메뉴 건너뛰기




Volumn 400, Issue 1-2, 1998, Pages 439-446

Mutagenesis induced by the tumor microenvironment

Author keywords

Genetic instability; Hypoxia; pH; supF

Indexed keywords

ARTICLE; CANCER GENETICS; CARCINOGENESIS; ENVIRONMENT; HUMAN; HYPOXIA; MALIGNANT NEOPLASTIC DISEASE; MUTAGENESIS; NONHUMAN; NUTRIENT; PH; PRIORITY JOURNAL;

EID: 0032565578     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(98)00042-6     Document Type: Article
Times cited : (105)

References (47)
  • 1
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • [1] P.C. Nowell, The clonal evolution of tumor cell populations, Science 194 (1976) 23-28.
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 2
    • 0025773554 scopus 로고
    • Mutator phenotype may be required for multistage carcinogenesis
    • [2] L.A. Loeb, Mutator phenotype may be required for multistage carcinogenesis, Cancer Res. 51 (1991) 3075-3079.
    • (1991) Cancer Res. , vol.51 , pp. 3075-3079
    • Loeb, L.A.1
  • 3
    • 0028221943 scopus 로고
    • Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer
    • [3] C.E. Bronner et al., Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer, Nature 368 (1994) 258-261.
    • (1994) Nature , vol.368 , pp. 258-261
    • Bronner, C.E.1
  • 4
    • 0027489384 scopus 로고
    • Clinical implications of the p53 tumor-suppressor gene
    • see comments
    • [4] C.C. Harris, M. Hollstein, Clinical implications of the p53 tumor-suppressor gene, New Engl. J. Med. 329 (1993) 1318-1327, [see comments].
    • (1993) New Engl. J. Med. , vol.329 , pp. 1318-1327
    • Harris, C.C.1    Hollstein, M.2
  • 5
    • 0030817162 scopus 로고    scopus 로고
    • Conditional mutator phenotypes in hMSH2-deficient tumor cell lines
    • [5] B. Richards, H. Zhang, G. Phear, M. Meuth, Conditional mutator phenotypes in hMSH2-deficient tumor cell lines, Science 277 (1997) 1523-1526.
    • (1997) Science , vol.277 , pp. 1523-1526
    • Richards, B.1    Zhang, H.2    Phear, G.3    Meuth, M.4
  • 6
    • 0029753768 scopus 로고    scopus 로고
    • Genetic instability induced by the tumor microenvironment
    • [6] T.Y. Reynolds, S. Rockwell, P.M. Glazer, Genetic instability induced by the tumor microenvironment, Cancer Res. 56 (1996) 5754-5757.
    • (1996) Cancer Res. , vol.56 , pp. 5754-5757
    • Reynolds, T.Y.1    Rockwell, S.2    Glazer, P.M.3
  • 7
    • 0028792556 scopus 로고
    • Hprt mutants in a transplantable murine tumour arise more frequently in vivo than in vitro
    • [7] D. Wilkinson, J.K. Sandhu, J.W. Breneman, J.D. Tucker, H.C. Birnboim, Hprt mutants in a transplantable murine tumour arise more frequently in vivo than in vitro, Br. J. Cancer 72 (1995) 1234-1240.
    • (1995) Br. J. Cancer , vol.72 , pp. 1234-1240
    • Wilkinson, D.1    Sandhu, J.K.2    Breneman, J.W.3    Tucker, J.D.4    Birnboim, H.C.5
  • 8
    • 0023082510 scopus 로고
    • Tumor hypoxia: Its impact on cancer therapy
    • [8] J.E. Moulder, S. Rockwell, Tumor hypoxia: its impact on cancer therapy, Cancer Metastasis Rev. 5 (1987) 313-341.
    • (1987) Cancer Metastasis Rev. , vol.5 , pp. 313-341
    • Moulder, J.E.1    Rockwell, S.2
  • 9
    • 0026698228 scopus 로고
    • Use of hypoxia-directed drugs in the therapy of solid tumors
    • [9] S. Rockwell, Use of hypoxia-directed drugs in the therapy of solid tumors, Semin. Oncol. 19 (1992) 29-40.
    • (1992) Semin. Oncol. , vol.19 , pp. 29-40
    • Rockwell, S.1
  • 11
    • 0030476061 scopus 로고    scopus 로고
    • Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma
    • [11] H. Kimura et al., Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma, Cancer Res. 56 (1996) 5522-5528.
