Mechanism, factors, and physiological role of nonsense-mediated mRNA decay

Cellular and Molecular Life Sciences

Volumn 72, Issue 23, 2015, Pages 4523-4544

  Fatscher, Tobias ^a   Boehm, Volker ^a   Gehring, Niels H ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Exon junction complex; Genetic disease; NMD; Quality control; UPF1

Indexed keywords

AMINOGLYCOSIDE; ATALUREN; GENTAMICIN; MESSENGER RNA; PHOSPHOPROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2A; 3' UNTRANSLATED REGION; DEAD BOX PROTEIN; EIF4A3 PROTEIN, HUMAN; INITIATION FACTOR 4A; RBM8A PROTEIN, HUMAN; RNA BINDING PROTEIN; SMG6 PROTEIN, HUMAN; STOP CODON; TELOMERASE; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; UPF1 PROTEIN, HUMAN; UPF2 PROTEIN, HUMAN; UPF3A PROTEIN, HUMAN;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CODON; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; DUCHENNE MUSCULAR DYSTROPHY; EIF4A3 GENE; ENZYME SUBSTRATE; EXON JUNCTION COMPLEX; FRAMESHIFT MUTATION; GENE; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC DISORDER; HUMAN; MOLECULAR PATHOLOGY; MOLECULAR RECOGNITION; MUTATIONAL ANALYSIS; NONHUMAN; NONSENSE MEDIATED MRNA DECAY; NONSENSE MUTATION; OPEN READING FRAME; PREMATURE TERMINATION CODON; PROTEIN CLEAVAGE; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; REVIEW; RNA ANALYSIS; RNA BINDING; RNA DEGRADATION; RNA TRANSLATION; STOP CODON; UPF1 GENE; UPF2 GENE; UPF3 GENE; UPF3B GENE; Y14 GENE; ANIMAL; GENETIC PREDISPOSITION; GENETICS; METABOLISM; MUTATION; PHOSPHORYLATION; PHYSIOLOGY; X LINKED MENTAL RETARDATION;

3' UNTRANSLATED REGIONS; ANIMALS; CODON, NONSENSE; DEAD-BOX RNA HELICASES; EUKARYOTIC INITIATION FACTOR-4A; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MENTAL RETARDATION, X-LINKED; MUTATION; NONSENSE MEDIATED MRNA DECAY; PEPTIDE CHAIN TERMINATION, TRANSLATIONAL; PHOSPHORYLATION; RNA-BINDING PROTEINS; TELOMERASE; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 84946482619     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-015-2017-9     Document Type: Review

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