Mitochondria: key players in the neurotoxic effects of amphetamines

Archives of Toxicology

Volumn 89, Issue 10, 2015, Pages 1695-1725

  Barbosa, Daniel José ^a,b,c   Capela, João Paulo ^a,d   Feio Azevedo, Rita ^a   Teixeira Gomes, Armanda ^a   Bastos, Maria de Lourdes ^a   Carvalho, Félix ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c UNIVERSITY OF PORTO   (Portugal)

^d UNIVERSIDADE FERNANDO PESSOA   (Portugal)

Author keywords

3,4 Methylenedioxymethamphetamine (MDMA; ecstasy ); Amphetamine (AMPH); Methamphetamine (METH); Mitochondria; Neurotoxicity; Oxidative stress

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; AMPHETAMINE; AMPHETAMINE DERIVATIVE; CATHINONE; CENTRAL STIMULANT AGENT; EPHEDRINE; METHAMPHETAMINE; NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) TRANSHYDROGENASE; PSYCHEDELIC AGENT; PSYCHOTROPIC AGENT;

ARTICLE; BLOOD BRAIN BARRIER; CITRIC ACID CYCLE; DRUG STRUCTURE; HOMEOSTASIS; HUMAN; INNER MEMBRANE; ION TRANSPORT; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NEUROTOXICITY; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTON MOTIVE FORCE; RESPIRATORY CHAIN; ANIMAL; COMPLICATION; DRUG ABUSE; DRUG EFFECTS; ELECTRON TRANSPORT; METABOLISM; NEUROTOXICITY SYNDROMES; PATHOPHYSIOLOGY;

AMPHETAMINE-RELATED DISORDERS; AMPHETAMINES; ANIMALS; BLOOD-BRAIN BARRIER; CENTRAL NERVOUS SYSTEM STIMULANTS; ELECTRON TRANSPORT; HUMANS; MITOCHONDRIA; NEUROTOXICITY SYNDROMES;

EID: 84942195353     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-015-1478-9     Document Type: Article

References (295)

1. Acin-Perez R, Salazar E, Brosel S, Yang H, Schon EA, Manfredi G (2009) Modulation of mitochondrial protein phosphorylation by soluble adenylyl cyclase ameliorates cytochrome oxidase defects. EMBO Mol Med 1:392–406
2. Adam-Vizi V (2005) Production of reactive oxygen species in brain mitochondria: contribution by electron transport chain and non-electron transport chain sources. Antioxid Redox Signal 7:1140–1149
3. Ádori C, Lőw P, Andó RD et al (2011) Ultrastructural characterization of tryptophan hydroxylase 2-specific cortical serotonergic fibers and dorsal raphe neuronal cell bodies after MDMA treatment in rat. Psychopharmacology 213:377–391
4. Ajjimaporn A, Swinscoe J, Shavali S, Govitrapong P, Ebadi M (2005) Metallothionein provides zinc-mediated protective effects against methamphetamine toxicity in SK-N-SH cells. Brain Res Bull 67:466–475
5. Akiyama K (2006) Longitudinal clinical course following pharmacological treatment of methamphetamine psychosis which persists after long-term abstinence. Ann N Y Acad Sci 1074:125–134
6. Albers DS, Zeevalk GD, Sonsalla PK (1996) Damage to dopaminergic nerve terminals in mice by combined treatment of intrastriatal malonate with systemic methamphetamine or MPTP. Brain Res 718:217–220
7. Alves E, Summavielle T, Alves CJ et al (2007) Monoamine oxidase-B mediates ecstasy-induced neurotoxic effects to adolescent rat brain mitochondria. J Neurosci 27:10203–10210
8. Alves E, Binienda Z, Carvalho F et al (2009a) Acetyl-l-carnitine provides effective in vivo neuroprotection over 3,4-methylenedioximethamphetamine-induced mitochondrial neurotoxicity in the adolescent rat brain. Neuroscience 158:514–523
9. Alves E, Summavielle T, Alves CJ et al (2009b) Ecstasy-induced oxidative stress to adolescent rat brain mitochondria in vivo: influence of monoamine oxidase type A. Addict Biol 14:185–193
10. Arai Y, Se KK, Kinemuchi H et al (1990) Selective inhibition of MAO-A in serotonergic synaptosomes by two amphetamine metabolites, p-hydroxyamphetamine and p-hydroxynorephedrine. Neurochem Int 17:587–592
11. Ashrafi G, Schwarz TL (2013) The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ 20:31–42
12. Ask AL, Fagervall I, Florvall L, Ross SB, Ytterborn S (1985) Inhibition of monoamine oxidase in 5-hydroxytryptaminergic neurones by substituted p-aminophenylalkylamines. Br J Pharmacol 85:683–690
13. Axt KJ, Molliver ME (1991) Immunocytochemical evidence for methamphetamine-induced serotonergic axon loss in the rat brain. Synapse 9:302–313
14. Bachmann RF, Wang Y, Yuan P et al (2009) Common effects of lithium and valproate on mitochondrial functions: protection against methamphetamine-induced mitochondrial damage. Int J Neuropsychopharmacol 12:805–822
15. Baker MJ, Tatsuta T, Langer T (2011) Quality control of mitochondrial proteostasis. Cold Spring Harb Perspect Biol 3(7)
16. Barbosa DJ, Capela JP, Oliveira JMA et al (2012) Pro-oxidant effects of Ecstasy and its metabolites in mouse brain synaptosomes. Br J Pharmacol 165:1017–1033
17. Barbosa DJ, Capela JP, Silva R et al (2014a) “Ecstasy”-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites. Arch Toxicol 88:515–531
18. Barbosa DJ, Capela JP, Silva R et al (2014b) The mixture of “ecstasy” and its metabolites is toxic to human SH-SY5Y differentiated cells at in vivo relevant concentrations. Arch Toxicol 88:455–473
19. Barbosa DJ, Serrat R, Mirra S et al (2014c) MDMA impairs mitochondrial neuronal trafficking in a Tau- and Mitofusin2/Drp1-dependent manner. Arch Toxicol 88:1561–1572
20. Barbosa DJ, Serrat R, Ferreira LM et al (2014d) Neuronal mitochondrial trafficking impairment: the cause or a consequence of neuronal dysfunction caused by amphetamine-like drugs. J Drug Alcohol Res 3:235868
21. Barbosa DJ, Serrat R, Mirra S et al (2014e) The mixture of “ecstasy” and its metabolites impairs mitochondrial fusion/fission equilibrium and trafficking in hippocampal neurons, at in vivo relevant concentrations. Toxicol Sci 139:407–420
22. Barrett T, Xie T, Piao Y et al (2001) A murine dopamine neuron-specific cDNA library and microarray: increased COXI expression during methamphetamine neurotoxicity. Neurobiol Dis 8:822–833
23. Barsoum MJ, Yuan H, Gerencser AA et al (2006) Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J 25:3900–3911
24. Beauvais G, Atwell K, Jayanthi S, Ladenheim B, Cadet JL (2011) Involvement of dopamine receptors in binge methamphetamine-induced activation of endoplasmic reticulum and mitochondrial stress pathways. PLoS ONE 6:e28946
25. Beeson CC, Beeson GC, Schnellmann RG (2010) A high-throughput respirometric assay for mitochondrial biogenesis and toxicity. Anal Biochem 404:75–81
26. Berntman L, Carlsson C, Hägerdal M, Siesjö BK (1978) Circulatory and metabolic effects in the brain induced by amphetamine sulphate. Acta Physiol Scand 102:310–323
27. Bratton SB, Salvesen GS (2010) Regulation of the Apaf-1–caspase-9 apoptosome. J Cell Sci 123:3209–3214
28. Bratton SB, Walker G, Srinivasula SM et al (2001) Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes. EMBO J 20:998–1009
29. Brown JM, Yamamoto BK (2003) Effects of amphetamines on mitochondrial function: role of free radicals and oxidative stress. Pharmacol Ther 99:45–53
30. Brown JM, Quinton MS, Yamamoto BK (2005) Methamphetamine-induced inhibition of mitochondrial complex II: roles of glutamate and peroxynitrite. J Neurochem 95:429–436
31. Brunelle JK, Letai A (2009) Control of mitochondrial apoptosis by the Bcl-2 family. J Cell Sci 122:437–441
32. Büeler H (2009) Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson’s disease. Exp Neurol 218:235–246
33. Burrows KB, Gudelsky G, Yamamoto BK (2000) Rapid and transient inhibition of mitochondrial function following methamphetamine or 3,4-methylenedioxymethamphetamine administration. Eur J Pharmacol 398:11–18
34. Busceti CL, Biagioni F, Riozzi B et al (2008) Enhanced tau phosphorylation in the hippocampus of mice treated with 3,4-methylenedioxymethamphetamine (“ecstasy”). J Neurosci 28:3234–3245
35. Cadet JL, Ordonez SV, Ordonez JV (1997) Methamphetamine induces apoptosis in immortalized neural cells: protection by the proto-oncogene, bcl-2. Synapse 25:176–184
36. Cadet JL, Jayanthi S, McCoy MT, Vawter M, Ladenheim B (2001) Temporal profiling of methamphetamine-induced changes in gene expression in the mouse brain: evidence from cDNA array. Synapse 41:40–48
37. Cai J, Yang J, Jones DP (1998) Mitochondrial control of apoptosis: the role of cytochrome c. Biochim Biophys Acta 1366:139–149
38. Callahan BT, Cord BJ, Ricaurte GA (2001) Long-term impairment of anterograde axonal transport along fiber projections originating in the rostral raphe nuclei after treatment with fenfluramine or methylenedioxymethamphetamine. Synapse 40:113–121
39. 2A-receptor stimulation in cortical neurons. Neurotoxicology 28:868–875
40. Capela JP, Macedo C, Branco PS et al (2007b) Neurotoxicity mechanisms of thioether ecstasy metabolites. Neuroscience 146:1743–1757
41. Capela JP, Carmo H, Remião F, Bastos ML, Meisel A, Carvalho F (2009) Molecular and cellular mechanisms of ecstasy-induced neurotoxicity: an overview. Mol Neurobiol 39:210–271
42. Capela JP, da Costa Araújo S, Costa VM et al (2013) The neurotoxicity of hallucinogenic amphetamines in primary cultures of hippocampal neurons. Neurotoxicology 34:254–263
43. Cardoso SM, Santos S, Swerdlow RH, Oliveira CR (2001) Functional mitochondria are required for amyloid b-mediated neurotoxicity. FASEB J 15:1439–1441
44. +-induced neurodegeneration. J Neurochem 115:247–258
45. Carvalho M, Remiao F, Milhazes N et al (2004) The toxicity of N-methyl-alpha-methyldopamine to freshly isolated rat hepatocytes is prevented by ascorbic acid and N-acetylcysteine. Toxicology 200:193–203
46. Carvalho M, Carmo H, Costa VM et al (2012) Toxicity of amphetamines: an update. Arch Toxicol 86:1167–1231
47. Castino R, Lazzeri G, Lenzi P et al (2008) Suppression of autophagy precipitates neuronal cell death following low doses of methamphetamine. J Neurochem 106:1426–1439
48. Castro-Caldas M, Carvalho AN, Rodrigues E et al (2012) Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson’s disease. Mol Neurobiol 46:475–486
49. Cereghetti GM, Stangherlin A, de Brito OM et al (2008) Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria. Proc Natl Acad Sci USA 105:15803–15808
50. Cerretani D, Bello S, Cantatore S et al (2011) Acute administration of 3,4-methylenedioxymethamphetamine (MDMA) induces oxidative stress, lipoperoxidation and TNFα-mediated apoptosis in rat liver. Pharmacol Res 64:517–527
51. Chai J, Du C, Wu JW, Kyin S, Wang X, Shi Y (2000) Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature 406:855–862
52. Chan DC (2006) Mitochondria: dynamic organelles in disease, aging, and development. Cell 125:1241–1252
53. Chan P, Di Monte DA, Luo JJ, DeLanney LE, Irwin I, Langston JW (1994) Rapid ATP loss caused by methamphetamine in the mouse striatum: relationship between energy impairment and dopaminergic neurotoxicity. J Neurochem 62:2484–2487
54. Chang DTW, Honick AS, Reynolds IJ (2006) Mitochondrial trafficking to synapses in cultured primary cortical neurons. J Neurosci 26:7035–7045
55. 2+ as an intrinsic signal regulating mitochondrial motility in axons. Proc Natl Acad Sci USA 108:15456–15461
56. Chen H, Detmer SA, Ewald AJ, Griffin EE, Fraser SE, Chan DC (2003) Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J Cell Biol 160:189–200
57. Chen H, McCaffery JM, Chan DC (2007a) Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell 130:548–562
58. Chen S, Owens GC, Crossin KL, Edelman DB (2007b) Serotonin stimulates mitochondrial transport in hippocampal neurons. Mol Cell Neurosci 36:472–483
59. Chen S, Owens GC, Edelman DB (2008) Dopamine inhibits mitochondrial motility in hippocampal neurons. PLoS ONE 3:e2804
60. Chen S, Owens GC, Makarenkova H, Edelman DB (2010) HDAC6 regulates mitochondrial transport in hippocampal neurons. PLoS ONE 5:e10848
61. Chipana C, Camarasa J, Pubill D, Escubedo E (2006) Protection against MDMA-induced dopaminergic neurotoxicity in mice by methyllycaconitine: involvement of nicotinic receptors. Neuropharmacology 51:885–895
62. Chipana C, Camarasa J, Pubill D, Escubedo E (2008) Memantine prevents MDMA-induced neurotoxicity. Neurotoxicology 29:179–183
63. Chipuk JE, Moldoveanu T, Llambi F, Parsons MJ, Green DR (2010) The BCL-2 family reunion. Mol Cell 37:299–310
64. Chu T, Kumagai Y, DiStefano EW, Cho AK (1996) Disposition of methylenedioxymethamphetamine and three metabolites in the brains of different rat strains and their possible roles in acute serotonin depletion. Biochem Pharmacol 51:789–796
