메뉴 건너뛰기




Volumn 4, Issue 7, 1998, Pages 801-815

Intron function in the nonsense-mediated decay of β-globin mRNA: Indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm

Author keywords

Introns; mRNA destabilizing elements; Nonsense codons; Nucleus associated mRNA

Indexed keywords

BETA GLOBIN; MESSENGER RNA; MESSENGER RNA PRECURSOR;

EID: 0031870169     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1355838298971849     Document Type: Article
Times cited : (252)

References (46)
  • 1
    • 15844406352 scopus 로고    scopus 로고
    • Nonsense mutations inhibit RNa splicing in a cell free system: Recognition of mutant codon is independent of protein synthesis and tissue specific
    • Aoufouchi S, Ylamos J, Milstein C. 1996. Nonsense mutations inhibit RNA splicing in a cell free system: Recognition of mutant codon is independent of protein synthesis and tissue specific. Cell 85:415-422.
    • (1996) Cell , vol.85 , pp. 415-422
    • Aoufouchi, S.1    Ylamos, J.2    Milstein, C.3
  • 2
    • 0030745114 scopus 로고    scopus 로고
    • Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein
    • Applequist SE, Selg M, Raman C, Jäck HM. 1997. Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein. Nucleic Acids Res 25:814-821.
    • (1997) Nucleic Acids Res , vol.25 , pp. 814-821
    • Applequist, S.E.1    Selg, M.2    Raman, C.3    Jäck, H.M.4
  • 3
    • 0026315967 scopus 로고
    • Nonsense codons within the Rous sarcoma virus gag gene decrease the stability of unspliced viral RNA
    • Barker GF, Beemon K. 1991. Nonsense codons within the Rous sarcoma virus gag gene decrease the stability of unspliced viral RNA. Mol Cell Biol 11:2760-2768.
    • (1991) Mol Cell Biol , vol.11 , pp. 2760-2768
    • Barker, G.F.1    Beemon, K.2
  • 4
    • 0028210434 scopus 로고
    • Rous sarcoma virus RNA stability requires an open reading frame in the gag gene and sequences downstream of the gag-pol junction
    • Barker GF, Beemon K. 1994. Rous sarcoma virus RNA stability requires an open reading frame in the gag gene and sequences downstream of the gag-pol junction. Mol Cell Biol 14:1986-1996.
    • (1994) Mol Cell Biol , vol.14 , pp. 1986-1996
    • Barker, G.F.1    Beemon, K.2
  • 5
    • 0027388887 scopus 로고
    • Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA
    • Belgrader P, Cheng J, Maquat LE. 1993. Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA. Proc Natl Acad Sci USA 90:482-486.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 482-486
    • Belgrader, P.1    Cheng, J.2    Maquat, L.E.3
  • 6
  • 7
    • 0027981640 scopus 로고
    • Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, whereas both types of mutations can facilitate exon skipping
    • Belgrader P, Maquat LE. 1994. Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, whereas both types of mutations can facilitate exon skipping. Mol Cell Biol 14:6326-6336.
    • (1994) Mol Cell Biol , vol.14 , pp. 6326-6336
    • Belgrader, P.1    Maquat, L.E.2
  • 8
    • 0029871812 scopus 로고    scopus 로고
    • Mechanisms and control of mRNA turnover in Saccharomyces cerevisiae
    • Caponigro G, Parker R. 1996. Mechanisms and control of mRNA turnover in Saccharomyces cerevisiae. Microbiol Rev 60:233-249.
    • (1996) Microbiol Rev , vol.60 , pp. 233-249
    • Caponigro, G.1    Parker, R.2
  • 9
    • 0029908912 scopus 로고    scopus 로고
    • A splicing-dependent regulatory mechanism that detects translation signals
    • Carter MS, Li S, Wilkinson MF. 1996. A splicing-dependent regulatory mechanism that detects translation signals. EMBO J 15:5965-5975.
