Eukaryote-specific domains in translation initiation factors: Implications for translation regulation and evolution of the translation system

Genome Research

Volumn 10, Issue 8, 2000, Pages 1172-1184

  Aravind, L ^a   Koonin, E V ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INITIATION FACTOR; INITIATION FACTOR 1; INITIATION FACTOR 2; INITIATION FACTOR 3; INITIATION FACTOR 4E; INITIATION FACTOR 5A; MESSENGER RNA;

ALPHA HELIX; ARTICLE; CONTROLLED STUDY; EUKARYOTE; EVOLUTION; GENETIC CONSERVATION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; RNA DEGRADATION; RNA PROCESSING; RNA TRANSLATION; TRANSLATION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; CONSERVED SEQUENCE; DATABASES, FACTUAL; EUKARYOTIC CELLS; EVOLUTION, MOLECULAR; FUNGAL PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDE INITIATION FACTORS; PHYLOGENY; PROTEIN BIOSYNTHESIS; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE PROTEINS; TRANS-ACTIVATORS;

EID: 0033828440     PISSN: 10889051     EISSN: None     Source Type: Journal    
DOI: 10.1101/gr.10.8.1172     Document Type: Article

References (60)

1. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
2. Molecular characterization of the prokaryotic efp gene product involved in a peptidyltransferase reaction
3. Gleaning non-trivial structural, functional and evolutionary information about proteins by iterative database searches
4. Novel predicted RNA-binding domains associated with the translation machinery
5. Homologues of 26S proteasome subunits are regulators of transcription and translation
6. Conserved bipartite motifs in yeast eIF5 and eIF2Bandepsilon;, GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2
7. Complex formation by all five homologues of mammalian translation initiation factor 3 subunits from yeast Saccharomyces cerevisiae
8. Upf1 and Upf2 proteins mediate normal yeast mRNA degradation when translation initiation is limited
9. The eIF1A solution structure reveals a large RNA-binding surface important for scanning function
10. Overexpression of truncated Nmd3p inhibits protein synthesis in yeast
11. SR-Related proteins and the processing of messenger RNA precursors
12. Promotion of Met-tRNA(iMet) binding to ribosomes by yIF2, a bacterial IF2 homolog in yeast
13. Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation
14. Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation
15. Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon
16. Translation driven by an eIF4G core domain in vivo
17. Translation initiation: Adept at adapting Trends
18. Interaction of translation initiation factor eIF4G with eIF4A in the yeast Saccharomyces cerevisiae
19. Genetic and physical interactions involving the yeast nuclear cap-binding complex
20. TIF4631 and TIF4632: Two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and carry out an essential function
21. Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway
22. A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation
23. NMD3 encodes an essential cytoplasmic protein required for stable 60S ribosomal subunits in Saccharomyces cerevisiae
24. The PCI domain: A common theme in three multiprotein complexes
25. A new translational regulator with homology to eukaryotic translation initiation factor 4G
26. Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A
27. A nuclear cap binding protein complex involved in pre-mRNA splicing
28. Protein secondary structure prediction based on position-specific scoring matrices
29. Distinct requirements for somatic and germline expression of a generally expressed Caernorhabditis elegans gene
30. Identification of a nucleic acid binding domain in eukaryotic initiation factor eIFiso4G from wheat
31. Crystal structures of eukaryotic translation initiation factor 5A from Methanococcus jannaschii at 1.8 A resolution
32. Multidomain organization of eukaryotic guanine nucleotide exchange translation initiation factor eIF-2B subunits revealed by analysis of conserved sequence motifs
33. A new heat shock protein that binds nucleic acids
34. Messenger RNA translation in prokaryotes: GTPase centers associated with translational factors
35. Structural and functional domains of E. coli initiation factor IF2
36. Mapping of functional domains in eukaryotic protein synthesis initiation factor 4G (eIF4G) with picornaviral proteases. Implications for cap-dependent and cap-independent translational initiation
37. Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2
38. DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death
39. Comparative genomics of the Archaea (Euryarchaeota): Evolution of conserved protein families, the stable core, and the variable shell
40. Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP
41. Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G
42. Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein
43. Eukaryotic translation initiation factor 4E (eIF4E) binding site and the middle one-third of eIF4GI constitute the core domain for cap-dependent translation, and the C-terminal one-third functions as a modulatory region
44. Eukaryotic translation initiation factors 4G and 4A from Saccharomyces cerevisiae interact physically and functionally
45. Precocious sporulation and developmental lethality in yelA null mutants of Dictyostelium
46. Structure of translation initiation factor 5A from Pyrobaculum aerophilum at 1.75 Å resolution
47. Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons
48. Ribosome recruitment and scanning: What's new?
49. The joining of ribosomal subunits in eukaryotes requires eIF5B
50. Eukaryotic signalling domain homologues in archaea and bacteria. Ancient ancestry and horizontal gene transfer
51. Structural basis of mRNA cap recognition by proteins
52. Prediction of protein secondary structure at better than 70% accuracy
53. The structure of the translational initiation factor IF1 from E. coli contains an oligomer-binding motif
54. Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death
55. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
56. Making sense of the COP9 signalosome. A regulatory protein complex conserved from Arabidopsis to human
57. Evolution of aminoacyl-tRNA synthetases-analysis of unique domain architectures and phylogenetic trees reveals a complex history of horizontal gene transfer events
58. Analysis of compositionally biased regions in sequence databases
59. A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme
60. Molecular cloning and characterization of a rabbit eIF2C protein