Boundary-independent polar nonsense-mediated decay

EMBO Reports

Volumn 3, Issue 3, 2002, Pages 274-279

  Wang, Jun ^a   Gudikote, Jayanthi P ^a   Olivas, O Renee ^a   Wilkinson, Miles F ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; NUCLEOTIDE; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DOWNSTREAM PROCESSING; EXON; GENE EXPRESSION; GENE IDENTIFICATION; GENE SEQUENCE; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN CELL; INTRON; MAMMAL CELL; MISSENSE MUTATION; NONSENSE MUTATION; PRIORITY JOURNAL; RNA DEGRADATION; RNA SPLICING; STOP CODON; T LYMPHOCYTE RECEPTOR GENE;

ANIMALS; BASE SEQUENCE; CODON, NONSENSE; GENES, T-CELL RECEPTOR BETA; INTRONS; MICE; RIBONUCLEASES; RNA, MESSENGER; SEQUENCE DELETION;

MAMMALIA;

EID: 0036205348     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kvf036     Document Type: Article

References (34)

1. A regulatory mechanism that detects premature nonsense codons in T-cell receptor transcripts in vivo is reversed by protein synthesis inhibitors in vitro
2. A splicing-dependent regulatory mechanism that detects translation signals
3. Introns are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abundance
4. RNA surveillance: Unforeseen consequences for gene expression, inherited genetic disorders and cancer
5. T-cell receptor sequences that elicit strong down-regulation of premature termination codon-bearing transcripts
6. A perfect message: RNA surveillance and nonsense-mediated decay
7. mRNA surveillance in eukaryotes: Kinetic proofreading of proper translation termination as assessed by mRNP domain organization?
8. Coupled transcription and translation within nuclei of mammalian cells
9. Destabilization of nonsense-containing transcripts in Saccharomyces cerevisiae
10. The Y14 protein communicates to the cytoplasm the position of exon-exon junctions
11. Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex
12. The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions
13. Pre-mRNA splicing alters mRNP composition: Evidence for stable association of proteins at exon-exon junctions
14. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay
15. Nonsense surveillance in lymphocytes?
16. T cell receptor (TCR) mini-gene mRNA expression regulated by nonsense codons: A nuclear-associated translation-like mechanism
17. Pem: A testosterone- and LH-regulated homeobox gene expressed in mouse Sertoli cells and epididymis
18. Interference of nonsense mutations with eukaryotic messenger RNA stability
19. Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon
20. Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1
21. The Pem homeobox gene: Rapid evolution of the homeodomain, X chromosomal localization and expression in reproductive tissue
22. When cells stop making sense: Effects of nonsense codons on RNA metabolism in vertebrate cells
23. Precursor RNAs harboring nonsense codons accumulate near the site of transcription
24. A rule for termination-codon position within intron-containing genes: When nonsense affects RNA abundance
25. mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor
26. Nonsense-mediated mRNA decay in yeast
27. mRNA surveillance by the Caenorhabditis elegans smg genes
28. The double lives of shuttling mRNA binding proteins
29. mRNA surveillance in mammalian cells: The relationship between introns and translation termination
30. Binary specification of nonsense codons by splicing and cytoplasmic translation
31. Site-directed mutagenesis of large (13-kb) plasmids in a single-PCR procedure
32. Deletion mutagenesis of large (12-kb) plasmids by a one-step PCR protocol
33. Multifunctional regulatory preteins that control gene expression in both the nucleus and cytoplasm
34. At least one intron is required for the nonsense-mediated decay of triosephosphate ismoerase mRNA: A possible link between nuclear splicing and cytoplasmic translation