Molecular identification of smg-4, required for mRNA surveillance in C. elegans

Gene

Volumn 268, Issue 1-2, 2001, Pages 153-164

  Aronoff, Rachel ^a,b,c   Baran, Renee ^b   Hodgkin, Jonathan ^c  

^a MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Alternative splice; Mutant rescue; Nonsense mRNA

Indexed keywords

BACTERIAL RNA; GREEN FLUORESCENT PROTEIN; ISOPROTEIN;

ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; EXON; EXPRESSED SEQUENCE TAG; GENE EXPRESSION; GENE FUSION; GENE MAPPING; GENE SEQUENCE; GENETIC CODE; NONHUMAN; OPERON; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; RNA SPLICING; SEQUENCE HOMOLOGY;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL NUCLEUS; CLONING, MOLECULAR; CYTOPLASM; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; LUMINESCENT PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR PROTEINS; OPERON; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; TRANSFORMATION, GENETIC;

EID: 0035795577     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(01)00414-0     Document Type: Article

References (35)

1. Altschul S.F., Madden T.L., Schaffer A.A., Zhang J., Zhang Z., Miller W., Lipman D.J. Gapped BLAST and PSI-BLAST: a new generation of protein databases search programs. Nucleic Acids Res. 25:(17):1997;3389-3402.
2. Applequist S.E., Selg M., Raman C., Jäck H.M. Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein. Nucleic Acids Res. 25:1997;15-23.
3. Atkin A.L., Schenkman L.R., Eastham M., Dahlseid J.N., Lelivelt M.J., Culbertson M.R. Relationship between yeast polyribosomes and Upf proteins required for nonsense mRNA decay. J. Biol. Chem. 272:1997;22163-22172.
4. Brenner S. The genetics of Caenorhabditis elegans. Genetics. 77:1974;71-94.
5. Cali B.M., Kuchma S.L., Latham J., Anderson P. smg-7 is required for mRNA surveillance in Caenorhabditis elegans. Genetics. 151:1999;605-616.
6. Chapin S.J., Lue C.M., Yu M.T., Bulinski J.C. Differential expression of alternatively spliced forms of MAP4: a repertoire of structurally different microtubule-binding domains. Biochemistry. 34:1995;2289-2301.
7. Cui Y., Hagan K.W., Zhang S., Peltz S.W. Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon. Genes Dev. 9:1995;423-436.
8. Culbertson M.R. RNA surveillance. Unforeseen consequences for gene expression, inherited genetic disorders and cancer. Trends Genet. 15:1999;74-80.
9. Czaplinski K., Ruiz-Echevarria M.J., Paushkin S.V., Han X., Weng Y., Perlick H.A., Dietz H.C., Ter-Avanesyan M.D., Peltz S.W. The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs. Genes Dev. 12:1998;1665-1677.
10. Czaplinski K., Ruiz-Echevarria M.J., Gonzalez C.I., Peltz S.W. Should we kill the messenger? The role of the surveillance complex in translation termination and mRNA turnover. Bioessays. 21:1999;685-696.
11. Favello A., Hillier L., Wilson R.K. Genomic DNA sequencing methods. Methods Cell Biol. 48:1995;551-569.
12. He F., Brown A.H., Jacobson A. Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway. Mol. Cell. Biol. 17:1997;1580-1594.
13. Hentze M.W., Kulozik A.E. A perfect message: RNA surveillance and nonsense-mediated decay. Cell. 96:1999;307-310.
14. Hobohm U., Sander C. A sequence property approach to searching protein databases. J. Mol. Biol. 251:1995;390-399.
15. Hodgkin J., Papp A., Pulak R., Ambros V., Anderson P. A new kind of informational suppression in the nematode Caenorhabditis elegans. Genetics. 123:1989;301-313.
16. Kohara, Y., 1997. Expression Map of the C. elegans genome. see http://www.ddbj.nig.ac.jp/htmls/c-elegans/htmls/CE_INDEX.html.
17. Lee B.S., Culbertson M.R. Identification of an additional gene required for eukaryotic nonsense mRNA turnover. Proc. Natl. Acad. Sci. USA. 92:1995;10354-10358.
18. Leeds P., Wood J.M., Lee B.S., Culbertson M.R. Gene products that promote mRNA turnover in Saccharomyces cerevisiae. Mol. Cell. Biol. 12:1992;2165-2177.
19. Lelivelt M.J., Culbertson M.R. Yeast Upf proteins required for RNA surveillance affect global expression of the yeast transcriptome. Mol. Cell. Biol. 19:1999;6710-6719.
20. Lykke-Anderson J., Shu M.-D., Steitz J.A. Human Upf proteins target and mRNA for nonsense-mediated decay when bound downstream of a termination codon. Cell. 103:2000;1121-1131.
21. Maderazo A.B., He F., Mangus D.A., Jacobson A. Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3p. Mol. Cell. Biol. 20:2000;4591-4603.
22. Mello C.C., Kramer J.M., Stinchcomb D., Ambros V. Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J. 10:1991;3959-3970.
23. Mendell J.T., Medghalchi S.M., Lake R.G., Noensie E.N., Dietz H.C. Novel upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes. Mol. Cell. Biol. 20:2000;8944-8957.
24. Mitrovich Q.M., Anderson P. Unproductively spliced ribosomal protein mRNAs are natural targets of mRNA surveillance in C. elegans. Genes Dev. 14:2000;2173-2184.
25. Muhlrad D., Parker R. Premature translational termination triggers mRNA decapping. Nature. 370:1994;578-581.
26. Page M.F., Carr B., Anders K.R., Grimson A., Anderson P. SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast. Mol. Cell. Biol. 19:1999;5943-5951.
27. Perlick H.A., Medghalchi S.M., Spencer F.A., Kendzior R.J. Jr, Dietz H.C. Mammalian orthologues of a yeast regulator of nonsense transcript stability. Proc. Natl. Acad. Sci. USA. 93:1996;10928-10932.
28. Pulak R., Anderson P. mRNA surveillance by the Caenorhabditis elegans smg genes. Genes Dev. 7:1993;1885-1897.
29. Sambrook J., Fritsch E.F., Maniatis T. Molecular Cloning: A Laboratory Manual. 1989;Cold Spring Harbor Press, Cold Spring Harbor, NY.
30. Serin G., Gersappe A., Black J.D., Aronoff R., Maquat L. Identification and characterization of human orthologues to S. cerevisiae Upf2 protein and S. cerevisiae Upf3 protein/C. elegans SMG-4. Mol. Cell. Biol. 21:2001;209-223.
31. Shirley R.L., Lelivelt M.J., Schenkman L.R., Dahlseid J.N., Culbertson M.R. A factor required for nonsense-mediated mRNA decay in yeast is exported from the nucleus to the cytoplasm by a nuclear export signal sequence. J. Cell Sci. 111:1998;3129-3143.
32. Weng Y., Czaplinski K., Peltz S.W. ATP is a cofactor of the Upf1 protein that modulates its translation termination and RNA binding activities. RNA. 4:1998;205-214.
33. Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., Burton J., Connell M., Copsey T., Cooper J., et al. 2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans. Nature. 368:1994;32-38.
34. Zhang S., Welch E.M., Hogan K., Brown A.H., Peltz S.W., Jacobson A. Polysome-associated mRNAs are substrates for the nonsense-mediated mRNA decay pathway in Saccharomyces cerevisiae. RNA. 3:1997;234-244.
35. Zorio D.A., Cheng N.N., Blumenthal T., Spieth J. Operons as a common form of chromosomal organization in C. elegans. Nature. 372:1994;270-272.