bassilian S, Yusuf FI, Williams RD, Muscarella P, Melvin WS, Schirmer WJ (1997) Oxythiamine and dehydroepiandrosterone inhibit the nonoxidative synthesis of ribose and tumour cell proliferation. Cancer Res 57: 4242-4248
4. Braun L, Puskas F, Csala M, Meszaros G, Mandl J, Banhegyi G (1997) Ascorbate as a substrate for glycolysis or gluconeogenesis: evidence for an interorgan ascorbate cycle. Free Radic Biol Med 23: 804-808
5. Buzzai M, Bauer DE, Jones RG, Deberardinis RJ, Hatzivassiliou G, Elstrom RL, Thompson CB (2005) The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation. Oncogene 24: 4165-4173
6. Comin-Anduix B, Boren J, Martinez S, Moro C, Centelles JJ, Trebukhina R, Petushok N, Lee W-NP, Boros LG, Cascante M (2001) The effect of thiamine supplementation on tumour proliferation. A metabolic control analysis study. Eur J Biochem 268: 4177-4182
7. Comin-Anduix B, Boros LG, Marin S, Boren J, Callol-Massot C, Centelles JJ, Torres JL, Agell N, Bassilian S, Cascante M (2002) Fermented wheat germ extract inhibits glycolysis/pentose cycle enzymes and induces apoptosis through poly(ADP-ribose) polymerase activation in Jurkat T-cell leukemia tumour cells. J Biol Chem 277: 46408-46414
8. Coy JF, Dressler D, Wilde J, Schubert P (2005) Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer. Clin Lab 51: 257-273
9. Coy JF, Dübel S, Kioschis P, Thomas K, Micklem G, Delius H, Poustka A (1996) Molecular cloning of tissue-specific transcripts of a transketolase-related gene: implications for the evolution of new vertebrate genes. Genomics 32: 309-316
10. Di Chiro G, Hatazawa J, Katz DA, Rizzoli HV, De Michele DJ (1987) Glucose utilization by intracranial meningiomas as an index of tumor aggressivity and probability of recurrence: a PET study. Radiology 164: 521-526
11. Downey RJ, Akhurst T, Gonen M, Vincent A, Bains MS, Larson S, Rusch V (2004) Preoperative F-18 fluorodeoxyglucose-positron emission tomography maximal standardized uptake value predicts survival after lung cancer resection. J Clin Oncol 22: 3255-3260
12. Du MX, Sim J, Fang L, Yin Z, Koh S, Stratton J, Pons J, Wang JJ, Carte B (2004) Identification of novel small-molecule inhibitors for human transketolase by high-throughput screening with fluorescent intensity (FLINT) assay. J Biomol Screen 9: 427-433
13. Elstrom RL, Bauer DE, Buzzai M, Karnauskas R, Harris MH, Plas DR, Zhuang H, Cinalli RM, Alavi A, Rudin CM, Thompson CB (2004) Akt stimulates aerobic glycolysis in cancer cells. Cancer Res 64: 3892-3899
14. Garber K (2004) Energy boost: the Warburg effect returns in a new theory of cancer. J Natl Cancer Inst 96: 1805-1806
15. Gatenby RA, Gawlinski ET (2003) The glycolytic phenotype in carcinogenesis and tumor invasion: insights through mathematical models. Cancer Res 63: 3847-3854
16. Gatenby RA, Gillies RJ (2004) Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4: 891-899
17. Guppy M, Leedman P, Zu XL, Russell V (2002) Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells. Biochem J 364: 309-315
18. Haberkorn U, Strauss LG, Reisser C, Haag D, Dimitrakopoulou A, Ziegler S, Oberdorfer F, Rudat V, van Kaick G (1991) Glucose uptake, perfusion, and cell proliferation in head and neck tumors: relation of positron emission tomography to flow cytometry. J Nucl Med 32: 1548-1555
