The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2

Genes and Development

Volumn 27, Issue 19, 2013, Pages 2125-2138

  Loh, Belinda ^a   Jonas, Stefanie ^a   Izaurralde, Elisa ^a  

^a MAX PLANCK INSTITUTE FOR DEVELOPMENTAL BIOLOGY   (Germany)

Author keywords

Deadenylation; mRNA decay; NMD; UPF1

Indexed keywords

CHEMOKINE RECEPTOR CCR4; HETERODIMER; MESSENGER RNA; PNRC2 PROTEIN; POP2 PROTEIN; PROTEIN; SMG5 PROTEIN; SMG6 PROTEIN; SMG7 PROTEIN; UNCLASSIFIED DRUG; UPF1 PROTEIN; CARRIER PROTEIN; CCR4 PROTEIN, HUMAN; CNOT8 PROTEIN, HUMAN; NR4A2 PROTEIN, HUMAN; NUCLEAR RECEPTOR RELATED FACTOR 1; PROTEIN BINDING; PROTEIN SUBUNIT; STOP CODON; TRANSCRIPTION FACTOR;

ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVE SITE; HUMAN; HUMAN CELL; NONSENSE MEDIATED MRNA DECAY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; STOP CODON; WILD TYPE; DIMERIZATION; GENETIC COMPLEMENTATION; GENETICS; HEK293 CELL LINE; HELA CELL LINE; METABOLISM; MUTATION; PROTEIN SUBUNIT; RNA STABILITY;

EUKARYOTA;

CARRIER PROTEINS; CATALYTIC DOMAIN; CODON, NONSENSE; DIMERIZATION; GENETIC COMPLEMENTATION TEST; HEK293 CELLS; HELA CELLS; HUMANS; MUTATION; NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 2; PROTEIN BINDING; PROTEIN SUBUNITS; RECEPTORS, CCR4; RNA STABILITY; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 84885356907     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.226951.113     Document Type: Article

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