Lactate stimulates fibroblast expression of hyaluronan and CD44: The Warburg effect revisited

Experimental Cell Research

Volumn 276, Issue 1, 2002, Pages 24-31

  Stern, Robert ^a   Shuster, Svetlana ^a   Neudecker, Birgit A ^a   Formby, Bent ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Rasmus Institute for Medical Research   (United States)

Author keywords

CD44; CD44 variant exons; Extracellular matrix; Hyaluronan; Lactate; Warburg effect

Indexed keywords

GLYCOSAMINOGLYCAN; HERMES ANTIGEN; HYALURONIC ACID; LACTIC ACID;

ANAEROBIC METABOLISM; ARTICLE; CANCER CELL; CANCER INVASION; CELL CULTURE; CELL MOTILITY; CELL MOTION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; LACTATE BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SIMULATION; STROMA; TISSUE GROWTH; TISSUE REPAIR; TUMOR CELL;

EID: 0036347515     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2002.5508     Document Type: Article

References (57)

1. Proteoglycans and hyaluronan in morphogenesis and differentiation
2. Hyaluronan
3. The origin of hyaluronectin in human tumors
4. Hyaluronan: RHAMM mediated cell locomotion and signaling in tumorigenesis
5. Rapid hyaluronan uptake is associated with enhanced motility: Implications for an intracellular mode of action
6. Dynamics and control of transmicrovascular fluid exchange
7. Structure and function of CD44: Characteristic molecular features and analysis of the hyaluronan binding site
8. CD44 structure and function
9. Interaction between CD44 and the repeat domain of ankyrin promotes hyaluronic acid-mediated ovarian tumor cell migration
10. HA receptors: Regulators of signalling to the cytoskeleton
11. CD44 isoform-cytoskeleton interaction in oncogenic signaling and tumor progression
12. Studies in fetal wound healing. V prolonged presence of hyaluronic acid in fetal wound fluid
13. Tumor-associated hyaluronan. Providing an extracellular matrix that facilitates invasion
14. Hyaluronan distribution in the normal epithelium of esophagus, stomach, and colon and their cancers
15. High levels of stromal hyaluronan predict poor disease outcome in epithelial ovarian cancer
16. Ueber den stoffwechsel der carcinomzelle
17. On the origin of cancer cells
18. Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing
19. Tumor invasion: A consequence of destructive and compositional matrix alterations
20. The microenvironment of the tumour-host interface
21. An ELISA plate-based assay for hyaluronan using biotinylated proteoglycan G1 domain (HA-binding region)
22. Affinity chromatography on immobilized hyaluronate and its application to the isolation of hyaluronate binding properties from cartilage
23. Patterns of hyaluronan staining are modified by fixation techniques
24. Adhesion and costimulation of proliferative responses of human gamma delta T cells by interaction of VLA-4 and VLA-5 with fibronectin
25. 3H]glucosamine incorporation into hyaluronic acid by fibroblasts is modulated by culture conditions
26. A serum factor capable of stimulating hyaluronic acid synthesis in cultured rat fibroblasts
27. Hyaluronic acid-stimulating activity in sera from the bovine fetus and from breast cancer patients
28. New CD44 splice variants associated with human breast cancers
29. Comparison of immunohistochemistry and RT-PCR for detection of CD44v-expression, a new prognostic factor in human breast cancer
30. Hyaluronan on the surface of tumor cells is correlated with metastatic behavior
31. Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival
32. Overproduction of hyaluronan by expression of the hyaluronan synthase Has2 enhances anchorage-independent growth and tumorigenicity
33. Hyaluronidase-sensitive halos around adherent cells. Their role in blocking lymphocyte-mediated cytolysis
34. The selective suppression of immunogenicity by hyaluronic acid
35. Induction of apoptosis of metastatic mammary carcinoma cells in vivo by disruption of tumor cell surface CD44 function
36. Hyaluronic acid inhibits apoptosis in granulosa cells via CD44
37. Transforming growth factor beta 1-hyaluronic acid interaction
38. Intracellular localization of hyaluronan in proliferating cells
39. A novel glycosaminoglycan-binding protein is the vertebrate homologue of the cell cycle control protein, Cdc37
40. Molecular cloning of human fibroblast hyaluronic acid-binding protein confirms its identity with P-32, a protein co-purified with splicing factor SF2
41. Heat-shock protein 70 mRNA is induced by anaerobic metabolism in rat hearts
42. Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress
43. Molecular and biological properties of vascular endothelial growth factor
44. Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status
45. Activation of the HIF pathway in cancer
46. Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia
47. Insights into the role of the von Hippel-Lindau gene product. A key player in hypoxic regulation
48. Hypoxia in fibroblast cultures. 2. Influence of pH on the distribution pattern of acid mucopolysaccharides
49. Glucose-induced stimulation of human insulin-receptor mRNA and tyrosine kinase activity in cultured cells
50. Hyaluronidase can modulate expression of CD44
51. Phosphorylation stabilizes alternatively spliced CD44 mRNA transcripts in breast cancer cells: Inhibition by antisense complementary to casein kinase II mRNA
52. Up-regulation of putative hyaluronan synthase mRNA by basic fibroblast growth factor and insulin-like growth factor-1 in human skin fibroblasts
53. Differential motogenic and biosynthetic response of fetal and adult skin fibroblasts to TGF-beta isoforms
54. Putative hyaluronan synthase mRNA are expressed in mouse skin and TGF-beta upregulates their expression in cultured human skin cells
55. Phenotypic and genetic alterations in mammary stroma: Implications for tumour progression
56. Cellular changes involved in conversion of normal to malignant breast: Importance of the stromal reaction