Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells

British Journal of Cancer

Volumn 86, Issue 12, 2002, Pages 1914-1919

  Niizeki, H ^a,b   Kobayashi, M ^a   Horiuchi, I ^a   Akakura, N ^a,b   Chen, J ^a,b   Wang, J ^a   Hamada, J I ^a   Seth, P ^a   Katoh, H ^b   Watanabe, H ^c   Raz, A ^d   Hosokawa, M ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c GUNMA UNIVERSITY   (Japan)

^d WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AMF; HIF 1; Hypoxia; Metastasis; Motility

Indexed keywords

AUTOCRINE MOTILITY FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; NEUROLEUKIN;

ANAEROBIC METABOLISM; ANGIOGENESIS; ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; HUMAN; HUMAN CELL; HYPOXIA; METASTASIS; NORTHERN BLOTTING; OXYGEN TENSION; PANCREAS CANCER; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

ANOXIA; AUTOCRINE MOTILITY FACTOR; BLOTTING, NORTHERN; DNA-BINDING PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, DOMINANT; GLUCOSE-6-PHOSPHATE ISOMERASE; HELIX-LOOP-HELIX MOTIFS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; NEUROLEUKIN; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PANCREATIC NEOPLASMS; RECEPTORS, CYTOKINE; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 18544384240     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600331     Document Type: Article

References (34)

1. Constitutive expression of hypoxia-inducible factor-1α (HIF-1α) renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation
2. Phagokinetic tracks of 3T3 cells: Parallels between the orientation of track segments and of cellular structures which contain actin or tubulin
3. Bcl-2 overexpression and hypoxia synergistically act to modulate vascular endothelial growth factor expression and in vivo angiogenesis in a breast carcinoma line
4. The molecular basis of the hypoxia response pathway: Tumour hypoxia as a therapy target
5. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma
6. Activated leukocyte cell adhesion molecule (ALCAM) and annexin II are involved in the metastatic progression of tumor cells after chemotherapy with adriamycin
7. Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis
8. Regulation of VEGF/VPF expression in tumor cells: Consequences for tumor growth and metastasis
9. Oncogenic alterations of metabolism
10. Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy
11. The hypoxic response: Huffing and HIFing
12. Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53
13. Tumor hypoxia in pelvic recurrences of cervical cancer
14. Suppression of tumor growth through disruption of hypoxia-inducible transcription
15. Tumor invasion and metastases - Role of the extracellular matrix: Rhoads Memorial Award lecture
16. Tumor cell autocrine motility factor
17. Gene products which play a role in cancer invasion and metastasis
18. Glucose uptake and glycolysis reduce hypoxia-induced apoptosis in cultured neonatal rat cardiac myocytes
19. Autocrine motility factor and its receptor: Role in cell locomotion and metastasis
20. Cancer metastasis: Tumor cell and host organ properties important in metastasis to specific secondary sites
21. Expression and secretion of neuroleukin/phosphohexose isomerase/maturation factor as autocrine motility factor by tumor cells
22. The pathogenesis of cancer metastasis
23. Hypoxia-induced metastasis of human melanoma cells: Involvement of vascular endothelial growth factor-mediated angiogenesis
24. Microenvironment-induced cancer metastasis
25. Expression of hypoxia-inducible factor 1: Mechanisms and consequences
26. Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic
27. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
28. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
29. Molecular basis of hypoxia-induced erythropoietin expression
30. The relationship between motility factor receptor internalization and the lung colonization capacity of murine melanoma cells
31. Tumor cell autocrine motility factor is the neuroleukin/phosphohexose isomerase polypeptide
32. Identification of genes differentially induced by hypoxia in pancreatic cancer cells
33. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases