Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)

Molecular and Cellular Biology

Volumn 21, Issue 1, 2001, Pages 209-223

  Serin, G ^a   Gersappe, A ^a   Black, J D ^a   Aronoff, R ^a   Maquat, L E ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; EPITOPE; FUNGAL PROTEIN; GENE PRODUCT; MESSENGER RNA; PROTEIN SUBUNIT; PROTEIN UPF1P; PROTEIN UPF2; PROTEIN UPF3; PROTOZOAL PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CAENORHABDITIS ELEGANS; CELL INTERACTION; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; RNA SPLICING; RNA TRANSLATION; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CAENORHABDITIS ELEGANS; CELL NUCLEUS; CLONING, MOLECULAR; CONSERVED SEQUENCE; CYTOPLASM; FLUORESCENT ANTIBODY TECHNIQUE; FUNGAL PROTEINS; HELA CELLS; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; RNA HELICASES; RNA, MESSENGER; RNA-BINDING PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ALIGNMENT; TRANS-ACTIVATORS;

CAENORHABDITIS ELEGANS; MAMMALIA; SACCHAROMYCES CEREVISIAE;

EID: 0034751160     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.1.209-223.2001     Document Type: Article

References (51)

1. Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein
2. Eukaryote-specific domains in translation initiation factors: Implications for translational regulation and evolution of the translational system
3. The majority of yeast UPF1 co-localizes with polyribosomes in the cytoplasm
4. Relationship between yeast polyribosomes and Upf proteins required for nonsense mRNA decay
5. A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm
6. smg-7 is required for mRNA surveillance in Caenorhabditis elegans
7. A splicing-dependent regulatory mechanism that detects translation signals
8. Introns are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abundance
9. Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon
10. Mof4-f1 is an allele of the UPF1/IFS2 gene which affects both mRNA turnover and -1 ribosomal frameshifting efficiency
11. The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs
12. Purification and characterization of the Upf1 protein: A factor involved in translation and mRNA degradation
13. The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif
14. Structure and functions of nucleolin
15. The yeast hnRNP-like protein Hrp1/Nab4 marks a transcript for nonsense-mediated mRNA decay
16. Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen
17. Interaction between Nmd2p and Upf1p is required for activity but not for dominant-negative inhibition of the nonsense-mediated mRNA decay pathway in yeast
18. Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway
19. A perfect message: RNA surveillance and nonsense-mediated decay
20. Site-directed mutagenesis by overlap extension using the polymerase chain reaction
21. Initiation of translation in prokaryotes and eukaryotes
22. Identification of an additional gene required for eukaryotic nonsense mRNA turnover
23. The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon
24. Gene products that promote mRNA turnover in Saccharomyces cerevisiae
25. Pre-mRNA splicing alters mRNP composition: Evidence for a stable association of proteins at exonexon junctions
26. Eukaryotic translation initiation factor 4AIII(eIF4AIII) is functionally distinct from alF41 and elF4AII
27. Nonsense surveillance in lymphocytes?
28. Human β-globin mRNAs that harbor a nonsense codon are degraded in murine erythroid tissues to intermediates that have a 5' cap-like structure
29. When cells stop making sense: Effects of nonsense codons on RNA metabolism in vertebrate cells
30. Defects in RNA splicing and the consequence of shortened translational reading frames
31. Nonsense-mediated RNA decay in mammalian cells: A splicing-dependent means to down-regulate the levels of mRNAs that prematurely terminate translation
32. The K nuclear shuttling domain: A novel signal for nuclear import and nuclear export in the hnRNP K protein
33. A rule for termination-codon position within intron-containing genes: When nonsense affects RNA abundance
34. SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast
35. Evidence that phosphorylation of human Upf1 protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathway
36. Mammalian orthologues of a yeast regulator of nonsense transcript stability
37. Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm
38. mRNA surveillance by the Caenorhabditis elegans smg genes
39. The Upf3 protein is a component of the surveillance complex that monitors both translation and mRNA turnover and affects viral propagation
40. A factor required for nonsense-mediated mRNA decay in yeast is exported from the nucleus to the cytoplasm by a nuclear export signal sequence
41. Nonsense-mediated decay of glutathione peroxidase 1 mRNA in the cytoplasm is dependent on intron position and not restricted to newly synthesized mRNA
42. A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells
43. mRNA surveillance in mammalian cells: The relationship between introns and translation termination
44. Binary specification of nonsense codons by splicing and cytoplasmic translation
45. Genetic and biochemical characterization of the mutations in the ATPase and helicase regions of Upf1 protein
46. Identification and characterization of mutations in the UPF1 gene that affect nonsense suppression and the formation of the Upf protein complex but not mRNA turnover
47. ATP is a cofactor of the Upf1 protein that modulates its translation termination and RNA binding activities
48. At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: A possible link between nuclear splicing and cytoplasmic translation
49. Intron function in the nonsense-mediated decay of β-globin mRNA: Indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm
50. Polysome-associated mRNAs are substrates for the nonsense-mediated mRNA decay pathway in Saccharomyces cerevisiae