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Volumn 56, Issue 6, 1996, Pages 1194-1198

Cellular pH gradient in tumor versus normal tissue: Potential exploitation for the treatment of cancer

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER RESEARCH; CONTROLLED STUDY; DRUG TRANSPORT; DRUG UPTAKE; HUMAN; HUMAN TISSUE; MALIGNANT NEOPLASTIC DISEASE; PH MEASUREMENT; PRIORITY JOURNAL;

EID: 0029971428     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (1114)

References (38)
  • 1
    • 0021732164 scopus 로고
    • The relevance of tumour pH to the treatment of malignant disease
    • Wike-Hooley, J L., Haveman J., and Reinhold, H. S. The relevance of tumour pH to the treatment of malignant disease. Radiother. Oncol., 2: 343-366, 1984
    • (1984) Radiother. Oncol. , vol.2 , pp. 343-366
    • Wike-Hooley, J.L.1    Haveman, J.2    Reinhold, H.S.3
  • 2
    • 0002639767 scopus 로고
    • Intra- and extracellular pH in solid tumors. influence on therapeutic response
    • B. A. Teicher (ed.), New York: Marcel Dekker, Inc.
    • Song, C. W., Lyons, J. C , and Luo, Y Intra- and extracellular pH in solid tumors. influence on therapeutic response. In: B. A. Teicher (ed.), Drug Resistance in Oncology New York: Marcel Dekker, Inc., 1993.
    • (1993) Drug Resistance in Oncology
    • Song, C.W.1    Lyons, J.C.2    Luo, Y.3
  • 3
    • 0024308302 scopus 로고
    • Reduction of intracellular pH as a possible mechanism for killing cells in acidic regions of solid tumors: Effects of carbonylcyanide-3-chlorophenylhydrazone
    • Newell, K. J., and Tannock, I F Reduction of intracellular pH as a possible mechanism for killing cells in acidic regions of solid tumors: effects of carbonylcyanide-3-chlorophenylhydrazone. Cancer Res., 49: 4477-4482, 1989
    • (1989) Cancer Res. , vol.49 , pp. 4477-4482
    • Newell, K.J.1    Tannock, I.F.2
  • 4
    • 0024379967 scopus 로고
    • Acid pH in tumors and its potential for therapeutic exploitation
    • Tannock I. F., and Rotin, D. Acid pH in tumors and its potential for therapeutic exploitation Cancer Res , 49: 4373-4384, 1989.
    • (1989) Cancer Res , vol.49 , pp. 4373-4384
    • Tannock, I.F.1    Rotin, D.2
  • 7
    • 0022639884 scopus 로고
    • Biochemical investigation of human tumours in vivo with phosphorous-31 magnetic resonance spectroscopy
    • Oberhaensli, R. D., Bore, P. J., Rampling, R. P , Hilton-Jones, D., Hands, L. J., and Radda, G K. Biochemical investigation of human tumours in vivo with phosphorous-31 magnetic resonance spectroscopy. Lancet I. 811, 1986.
    • (1986) Lancet , vol.1 , pp. 811
    • Oberhaensli, R.D.1    Bore, P.J.2    Rampling, R.P.3    Hilton-Jones, D.4    Hands, L.J.5    Radda, G.K.6
  • 16
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
    • Vaupel, P , Kallinowski, F., and Okunieff, P Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review Cancer Res , 49: 6449-6465, 1989.
    • (1989) Cancer Res , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 20
    • 0017250935 scopus 로고
    • Development of a special electrode for continuous subcutaneous pH measurement in the infant scalp
    • Stamm, O , Latscha, U , Janecek, P., and Campana, A. Development of a special electrode for continuous subcutaneous pH measurement in the infant scalp. Am. J. Obstet. Gynecol., 124: 193-195, 1976
    • (1976) Am. J. Obstet. Gynecol. , vol.124 , pp. 193-195
    • Stamm, O.1    Latscha, U.2    Janecek, P.3    Campana, A.4
  • 22
    • 0018657452 scopus 로고
    • Microelectrode measurement of skin pH in humans during ischemia, hypoxia and local hyperthermia
    • Lond.
    • Harrison, O. K., and Walker, D. F Microelectrode measurement of skin pH in humans during ischemia, hypoxia and local hyperthermia. J. Physiol. (Lond.), 291: 339-350, 1979
    • (1979) J. Physiol. , vol.291 , pp. 339-350
    • Harrison, O.K.1    Walker, D.F.2
  • 23
    • 0004020610 scopus 로고
    • Die Wasserstoffionenkonzentration des Hirngewebes bei raumfordernden intracraniellen Prozessen
    • Pampus, F. Die Wasserstoffionenkonzentration des Hirngewebes bei raumfordernden intracraniellen Prozessen. Acta Neurochir., 11: 305-318, 1963.
    • (1963) Acta Neurochir. , vol.11 , pp. 305-318
    • Pampus, F.1
  • 24
    • 84965107638 scopus 로고
    • Investigations on the pH of malignant tumours in mice and humans after the administration of glucose
