The effect of eukaryotic release factor depletion on translation termination in human cell lines

Nucleic Acids Research

Volumn 32, Issue 15, 2004, Pages 4491-4502

  Janzen, Deanna M ^a,b   Geballe, Adam P ^a,b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; TRANSFER RNA; TRANSLATION TERMINATION FACTOR; ETF1 PROTEIN, HUMAN; PEPTIDE CHAIN RELEASE FACTOR 3; PEPTIDE CHAIN TERMINATION RELEASE FACTOR 1; PEPTIDE CHAIN-TERMINATION RELEASE FACTOR 1; PEPTIDE-CHAIN-RELEASE FACTOR 3;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; GENE CONSTRUCT; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC CODE; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; HYDROLYSIS; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; PROTEIN BINDING; RNA BINDING; RNA INTERFERENCE; RNA TRANSLATION; STOP CODON; TRANSLATION REGULATION; WESTERN BLOTTING; CELL LINE; DRUG ANTAGONISM; GENETICS; PHYSIOLOGY;

EUKARYOTA; MAMMALIA;

ALKALINE PHOSPHATASE; CELL LINE; CODON, TERMINATOR; HELA CELLS; HUMANS; PEPTIDE CHAIN TERMINATION, TRANSLATIONAL; PEPTIDE TERMINATION FACTORS; RNA INTERFERENCE;

EID: 4344573158     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkh791     Document Type: Article

References (46)

