A faux 3′-UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay

Nature

Volumn 432, Issue 7013, 2004, Pages 112-118

  Amrani, Nadia ^a   Ganesan, Robin ^a   Kervestin, Stephanie ^a   Mangus, David A ^a   Ghosh, Shubhendu ^a   Jacobson, Allan ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; PHYSIOLOGICAL MODELS; PROTEINS; RNA; STABILITY; YEAST;

PREMATURE TERMINATION; RIBOSOMES;

GENETIC ENGINEERING;

MESSENGER RNA; NUCLEIC ACID BINDING PROTEIN; POLYADENYLIC ACID BINDING PROTEIN; PROTEIN UPF1P; TRANSCRIPTION FACTOR; TRANSCRIPTION TERMINATION FACTOR SUP35P; UNCLASSIFIED DRUG; CELL EXTRACT; CYCLOHEXIMIDE; FUNGAL RNA;

BIOLOGY;

3' UNTRANSLATED REGION; ARTICLE; ASSAY; CONTROLLED STUDY; MOLECULAR MIMICRY; MOLECULAR RECOGNITION; NONHUMAN; PRIMER EXTENSION INHIBITION ASSAY; PRIORITY JOURNAL; RIBOSOME; RNA DEGRADATION; RNA PROCESSING; RNA STABILITY; RNA TRANSLATION; SACCHAROMYCES CEREVISIAE; STOP CODON; BINDING SITE; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

3' UNTRANSLATED REGIONS; BASE SEQUENCE; BINDING SITES; CELL EXTRACTS; CODON, NONSENSE; CYCLOHEXIMIDE; PEPTIDE CHAIN TERMINATION, TRANSLATIONAL; RNA STABILITY; RNA, FUNGAL; SACCHAROMYCES CEREVISIAE;

EID: 8544253956     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03060     Document Type: Article

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