Autocrine motility factor signals integrin-mediated metastatic melanoma cell adhesion and invasion

Cancer Research

Volumn 56, Issue 8, 1996, Pages 1902-1908

  Timar, Jozsef ^a   Trikha, Mohit ^b   Szekeres, Karoly ^b   Bazaz, Rajesh ^b   Tovari, Jozsef ^a   Silletti, Steve ^c   Raz, Avraham ^c   Honn, Kenneth V ^b  

^a SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^b WAYNE STATE UNIVERSITY   (United States)

^c KARMANOS CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE 12 LIPOXYGENASE; AUTOCRINE MOTILITY FACTOR; CALPHOSTIN C; CELL SURFACE RECEPTOR; FIBRONECTIN; INTEGRIN; PROTEIN KINASE C;

ANIMAL CELL; ARTICLE; CANCER INVASION; CELL ADHESION; CELL MOTILITY; CELL SPREADING; CELLULAR DISTRIBUTION; GENE TRANSLOCATION; MELANOMA; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; AUTOCRINE MOTILITY FACTOR; CELL ADHESION; CELL LINE; CELL MEMBRANE; COLLAGEN; CULTURE MEDIA, CONDITIONED; CYCLOOXYGENASE INHIBITORS; DRUG COMBINATIONS; FIBRONECTINS; FIBROSARCOMA; FLOW CYTOMETRY; HUMANS; LAMININ; LIPOXYGENASE INHIBITORS; MELANOMA, EXPERIMENTAL; MICE; MODELS, BIOLOGICAL; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEOGLYCANS; RECEPTORS, FIBRONECTIN; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0029986708     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Liotta, L. A. Tumor invasion and metastasis: role of the extracellular matrix. Cancer Res., 46: 1-7, 1986.
2. Honn, K. V., and Tang, D. G. Adhesion molecules and tumor cell interaction with the endothelium and subendothelial matrix Cancer Metastasis Rev., 11: 353-375, 1992.
3. Hynes, R. O Integrins versatility, modulation, and signaling in cell adhesion Cell, 69: 11-25, 1992.
4. Smyth, S. S , Joneckis, C. C., and Parise, L. V. Regulation of vascular integrins. Blood, 81: 2827-2843, 1993.
5. Seftor, R. E. B., Seftor, E A., Stetler-Stevenson, W G., and Hendrix, M J C. The 72-kDa type IV collagenase is modulated via differential expression of αvα3 and α5β1 integrin expression during human melanoma cell invasion. Cancer Res., 53: 3411-3415, 1993.
6. Kramer, R H , Vu, M., Cheng, Y. F., and Ramos, D. M. Integrin expression in malignant melanoma. Cancer Metastasis Rev., 10: 49-59, 1991.
7. Ruoslahti, E The Walter Herbert lecture: control of cell motility and tumor invasion by extracellular matrix integrins. Br. J. Cancer, 66: 239-242, 1992.
8. Chen, Y Q , Gao, X., Timar, J., Tang, D. G., Grossi, I M., Chelladurai, M., Kunicki, T. J , Fligiel, S E G., Taylor, J. D , and Honn, K V Identification of the αIIbβ3 integrin in murine melanoma tumor cells. J Biol. Chem , 267: 17314-17320, 1992.
9. Chopra, H., Timar, J., Chen, Y. Q , Rong, X., Grossi, I. M , Fitzgerald, L. A., Taylor, J. D., and Honn, K V. The lipoxygenase metabolite 12(S)-HETE induces a cytoskeleton-dependent increase in surface expression of integrin αIIbβ3 on melanoma cells. Int. J. Cancer, 49. 774-786, 1991.
10. Timar, J., Chen, Y. Q., Liu, B , Bazaz, R., Taylor, J. D., and Honn, K. V The lipoxygenase metabolite 12(S)-HETE promotes αIIbβ3 integrin-mediated tumor cell spreading on fibronectin. Int. J. Cancer, 52: 594-603, 1992.
11. Honn, K. V., Chen, Y Q , Timar, J , Onoda, J. M., Hatfield, J. S , Fligiel, S. E., Steinert, B. W , Diglio, C A., Grossi, I. M., Nelson, K. K., and Taylor, J. D. αIIbβ3 integrin expression and function in subpopulations of murine tumors Exp. Cell Res., 201: 23-32, 1992.
12. Chang, Y. S., Chen, Y. Q., Timar, J., Nelson, K K., Grossi, I M , Fitzgerald, L. A., Diglio, C A , and Honn K. V. Increased expression of αIIbβ3 integrin in subpopulations of murine melanoma cells with high lung-colonizing ability. Int. J. Cancer, 51: 443-451, 1992
13. Tang, D. G., Onoda, J. M., Steinert, B W , Grossi, I. M., Nelson, K K., Umbarger, L., Diglio, C. A , Taylor, J D., and Honn, K V. Phenotypic properties of cultured tumor cells: integrin αIIbβ3 expression, tumor-cell-induced platelet aggregation, and tumor-cell adhesion to endothelium as important parameters of experimental metastasis. Int. J. Cancer, 54. 338-347, 1993.
14. Chang, S. Y., Chen, Y. Q., Fitzgerald, L A , and Honn, K. V Analysis of integrin mRNA in human and rodent tumor cells. Biochem. Biophys. Res. Commun., 176. 108-113, 1991
15. Heino, J , and Massague, J Transforming growth factor β switches the pattern of integrins expressed in MG-63 human osteosarcoma cells and causes a selective loss of cell adhesion to laminin J. Biol. Chem., 264: 21806-21811, 1989.
16. Burrow, F. J , Haskard, D. O., Hart, I. R., Marshall, J. F., Selkirk, S , Poole, S., and Thorpe, P. E Influence of tumor-derived interleukin-1 on melanoma-endothelial cell interactions in vitro. Cancer Res., 51: 4768-4775, 1991.
17. Defilippi, P., Truffa, G., Stefanuto, G., Altruda, F., Silengo, L., and Tarone, G. Tumor necrosis factor α and Interferon γ modulate the expression of the vitronecrln receptor (αvβ3) in human endothelial cells J. Biol. Chem., 266: 7638-7645, 1991.
18. Klein, S , Giancotti, F. G., Presta, M., Albelda, S M., Buck, C A , and Rifkin, D. B. Basic fibroblast growth factor modulates integrin expression in microvascular endothelial cells. Mol. Biol. Cell, 4: 973-982, 1993.
19. Ahlen, K., and Rubin, K. Platelet derived growth factor-BB stimulates synthesis of the integrin α2 subunit in human diploid fibroblasts. Exp. Cell Res., 215: 347-353, 1994.
20. Tang, D. G., Grossi, I M , Chen, Y. Q , Diglio, C A., and Honn, K. V. 12(S)-HETE promotes tumor-cell adhesion by increasing surface expression of αvβ3 integrins on endothelial cells. Int. J. Cancer, 54: 102-111, 1993.
21. Tang, D. G., Chen, Y. Q . Diglio, C. A., and Honn, K. V. Protein kinase C-dependent effects of 12(S)-HETE on endothelial cell vitronectin receptor and fibronectin receptor. J. Cell Biol , 127: 689-704, 1993.
22. Timar, J., Bazaz, R. Kimler, V. A., Haddad, M. M., Tang, D. G., Robertson, D., Taylor, J. D., and Honn, K. V. Immunomorphological characterization and effects of 12(S)-HETE on a dynamic intracellular pool of the αIIbβ3-integrin in melanoma cells J Cell Sci., 108: 2175-2186, 1995.
23. Tang, D. G., Diglio, C. A. Bazaz, R., and Honn, K. V. Transcriptional activation of endothelial cell integrin αv by protein kinase C activator 12(S)-HETE. J. Cell Sci., 108: 2629-2644, 1995.
24. Timar, J., Silletti, S , Bazaz, R , Raz, A., and Honn, K. V. Regulation of melanoma cell motility by the lipoxygenase metabolite 12(S)-HETE Int. J Cancer, 55. 1003-1010, 1993.
25. Silletti, S , Timar, J , Honn, K. V., and Raz, A. Autocrine motility factor induces differential 12-lipoxygenase expression and activity in high- and low-metastatic K1735 melanoma cell variants Cancer Res., 54: 5752-5756, 1994.
26. Stocker, M., and Gherardi, E Regulation of cell movement: the motogenic cytokines. Biochim Biophys. Acta, 1072: 81-102, 1991
27. Nabi, I. R., Watanabe, H., and Raz, A. Identification of B16a-FI melanoma autocrine motility-like factor receptor Cancer Res., 50: 409-414, 1990
28. Watanabe, H., Carmi, P., Hogan, V , Raz, T., Silletti, S., Nabi, I R., and Raz, A Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor. J Biol. Chem., 266 13442-13448, 1991.
29. Watanabe, H , Nabi, I. R., and Raz, A The relationship between motility factor receptor internalization and the lung colonization capacity of murine melanoma cells. Cancer Res , 51. 2699-2705, 1991.
30. Silletti, S., and Raz, A. Autocrine motility factor is a growth factor. Biochem. Biophys Res Commun., 194: 446-457, 1993.
31. Stracke, M. L., Guirguis, R., Liotta, L. A , and Schiffman, E. Pertussis toxin inhibits stimulated motility independently of the adenylate cyclase pathway in human melanoma cells. Biochem. Biophys Res. Commun., 146. 339-345, 1987.
32. Kohn, E C , Liotta, L. A., and Schiffman, E Autocrine motility factor stimulates a threefold increase in inositol phosphate in human melanoma cells. Biochem. Biophys. Res Commun , 166. 757-764, 1990.
33. Pidard, D , Montgomery, R R , Bennett, J. S., and Kunicki, T. J. Interaction of AP-2, a monoclonal antibody specific for the human platelet glycoprotein IIb-IIIa complex, with intact platelets. J. Biol. Chem , 258. 12582-12586, 1983.
34. Liu, B , Khan, W. A., Hannun, Y A , Bazaz, R., Renaud, C., Stojakovic, S , Timar, J., Taylor, J., and Honn, K. V. 12(S)-HETE and 13(S)-HODE regulation of protein kinase C α in melanoma cells: role of receptor mediated hydrolysis of inositol phospholipids. Proc. Natl. Acad Sci. USA, 92: 9323-9327, 1995
35. Tang, D. G., and Honn, K V Adhesion molecules and tumor metastasis: an update. Invasion Metastasis, 14. 109-122, 1995
36. Seftor, R. E. B , Seftor, E A., Gehlsen, K R , Stetler-Stevenson W G., Brown, P. D., Ruoslahti, E., and Hendrix, M. J. C Role of the αvβ3 integrin in human melanoma invasion Proc Natl. Acad. Sci. USA, 89 1557-1561, 1992.