Quantitative flux analysis reveals folate-dependent NADPH production

Nature

Volumn 510, Issue 7504, 2014, Pages 298-302

  Fan, Jing ^a   Ye, Jiangbin ^b   Kamphorst, Jurre J ^a   Shlomi, Tomer ^a,c   Thompson, Craig B ^b   Rabinowitz, Joshua D ^a  

^a PRINCETON UNIVERSITY   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

10 FORMYL TETRAHYDROFOLATE; DEUTERIUM; FOLIC ACID; GLUTATHIONE DISULFIDE; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE 2; MALATE DEHYDROGENASE (DECARBOXYLATING); METHYLENETETRAHYDROFOLATE DEHYDROGENASE; METHYLENETETRAHYDROFOLIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TETRAHYDROFOLIC ACID; UNCLASSIFIED DRUG;

DEUTERIUM; ENZYME ACTIVITY; METABOLISM; MITOCHONDRION; NUCLEIC ACID; OXIDATION; PHOSPHORUS; QUANTITATIVE ANALYSIS;

ARTICLE; CARBON METABOLISM; CELL PROLIFERATION; CYTOSOL; FOLATE METABOLISM; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MITOCHONDRION; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL;

ANIMALIA;

ANIMALS; CARBON; CELL LINE; CELL LINE, TUMOR; CYTOSOL; FOLIC ACID; GLUTATHIONE; GLYCINE; HEK293 CELLS; HUMANS; ISOENZYMES; LEUCOVORIN; METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP); MICE; MITOCHONDRIA; NADP; OXIDATION-REDUCTION; OXIDATIVE STRESS; PENTOSE PHOSPHATE PATHWAY; SERINE; TETRAHYDROFOLATES;

EID: 84902332213     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13236     Document Type: Article

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