65. Cipolat S, Martins de Brito O, Dal Zilio B, Scorrano L (2004) OPA1 requires mitofusin 1 to promote mitochondrial fusion. Proc Natl Acad Sci USA 101:15927–15932
66. Cipolat S, Rudka T, Hartmann D et al (2006) Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell 126:163–175
67. Colado MI, O’Shea E, Granados R, Murray TK, Green AR (1997) In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA (“ecstasy”) and p-chloroamphetamine but not the degeneration following fenfluramine. Br J Pharmacol 121:889–900
68. Colado MI, O’Shea E, Esteban B, Granados R, Green AR (1999) In vivo evidence against clomethiazole being neuroprotective against MDMA (‘ecstasy’)-induced degeneration of rat brain 5-HT nerve terminals by a free radical scavenging mechanism. Neuropharmacology 38:307–314
69. Cruz CM, Rinna A, Forman HJ, Ventura ALM, Persechini PM, Ojcius DM (2007) ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages. J Biol Chem 282:2871–2879
70. Cunha-Oliveira T, Rego AC, Cardoso SM et al (2006) Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine. Brain Res 1089:44–54
71. Cuyas E, Robledo P, Pizarro N et al (2013) 3,4-Methylenedioxymethamphetamine induces gene expression changes in rats related to serotonergic and dopaminergic systems, but not to neurotoxicity. Neurotox Res 25:161–169
72. Darvesh AS, Gudelsky GA (2005) Evidence for a role of energy dysregulation in the MDMA-induced depletion of brain 5-HT. Brain Res 1056:168–175
73. Delettre C, Yuste VJ, Moubarak RS et al (2006) AIFsh, a novel apoptosis-inducing factor (AIF) pro-apoptotic isoform with potential pathological relevance in human cancer. J Biol Chem 281:6413–6427
74. Deng X, Cai NS, McCoy MT, Chen W, Trush MA, Cadet JL (2002) Methamphetamine induces apoptosis in an immortalized rat striatal cell line by activating the mitochondrial cell death pathway. Neuropharmacology 42:837–845
75. Devaux F, Lelandais G, Garcia M, Goussard S, Jacq C (2010) Posttranscriptional control of mitochondrial biogenesis: spatio-temporal regulation of the protein import process. FEBS Lett 584:4273–4279
76. Du C, Fang M, Li Y, Li L, Wang X (2000) Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 102:33–42
77. Ebneth A, Godemann R, Stamer K et al (1998) Overexpression of Tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer’s disease. J Cell Biol 143:777–794
78. Edmondson DE, Binda C, Wang J, Upadhyay AK, Mattevi A (2009) Molecular and mechanistic properties of the membrane-bound mitochondrial monoamine oxidases. Biochemistry 48:4220–4230
79. EMCDDA (2014) European drug report 2014: trends and developments. European Monitoring Centre for Drugs and Drug Addiction, Lisbon
80. Erives GV, Lau SS, Monks TJ (2008) Accumulation of neurotoxic thioether metabolites of 3,4-(±)-methylenedioxymethamphetamine in rat brain. J Pharmacol Exp Ther 324:284–291
81. Escubedo E, Chipana C, Pérez-Sánchez M, Camarasa J, Pubill D (2005) Methyllycaconitine prevents methamphetamine-induced effects in mouse striatum: involvement of alpha7 nicotinic receptors. J Pharmacol Exp Ther 315:658–667
82. Escubedo E, Abad S, Torres I, Camarasa J, Pubill D (2011) Comparative neurochemical profile of 3,4-methylenedioxymethamphetamine and its metabolite alpha-methyldopamine on key targets of MDMA neurotoxicity. Neurochem Int 58:92–101
83. Estaquier J, Arnoult D (2007) Inhibiting Drp1-mediated mitochondrial fission selectively prevents the release of cytochrome c during apoptosis. Cell Death Differ 14:1086–1094
84. Falk EM, Cook VJ, Nichols DE, Sprague JE (2002) An antisense oligonucleotide targeted at MAO-B attenuates rat striatal serotonergic neurotoxicity induced by MDMA. Pharmacol Biochem Behav 72:617–622
85. Feier G, Valvassori SS, Lopes-Borges J et al (2012) Behavioral changes and brain energy metabolism dysfunction in rats treated with methamphetamine or dextroamphetamine. Neurosci Lett 530:75–79
86. Feier G, Valvassori SS, Varela RB et al (2013) Lithium and valproate modulate energy metabolism in an animal model of mania induced by methamphetamine. Pharmacol Biochem Behav 103:589–596