    • Naeslund, J., and Swenson, K. E. Investigations on the pH of malignant tumours in mice and humans after the administration of glucose. Acta Obstet. Gynecol. Scand., 32: 359-367, 1953.
    • (1953) Acta Obstet. Gynecol. Scand. , vol.32 , pp. 359-367
    • Naeslund, J.1    Swenson, K.E.2
  • 25
    • 0014007589 scopus 로고
    • pH studies in human malignant tumours
    • Ashby, B S., and Cantab, M. B. pH studies in human malignant tumours. Lancet, 1: 312-315, 1966.
    • (1966) Lancet , vol.1 , pp. 312-315
    • Ashby, B.S.1    Cantab, M.B.2
  • 26
    • 0001198399 scopus 로고
    • Capillary permeability to small solutes
    • E M. Renkinand and C. C Michel (eds.), Bethesda, MD. American Physiological Society
    • Crone, C., and Levitt, D. G. Capillary permeability to small solutes. In: E M. Renkinand and C. C Michel (eds.), Handbook of Physiology - The Cardiovascular System IV, Vol. 4, pp. 411-466. Bethesda, MD. American Physiological Society, 1984.
    • (1984) Handbook of Physiology - The Cardiovascular System IV , vol.4 , pp. 411-466
    • Crone, C.1    Levitt, D.G.2
  • 27
    • 0007297017 scopus 로고
    • Extravasation and interstitial transport in tumors
    • K. L. Audus and R. J. Raub (eds), New York. Plenum Press
    • Jain, R. K., and Baxter, L. T. Extravasation and interstitial transport in tumors. In: K. L. Audus and R. J. Raub (eds), Biological Barriers to Protein Delivery, pp. 441-465. New York. Plenum Press, 1993.
    • (1993) Biological Barriers to Protein Delivery , pp. 441-465
    • Jain, R.K.1    Baxter, L.T.2
  • 28
    • 13344271672 scopus 로고
    • Pharmacokinetics of antineoplastic agents at the cellular level
    • B. Chabner (ed.), Philadelphia: W B. Saunders
    • Goldman, I D. Pharmacokinetics of antineoplastic agents at the cellular level. In: B. Chabner (ed.), Pharmacalogic Principles of Cancer Treatment, pp. 15-44. Philadelphia: W B. Saunders, 1982.
    • (1982) Pharmacalogic Principles of Cancer Treatment , pp. 15-44
    • Goldman, I.D.1
  • 29
    • 0019554835 scopus 로고
    • Intracellular pH
    • Roos, A., and Boron, W. F. Intracellular pH. Physiol. Rev. 61: 296-434, 1981.
    • (1981) Physiol. Rev. , vol.61 , pp. 296-434
    • Roos, A.1    Boron, W.F.2
  • 30
    • 0021847087 scopus 로고
    • Extracellular pH transmembrane distribution and cytotoxicity of chlorambucil
    • Mikkelsen, R. B., Asher, C., and Hicks, T. Extracellular pH transmembrane distribution and cytotoxicity of chlorambucil. Biochem. Pharmacol., 34. 2531-2534, 1985
    • (1985) Biochem. Pharmacol. , vol.34 , pp. 2531-2534
    • Mikkelsen, R.B.1    Asher, C.2    Hicks, T.3
  • 31
    • 0021860841 scopus 로고
    • Cellular uptake of misonidazole and analogues with acidic or basic functions
    • Dennis, M. F., Stratford, M. R. L., Wardman, P., and Watts, M. E. Cellular uptake of misonidazole and analogues with acidic or basic functions. Int. J. Radiat Biol., 47: 629-643, 1985.
    • (1985) Int. J. Radiat Biol. , vol.47 , pp. 629-643
    • Dennis, M.F.1    Stratford, M.R.L.2    Wardman, P.3    Watts, M.E.4
  • 33
    • 0023792610 scopus 로고
    • pH distribution in spontaneous and isotransplanted rat tumors
    • Kallinowski, F., and Vaupel, P. pH distribution in spontaneous and isotransplanted rat tumors. Br. J. Cancer, 38: 314-321, 1989.
    • (1989) Br. J. Cancer , vol.38 , pp. 314-321
    • Kallinowski, F.1    Vaupel, P.2
  • 34
    • 0028072842 scopus 로고
    • Noninvasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy
    • Martin, R. G., and Jain, R. R. Noninvasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy. Cancer Res., 54: 5670-5674, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 5670-5674
    • Martin, R.G.1    Jain, R.R.2
  • 35
    • 0028245339 scopus 로고
    • Targeting the cytotoxicity of topoisomerase II-directed epipodopllotoxins to tumor cells in acidic environments
    • Jensen, P. B , Sorensen, B. S., Sehested, M., Grue, P., Demant, E J. F., and Hansen, H. H. Targeting the cytotoxicity of topoisomerase II-directed epipodopllotoxins to tumor cells in acidic environments. Cancer Res., 54. 2659-2963, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 2659-2963
    • Jensen, P.B.1    Sorensen, B.S.2    Sehested, M.3    Grue, P.4    Demant, E.J.F.5    Hansen, H.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.