Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation

RNA

Volumn 12, Issue 6, 2006, Pages 1015-1022

  Kunz, Joachim B ^a   Neu Yilik, Gabriele ^a   Hentze, Matthias W ^a,b   Kulozik, Andreas E ^a   Gehring, Niels H ^a,c  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Exon junction complex; Nonsense mediated mRNA decay; Tethering; Upf3

Indexed keywords

INITIATION FACTOR 4A; PROTEIN; PROTEIN BTZ; PROTEIN MAGOH; PROTEIN UPF3A; PROTEIN UPF3B; PROTEIN Y14; TRANS ACTING FACTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RNA DEGRADATION; RNA TRANSLATION;

AMINO ACID SEQUENCE; ANIMALS; CODON, NONSENSE; EUKARYOTIC INITIATION FACTOR-4A; HELA CELLS; HUMANS; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PROTEIN BIOSYNTHESIS; RNA STABILITY; RNA, MESSENGER; RNA-BINDING PROTEINS; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 33646865949     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.12506     Document Type: Article

References (36)

1. Bono, F., Ebert, J., Unterholzner, L., Guttler, T., Izaurralde, E., and Conti, E. 2004. Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex. EMBO Rep. 5: 304-310.
2. Chan, C.C., Dostie, J., Diem, M.D., Feng, W., Mann, M., Rappsilber, J., and Dreyfuss, G. 2004. eIF4A3 is a novel component of the exon junction complex. RNA 10: 200-209.
3. Creancier, L., Morello, D., Mercier, P., and Prats, C. 2000. Fibroblast growth factor 2 internal ribosome entry site (IRES) activity ex vivo and in transgenic mice reveals a stringent tissue-specific regulation. J. Cell Biol. 150: 275-281.
4. Danckwardt, S., Gehring, N.H., Neu-Yilik, G., Hundsdoerfer, P., Pforsich, M., Frede, U., Hentze, M.W., and Kulozik, A.E. 2004. The prothrombin 3′ end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations. Blood 104: 428-435.
5. Degot, S., Le Hir, H., Alpy, F., Kedinger, V., Stoll, I., Wendling, C., Seraphin, B., Rio, M.C., and Tomasetto, C. 2004. Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module. J. Biol. Chem. 279: 33702-33715.
6. Ferraiuolo, M.A., Lee, C.S., Ler, L.W., Hsu, J.L., Costa-Mattioli, M., Luo, M.J., Reed, R., and Sonnenberg, N. 2004. A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay. Proc. Natl. Acad. Sci. 101: 4118-4123.
7. Fribourg, S., Gatfield, D., Izaurralde, E., and Conti, E. 2003. A novel mode of RBD-protein recognition in the Y14-Mago complex. Nat. Struct. Biol. 10: 433-439.
8. Gehring, N.H., Neu-Yilik, G., Schell, T., Hentze, M.W., and Kulozik, A.E. 2003. Y14 and hUpf3b form an NMD-activating complex. Mol. Cell 11: 939-949.
9. Gehring, N.H., Kunz, J.B., Neu-Yilik, G., Breit, S., Viegas, M.H., Hentze, M.W., and Kulozik, A.E. 2005. Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements. Mol. Cell 20: 65-75.
10. Gonzalez, C.I., Bhattacharya, A., Wang, W., and Peltz, S.W. 2001. Nonsense-mediated mRNA decay in Saccharomyces cerevisiae. Gene 274: 15-25.
11. Hall, G.W. and Thein, S. 1994. Nonsense codon mutations in the terminal exon of the β-globin gene are not associated with a reduction in β-globin-mRNA accumulation: A mechanism for the phenotype of dominant β-thalassemia. Blood 83: 2013-2017.
12. He, F., Li, X., Spatrick, P., Casillo, R., Dong, S., and Jacobson, A. 2003. Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 5′ to 3′ mRNA decay pathways in yeast. Mol. Cell 12: 1439-1452.
13. Holbrook, J.A., Neu-Yilik, G., Hentze, M.W., and Kulozik, A.E. 2004. Nonsense-mediated decay approaches the clinic. Nat. Genet. 36: 801-808.
14. Kadlec, J., Izaurralde, E., and Cusack, S. 2004. The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3. Nat. Struct. Mol. Biol. 11: 330-337.