87. Fišar Z (2012) Cannabinoids and monoamine neurotransmission with focus on monoamine oxidase. Prog Neuropsychopharmacol Biol Psychiatry 38:68–77
88. Fischer F, Hamann A, Osiewacz HD (2012) Mitochondrial quality control: an integrated network of pathways. Trends Biochem Sci 37:284–292
89. Forman HJ, Azzi A (1997) On the virtual existence of superoxide anions in mitochondria: thoughts regarding its role in pathophysiology. FASEB J 11:374–375
90. Fornai F, Giorgi FS, Gesi M, Chen K, Alessrì MG, Shih JC (2001) Biochemical effects of the monoamine neurotoxins DSP-4 and MDMA in specific brain regions of MAO-B-deficient mice. Synapse 39:213–221
91. Frank S, Gaume B, Bergmann-Leitner ES et al (2001) The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev Cell 1:515–525
92. Freezer A, Salem A, Irvine RJ (2005) Effects of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) and para-methoxyamphetamine on striatal 5-HT when co-administered with moclobemide. Brain Res 1041:48–55
93. Frey K, Kilbourn M, Robinson T (1997) Reduced striatal vesicular monoamine transporters after neurotoxic but not after behaviorally-sensitizing doses of methamphetamine. Eur J Pharmacol 334:273–279
94. Frey BN, Valvassori SS, Gomes KM et al (2006) Increased oxidative stress in submitochondrial particles after chronic amphetamine exposure. Brain Res 1097:224–229
95. Frezza C, Cipolat S, Martins de Brito O et al (2006) OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Cell 126:177–189
96. Fridovich I (1995) Superoxide radical and superoxide dismutases. Annu Rev Biochem 64:97–112
97. Friedman JR, Lackner LL, West M, Di Benedetto JR, Nunnari J, Voeltz GK (2011) ER tubules mark sites of mitochondrial division. Science 334:358–362
98. Gandre-Babbe S, van der Bliek AM (2008) The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. Mol Biol Cell 19:2402–2412
99. Gegg ME, Cooper JM, Chau KY, Rojo M, Schapira AHV, Taanman JW (2010) Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy. Hum Mol Genet 19:4861–4870
100. Geisler S, Holmström KM, Skujat D et al (2010) PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol 12:119–131
101. Gonçalves J, Baptista S, Olesen MV et al (2012) Methamphetamine-induced changes in the mice hippocampal neuropeptide Y system: implications for memory impairment. J Neurochem 123:1041–1053
102. Gouzoulis-Mayfrank E, Daumann J (2009) Neurotoxicity of drugs of abuse—the case of methylenedioxyamphetamines (MDMA, ecstasy), and amphetamines. Dialogues Clin Neurosci 11:305–317
103. Green AL, El Hait MA (1980) p-Methoxyamphetamine, a potent reversible inhibitor of type-A monoamine oxidase in vitro and In vivo. J Pharm Pharmacol 32:262–266
104. Grelotti DJ, Kanayama G, Pope HG (2010) Remission of persistent methamphetamine-induced psychosis after electroconvulsive therapy: presentation of a case and review of the literature. Am J Psychiatry 167:17–23
105. Hatefi Y, Hanstein WG, Galante Y, Stiggall DL (1975) Mitochondrial ATP-Pi exchange complex and the site of uncoupling of oxidative phosphorylation. Fed Proc 34:1699–1706
106. Herrmann JM, Longen S, Weckbecker D, Depuydt M (2012) Biogenesis of mitochondrial proteins. Adv Exp Med Biol 748:41–64
107. Hewton R, Salem A, Irvine RJ (2007) Potentiation of 3,4-methylenedioxymethamphetamine-induced 5-HT release in the rat substantia nigra by clorgyline, a monoamine oxidase A inhibitor. Clin Exp Pharmacol Physiol 34:1051–1057
108. Ho P, Ho J, Liu H et al (2012) Mitochondrial neuronal uncoupling proteins: a target for potential disease-modification in Parkinson’s disease. Transl Neurodegener 1:3
109. Hock MB, Kralli A (2009) Transcriptional control of mitochondrial biogenesis and function. Annu Rev Physiol 71:177–203
110. Hotchkiss AJ, Morgan ME, Gibb JW (1979) The long-term effects of multiple doses of methamphetamine on neostriatal tryptophan hydroxylase, tyrosine hydroxylase, choline acetyltransferase and glutamate decarboxylase activities. Life Sci 25:373–378
111. Imam SZ, Jankovic J, Ali SF et al (2005) Nitric oxide mediates increased susceptibility to dopaminergic damage in Nurr1 heterozygous mice. FASEB J 19:1441–1450
