Metabolic acidosis and the importance of balanced equations

Metabolomics

Volumn 5, Issue 2, 2009, Pages 163-165

  Lane, Andrew N ^a   Fan, Teresa W M ^a   Higashi, Richard M ^a  

^a UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

Balanced equation; Lactic acidosis

Indexed keywords

EID: 67349275453     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-008-0142-2     Document Type: Article

References (14)

1. Allen, D., & Westerblad, H. (2004). Lactic acid - The latest performance-enhancing drug. Science, 305, 1112-1113. doi: 10.1126/ science.1103078.
2. Brahimi-Horn, M. C., & Pouyssegur, J. (2007). Hypoxia in cancer cell metabolism and pH regulation. Essays in Biochemistry, 43, 165-178.
3. Enerson, B. E., & Drewes, L. R. (2003). Molecular features, regulation, and function of monocarboxylate transporters: Implications for drug delivery. Journal of Pharmaceutical Sciences, 92, 1531-1544. doi: 10.1002/jps.10389.
4. Fan, T. W. M., Higashi, R. M., & Lane, A. N. (1988). An In vivo H-1 and P-31 NMR investigation of the effect of nitrate on hypoxic metabolism in maize roots. Archives of Biochemistry and Biophysics, 266, 592-606. doi: 10.1016/0003-9861(88)90292-5.
5. Gatenby, R. A., & Gillies, R. J. (2004). Why do cancers have high aerobic glycolysis? Nature Reviews. Cancer, 4, 891-899. doi: 10.1038/ nrc1478.
6. Hackam, D. J., Grinstein, S., & Rotstein, O. D. (1996). Intracellular pH regulation in leukocytes: Mechanisms and functional significance. Shock (Augusta, Ga.), 5, 17-21. doi: 10.1097/ 00024382-199601000-00005.
7. Halestrap, A. P., & Price, N. T. (1999). The proton-linked monocarboxylate transporter (MCT) family: Structure, function and regulation. The Biochemical Journal, 343, 281-299. doi: 10.1042/ 0264-6021:3430281.
8. Helmlinger, G., Schell, A., Dellian, M., Forbes, N. S., & Jain, R. K. (2002). Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism. Clinical Cancer Research, 8, 1284-1291.
9. Mathupala, S. P., Colen, C. B., Parajuli, P., & Sloan, A. E. (2007). Lactate and malignant tumors: A therapeutic target at the end stage of glycolysis. Journal of Bioenergetics and Biomembranes, 39, 73-77. doi: 10.1007/s10863-006-9062-x.
10. + exchange. Trends in Biochemical Sciences, 11, 141-143. doi: 10.1016/0968-0004(86)90069-1.
11. Pedersen, T. H., Nielsen, O. B., Lamb, G. D., & Stephenson, D. G. (2004). Intracellular acidosis enhances the excitability of working muscle. Science, 305, 1144-1147. doi: 10.1126/science.1101141.
12. Roberts, J. K. M., Wade-Jardetzky, N., & Jardetzky, O. (1981). Intracellular Ph measurements by P-31 nuclear magnetic-resonance influence of factors other than Ph on P-31 chemical-shifts. Biochemistry, 20, 5389-5394. doi: 10.1021/bi00522a006.
13. Schwartz, M. A., Both, G., & Lechene, C. (1989). Effect of cell spreading on cytoplasmic pH in normal and transformed fibroblasts. Proceedings of the National Academy of Sciences of the United States of America, 86, 4525-4529. doi: 10.1073/pnas.86.12.4525.
14. Warburg, O. (1956). On the origin of cancer cells. Science, 123, 309-314. doi: 10.1126/science.123.3191.309.