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Volumn 21, Issue 22, 2013, Pages 7107-7117

Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells

(15) Draoui, Nihed a Schicke, Olivier a Fernandes, Antony a Drozak, Xavier a Nahra, Fady a Dumont, Amélie a Douxfils, Jonathan b Hermans, Emmanuel a Dogné, Jean Michel b Corbau, Romu c Marchand, Arnaud c Chaltin, Patrick c,d Sonveaux, Pierre a Feron, Olivier a Riant, Olivier a

a UNIVERSITÉ CATHOLIQUE DE LOUVAIN (Belgium)

b UNIVERSITY OF NAMUR (Belgium)

c CISTIM Leuven Vzw (Belgium)

d UNIVERSITY OF LEUVEN (Belgium)

Author keywords

Cancer; Carboxycoumarins; Lactate; Monocarboxylate transporter

Indexed keywords

2 OXO 7 (PIPERIDIN 1 YL) 2H CHROMENE 3 CARBOXYLIC ACID; 2 OXO 7 (PYRROLIDIN 1 YL) 2H CHROMENE 3 CARBOXYLIC ACID; 7 (BENZYLOXY) 2 OXO 2H CHROMENE 3 CARBOXYLIC ACID; 7 (BENZYLOXY) 4 METHYL 2 OXO 2H CHROMENE 3CARBOXYLIC ACID; 7 (DIETHYLAMINO) 2 OXO 2H CHROMENE 3 CARBOXYLIC ACID; 7 (DIMETHYLAMINO) 2 OXO 2H CHROMENE 3 CARBOXYLIC ACID; 7 (JULOIDINO) 2 OXO 2H CHROMENE 3 CARBOXYLIC ACID; 7 (N BENZYL N METHYLAMINO) 2 OXO 2H CHROMENE 3; 7 (N BENZYL N METHYLAMINO) 2 OXO 2H CHROMENE 3 CARBOXYLIC ACID; 7 HYDROXY 4 METHYL 2 OXO 2H CHROMENE 3 CARBOXYLIC ACID; 7 METHOXY 2 OXO 2H CHROMENE 3 CARBOXYLIC ACID; 7 METHOXY 4 METHYL 2 OXO 2H CHROMENE 3CARBOXYLIC ACID; 7 MORPHOLINO 2 OXO 2H CHROMENE 3 CARBOXYLIC ACID; ANTINEOPLASTIC AGENT; CARBOXYCOUMARIN DERIVATIVE; LACTIC ACID; MONOCARBOXYLATE TRANSPORTER INHIBITOR; PALLADIUM; QUINOLINONE DERIVATIVE; UNCLASSIFIED DRUG; WARFARIN;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CANCER CELL; CATALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DISTRIBUTION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PLASMA HALF LIFE; PROTHROMBIN TIME; TIME TO MAXIMUM PLASMA CONCENTRATION;

CANCER; CARBOXYCOUMARINS; LACTATE; MONOCARBOXYLATE TRANSPORTER;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; COUMARINS; HALF-LIFE; HUMANS; LACTATES; MICE; MICROSOMES, LIVER; MONOCARBOXYLIC ACID TRANSPORTERS; QUINOLONES;

EID: 84885852231 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2013.09.010 Document Type: Article

Times cited : (53)

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