CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion

Journal of Biological Chemistry

Volumn 279, Issue 26, 2004, Pages 26991-27007

  Bourguignon, Lilly Y W ^a   Singleton, Patrick A ^a   Diedrich, Falko ^a   Stern, Robert ^a   Gilad, Eli ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CHOLESTEROL; LIPIDS; RNA; TUMORS;

IMMUNOLOGICAL ANALYSIS; INTRACELLULAR ACIDIFICATION;

BIOCHEMISTRY;

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; AMILORIDE DERIVATIVE; AMMONIUM CHLORIDE; CATHEPSIN B; CAVEOLIN; CELL MEMBRANE PROTEIN; CHOLESTEROL; CYSTEINE PROTEINASE; FLOTILLIN; GANGLIOSIDE; HERMES ANTIGEN; HYALURONIDASE; HYALURONIDASE 2; RHO KINASE; S (N ETHYL N ISOPROPYL)AMILORIDE; SMALL INTERFERING RNA; SODIUM PROTON EXCHANGE PROTEIN; UNCLASSIFIED DRUG;

ACIDIFICATION; ARTICLE; BREAST TUMOR; CANCER INVASION; CELL MEMBRANE; CELL PH; CONTROLLED STUDY; ENDOSOME; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; LYSOSOME; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTON SODIUM EXCHANGE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR GROWTH;

AMIDES; AMILORIDE; ANIMALS; ANTIGENS, CD44; BREAST NEOPLASMS; CATHEPSIN B; CAVEOLIN 1; CAVEOLINS; CELL LINE, TUMOR; ENDOSOMES; ENZYME INHIBITORS; HUMANS; HYALURONIC ACID; HYALURONOGLUCOSAMINIDASE; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN G; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LYSOSOMES; MEMBRANE MICRODOMAINS; MEMBRANE PROTEINS; NEOPLASM INVASIVENESS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; RATS; RNA, SMALL INTERFERING; SODIUM-HYDROGEN ANTIPORTER;

EID: 3042692979     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M311838200     Document Type: Article

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