112. Ingerman E, Perkins EM, Marino M et al (2005) Dnm1 forms spirals that are structurally tailored to fit mitochondria. J Cell Biol 170:1021–1027
113. Ishihara N, Eura Y, Mihara K (2004) Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity. J Cell Sci 117:6535–6546
114. Iwazaki T, McGregor IS, Matsumoto I (2008) Protein expression profile in the amygdala of rats with methamphetamine-induced behavioral sensitization. Neurosci Lett 435:113–119
115. James DI, Parone PA, Mattenberger Y, Martinou JC (2003) hFis1, a novel component of the mammalian mitochondrial fission machinery. J Biol Chem 278:36373–36379
116. Jayanthi S, Deng X, Bordelon M, McCoy MT, Cadet JL (2001) Methamphetamine causes differential regulation of pro-death and anti-death Bcl-2 genes in the mouse neocortex. FASEB J 15:1745–1752
117. Jayanthi S, Deng X, Noailles PA, Ladenheim B, Cadet JL (2004) Methamphetamine induces neuronal apoptosis via cross-talks between endoplasmic reticulum and mitochondria-dependent death cascades. FASEB J 18:238–251
118. Jiménez A, Jordà EG, Verdaguer E et al (2004) Neurotoxicity of amphetamine derivatives is mediated by caspase pathway activation in rat cerebellar granule cells. Toxicol Appl Pharmacol 196:223–234
119. Jiménez-Mateos EM, González-Billault C, Dawson HN, Vitek MP, Avila J (2006) Role of MAP1B in axonal retrograde transport of mitochondria. Biochem J 397:53–59
120. Jin SM, Lazarou M, Wang C, Kane LA, Narendra DP, Youle RJ (2010) Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL. J Cell Biol 191:933–942
121. Johanson CE, Frey KA, Lundahl LH et al (2006) Cognitive function and nigrostriatal markers in abstinent methamphetamine abusers. Psychopharmacology 185:327–338
122. Jones DC, Lau SS, Monks TJ (2004) Thioether metabolites of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine inhibit human serotonin transporter (hSERT) function and simultaneously stimulate dopamine uptake into hSERT-expressing SK-N-MC cells. J Pharmacol Exp Ther 311:298–306
123. Jones DC, Duvauchelle C, Ikegami A et al (2005) Serotonergic neurotoxic metabolites of ecstasy identified in rat brain. J Pharmacol Exp Ther 313:422–431
124. Kageyama Y, Zhang Z, Roda R et al (2012) Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage. J Cell Biol 197:535–551
125. Kang D, Hamasaki N (2005) Mitochondrial transcription factor A in the maintenance of mitochondrial DNA. Ann N Y Acad Sci 1042:101–108
126. Kim Y, Park J, Kim S et al (2008) PINK1 controls mitochondrial localization of Parkin through direct phosphorylation. Biochem Biophys Res Commun 377:975–980
127. Kim JY, Shen S, Dietz K et al (2010) HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage. Nat Neurosci 13:180–189
128. Kim SH, Lu HF, Alano CC (2011) Neuronal Sirt3 protects against excitotoxic injury in mouse cortical neuron culture. PLoS ONE 6:e14731
129. +, specifically impairs mitochondrial transport in dopamine axons. J Neurosci 31:7212–7221
130. Kish SJ, Fitzmaurice PS, Boileau I et al (2009) Brain serotonin transporter in human methamphetamine users. Psychopharmacology 202:649–661
131. Klongpanichapak S, Govitrapong P, Sharma S, Ebadi M (2006) Attenuation of cocaine and methamphetamine neurotoxicity by coenzyme Q10. Neurochem Res 31:303–311
132. Klongpanichapak S, Phansuwan-Pujito P, Ebadi M, Govitrapong P (2007) Melatonin protects SK-N-SH neuroblastoma cells from amphetamine-induced neurotoxicity. J Pineal Res 43:65–73
133. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD (1997) The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275:1132–1136
134. Kongsuphol P, Mukda S, Nopparat C, Villarroel A, Govitrapong P (2009) Melatonin attenuates methamphetamine-induced deactivation of the mammalian target of rapamycin signaling to induce autophagy in SK-N-SH cells. J Pineal Res 46:199–206
135. Koppen M, Langer T (2007) Protein degradation within mitochondria: versatile activities of AAA proteases and other peptidases. Crit Rev Biochem Mol Biol 42:221–242
