Rules that govern UPF1 binding to mRNA 3' UTRs

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 9, 2013, Pages 3357-3362

  Kurosaki, Tatsuaki ^a   Maquat, Lynne E ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Messenger ribonucleoprotein structure; Messenger RNA quality control; RNA binding protein

Indexed keywords

HELICASE UP FRAMESHIFT 1; MESSENGER RNA; RIBONUCLEOPROTEIN; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; EXON; EXON JUNCTION COMPLEX; GENE LOCUS; HUMAN; HUMAN CELL; NONSENSE MEDIATED MRNA DECAY; PREMATURE TERMINATION CODON; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN RNA BINDING; PROTEIN STRUCTURE; RNA TRANSLATION; STOP CODON; TRANSLATION REGULATION;

3' UNTRANSLATED REGIONS; BETA-GLOBINS; CODON, NONSENSE; EXONS; HUMANS; NUCLEOTIDES; PEPTIDE TERMINATION FACTORS; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; TRANS-ACTIVATORS;

EID: 84874504687     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1219908110     Document Type: Article

References (38)

1. Maquat LE, Tarn WY, Isken O (2010) The pioneer round of translation: Features and functions. Cell 142(3): 368-374.
2. Zhang J, Sun X, Qian Y, Maquat LE (1998) Intron function in the nonsense-mediated decay of beta-globin mRNA: Indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm. RNA 4(7): 801-815.
3. Ishigaki Y, Li X, Serin G, Maquat LE (2001) Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20. Cell 106(5): 607-617.
4. Matsuda D, Hosoda N, Kim YK, Maquat LE (2007) Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA. Nat Struct Mol Biol 14(10): 974-979.
5. Eberle AB, Stalder L,Mathys H, Orozco RZ,Mühlemann O (2008) Posttranscriptional gene regulation by spatial rearrangement of the 3' untranslated region. PLoS Biol 6(4):e92.
6. Singh G, Rebbapragada I, Lykke-Andersen J (2008) A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay. PLoS Biol 6(4):e111.
7. Trcek T, Sato H, Singer RH, Maquat LE (2013) Temporal and spatial characterization of nonsense-mediated mRNA decay. Genes Dev, in press.
8. Gehring NH, Lamprinaki S, Kulozik AE, Hentze MW (2009) Disassembly of exon junction complexes by PYM. Cell 137(3): 536-548.
9. Sato H, Maquat LE (2009) Remodeling of the pioneer translation initiation complex involves translation and the karyopherin importin beta. Genes Dev 23(21): 2537-2550.
10. Kashima I, et al. (2006) Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. Genes Dev 20(3): 355-367.
11. Yamashita A, et al. (2009) SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsensemediated mRNA decay. Genes Dev 23(9): 1091-1105.
12. Hwang J, Sato H, Tang Y, Matsuda D, Maquat LE (2010) UPF1 association with the capbinding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps. Mol Cell 39(3): 396-409.
13. Fernández IS, et al. (2011) Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex. Nucleic Acids Res 39(1): 347-358.
14. Isken O, et al. (2008) Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay. Cell 133(2): 314-327.
15. Lejeune F, Li X, Maquat LE (2003) Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. Mol Cell 12(3): 675-687.
16. Huntzinger E, Kashima I, Fauser M, Saulière J, Izaurralde E (2008) SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan. RNA 14(12): 2609-2617.
17. Eberle AB, Lykke-Andersen S, Mühlemann O, Jensen TH (2009) SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells. Nat Struct Mol Biol 16(1): 49-55.
18. Franks TM, Singh G, Lykke-Andersen J (2010) Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense-mediated mRNA decay. Cell 143(6): 938-950.
19. Chiu SY, Serin G, Ohara O, Maquat LE (2003) Characterization of human Smg5/7a: A protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1. RNA 9(1): 77-87.
20. Ohnishi T, et al. (2003) Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Mol Cell 12(5): 1187-1200.
21. Fukuhara N, et al. (2005) SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. Mol Cell 17(4): 537-547.
22. Okada-Katsuhata Y, et al. (2012) N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD. Nucleic Acids Res 40(3): 1251-1266.
23. Frischmeyer PA, Dietz HC (1999) Nonsense-mediated mRNA decay in health and disease. Hum Mol Genet 8(10): 1893-1900.
24. Khajavi M, Inoue K, Lupski JR (2006) Nonsense-mediated mRNA decay modulates clinical outcome of genetic disease. Eur J Hum Genet 14(10): 1074-1081.
25. Nicholson P, et al. (2010) Nonsense-mediated mRNA decay in human cells: Mechanistic insights, functions beyond quality control and the double-life of NMD factors. Cell Mol Life Sci 67(5): 677-700.
26. Linde L, Kerem B (2008) Introducing sense into nonsense in treatments of human genetic diseases. Trends Genet 24(11): 552-563.
27. Bhuvanagiri M, Schlitter AM, Hentze MW, Kulozik AE (2010) NMD: RNA biology meets human genetic medicine. Biochem J 430(3): 365-377.
28. Hogg JR, Goff SP (2010) Upf1 senses 3'UTR length to potentiate mRNA decay. Cell 143(3): 379-389.
29. Shigeoka T, Kato S, Kawaichi M, Ishida Y (2012) Evidence that the Upf1-related molecular motor scans the 3'-UTR to ensure mRNA integrity. Nucleic Acids Res 40(14): 6887-6897.
30. Nesic D, Maquat LE (1994) Upstream introns influence the efficiency of final intron removal and RNA 3'-end formation. Genes Dev 8(3): 363-375.
31. Thermann R, et al. (1998) Binary specification of nonsense codons by splicing and cytoplasmic translation. EMBO J 17(12): 3484-3494.
32. Shyu AB, Greenberg ME, Belasco JG (1989) The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways. Genes Dev 3(1): 60-72.
33. Czaplinski K, et al. (1998) The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs. Genes Dev 12(11): 1665-1677.
34. Ivanov PV, Gehring NH, Kunz JB, Hentze MW, Kulozik AE (2008) Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways. EMBO J 27(5): 736-747.
35. Kervestin S, Li C, Buckingham R, Jacobson A (2012) Testing the faux-UTR model for NMD: Analysis of Upf1p and Pab1p competition for binding to eRF3/Sup35p. Biochimie 94(7): 1560-1571.
36. Chakrabarti S, et al. (2011) Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2. Mol Cell 41(6): 693-703.
37. Ghosh S, Ganesan R, Amrani N, Jacobson A (2010) Translational competence of ribosomes released from a premature termination codon is modulated by NMD factors. RNA 16(9): 1832-1847.
38. Lykke-Andersen J, Shu MD, Steitz JA (2000) Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. Cell 103(7): 1121-1131.