15. Kim, V.N., Kataoka, N., and Dreyfuss, G. 2001. Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex. Science 293: 1832-1836.
16. Le Hir, H., Gatfield, D., Izaurralde, E., and Moore, M.J. 2001. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. EMBO J. 20: 4987-4997.
17. Lejeune, F., Li, X., and Maquat, L.E. 2003. Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. Mol. Cell 12: 675-687.
18. Lu, S. and Cullen, B.R. 2003. Analysis of the stimulatory effect of splicing on mRNA production and utilization in mammalian cells. RNA 9: 618-630.
19. Lykke-Andersen, J., Shu, M.D., and Steitz, J.A. 2000. Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. Cell 103: 1121-1131.
20. _. 2001. Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. Science 293: 1836-1839.
21. Maquat, L.E. 2004. Nonsense-mediated mRNA decay: Splicing, translation and mRNP dynamics. Nat. Rev. Mol. Cell Biol. 5: 89-99.
22. Mendell, J.T., Sharifi, N.A., Meyers, J.L., Martinez-Murillo, F., and Dietz, H.C. 2004. Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise. Nat. Genet. 36: 1073-1078.
23. Nott, A., Meislin, S.H., and Moore, M.J. 2003. A quantitative analysis of intron effects on mammalian gene expression. RNA 9: 607-617.
24. Nott, A., Le Hir, H., and Moore, M.J. 2004. Splicing enhances translation in mammalian cells: An additional function of the exon junction complex. Genes & Dev. 18: 210-222.
25. Ohnishi, T., Yamashita, A., Kashima, L., Schell, T., Anders, K.R., Grimson, A., Hachiya, T., Hentze, M.W., Anderson, P., and Ohno, S. 2003. Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Mol. Cell 12: 1187-1200.
26. Palacios, I.M., Gatfield, D., St Johnston, D., and Izaurralde, E. 2004. An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay. Nature 427: 753-757.
27. Schell, T., Kulozik, A.E., and Hentze, M.W. 2002. Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway. Genome Biol. 3: REVIEWS1006.1-1006.6.
28. Schell, T., Kocher, T., Wilm, M., Seraphin, B., Kulozik, A.E., and Hentze, M.W. 2003. Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells. Biochem. J. 373: 775-783.
29. Serin, G., Gersappe, A., Black, J.D., Aronoff, R., and Maquat, L.E. 2001. Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4). Mol. Cell. Biol. 21: 209-223.
30. Shibuya, T., Tange, T.O., Sonenberg, N., and Moore, M.J. 2004. eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay. Nat. Struct. Mol. Biol. 11: 346-351.
31. Stutz, F., Bachi, A., Doerks, T., Braun, I.C., Seraphin, B., Wilm, M., Bork, P., and Izaurralde, E. 2000. REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA export. RNA 6: 638-650.
32. Tange, T.O., Nott, A., and Moore, M.J. 2004. The ever-increasing complexities of the exon junction complex. Curr. Opin. Cell Biol. 16: 279-284.
33. Thermann, R., Neu-Yilik, G., Deters, A., Frede, U., Wehr, K., Hagemaier, C., Hentze, M.W., and Kulozik, A.E. 1998. Binary specification of nonsense codons by splicing and cytoplasmic translation. EMBO J. 17: 3484-3494.
34. Wiegand, H.L., Lu, S., and Cullen, B.R. 2003. Exon junction complexes mediate the enhancing effect of splicing on mRNA expression. Proc. Natl. Acad. Sci. 100: 11327-11332.
35. Wilschanski, M., Yahav, Y., Yaacov, Y., Blau, H., Bentur, L., Rivlin, J., Aviram, M., Bdolah-Abram, T., Bebok, Z., Shushi, L., et al. 2003. Gentamicin-induced correction of CFTR function in patients with cystic fibrosis and CFTR stop mutations. N. Engl. J. Med. 349: 1433-1441.
36. Zhou, Z., Luo, M.J., Straesser, K., Katahira, J., Hurt, E., and Reed, R. 2000. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans. Nature 407: 401-405.