1. Seit-Nebi,A., Frolova,L. and Kisselev,L. (2002) Conversion of omnipotent translation termination factor eRF1 into ciliate-like UGA-only unipotent eRF1. EMBO Rep., 3, 881-886.
2. Ito,K., Frolova,L., Seit-Nebi,A., Karamyshev,A., Kisselev,L. and Nakamura,Y. (2002) Omnipotent decoding potential resides in eukaryotic translation termination factor eRF1 of variant-code organisms and is modulated by the interactions of amino acid sequences within domain 1. Proc. Natl Acad. Sci. USA, 99, 8494-8499.
3. Chavatte,L., Frolova,L., Kissetev,L. and Favre,A. (2001) The polypeptide chain release factor eRF1 specifically contacts the s(4)UGA stop codon located in the A site of eukaryotic ribosomes. Eur. J. Biochem., 268, 2896-2904.
4. Chavatte,L., Seit-Nebi,A., Dubovaya,V. and Favre,A. (2002) The invariant uridine of stop codons contacts the conserved NIKSR loop of human eRF1 in the ribosome. EMBO J., 21, 5302-5311.
5. Frolova,L.Y., Tsivkovskii,R.Y., Sivolobova,G.F., Oparina,N.Y., Serpinsky,O.I., Blinov,V.M., Tatkov,S.I. and Kisselev,L.L. (1999) Mutations in the highly conserved GGQ motif of class 1 polypeptide release factors abolish ability of human eRF1 to trigger peptidyl-tRNA hydrolysis. RNA, 5, 1014-1020.
6. Seit-Nebi,A., Frolova,L., Justesen,J. and Kisselev,L. (2001) Class-1 translation termination factors: invariant GGQ minidomain is essential for release activity and ribosome binding but not for stop codon recognition. Nucleic Acids Res., 29, 3982-3987.
7. Janzen,D.M., Frolova,L. and Geballe,A.P. (2002) Inhibition of translation termination mediated by an interaction of eukaryotic release factor 1 with a nascent peptidyl-tRNA. Mol. Cell. Biol., 22, 8562-8570.
8. Frolova,L.Y., Simonsen,J.L., Merkulova,T.I., Litvinov,D.Y., Martensen,P.M., Rechinsky,V.O., Camonis,J.H., Kisselev,L.L. and Justesen,J. (1998) Functional expression of eukaryotic polypeptide chain release factors 1 and 3 by means of baculovirus/insect cells and complex formation between the factors. Eur. J. Biochem., 256, 36-44.
9. Frolova,L., Le Goff,X., Zhouravleva,G., Davydova,E., Philippe,M. and Kisselev,L. (1996) Eukaryotic polypeptide chain release factor eRF3 is an eRF1- and ribosome-dependent guanosine triphosphatase. RNA, 2, 334-341.
10. Zhouravleva,G., Frolova,L., Le Goff,X., Le Guellec,R., Inge-Vechtomov,S., Kisselev,L. and Philippe,M. (1995) Termination of translation in eukaryotes is governed by two interacting polypeptide chain release factors, eRF1 and eRF3. EMBO J., 14, 4065-4072.
11. Frolova,L., Le Goff,X., Rasmussen,H.H., Cheperegin,S., Drugeon,G., Kress,M., Arman,I., Haenni,A.L., Celis,J.E., Philippe,M. et al. (1994) A highly conserved eukaryotic protein family possessing properties of polypeptide chain release factor. Nature, 372, 701-703.
12. Grentzmann,G., Brechemier-Baey,D., Heurgue,V., Mora,L. and Buckingham,R.H. (1994) Localization and characterization of the gene encoding release factor RF3 in Escherichia coli. Proc. Natl Acad. Sci. USA, 91, 5848-5852.
13. Stansfield,I. and Tuite,M.F. (1994) Polypeptide chain termination in Saccharomyces cerevisiae. Curr. Genet., 25, 385-395.
14. Chao,A.T., Dierick,H.A., Addy,T.M. and Bejsovec,A. (2003) Mutations in eukaryotic release factors 1 and 3 act as general nonsense suppressors in Drosophila. Genetics, 165, 601-612.
15. Valouev,I.A., Kushnirov,V.V. and Ter-Avanesyan,M.D. (2002) Yeast polypeptide chain release factors eRF1 and eRF3 are involved in cytoskeleton organization and cell cycle regulation. Cell Motil. Cytoskeleton, 52, 161-173.
16. Basu,J., Williams,B.C., Li,Z., Williams,E.V. and Goldberg,M.L. (1998) Depletion of a Drosophila homolog of yeast Sup35p disrupts spindle assembly, chromosome segregation, and cytokinesis during male meiosis. Cell Motil. Cytoskeleton, 39, 286-302.
17. Hoshino,S., Imai,M., Kobayashi,T., Uchida,N. and Katada,T. (1999) The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3′-poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein. J. Biol. Chem., 274, 16677-16680.
18. Uchida,N., Hoshino,S., Imataka,H., Sonenberg,N. and Katada,T. (2002) A novel role of the mammalian GSPT/eRF3 associating with poly(A)-binding protein in Cap/Poly(A)-dependent translation. J. Biol. Chem., 277, 50286-50292.
19. Wang,W., Czaplinski,K., Rao,Y. and Peltz,S.W. (2001) The role of Upf proteins in modulating the translation read-through of nonsense-containing transcripts. EMBO J., 20, 880-890.
20. Czaplinski,K., Ruiz-Echevarria,M.J., Paushkin,S.V., Han,X., Weng,Y., Perlick,H.A., Dietz,H.C., Ter-Avanesyan,M.D. and Peltz,S.W. (1998) The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs. Genes Dev., 12, 1665-1677.
21. Weng,Y., Czaplinski,K. and Peltz,S.W. (1996) Identification and characterization of mutations in the UPF1 gene that affect nonsense suppression and the formation of the Upf protein complex but not mRNA turnover. Mol. Cell. Biol., 16, 5491-5506.
