Aberrant mRNAs with extended 3' UTRs are substrates for rapid degradation by mRNA surveillance

RNA

Volumn 5, Issue 10, 1999, Pages 1299-1307

  Muhlrad, Denise ^a   Parker, Roy ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

3' UTR; mRNA decay; mRNA turnover; Nonsense mediated decay; Yeast

Indexed keywords

MESSENGER RNA;

ARTICLE; MOLECULAR RECOGNITION; NONHUMAN; POLYADENYLATION; PRIORITY JOURNAL; RNA DEGRADATION; RNA SEQUENCE; STOP CODON; YEAST;

3' UNTRANSLATED REGIONS; CARRIER PROTEINS; CODON, NONSENSE; CYTOCHROME C GROUP; CYTOCHROMES C; ENDORIBONUCLEASES; EXODEOXYRIBONUCLEASE V; EXODEOXYRIBONUCLEASES; EXORIBONUCLEASES; FUNGAL PROTEINS; METALLOTHIONEIN; MUTAGENESIS, SITE-DIRECTED; PHENOTYPE; PHOSPHOGLYCERATE KINASE; RNA CAPS; RNA HELICASES; RNA STABILITY; RNA, MESSENGER; RNA-BINDING PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; SUBSTRATE SPECIFICITY; TRANS-ACTIVATORS;

EID: 0032880399     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1355838299990829     Document Type: Article

References (35)