    • (1996) Cancer Res. , vol.56 , pp. 5522-5528
    • Kimura, H.1
  • 12
    • 0025328583 scopus 로고
    • Hypoxic fractions of human tumors xenografted into mice: A review
    • [12] S. Rockwell, J.E. Moulder, Hypoxic fractions of human tumors xenografted into mice: a review, Int. J. Radiat. Oncol. Biol. Phys. 19 (1990) 197-202.
    • (1990) Int. J. Radiat. Oncol. Biol. Phys. , vol.19 , pp. 197-202
    • Rockwell, S.1    Moulder, J.E.2
  • 13
    • 0024213268 scopus 로고
    • Glucose uptake, lactate release, ketone body turnover, metabolic micromilieu, and pH distributions in human breast cancer xenografts in nude rats
    • [13] F. Kallinowski et al., Glucose uptake, lactate release, ketone body turnover, metabolic micromilieu, and pH distributions in human breast cancer xenografts in nude rats, Cancer Res. 48 (1988) 7264-7272.
    • (1988) Cancer Res. , vol.48 , pp. 7264-7272
    • Kallinowski, F.1
  • 14
    • 0021732164 scopus 로고
    • The relevance of tumour pH to the treatment of malignant disease, Radiother
    • [14] J.L. Wike-Hooley, J. Haveman, H.S. Reinhold, The relevance of tumour pH to the treatment of malignant disease, Radiother. Oncol. 2 (1984) 343-366.
    • (1984) Oncol. , vol.2 , pp. 343-366
    • Wike-Hooley, J.L.1    Haveman, J.2    Reinhold, H.S.3
  • 15
    • 0024379967 scopus 로고
    • Acid pH in tumors and its potential for therapeutic exploitation
    • [15] I.F. Tannock, D. Rotin, Acid pH in tumors and its potential for therapeutic exploitation, Cancer Res. 49 (1989) 4373-4384.
    • (1989) Cancer Res. , vol.49 , pp. 4373-4384
    • Tannock, I.F.1    Rotin, D.2
  • 16
    • 0025293207 scopus 로고
    • Enhanced synthesis of stress proteins caused by hypoxia and relation to altered cell growth and metabolism
    • [16] C.S. Heacock, R.M. Sutherland, Enhanced synthesis of stress proteins caused by hypoxia and relation to altered cell growth and metabolism, Br. J. Cancer 62 (1990) 217-225.
    • (1990) Br. J. Cancer , vol.62 , pp. 217-225
    • Heacock, C.S.1    Sutherland, R.M.2
  • 17
    • 0028110809 scopus 로고
    • Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status
    • [17] T.G. Graeber et al., Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status, Mol. Cell. Biol. 14 (1994) 6264-6277.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 6264-6277
    • Graeber, T.G.1
  • 18
    • 0022450587 scopus 로고
    • Regulation of protein metabolism of human cells during and after acute hypoxia
    • [18] E.O. Pettersen, N.O. Juul, O.W. Ronning, Regulation of protein metabolism of human cells during and after acute hypoxia, Cancer Res. 46 (1986) 4346-4351.
    • (1986) Cancer Res. , vol.46 , pp. 4346-4351
    • Pettersen, E.O.1    Juul, N.O.2    Ronning, O.W.3
  • 19
    • 0028084787 scopus 로고
    • Tumour hypoxia: The picture has changed in the 1990s
    • [19] J.M. Brown, A.J. Giaccia, Tumour hypoxia: the picture has changed in the 1990s, Int. J. Radiat. Biol. 65 (1994) 95-102.
    • (1994) Int. J. Radiat. Biol. , vol.65 , pp. 95-102
    • Brown, J.M.1    Giaccia, A.J.2
  • 20
    • 0025765456 scopus 로고
    • Cell inactivation and cell cycle inhibition as induced by extreme hypoxia: The possible role of cell cycle arrest as a protection against hypoxia-induced lethal damage
    • [20] O. Amellem, E.O. Pettersen, Cell inactivation and cell cycle inhibition as induced by extreme hypoxia: the possible role of cell cycle arrest as a protection against hypoxia-induced lethal damage, Cell Prolif. 24 (1991) 127-141.