136. Koshiba T, Detmer SA, Kaiser JT, Chen H, McCaffery JM, Chan DC (2004) Structural basis of mitochondrial tethering by mitofusin complexes. Science 305:858–862
137. Krantic S, Mechawar N, Reix S, Quirion R (2007) Apoptosis-inducing factor: a matter of neuron life and death. Prog Neurobiol 81:179–196
138. Krasnova IN, Ladenheim B, Cadet JL (2005) Amphetamine induces apoptosis of medium spiny striatal projection neurons via the mitochondria-dependent pathway. FASEB J 19:851–853
139. Kuczenski R, Segal DS, Cho AK, Melega W (1995) Hippocampus norepinephrine, caudate dopamine and serotonin, and behavioral responses to the stereoisomers of amphetamine and methamphetamine. J Neurosci 15:1308–1317
140. Kuhar MJ, Couceyro PR, Lambert PD (1999) Storage and Release of Catecholamines. In: Siegel GJ, Agranoff BW (eds) Basic neurochemistry: molecular, cellular and medical aspects, vol 6. Lippincott Williams & Wilkins, Philadelphia
141. Langsdorf EF, Chang SL (2011) Methamphetamine-mediated modulation of MOR expression in the SH-SY5Y neuroblastoma cell line. Synapse 65:858–865
142. Lau JWS, Senok S, Stadlin A (2000) Methamphetamine-induced oxidative stress in cultured mouse astrocytes. Ann N Y Acad Sci 914:146–156
143. Lenzi P, Marongiu R, Falleni A et al (2012) A subcellular analysis of genetic modulation of PINK1 on mitochondrial alterations, autophagy and cell death. Arch Ital Biol 150:194–217
144. Leonardi ET, Azmitia EC (1994) MDMA (ecstasy) inhibition of MAO type A and type B: comparisons with fenfluramine and fluoxetine (Prozac). Neuropsychopharmacology 10:231–238
145. Li H, Chen Y, Jones AF et al (2008) Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons. Proc Natl Acad Sci USA 105:2169–2174
146. Li Y, Hu Z, Chen B et al (2012) Taurine attenuates methamphetamine-induced autophagy and apoptosis in PC12 cells through mTOR signaling pathway. Toxicol Lett 215:1–7
147. Lin M, Chandramani-Shivalingappa P, Jin H et al (2012) Methamphetamine-induced neurotoxicity linked to ubiquitin-proteasome system dysfunction and autophagy-related changes that can be modulated by protein kinase C delta in dopaminergic neuronal cells. Neuroscience 210:308–332
148. Liot G, Bossy B, Lubitz S, Kushnareva Y, Sejbuk N, Bossy-Wetzel E (2009) Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDA- and ROS-dependent pathway. Cell Death Differ 16:899–909
149. Liu S, Sawada T, Lee S et al (2012) Parkinson’s disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria. PLoS Genet 8:e1002537
150. Llorens-Martín M, López-Doménech G, Soriano E, Avila J (2011) GSK3β is involved in the relief of mitochondria pausing in a tau-dependent manner. PLoS ONE 6:e27686
151. Losón OC, Song Z, Chen H, Chan DC (2013) Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission. Mol Biol Cell 24:659–667
152. Macaskill AF, Rinholm JE, Twelvetrees AE et al (2009) Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses. Neuron 61:541–555
153. MacAskill AF, Atkin TA, Kittler JT (2010) Mitochondrial trafficking and the provision of energy and calcium buffering at excitatory synapses. Eur J Neurosci 32:231–240
154. Macedo C, Branco PS, Ferreira LM et al (2007) Synthesis and cyclic voltammetry studies of 3,4-methylenedioxymethamphetamine (MDMA) human metabolites. J Health Sci 53:31–42
155. Maragos WF, Jakel R, Chesnut D et al (2000) Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase. Brain Res 878:218–222
156. Marchetti P, Castedo M, Susin SA et al (1996) Mitochondrial permeability transition is a central coordinating event of apoptosis. J Exp Med 184:1155–1160
157. Martinez-Ruiz G, Maldonado V, Ceballos-Cancino G, Grajeda J, Melendez-Zajgla J (2008) Role of Smac/DIABLO in cancer progression. J Exp Clin Cancer Res 27:48
158. Marzo I, Brenner C, Zamzami N et al (1998) The permeability transition pore complex: a target for apoptosis regulation by caspases and Bcl-2–related proteins. J Exp Med 187:1261–1271
159. Matsuda N, Sato S, Shiba K et al (2010) PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J Cell Biol 189:211–221
