Mechanism of escape from nonsense-mediated mRNA decay of human β-globin transcripts with nonsense mutations in the first exon

RNA

Volumn 17, Issue 5, 2011, Pages 843-854

  Neu Yilik, Gabriele ^a,b   Amthor, Beate ^a,b   Gehring, Niels H ^a,b,c   Bahri, Sharif ^a,d   Paidassi, Helena ^a,e   Hentze, Matthias W ^b   Kulozik, Andreas E ^a,b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c UNIVERSITY OF COLOGNE   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

thalassemia; NMD resistant transcripts; Nonsense mediated mRNA decay; Premature termination; Translation reinitiation

Indexed keywords

BETA GLOBIN;

ARTICLE; BETA THALASSEMIA; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EXON; HETEROZYGOTE; HUMAN; HUMAN CELL; NONSENSE MEDIATED MRNA DECAY; NONSENSE MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUALITY CONTROL; RNA DEGRADATION; RNA TRANSCRIPTION; START CODON;

BETA-GLOBINS; CODON, NONSENSE; EXONS; HELA CELLS; HUMANS; RNA STABILITY; TRANSCRIPTION, GENETIC;

EID: 79955004808     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.2401811     Document Type: Article

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