    • (1996) EMBO J , vol.15 , pp. 5965-5975
    • Carter, M.S.1    Li, S.2    Wilkinson, M.F.3
  • 10
  • 11
    • 0027993583 scopus 로고
    • Introns are cis-effectors of the nonsense codon-mediated reduction in nuclear mRNA abundance
    • Cheng J, Belgrader P, Zhou X, Maquat LE. 1994. Introns are cis-effectors of the nonsense codon-mediated reduction in nuclear mRNA abundance. Mol Cell Biol 14:6317-6325.
    • (1994) Mol Cell Biol , vol.14 , pp. 6317-6325
    • Cheng, J.1    Belgrader, P.2    Zhou, X.3    Maquat, L.E.4
  • 12
    • 0025162587 scopus 로고
    • Translation to near the distal end of the penultimate exon is required for normal levels of spliced triosephosphate isomerase mRNA
    • Cheng J, Fogel-Petrovic M, Maquat LE. 1990. Translation to near the distal end of the penultimate exon is required for normal levels of spliced triosephosphate isomerase mRNA. Mol Cell Biol 10:5215-5225.
    • (1990) Mol Cell Biol , vol.10 , pp. 5215-5225
    • Cheng, J.1    Fogel-Petrovic, M.2    Maquat, L.E.3
  • 13
    • 0027536976 scopus 로고
    • Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA
    • Cheng J, Maquat LE. 1993. Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA. Mol Cell Biol 13: 1892-1902.
    • (1993) Mol Cell Biol , vol.13 , pp. 1892-1902
    • Cheng, J.1    Maquat, L.E.2
  • 14
    • 0028136599 scopus 로고
    • Maintenance of an open reading frame as an additional level of scrutiny during splice site selection
    • Dietz HC, Kendzior RJ Jr. 1994. Maintenance of an open reading frame as an additional level of scrutiny during splice site selection. Nature Genet 8:183-188.
    • (1994) Nature Genet , vol.8 , pp. 183-188
    • Dietz, H.C.1    Kendzior R.J., Jr.2
  • 16
    • 0028861358 scopus 로고
    • Characterization of cis-acting sequences and decay intermediates involved in nonsense-mediated mRNA turnover
    • Hagan KW, Ruiz-Echevarria MJ, Quan Y, Peltz SW. 1995. Characterization of cis-acting sequences and decay intermediates involved in nonsense-mediated mRNA turnover. Mol Cell Biol 15:809-823.
    • (1995) Mol Cell Biol , vol.15 , pp. 809-823
    • Hagan, K.W.1    Ruiz-Echevarria, M.J.2    Quan, Y.3    Peltz, S.W.4
  • 17
    • 0028344092 scopus 로고
    • Nonsense codon mutations in the terminal exon of the β-globin gene are not associated with a reduction in β-mRNA accumulation: A mechanism for the phenotype of dominant β-thalassemia
    • Hall GW, Thein S. 1994. Nonsense codon mutations in the terminal exon of the β-globin gene are not associated with a reduction in β-mRNA accumulation: A mechanism for the phenotype of dominant β-thalassemia. Blood 83:2031-2037.
    • (1994) Blood , vol.83 , pp. 2031-2037
    • Hall, G.W.1    Thein, S.2
  • 18
    • 0023685544 scopus 로고
    • A survey on intron and exon lengths
    • Hawkins JD. 1988. A survey on intron and exon lengths. Nucleic Acids Res 16:9893-9908.
    • (1988) Nucleic Acids Res , vol.16 , pp. 9893-9908
    • Hawkins, J.D.1
  • 19
    • 0029973094 scopus 로고    scopus 로고
    • Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells
    • Jacobson A, Peltz SW. 1996. Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells. Annu Rev Biochem 65:693-739.
    • (1996) Annu Rev Biochem , vol.65 , pp. 693-739
    • Jacobson, A.1    Peltz, S.W.2
  • 20
    • 0028941794 scopus 로고
    • Nuclear degradation of nonsense mutated β-globin mRNA: A post-transcriptional mechanism to protect heterozygotes from severe clinical manifestations of β-thalassemia?
    • Kugler W, Enssle J, Hentze MW, Kulozik AE. 1995. Nuclear degradation of nonsense mutated β-globin mRNA: A post-transcriptional mechanism to protect heterozygotes from severe clinical manifestations of β-thalassemia? Nucleic Acids Res 23:413-418.