    • (1991) Cell Prolif. , vol.24 , pp. 127-141
    • Amellem, O.1    Pettersen, E.O.2
  • 21
    • 0009581163 scopus 로고
    • Frequencies of independent and simultaneous selection of Chinese hamster cells for methotrexate and doxorubicin (adriamycin) resistance
    • [21] G.C. Rice, V. Ling, R.T. Schimke, Frequencies of independent and simultaneous selection of Chinese hamster cells for methotrexate and doxorubicin (adriamycin) resistance, Proc. Natl. Acad. Sci. U.S.A. 84 (1987) 9261-9264.
    • (1987) Proc. Natl. Acad. Sci. U.S.A. , vol.84 , pp. 9261-9264
    • Rice, G.C.1    Ling, V.2    Schimke, R.T.3
  • 22
    • 0023938135 scopus 로고
    • Oxygen dependent regulation of DNA synthesis and growth of Ehrlich ascites tumor cells in vitro and in vivo
    • [22] H. Probst et al., Oxygen dependent regulation of DNA synthesis and growth of Ehrlich ascites tumor cells in vitro and in vivo, Cancer Res. 48 (1988) 2053-2060.
    • (1988) Cancer Res. , vol.48 , pp. 2053-2060
    • Probst, H.1
  • 23
    • 0025764451 scopus 로고
    • Pathophysiology of ischaemia reperfusion injury: Central role of the neutrophil
    • [23] C.R. Welbourn et al., Pathophysiology of ischaemia reperfusion injury: central role of the neutrophil, Br. J. Surg. 78 (1991) 651-655.
    • (1991) Br. J. Surg. , vol.78 , pp. 651-655
    • Welbourn, C.R.1
  • 24
    • 0026592966 scopus 로고
    • 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions
    • [24] K.C. Cheng, D.S. Cahill, H. Kasai, S. Nishimura, L.A. Loeb, 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions, J. Biol. Chem. 267 (1992) 166-172.
    • (1992) J. Biol. Chem. , vol.267 , pp. 166-172
    • Cheng, K.C.1    Cahill, D.S.2    Kasai, H.3    Nishimura, S.4    Loeb, L.A.5
  • 25
    • 0026787669 scopus 로고
    • Anoxia-inducible endonuclease activity as a potential basis of the genomic instability of cancer cells
    • [25] D.L. Stoler, G.R. Anderson, C.A. Russo, A.M. Spina, T.A. Beerman, Anoxia-inducible endonuclease activity as a potential basis of the genomic instability of cancer cells, Cancer Res. 52 (1992) 4372-4378.
    • (1992) Cancer Res. , vol.52 , pp. 4372-4378
    • Stoler, D.L.1    Anderson, G.R.2    Russo, C.A.3    Spina, A.M.4    Beerman, T.A.5
  • 26
    • 0028931542 scopus 로고
    • An anoxia inducible endonuclease and enhanced DNA breakage as contributors to genomic instability in cancer
    • [26] C.A. Russo et al., An anoxia inducible endonuclease and enhanced DNA breakage as contributors to genomic instability in cancer, Cancer Res. 55 (1995) 1122-1128.
    • (1995) Cancer Res. , vol.55 , pp. 1122-1128
    • Russo, C.A.1
  • 27
    • 0004580887 scopus 로고
    • Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells
    • [27] G.C. Rice, C. Hoy, R.T. Schimke, Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells, Proc. Natl. Acad. Sci. U.S.A. 83 (1986) 5978-5982.
    • (1986) Proc. Natl. Acad. Sci. U.S.A. , vol.83 , pp. 5978-5982
    • Rice, G.C.1    Hoy, C.2    Schimke, R.T.3
  • 28
    • 0022374448 scopus 로고
    • Detection of S-phase over-replication following chronic hypoxia using a monoclonal anti-BrdUrd
    • [28] G.C. Rice, I.J. Spiro, C.C. Ling, Detection of S-phase over-replication following chronic hypoxia using a monoclonal anti-BrdUrd, Int. J. Radiat. Oncol. Biol. Phys. 11 (1985) 1817-1822.
    • (1985) Int. J. Radiat. Oncol. Biol. Phys. , vol.11 , pp. 1817-1822
    • Rice, G.C.1    Spiro, I.J.2    Ling, C.C.3
  • 29
    • 0010170555 scopus 로고
    • Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells
    • [29] S.D. Young, R.S. Marshall, R.P. Hill, Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells, Proc. Natl. Acad. Sci. U.S.A. 85 (1988) 9533-9537.