19. Hardt PD, Mazurek S, Toepler M, Schlierbach P, Bretzel RG, Eigenbrodt E, Kloer HU (2004) Faecal tumour M2 pyruvate kinase: a new, sensitive screening tool for colorectal cancer. Br J Cancer 91: 980-984
20. Hidvegi M, Raso E, Tomoskozi-Farkas R, Szende B, Paku S, Pronai L, Bocsi J, Lapis K (1999) MSC, a new benzoquinone-containing natural product with antimetastatic effect. Cancer Biother Radiopharm 14: 277-289
21. Horecker BL, Gibbs M, Klenow H, Smyrniotis PZ (1954) The mechanism of pentose phosphate conversion to hexose monophosphate. I. With a liver enzyme preparation. J Biol Chem 207: 393-403
22. Jakab F, Shoenfeld Y, Balogh A, Nichelatti M, Hoffmann A, Kahan Z, Lapis K, Mayer A, Sapy P, Szentpetery F, Telekes A, Thurzo L, Vagvolgyi A, Hidvegi M (2003) A medical nutriment has supportive value in the treatment of colorectal cancer. Br J Cancer 89: 465-469
23. Jones RG, Plas DR, Kubek S, Buzzai M, Mu J, Xu Y, Birnbaum MJ, Thompson CB (2005) AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell 18: 283-293
24. 2]glucose. Am J Physiol 274: 843-851
25. Lu H, Forbes RA, Verma A (2002) Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. J Biol Chem 277: 23111-23115
26. Menendez JA, Lupu R (2004) Fatty acid synthase-catalyzed de novo fatty acid biosynthesis: from anabolic-energy-storage pathway in normal tissues to jack-of-all-trades in cancer cells. Arch Immunol Ther Exp 52: 414-426
27. Nebeling LC, Miraldi F, Shurin SB, Lerner E (1995) Effects of a ketogenic diet on tumour metabolism and nutritional status in pediatric oncology patients: two case reports. J Am Coll Nutr 14: 202-208
28. Park HJ, Lyons JC, Ohtsubo T, Song CW (2000) Cell cycle progression and apoptosis after irradiation in an acidic environment. Cell Death Differ 7: 729-738
29. Rais B, Comin B, Puigjaner J, Brandes JL, Creppy E, Saboureau D, Ennamany R, Lee W-NP, Boros LG, Cascante M (1999) Oxythiamine and dehydroepiandrosterone induce a G1 phase cycle arrest in Ehrlich's tumour cells through inhibition of the pentose cycle. FEBS Lett 456: 113-118
30. Ramanathan A, Wang C, Schreiber SL (2005) Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements. Proc Natl Acad Sci USA 102: 5992-5997
31. Robertson N, Potter C, Harris AL (2004) Role of carbonic anhydrase IX in human tumor cell growth, survival, and invasion. Cancer Res 64: 6160-6165
32. Schenk G, Duggleby RG, Nixon PF (1998) Properties and functions of the thiamin diphosphate dependent enzyme transketolase. Int J Biochem Cell Biol 30: 1297-1318
33. Stern R, Shuster S, Neudecker BA, Formby B (2002) Lactate stimulates fibroblast expression of hyaluronan and CD44: the Warburg effect revisited. Exp Cell Res 276: 24-31
34. Walenta S, Schroeder T, Mueller-Klieser W (2004) Lactate in solid malignant tumours: potential basis of a metabolic classification in clinical oncology. Curr Med Chem 11: 2195-2204
35. Warburg O, Posener K, Negelein E (1924) Über den Stoffwechsel der Carcinomzelle. Biochem Z 152: 309-344
36. Williams AC, Collard TJ, Paraskeva C (1999) An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis. Oncogene 18: 3199-3204
37. Williams JF, Arora KK, Longenecker JP (1987) The pentose pathway: a random harvest. Int J Biochem 19: 749-817
38. Xu RH, Pelicano H, Zhou Y, Carew JS, Feng L, Bhalla KN, Keating MJ, Huang P (2005) Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. Cancer Res 65: 613-621