SC35 autoregulates its expression by promoting splicing events that destabilize its mRNAs

EMBO Journal

Volumn 20, Issue 7, 2001, Pages 1785-1796

  Sureau, A ^a   Gattoni, R ^b   Dooghe, Y ^a   Stevenin J ^b   Soret, J ^a,c  

^a CNRS   (France)

^b INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^c INSTITUT DE GÉNÉTIQUE MOLÉCULAIRE DE MONTPELLIER   (France)

Author keywords

Alternative splicing; Autoregulation; mRNA stability; SC35

Indexed keywords

MESSENGER RNA; PROTEIN DERIVATIVE; PROTEIN SC35; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; AUTOREGULATION; CONTROLLED STUDY; EXON; GENE CONTROL; GENE EXPRESSION; GENE OVEREXPRESSION; GENE STRUCTURE; HELA CELL; HUMAN; HUMAN CELL; INTRON; PRIORITY JOURNAL; RNA SPLICING; RNA STABILITY;

ALTERNATIVE SPLICING; DOWN-REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HELA CELLS; HOMEOSTASIS; HUMANS; NUCLEAR PROTEINS; PHOSPHOPROTEINS; RIBONUCLEOPROTEINS; RNA PRECURSORS; RNA STABILITY; RNA, MESSENGER;

EID: 0035794679     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.7.1785     Document Type: Article

References (40)

1. Identification of a bidirectional splicing enhancer: Differential involvement of SR proteins in 5′ or 3′ splice site activation
2. Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors
3. A regulatory mechanism that detects premature nonsense codons in T-cell receptor transcripts in vivo is reversed by protein synthesis inhibitors in vitro
4. The splicing factors 9G8 and SRp20 transactivate splicing through different and specific enhancers
5. Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or half-life of cytoplasmic mRNA
6. The superfamily of arginine/serine-rich splicing factors
7. Isolation of a complementary DNA that encodes the mammalian splicing factor SC35
8. The SR splicing factors ASF/SF2 and SC35 have antagonistic effects on intronic enhancer-dependent splicing of the β-tropomyosin alternative exon 6A
9. Primary structure of the human splicing factor ASF reveals similarities with Drosophila regulators
10. Transcriptional activation by tetracyclines in mammalian cells
11. Sorting out the complexity of SR protein functions
12. Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors
13. Pre-mRNA splicing by the essential Drosophila protein B52: Tissue and target specificity
14. Regulation of Ich-1 pre-mRNA alternative splicing and apoptosis by mammalian splicing factors
15. The splicing factor SRp20 modifies splicing of its own mRNA and ASF/SF2 antagonizes this regulation
16. The concentration of B52, an essential splicing factor and regulator of splice site choice in vitro, is critical for Drosophila development
17. Antagonism between RSF1 and SR proteins for both splice-site recognition in vitro and Drosophila development
18. Exonic splicing enhancer motif recognized by human SC35 undersplicing conditions
19. atSRp30, one of two SF2/ASF-like proteins from Arabidopsis thaliana, regulates splicing of specific plant genes
20. SR proteins and splicing control
21. Autoregulation of the splicing of transcripts from the transformer-2 gene of Drosophila
22. Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins
23. Substrate specificities of SR proteins in constitutive splicing are determined by their RNA recognition motifs and composite pre-mRNA exonic elements
24. Unproductively spliced ribosomal protein mRNAs are natural targets of mRNA surveillance in C. elegans
25. smg mutants affect the expression of alternatively spliced SR protein mRNAs in Caenorhabditis elegans
26. The gene encoding human splicing factor 9G8. Structure, chromosomal localization, and expression of alternatively processed transcripts
27. Initial splice-site recognition and pairing during pre-mRNA splicing
28. Multiple distinct splicing enhancers in the protein-coding sequences of a constitutively spliced pre-mRNA
29. Selection and characterization of pre-mRNA splicing enhancers: Identification of novel SR protein-specific enhancer sequences
30. Identification and characterization of three members of the human SR family of pre-mRNA splicing factors
31. Alternative pre-mRNA splicing: The logic of combinatorial control
32. Characterization of SRp46, a novel human SR splicing factor encoded by a PR264/SC35 retropseudogene
33. mRNA surveillance in mammalian cells: The relationship between introns and translation termination
34. Several mRNAs with variable 3′ untranslated regions and different stability encode the human PR264/SC35 splicing factor
35. The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities
36. Determinants of SR protein specificity
37. A potential splicing factor is encoded by the opposite strand of the trans-spliced c-myb exon
38. Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability
39. Genetic analysis of the SR protein ASF/SF2: Interchangeability of RS domains and negative control of splicing
40. Analysis of autoregulation at the level of pre-mRNA splicing of the suppressor-of-white-apricot gene in Drosophila