SMG7 acts as a molecular link between mRNA surveillance and mRNA decay

Molecular Cell

Volumn 16, Issue 4, 2004, Pages 587-596

  Unterholzner, Leonie ^a   Izaurralde, Elisa ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN; MESSENGER RNA; SMG5 PROTEIN; SMG7 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CROSS LINKING; CYTOPLASM; DECOMPOSITION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOLECULAR BIOLOGY; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NONHUMAN; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN LOCALIZATION;

BLOTTING, WESTERN; CARBOCYANINES; CARRIER PROTEINS; CYTOPLASM; DACTINOMYCIN; FRAMESHIFT MUTATION; GENES, REPORTER; HELA CELLS; HUMANS; LUCIFERASES; MICROSCOPY, FLUORESCENCE; MUTATION; NUCLEIC ACID SYNTHESIS INHIBITORS; PLASMIDS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; RIBONUCLEOPROTEINS, SMALL NUCLEAR; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; TEMPLATES, GENETIC; TIME FACTORS; TRANS-ACTIVATORS; TRANSFECTION;

METAZOA;

EID: 8844245615     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2004.10.013     Document Type: Article

References (50)

1. Anders K.R., Grimson A., Anderson P. SMG-5, required for C. elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A. EMBO J. 22:2003;641-650
2. Applequist S.E., Selg M., Raman C., Jack H.M. Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein. Nucleic Acids Res. 25:1997;814-821
3. Bhattacharya A., Czaplinski K., Trifillis P., He F., Jacobson A., Peltz S.W. Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay. RNA. 6:2000;1226-1235
4. Cali B.M., Kuchma S.L., Latham J., Anderson P. smg-7 is required for mRNA surveillance in Caenorhabditis elegans. Genetics. 151:1999;605-616
5. Cao D., Parker R. Computational modeling and experimental analysis of nonsense-mediated decay in yeast. Cell. 113:2003;533-545
6. Chen C.Y., Shyu A.B. Rapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense-mediated decay pathway. Mol. Cell. Biol. 23:2003;4805-4813
7. Chiu S.Y., Serin G., Ohara O., Maquat L.E. Characterization of human Smg5/7a. a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1 RNA. 9:2003;77-87
8. Clissold P.M., Ponting C.P. PIN domains in nonsense-mediated mRNA decay and RNAi. Curr. Biol. 10:2000;R888-R890
9. Cougot N., Babajko S., Seraphin B. Cytoplasmic foci are sites of mRNA decay in human cells. J. Cell Biol. 165:2004;31-40
10. Couttet P., Grange T. Premature termination codons enhance mRNA decapping in human cells. Nucleic Acids Res. 32:2004;488-494
11. Cui Y., Hagan K.W., Zhang S., Peltz S.W. Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon. Genes Dev. 9:1995;423-436
12. Czaplinski K., Weng Y., Hagan K.W., Peltz S.W. Purification and characterization of the Upf1 protein. a factor involved in translation and mRNA degradation RNA. 1:1995;610-623
13. Czaplinski K., Ruiz-Echevarria M.J., Paushkin S.V., Han X., Weng Y., Perlick H.A., Dietz H.C., Ter-Avanesyan M.D., Peltz S.W. The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs. Genes Dev. 12:1998;1665-1677
14. Denning G., Jamieson L., Maquat L.E., Thompson E.A., Fields A.P. Cloning of a novel phosphatidylinositol kinase-related kinase. characterization of the human SMG-1 RNA surveillance protein J. Biol. Chem. 276:2001;22709-22714
15. Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 411:2001;494-498
16. Eystathioy T., Chan E.K., Tenenbaum S.A., Keene J.D., Griffith K., Fritzler M.J. A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles. Mol. Biol. Cell. 13:2002;1338-1351
17. Eystathioy T., Jakymiw A., Chan E.K., Seraphin B., Cougot N., Fritzler M.J. The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies. RNA. 9:2003;1171-1173
18. Fribourg S., Gatfield D., Izaurralde E., Conti E. A novel mode of RBD-protein recognition in the Y14-Mago complex. Nat. Struct. Biol. 10:2003;433-439
19. Frischmeyer P.A., Dietz H.C. Nonsense-mediated mRNA decay in health and disease. Hum. Mol. Genet. 8:1999;1893-1900
20. Gatfield D., Izaurralde E. Nonsense-mediated mRNA decay is initiated by endonucleolytic cleavage in Drosophila. Nature. 429:2004;575-578
21. Gatfield D., Unterholzner L., Ciccarelli F.D., Bork P., Izaurralde E. Nonsense-mediated mRNA decay in Drosophila. at the intersection of the yeast and mammalian pathways EMBO J. 22:2003;3960-3970
22. Gehring N.H., Neu-Yilik G., Schell T., Hentze M.W., Kulozik A.E. Y14 and hUpf3b form an NMD-activating complex. Mol. Cell. 11:2003;939-949
23. Green R.E., Lewis B.P., Hillman R.T., Blanchette M., Lareau L.F., Garnett A.T., Rio D.C., Brenner S.E. Widespread predicted nonsense-mediated mRNA decay of alternatively-spliced transcripts of human normal and disease genes. Bioinformatics. 19(Suppl. 1):2003;I118-I121
24. He F., Brown A.H., Jacobson A. Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway. Mol. Cell. Biol. 17:1997;1580-1594
25. He F., Li X., Spatrick P., Casillo R., Dong S., Jacobson A. Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 5′ to 3′ mRNA decay pathways in yeast. Mol. Cell. 12:2003;1439-1452
26. Hodgkin J., Papp A., Pulak R., Ambros V., Anderson P. A new kind of informational suppression in the nematode Caenorhabditis elegans. Genetics. 123:1989;301-313
27. Ingelfinger D., Arndt-Jovin D.J., Luhrmann R., Achsel T. The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. RNA. 8:2002;1489-1501
28. Ishigaki Y., Li X., Serin G., Maquat L.E. Evidence for a pioneer round of mRNA translation. mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20 Cell. 106:2001;607-617
29. Kadlec J., Izaurralde E., Cusack S. The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3. Nat. Struct. Mol. Biol. 11:2004;330-337
30. Kim V.N., Kataoka N., Dreyfuss G. Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex. Science. 293:2001;1832-1836
31. Le Hir H., Gatfield D., Izaurralde E., Moore M.J. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. EMBO J. 20:2001;4987-4997
32. Leeds P., Peltz S.W., Jacobson A., Culbertson M.R. The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon. Genes Dev. 5:1991;2303-2314
33. Lejeune F., Li X., Maquat L.E. Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. Mol. Cell. 12:2003;675-687
34. Lewis B.P., Green R.E., Brenner S.E. Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans. Proc. Natl. Acad. Sci. USA. 100:2003;189-192
35. Lykke-Andersen J., Shu M.D., Steitz J.A. Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. Cell. 103:2000;1121-1131
36. Lykke-Andersen J., Shu M.D., Steitz J.A. Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. Science. 293:2001;1836-1839
37. Maquat L.E. Nonsense-mediated mRNA decay. splicing, translation and mRNP dynamics Nat. Rev. Mol. Cell Biol. 5:2004;89-99
38. Mendell J.T., ap Rhys C.M., Dietz H.C. Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts. Science. 298:2002;419-422
39. Mitchell P., Tollervey D. An NMD pathway in yeast involving accelerated deadenylation and exosome-mediated 3′→5′ degradation. Mol. Cell. 11:2003;1405-1413
40. Muhlrad D., Parker R. Premature translational termination triggers mRNA decapping. Nature. 370:1994;578-581
41. Nagy E., Maquat L.E. A rule for termination-codon position within intron-containing genes. when nonsense affects RNA abundance Trends Biochem. Sci. 23:1998;198-199
42. Ohnishi T., Yamashita A., Kashima I., Schell T., Anders K.R., Grimson A., Hachiya T., Hentze M.W., Anderson P., Ohno S. Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Mol. Cell. 12:2003;1187-1200
43. Page M.F., Carr B., Anders K.R., Grimson A., Anderson P. SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast. Mol. Cell. Biol. 19:1999;5943-5951
44. Pal M., Ishigaki Y., Nagy E., Maquat L.E. Evidence that phosphorylation of human Upfl protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathway. RNA. 7:2001;5-15
45. Reichenbach P., Hoss M., Azzalin C.M., Nabholz M., Bucher P., Lingner J. A human homolog of yeast est1 associates with telomerase and uncaps chromosome ends when overexpressed. Curr. Biol. 13:2003;568-574
46. Serin G., Gersappe A., Black J.D., Aronoff R., Maquat L.E. Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4). Mol. Cell. Biol. 21:2001;209-223
47. Sheth U., Parker R. Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science. 300:2003;805-808
48. van Dijk E., Cougot N., Meyer S., Babajko S., Wahle E., Seraphin B. Human Dcp2. a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures EMBO J. 21:2002;6915-6924
49. Yamashita A., Ohnishi T., Kashima I., Taya Y., Ohno S. Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay. Genes Dev. 15:2001;2215-2228
50. Zhang S., Ruiz-Echevarria M.J., Quan Y., Peltz S.W. Identification and characterization of a sequence motif involved in nonsense-mediated mRNA decay. Mol. Cell. Biol. 15:1995;2231-2244