    • (1988) Proc. Natl. Acad. Sci. U.S.A. , vol.85 , pp. 9533-9537
    • Young, S.D.1    Marshall, R.S.2    Hill, R.P.3
  • 30
    • 1542697851 scopus 로고
    • Overreplication and recombination of DNA in higher eukaryotes: Potential consequences and biological implications
    • [30] R.T. Schimke, S.W. Sherwood, A.B. Hill, R.N. Johnston, Overreplication and recombination of DNA in higher eukaryotes: potential consequences and biological implications, Proc. Natl. Acad. Sci. U.S.A. 83 (1986) 2157-2161.
    • (1986) Proc. Natl. Acad. Sci. U.S.A. , vol.83 , pp. 2157-2161
    • Schimke, R.T.1    Sherwood, S.W.2    Hill, A.B.3    Johnston, R.N.4
  • 31
    • 0028307739 scopus 로고
    • Hypoxia and drug resistance
    • [31] B.A. Teicher, Hypoxia and drug resistance, Cancer Metastasis Rev. 13 (1994) 139-168.
    • (1994) Cancer Metastasis Rev. , vol.13 , pp. 139-168
    • Teicher, B.A.1
  • 32
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • [32] M. Hockel et al., Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix, Cancer Res. 56 (1996) 4509-4515.
    • (1996) Cancer Res. , vol.56 , pp. 4509-4515
    • Hockel, M.1
  • 33
    • 0030022252 scopus 로고    scopus 로고
    • Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma
    • [33] D.M. Brizel et al., Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma, Cancer Res. 56 (1996) 941-943.
    • (1996) Cancer Res. , vol.56 , pp. 941-943
    • Brizel, D.M.1
  • 34
    • 0031059664 scopus 로고    scopus 로고
    • Exposure to hypoxia, glucose starvation and acidosis: Effect on invasive capacity of murine tumor cells and correlation with cathepsin (L+ B) secretion
    • [34] C. Cuvier, A. Jang, R.P. Hill, Exposure to hypoxia, glucose starvation and acidosis: effect on invasive capacity of murine tumor cells and correlation with cathepsin (L+ B) secretion, Clin. Exp. Metastasis 15 (1997) 19-25.
    • (1997) Clin. Exp. Metastasis , vol.15 , pp. 19-25
    • Cuvier, C.1    Jang, A.2    Hill, R.P.3
  • 35
    • 0022533130 scopus 로고
    • Chromosomal changes without DNA overproduction in hydroxyurea-treated mammalian cells: Implications for gene amplification
    • [35] P. Hahn, L.N. Kapp, W.F. Morgan, R.B. Painter, Chromosomal changes without DNA overproduction in hydroxyurea-treated mammalian cells: implications for gene amplification, Cancer Res. 46 (1986) 4607-4612.
    • (1986) Cancer Res. , vol.46 , pp. 4607-4612
    • Hahn, P.1    Kapp, L.N.2    Morgan, W.F.3    Painter, R.B.4
  • 36
    • 0023576143 scopus 로고
    • Absence of DNA overreplication in Chinese hamster cells incubated with inhibitors of DNA synthesis
    • [36] R.B. Painter, B.R. Young, L.N. Kapp, Absence of DNA overreplication in Chinese hamster cells incubated with inhibitors of DNA synthesis, Cancer Res. 47 (1987) 5595-5599.
    • (1987) Cancer Res. , vol.47 , pp. 5595-5599
    • Painter, R.B.1    Young, B.R.2    Kapp, L.N.3
  • 37
    • 0029976686 scopus 로고    scopus 로고
    • Hypoxia-induced tetraploidisation of a diploid human melanoma cell line in vitro
    • [37] E.K. Rofstad, N.M. Johnsen, H. Lyng, Hypoxia-induced tetraploidisation of a diploid human melanoma cell line in vitro, Br. J. Cancer 74 (27) (1996) S136-S139.
    • (1996) Br. J. Cancer , vol.74 , Issue.27
    • Rofstad, E.K.1    Johnsen, N.M.2    Lyng, H.3
  • 38
    • 0027380678 scopus 로고
    • Fidelity of DNA synthesis catalyzed by human DNA polymerase alpha and HIV-1 reverse transcriptase: Effect of reaction pH
    • [38] K.A. Eckert, T.A. Kunkel, Fidelity of DNA synthesis catalyzed by human DNA polymerase alpha and HIV-1 reverse transcriptase: effect of reaction pH, Nucleic Acids Res. 21 (1993) 5212-5220.
