The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay

EMBO Journal

Volumn 20, Issue 17, 2001, Pages 4987-4997

  Le Hir, Hervé ^a   Gatfield, David ^b   Izaurralde, Elisa ^b   Moore, Melissa J ^a  

^a BRANDEIS UNIVERSITY   (United States)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

Exon exon junction complex; mRNA export; Nonsense mediated decay; Pre mRNA splicing

Indexed keywords

MESSENGER RNA; RIBONUCLEOPROTEIN;

ANIMAL CELL; ARTICLE; BINDING SITE; EXON; INTRACELLULAR TRANSPORT; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN TRANSPORT; RNA BINDING; SPLICEOSOME; XENOPUS LAEVIS;

ANIMALS; ANTIGENS, NUCLEAR; BINDING SITES; CLONING, MOLECULAR; DNA-BINDING PROTEINS; ESCHERICHIA COLI; EXONS; HUMANS; MODELS, GENETIC; NUCLEAR MATRIX-ASSOCIATED PROTEINS; NUCLEAR PROTEINS; OOCYTES; RECOMBINANT PROTEINS; RIBONUCLEOPROTEINS; RNA PRECURSORS; RNA SPLICING; RNA, MESSENGER; RNA-BINDING PROTEINS; XENOPUS LAEVIS;

ANIMALIA; XENOPUS LAEVIS;

EID: 0035801373     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.17.4987     Document Type: Article

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3. A coactivator of pre-mRNA splicing
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17. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human
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19. The Y14 protein communicates to the cytoplasm the position of exon-exon junctions
20. Initial sequencing and analysis of the human genome
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22. The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions
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39. Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)
40. REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export
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44. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans