Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathways

RNA

Volumn 19, Issue 10, 2013, Pages 1432-1448

  Metze, Stefanie ^a   Herzog, Veronika A ^a,b   Ruepp, Marc David ^a   Mühlemann, Oliver ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b INSTITUTE OF MOLECULAR BIOTECHNOLOGY   (Austria)

Author keywords

Endo and exonucleolytic mRNA degradation; Exon junction complex; mRNA surveillance; mRNA turnover; Nonsense mediated mRNA decay; Post transcriptional gene regulation; SMG1; SMG5; SMG6; SMG7; UPF1; UPF2; UPF3b

Indexed keywords

HEMOGLOBIN BETA CHAIN; IMMUNOGLOBULIN MU CHAIN; MESSENGER RNA; PROTEIN SMG1; PROTEIN SMG5; PROTEIN SMG6; PROTEIN SMG7; PROTEIN UPF1; PROTEIN UPF2; PROTEIN UPF3B; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL JUNCTION; COMPARATIVE STUDY; DEGRADATION; EXON JUNCTION COMPLEX; HUMAN; HUMAN CELL; INTRON; NONSENSE MEDIATED MRNA DECAY; PRIORITY JOURNAL; REPORTER GENE; RNA DEGRADATION; SIGNAL TRANSDUCTION; STOP CODON; TRANSCRIPTION REGULATION;

ENDO- AND EXONUCLEOLYTIC MRNA DEGRADATION; UPF1; UPF2; UPF3B; SMG1; SMG5; SMG6; SMG7; EXON-JUNCTION COMPLEX; MRNA SURVEILLANCE; MRNA TURNOVER; NONSENSE-MEDIATED MRNA DECAY; POST-TRANSCRIPTIONAL GENE REGULATION;

BLOTTING, WESTERN; CODON, NONSENSE; EXONS; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; NONSENSE MEDIATED MRNA DECAY; PHOSPHATIDYLINOSITOL 3-KINASES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA STABILITY; RNA, MESSENGER; RNA-BINDING PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 84884692094     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.038893.113     Document Type: Article

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