22. Inge-Vechtomov,S., Zhouravleva,G. and Philippe,M. (2003) Eukaryotic release factors (eRFs) history. Biol. Cell, 95, 195-209.
23. Hawthorne,D.C. and Leupold,U. (1974) Suppressors in yeast. Curr. Top. Microbiol. Immunol., 64, 1-47.
24. Stansfield,I., Jones,K.M., Kushnirov,V.V., Dagkesamanskaya,A.R., Poznyakovski,A.I., Paushkin,S.V., Nierras,C.R., Cox,B.S., Ter-Avanesyan,M.D. and Tuite,M.F. (1995) The products of the SUP45 (eRF1) and SUP35 genes interact to mediate translation termination in Saccharomyces cerevisiae. EMBO J., 14, 4365-4373.
25. Drugeon,G., Jean-Jean,O., Frolova,L., Le Goff,X., Philippe,M., Kisselev,L. and Haenni,A.L. (1997) Eukaryotic release factor 1 (eRF1) abolishes readthrough and competes with suppressor tRNAs at all three termination codons in messenger RNA. Nucleic Acids Res., 25, 2254-2258.
26. Le Goff,X., Philippe,M. and Jean-Jean,O. (1997) Overexpression of human release factor 1 alone has an antisuppressor effect in human cells. Mol. Cell. Biol., 17, 3164-3172.
27. Carnes,J., Jacobson,M., Leinwand,L. and Yarus,M. (2003) Stop codon suppression via inhibition of eRF1 expression. RNA, 9, 648-653.
28. Capone,J.P., Sharp,P.A. and RajBhandary,U.L. (1985) Amber, ochre and opal suppressor tRNA genes derived from a human serine tRNA gene. EMBO J., 4, 213-221.
29. Grandori,C., Wu,K.J., Fernandez,P., Ngouenet,C., Grim,J., Clurman,B.E., Moser,M.J., Oshima,J., Russell,D.W., Swisshelm,K. et al. (2003) Werner syndrome protein limits MYC-induced cellular senescence. Genes Dev., 17, 1569-1574.
30. Hoshino,S., Miyazawa,H., Enomoto,T., Hanaoka,F., Kikuchi,Y., Kikuchi,A. and Ui,M. (1989) A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells. EMBO J, 8,
31. Child,S.J., Hakki,M., De Niro,K.L. and Geballe,A.P. (2004) Evasion of cellular antiviral responses by human cytomegalovirus TRS1 and IRS1. J Virol., 78, 197-205.
32. Sogaard,T.M., Jakobsen,C.G. and Justesen,J. (1999) A sensitive assay of translational fidelity (readthrough and termination) in eukaryotic cells. Biochemistry (Mosc), 64, 1408-1417.
33. Kim,J.S. and Raines,R.T. (1993) Ribonuclease S-peptide as a carrier in fusion proteins. Protein Sci., 2, 348-356.
34. Karpeisky,M., Senchenko,V.N., Dianova,M.V. and Kanevsky,V. (1994) Formation and properties of S-protein complex with S-peptide-containing fusion protein. FEBS Lett., 339, 209-212.
35. Skuzeski,J.M., Nichols,L.M., Gesteland,R.F. and Atkins,J.F. (1991) The signal for a leaky UAG stop codon in several plant viruses includes the two downstream codons. J. Mol. Biol., 218, 365-373.
36. Jean-Jean,O., Le Goff,X. and Philippe,M. (1996) Is there a human [psi]? C R Acad. Sci. III, 319, 487-492.
37. Hoshino,S., Imai,M., Mizutani,M., Kikuchi,Y., Hanaoka,F., Ui,M. and Katada,T. (1998) Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1. J. Biol. Chem., 273, 22254-22259.
38. Le Goff,C., Zemlyanko,O., Moskalenko,S., Berkova,N., Inge-Vechtomov,S., Philippe,M. and Zhouravleva,G. (2002) Mouse GSPT2, but not GSPT1, can substitute for yeast eRF3 in vivo. Genes Cells, 7, 1043-1057.
39. Jakobsen,C.G., Segaard,T.M., Jean-Jean,O., Frolova,L. and Justesen,J. (2001) [Identification of a novel termination release factor eRF3b expressing the eRF3 activity in vitro and in vivo]. Mol. Biol. (Mosk), 35, 672-681.
40. Kisselev,L.L. and Buckingham,R.H. (2000) Translational termination comes of age. Trends Biochem. Sci., 25, 561-566.
41. Cassan,M. and Rousset,J.P. (2001) UAG readthrough in mammalian cells: effect of upstream and downstream stop codon contexts reveal different signals. BMC Mol. Biol., 2, 3.
42. Namy,O., Hatin,I. and Rousset,J.P. (2001) Impact of the six nucleotides downstream of the stop codon on translation termination. EMBO Rep., 2, 787-793.
43. Manuvakhova,M., Keeling,K. and Bedwell,D.M. (2000) Aminoglycoside antibiotics mediate context-dependent suppression of termination codons in a mammalian translation system. RNA, 6, 1044-1055.
44. Keeling,K.M. and Bedwell,D.M. (2002) Clinically relevant aminoglycosides can suppress disease-associated premature stop mutations in the IDUA and P53 cDNAs in a mammalian translation system. J. Mol. Med., 80, 367-376.
45. Howard,M.T., Shirts,B.H., Petros,L.M., Flanigan,K.M., Gesteland,R.F. and Atkins,J.F. (2000) Sequence specificity of aminoglycoside-induced stop condon readthrough: potential implications for treatment of Duchenne muscular dystrophy. Ann. Neurol., 48, 164-169.
46. Keeling,K.M., Brooks,D.A., Hopwood,J.J., Li,P., Thompson,J.N. and Bedwell,D.M. (2001) Gentamicin-mediated suppression of Hurler syndrome stop mutations restores a low level of alpha-L-iduronidase activity and reduces lysosomal glycosaminoglycan accumulation. Hum. Mol. Genet., 10, 291-299.