1. Amrani N, Minet M, Le Gouar M, Lacroute F, Wyers F. 1997. Yeast Pab1 interacts with Rna15 and participates in the control of the poly (A) tail length in vitro. Mol Cell Biol 17:3694-3701.
2. Beelman CA, Stevens A, Caponigro G, LaGrandeur TE, Hatfield L, Fortner DM. Parker R. 1996. An essential component of the decapping enzyme required for normal rates of mRNA turnover. Nature 332:642-646.
3. Bonneaud N, Minvielle-Sebastia L, Cullin C, Lacroute F. 1994. Cellular localization of RNA14p and RNA15p, two yeast proteins involved in mRNA stability. J Cell Sci 107:913-921.
4. Caponigro G, Muhlrad D, Parker R. 1993. A small segment of the MAT alpha 1 transcript promotes mRNA decay in Saccharomyces cerevisiae: A stimulatory role for rare codons. Mol Cell Biol 13:5141-5148.
5. Caponigro G, Parker R. 1995. Multiple functions for the poly (A)-binding protein in mRNA decapping and deadenylation in yeast. Genes & Dev 9:2421-2432.
6. Christianson TW, Sikorski RS, Dante M, Shero JH, Heiter P. 1992. Multifunctional yeast high-copy-number shuttle vectors. Gene 110:119-122.
7. Cui Y, Dinman JD, Peltz SW. 1996. Mof4-1 is an allele of the UPF1/ IFS2 gene which affects both mRNA turnover and -1 ribosomal frameshifting efficiency. EMBO J 15:5726-5736.
8. Czaplinski K, Ruiz-Echevarria MJ, Gonzalez CI, Peltz SW. 1999. Should we kill the messenger? The role of the surveillance complex in translation termination and mRNA turnover. Bioessays 21: 685-696.
9. Decker CJ, Parker R. 1993. A turnover pathway for both stable and unstable mRNAs in yeast: Evidence for a requirement for deadenylation. Genes & Dev 7:1632-1643.
10. Decker CJ, Parker R. 1995. Diversity of cytoplasmic functions for the 3′ untranslated region of eukaryotic transcripts. Curr Opin Cell Biol 7:386-392.
11. Graber JH, Cantor CR, Mohr SC, Smith TF. 1999. Genomic detection of new yeast pre-mRNA 3′-end-processing signals. Nucleic Acids Res 27:888-894.
12. Hagan KW, Ruiz-Echevarria MJ, Quan Y, Peltz SW. 1995. Characterization of cis-acting sequences and decay intermediates involved in nonsense-mediated mRNA turnover. Mol Cell Biol 15:809-823.
13. Hatfield L, Beelman CA, Stevens A, Parker R. 1996. Mutations in trans-acting factors affecting mRNA decapping in Saccharomyces cerevisiae. Mol Cell Biol 16:5830-5838.
14. He F, Brown AH, Jacobson A. 1996. Interaction between Nmd2p and Upf1 p is required for activity but not for dominant-negative inhibition of the nonsense-mediated mRNA decay pathway in yeast. RNA 2:153-170.
15. He F, Peltz SW, Donahue JL, Rosbash M, Jacobson A. 1993. Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1 mutant. Proc Natl Acad Sci USA 90:7034-7038.
16. Heaton B, Decker C, Muhlrad D, Donahue J, Jacobson A, Parker R. 1992. Analysis of chimeric mRNAs derived from the STE3 mRNA identifies multiple regions within yeast mRNAs that modulate mRNA decay. Nucleic Acids Res 20:5365-5373.
17. Hentze MW, Kulozik AE. 1999. A perfect message: RNA surveillance and nonsense-mediated decay. Cell 96:307-310.
18. Hsu CL, Stevens A. 1993. Yeast cells lacking 5′ to 3′ exoribonuclease 1 contain mRNA species that are poly(A) deficient and partially lack the 5′ cap structure. Mol Cell Biol 13:4826-4835.
19. LaGrandeur TE, Parker R. 1998. Isolation and characterization of Dcplp, the yeast mRNA decapping enzyme. EMBO J 17:1487-1496.
20. LaGrandeur T, Parker R. 1999. The cis acting sequences responsible for the differential decay of the unstable MFA2 and stable PGK1 transcripts in yeast include the context of the translational start codon. RNA 5:420-433.
21. Larimer FW, Stevens A. 1990. Disruption of the gene XRN1, coding for a 5′ → 3′ exoribonuclease, restricts yeast cell growth. Gene 95:85-90.
22. Lee B-S, Culbertson MR. 1995. Identification of an additional gene required for eukaryotic nonsense mRNA turnover. Proc Natl Acad Sci USA 92:10354-10358.
23. Leeds P, Peltz SW, Jacobson A, Culbertson MR. 1991. The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon. Genes & Dev 5:2303-2314.
24. Leeds P, Wood JM, Lee B-S, Culbertson, MR. 1992. Gene products that promote mRNA turnover in Saccharomyces cerevisiae. Mol Cell Biol 12:2165-2177.
25. Minvielle-Sebastia L, Preker PJ, Keller W. 1994. RNA14 and RNA15 proteins as components of a yeast pre-mRNA 3′-end processing factor. Science 266:1702-1705.
26. Minvielle-Sebastia L, Winsor B, Bonneaud N, Lacroute F. 1991. Mutations in the yeast RNA14 and RNA15 genes result in an abnormal mRNA decay rate; sequence analysis reveals an RNA-binding domain in the RNA15 protein. Mol Cell Biol 6:3075-3087.
27. Morrison M, Harris KS, Roth MB. 1997. smg mutants affect the expression of alternatively spliced SR protein mRNAs in Caenorhabditis elegans. Proc Natl Acad Sci USA 94:9782-9785.
28. Muhlrad D, Decker CJ, Parker R. 1994. Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5′ → 3′ digestion of the transcript. Genes Dev 8: 855-866.
29. Muhlrad D, Parker R. 1994. Premature translational termination triggers mRNA decapping. Nature 370:578-581.
30. Nagy E, Maquat LE. 1998. A rule for termination-codon position within intron-containing genes: When nonsense affects RNA abundance. Trends Biochem Sci 23:198-199.
31. Peltz SW, Brown AH, Jacobson A. 1993. mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor. Genes & Dev 7:1737-1754.
32. Petitjean A, Bonneaud N, Lacroute F. 1995. The duplicated Saccharomyces cerevisiae gene SSM1 encodes a eucaryotic homolog of the eubacterial and archaebacterial L1 ribosomal proteins. Mol Cell Biol 15:5071-5081.
33. Pulak R, Anderson P. 1993. mRNA surveillance by the Caenorhabditis elegans smg genes. Genes & Dev 7:1885-1897.
34. Weng Y, Czaplinski K, Peltz SW 1996. Identification and characterization of mutations in the UPF1 gene that affect nonsense suppression and the formation of the Upf protein complex but not mRNA turnover. Mol Cell Biol 10:5491-5506.
35. Zaret KS, Sherman F. 1984. Mutationally altered 3′ ends of yeast CYC1 mRNA affect transcript stability and translational efficiency. J Mol Biol 176:107-135.-