    • (1995) Nucleic Acids Res , vol.23 , pp. 413-418
    • Kugler, W.1    Enssle, J.2    Hentze, M.W.3    Kulozik, A.E.4
  • 21
    • 0031004756 scopus 로고    scopus 로고
    • T cell receptor (TCR) minigene mRNA expression regulated by nonsense codons: A nuclear-associated translation-like mechanism
    • Li SL, Leonard D, Wilkinson MF. 1997. T cell receptor (TCR) minigene mRNA expression regulated by nonsense codons: A nuclear-associated translation-like mechanism. J Exp E Med 185:985-992.
    • (1997) J Exp e Med , vol.185 , pp. 985-992
    • Li, S.L.1    Leonard, D.2    Wilkinson, M.F.3
  • 22
    • 0026641165 scopus 로고
    • Human β-globin mRNAs that harbor a nonsense codon are degraded in murine erythroid tissues to intermediates that have a 5′ cap-like structure
    • Lim SK, Maquat LE. 1992. Human β-globin mRNAs that harbor a nonsense codon are degraded in murine erythroid tissues to intermediates that have a 5′ cap-like structure. EMBO J 11:3271-3278.
    • (1992) EMBO J , vol.11 , pp. 3271-3278
    • Lim, S.K.1    Maquat, L.E.2
  • 23
    • 0024443107 scopus 로고
    • Novel metabolism of several β-thalassemic β-globin RNAs in the erythroid tissues of transgenic mice
    • Lim SK, Mullins JJ, Chen CM, Gross KW, Maquat LE. 1989. Novel metabolism of several β-thalassemic β-globin RNAs in the erythroid tissues of transgenic mice. EMBO J 8:2613-2619.
    • (1989) EMBO J , vol.8 , pp. 2613-2619
    • Lim, S.K.1    Mullins, J.J.2    Chen, C.M.3    Gross, K.W.4    Maquat, L.E.5
  • 24
    • 0026583873 scopus 로고
    • Nonsense codons in human β-globin mRNA result in the production of mRNA degradation products
    • Lim SK, Sigmund C, Gross KW, Maquat LE. 1992. Nonsense codons in human β-globin mRNA result in the production of mRNA degradation products. Mol Cell Biol 12:1149-1161.
    • (1992) Mol Cell Biol , vol.12 , pp. 1149-1161
    • Lim, S.K.1    Sigmund, C.2    Gross, K.W.3    Maquat, L.E.4
  • 25
    • 0028147091 scopus 로고
    • Low cytoplasmic mRNA levels of immunoglobulin light chain genes containing nonsense codons correlate with inefficient splicing
    • Lozano F, Maertzdorf B, Pannell R, Milstein C. 1994. Low cytoplasmic mRNA levels of immunoglobulin light chain genes containing nonsense codons correlate with inefficient splicing. EMBO J 13:4617-4622.
    • (1994) EMBO J , vol.13 , pp. 4617-4622
    • Lozano, F.1    Maertzdorf, B.2    Pannell, R.3    Milstein, C.4
  • 26
    • 0029330286 scopus 로고
    • When cells stop making sense: Effects of nonsense codons on RNA metabolism in vertebrate cells
    • Maquat LE. 1995. When cells stop making sense: Effects of nonsense codons on RNA metabolism in vertebrate cells. RNA 1:453-465.
    • (1995) RNA , vol.1 , pp. 453-465
    • Maquat, L.E.1
  • 27
    • 0029835707 scopus 로고    scopus 로고
    • Defects in RNA splicing and the consequence of shortened translational reading frames
    • Maquat LE. 1996. Defects in RNA splicing and the consequence of shortened translational reading frames. Am J Hum Gen 59:279-286.
    • (1996) Am J Hum Gen , vol.59 , pp. 279-286
    • Maquat, L.E.1
  • 28
    • 0026704012 scopus 로고
    • Translocation of a specific pre-messenger ribonucleoprotein particle through the nuclear pore studied with electron microscope tomography
    • Mehlin H, Daneholt B, Skoglund U. 1992. Translocation of a specific pre-messenger ribonucleoprotein particle through the nuclear pore studied with electron microscope tomography. Cell 69:605-613.