    • (1993) Nucleic Acids Res. , vol.21 , pp. 5212-5220
    • Eckert, K.A.1    Kunkel, T.A.2
  • 39
    • 0027491535 scopus 로고
    • Effect of reaction pH on the fidelity and processivity of exonuclease-deficient Klenow polymerase
    • [39] K.A. Eckert, T.A. Kunkel, Effect of reaction pH on the fidelity and processivity of exonuclease-deficient Klenow polymerase, J. Biol. Chem. 268 (1993) 13462-13471.
    • (1993) J. Biol. Chem. , vol.268 , pp. 13462-13471
    • Eckert, K.A.1    Kunkel, T.A.2
  • 40
    • 0025771024 scopus 로고
    • Glucose starvation and acidosis: Effect on experimental metastatic potential, DNA content and MTX resistance of murine tumour cells
    • [40] O.K. Schlappack, A. Zimmermann, R.P. Hill, Glucose starvation and acidosis: effect on experimental metastatic potential, DNA content and MTX resistance of murine tumour cells, Br. J. Cancer 64 (1991) 663-670.
    • (1991) Br. J. Cancer , vol.64 , pp. 663-670
    • Schlappack, O.K.1    Zimmermann, A.2    Hill, R.P.3
  • 41
    • 0030021918 scopus 로고    scopus 로고
    • Serum deprivation, but not inhibition of growth per se, induces a hypermutable state in Chinese hamster G12 cells
    • [41] E.I. Goncharova, A. Nadas, T.G. Rossman, Serum deprivation, but not inhibition of growth per se, induces a hypermutable state in Chinese hamster G12 cells, Cancer. Res. 56 (1996) 752-756.
    • (1996) Cancer. Res. , vol.56 , pp. 752-756
    • Goncharova, E.I.1    Nadas, A.2    Rossman, T.G.3
  • 42
    • 0026795032 scopus 로고
    • Regulation of intracellular pH in tumor cell lines: Influence of microenvironmental conditions
    • [42] M.J. Boyer, I.E. Tannock, Regulation of intracellular pH in tumor cell lines: influence of microenvironmental conditions, Cancer Res. 52 (1992) 4441-4447.
    • (1992) Cancer Res. , vol.52 , pp. 4441-4447
    • Boyer, M.J.1    Tannock, I.E.2
  • 43
    • 0022481177 scopus 로고
    • Influence of hypoxia and an acidic environment on the metabolism and viability of cultured cells: Potential implications for cell death in tumors
    • [43] D. Rotin, B. Robinson, I.F. Tannock, Influence of hypoxia and an acidic environment on the metabolism and viability of cultured cells: potential implications for cell death in tumors, Cancer Res. 46 (1986) 2821-2826.
    • (1986) Cancer Res. , vol.46 , pp. 2821-2826
    • Rotin, D.1    Robinson, B.2    Tannock, I.F.3
  • 44
    • 0017603563 scopus 로고
    • In vivo-in vitro tumor systems: New models for studying the response of tumors to therapy
    • [44] S. Rockwell, In vivo-in vitro tumor systems: New models for studying the response of tumors to therapy, Lab. Anim. Sci. 27 (1977) 831-851.
    • (1977) Lab. Anim. Sci. , vol.27 , pp. 831-851
    • Rockwell, S.1
  • 45
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
    • [45] T.G. Graeber et al., Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours, Nature 379 (1996) 88-91.
    • (1996) Nature , vol.379 , pp. 88-91
    • Graeber, T.G.1
  • 46
    • 0030987686 scopus 로고    scopus 로고
    • Mismatch repair protein MutL becomes limiting during stationary-phase mutation
    • [46] R.S. Harris et al., Mismatch repair protein MutL becomes limiting during stationary-phase mutation, Genes Dev. 11 (1997) 2426-2437.
    • (1997) Genes Dev. , vol.11 , pp. 2426-2437
    • Harris, R.S.1
  • 47
    • 0030865954 scopus 로고    scopus 로고
    • Transient expression of a mutator phenotype in cancer cells
    • comment
    • [47] L.A. Loeb, Transient expression of a mutator phenotype in cancer cells, Science 277 (1997) 1449-1450, [comment].
    • (1997) Science , vol.277 , pp. 1449-1450
    • Loeb, L.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.