    • (1992) Cell , vol.69 , pp. 605-613
    • Mehlin, H.1    Daneholt, B.2    Skoglund, U.3
  • 29
    • 0031896755 scopus 로고    scopus 로고
    • Selenium deficiency reduces the abundance of mRNA for Se-dependent glutathione peroxidase 1 by a UGA-dependent mechanism likely to be cytoplasmic nonsense-mediated mRNA decay
    • Moriarty PM, Reddy CC, Maquat LE. 1998. Selenium deficiency reduces the abundance of mRNA for Se-dependent glutathione peroxidase 1 by a UGA-dependent mechanism likely to be cytoplasmic nonsense-mediated mRNA decay. Mol Cell Biol 18:2932-2939.
    • (1998) Mol Cell Biol , vol.18 , pp. 2932-2939
    • Moriarty, P.M.1    Reddy, C.C.2    Maquat, L.E.3
  • 30
    • 0027932513 scopus 로고
    • Premature translational termination triggers mRNA decapping
    • Muhlrad D, Parker R. 1994. Premature translational termination triggers mRNA decapping. Nature 370:578-581.
    • (1994) Nature , vol.370 , pp. 578-581
    • Muhlrad, D.1    Parker, R.2
  • 31
    • 0026694808 scopus 로고
    • Nonsense mutations inhibit splicing of MVM RNA in cis when they interrupt the reading frame of either exon of the final spliced product
    • Naeger LK, Schoborg RV, Zhao Q, Tullis GE, Pintel DJ. 1992. Nonsense mutations inhibit splicing of MVM RNA in cis when they interrupt the reading frame of either exon of the final spliced product. Genes & Dev 6:1107-1119.
    • (1992) Genes & Dev , vol.6 , pp. 1107-1119
    • Naeger, L.K.1    Schoborg, R.V.2    Zhao, Q.3    Tullis, G.E.4    Pintel, D.J.5
  • 32
    • 0032104190 scopus 로고    scopus 로고
    • A rule for termination codon position within intron-containing genes: When nonsense affects RNA abundance
    • Nagy E, Maquat LE. 1998. A rule for termination codon position within intron-containing genes: When nonsense affects RNA abundance. Trends Biochem Sci 23:198-199.
    • (1998) Trends Biochem Sci , vol.23 , pp. 198-199
    • Nagy, E.1    Maquat, L.E.2
  • 33
    • 0027219029 scopus 로고
    • mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor
    • Peltz SW, Brown AH, Jacobson A. 1993. mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor. Genes & Dev 7:1737-1754.
    • (1993) Genes & Dev , vol.7 , pp. 1737-1754
    • Peltz, S.W.1    Brown, A.H.2    Jacobson, A.3
  • 37
    • 18844463753 scopus 로고    scopus 로고
    • Identifying the right stop: Determining how the surveillance complex recognizes and degrades aberrant mRNA
    • Ruiz-Echevarria MJ, Gonzalez CI, Peltz SW. 1998. Identifying the right stop: Determining how the surveillance complex recognizes and degrades aberrant mRNA. EMBO J 17:575-589.
    • (1998) EMBO J , vol.17 , pp. 575-589
    • Ruiz-Echevarria, M.J.1    Gonzalez, C.I.2    Peltz, S.W.3
  • 38
    • 0029885420 scopus 로고    scopus 로고
    • Utilizing the GCN4 leader region to investigate the role of the sequence determinants in nonsense-mediated mRNA decay
    • Ruiz-Echevarria MJ, Peltz SW. 1996. Utilizing the GCN4 leader region to investigate the role of the sequence determinants in nonsense-mediated mRNA decay. EMBO J 15:2810-2819.
    • (1996) EMBO J , vol.15 , pp. 2810-2819
    • Ruiz-Echevarria, M.J.1    Peltz, S.W.2
  • 39
    • 0024488977 scopus 로고
    • The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways
    • Shyu AB, Belasco JG, Greenberg ME. 1989. The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways. Genes & Dev 3:60-72.
    • (1989) Genes & Dev , vol.3 , pp. 60-72
    • Shyu, A.B.1    Belasco, J.G.2    Greenberg, M.E.3
  • 40
    • 0030034421 scopus 로고    scopus 로고
    • A pre-mRNA-binding protein accompanies the RNA from the gene through the nuclear pores and into polysomes
    • Visa N, Alzhanova-Ericsson AT, Sun X, Kiseleva E, Bjorkroth B, Wurtz T, Daneholt B. 1996. A pre-mRNA-binding protein accompanies the RNA from the gene through the nuclear pores and into polysomes. Cell 84:253-264.
    • (1996) Cell , vol.84 , pp. 253-264
    • Visa, N.1    Alzhanova-Ericsson, A.T.2    Sun, X.3    Kiseleva, E.4    Bjorkroth, B.5    Wurtz, T.6    Daneholt, B.7
  • 41
    • 0029790557 scopus 로고    scopus 로고
    • Identification and characterization of mutations in the UPF1 gene that affect nonsense suppression and the formation of the Upf protein complex but not mRNA turnover
    • Weng Y, Czaplinski K, Peltz SW. 1996a. Identification and characterization of mutations in the UPF1 gene that affect nonsense suppression and the formation of the Upf protein complex but not mRNA turnover. Mol Cell Biol 16:5491-5506.
    • (1996) Mol Cell Biol , vol.16 , pp. 5491-5506
    • Weng, Y.1    Czaplinski, K.2    Peltz, S.W.3
  • 42
    • 0029791449 scopus 로고    scopus 로고
    • Genetic and biochemical characterization of the mutations in the ATPase and helicase regions of the Upf1 protein
    • Weng Y, Czaplinski K, Peltz SW. 1996b. Genetic and biochemical characterization of the mutations in the ATPase and helicase regions of the Upf1 protein. Mol Cell Biol 16:5447-5490.
    • (1996) Mol Cell Biol , vol.16 , pp. 5447-5490
    • Weng, Y.1    Czaplinski, K.2    Peltz, S.W.3
  • 43
    • 0029845144 scopus 로고    scopus 로고
    • Evidence that the decay of nucleus-associated nonsense mRNA for human triosephosphate isomerase involves nonsense codon recognition after splicing
    • Zhang J, Maquat LE. 1996. Evidence that the decay of nucleus-associated nonsense mRNA for human triosephosphate isomerase involves nonsense codon recognition after splicing. RNA 2:235-243.
    • (1996) RNA , vol.2 , pp. 235-243
    • Zhang, J.1    Maquat, L.E.2
  • 44
    • 0031046735 scopus 로고    scopus 로고
    • Evidence that translation reinitiation abrogates nonsense-mediated mRNA decay in mammalian cells
    • Zhang J, Maquat LE. 1997. Evidence that translation reinitiation abrogates nonsense-mediated mRNA decay in mammalian cells. EMBO J 16:826-833.
    • (1997) EMBO J , vol.16 , pp. 826-833
    • Zhang, J.1    Maquat, L.E.2
  • 45
    • 0031840487 scopus 로고    scopus 로고
    • At least one intron is required for nonsense-mediated decay of triosephosphate isomerase mRNA: A possible link between nuclear pre-mRNA splicing and cytoplasmic mRNa translation
    • In press
    • Zhang J, Sun X, Qian Y, Maquat LE. 1998. At least one intron is required for nonsense-mediated decay of triosephosphate isomerase mRNA: A possible link between nuclear pre-mRNA splicing and cytoplasmic mRNA translation. Mol Cell Biol. In press.
    • (1998) Mol Cell Biol.
    • Zhang, J.1    Sun, X.2    Qian, Y.3    Maquat, L.E.4
  • 46
    • 0028945345 scopus 로고
    • Identification and characterization of a sequence motif involved in nonsense-mediated mRNA decay
    • Zhang S, Ruiz-Echevarria MJ, Quan Y, Peltz SW. 1995. Identification and characterization of a sequence motif involved in nonsense-mediated mRNA decay. Mol Cell Biol 15:2231-2244.
    • (1995) Mol Cell Biol , vol.15 , pp. 2231-2244
    • Zhang, S.1    Ruiz-Echevarria, M.J.2    Quan, Y.3    Peltz, S.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.