160. Matsumoto T, Maeno Y, Kato H et al (2014) 5-hydroxytryptamine- and dopamine-releasing effects of ring-substituted amphetamines on rat brain: a comparative study using in vivo microdialysis. Eur Neuropsychopharmacol 24:1362–1370
161. McCann UD, Szabo Z, Seckin E et al (2005) Quantitative PET studies of the serotonin transporter in MDMA users and controls using [lsqb]11C[rsqb]McN5652 and [lsqb]11C[rsqb]DASB. Neuropsychopharmacology 30:1741–1750
162. Mehdizadeh M, Dabaghian F, Nejhadi A et al (2012) Zingiber officinale alters 3,4-methylenedioxymethamphetamine-induced neurotoxicity in rat brain. Cell J 14:177–184
163. Meyer JS, Grande M, Johnson K, Ali SF (2004) Neurotoxic effects of MDMA (“ecstasy”) administration to neonatal rats. Int J Dev Neurosci 22:261–271
164. Miramar MD, Costantini P, Ravagnan L et al (2001) NADH oxidase activity of mitochondrial apoptosis-inducing factor. J Biol Chem 276:16391–16398
165. Misko A, Jiang S, Wegorzewska I, Milbrandt J, Baloh RH (2010) Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex. J Neurosci 30:4232–4240
166. Misko AL, Sasaki Y, Tuck E, Milbrandt J, Baloh RH (2012) Mitofusin2 mutations disrupt axonal mitochondrial positioning and promote axon degeneration. J Neurosci 32:4145–4155
167. Mitcheel P (1961) Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. Nature 191:144–148
168. Moldoveanu T, Follis AV, Kriwacki RW, Green DR (2014) Many players in BCL-2 family affairs. Trends Biochem Sci 3:101–111
169. Moretti M, Valvassori SS, Steckert AV et al (2011) Tamoxifen effects on respiratory chain complexes and creatine kinase activities in an animal model of mania. Pharmacol Biochem Behav 98:304–310
170. Morfini G, Szebenyi G, Elluru R, Ratner N, Brady ST (2002) Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility. EMBO J 21:281–293
171. Mozdy AD, McCaffery JM, Shaw JM (2000) Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p. J Cell Biol 151:367–380
172. Narendra D, Tanaka A, Suen DF, Youle RJ (2008) Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 183:795–803
173. Nicholls DG (2009) Spare respiratory capacity, oxidative stress and excitotoxicity. Biochem Soc Trans 37:1385–1388
174. Nikoletopoulou V, Markaki M, Palikaras K, Tavernarakis N (2013) Crosstalk between apoptosis, necrosis and autophagy. Biochim Biophys Acta 1833:3448–3459
175. Nixdorf WL, Burrows KB, Gudelsky GA, Yamamoto BK (2001) Enhancement of 3,4-methylenedioxymethamphetamine neurotoxicity by the energy inhibitor malonate. J Neurochem 77:647–654
176. Oettinghaus B, Licci M, Scorrano L, Frank S (2012) Less than perfect divorces: dysregulated mitochondrial fission and neurodegeneration. Acta Neuropathol 123:189–203
177. Ola MS, Nawaz M, Ahsan H (2011) Role of Bcl-2 family proteins and caspases in the regulation of apoptosis. Mol Cell Biochem 351:41–58
178. Oliveira MT, Rego AC, Morgadinho MT, Macedo TRA, Oliveira CR (2002) Toxic affects of opioid and stimulant drugs on undifferentiated PC12 cells. Ann N Y Acad Sci 965:487–496
179. Oliveira MT, Rego AC, Macedo TA, Oliveira CR (2003) Drugs of abuse induce apoptotic features in PC12 cells. Ann N Y Acad Sci 1010:667–670
180. Onoue K, Jofuku A, Ban-Ishihara R et al (2013) Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology. J Cell Sci 126:176–185
181. Onyango IG, Lu J, Rodova M, Lezi E, Crafter AB, Swerdlow RH (2010) Regulation of neuron mitochondrial biogenesis and relevance to brain health. Biochim Biophys Acta 1802:228–234
182. Otera H, Mihara K (2011) Molecular mechanisms and physiologic functions of mitochondrial dynamics. J Biochem 149:241–251
183. Otera H, Wang C, Cleland MM et al (2010) Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J Cell Biol 191:1141–1158
184. Palmer CS, Osellame LD, Laine D, Koutsopoulos OS, Frazier AE, Ryan MT (2011) MiD49 and MiD51, new components of the mitochondrial fission machinery. EMBO Rep 12:565–573
185. Pereira C, Chaves S, Alves S et al (2010) Mitochondrial degradation in acetic acid-induced yeast apoptosis: the role of Pep4 and the ADP/ATP carrier. Mol Microbiol 76:1398–1410
186. Perlmann T, Wallén-Mackenzie Å (2004) Nurr1, an orphan nuclear receptor with essential functions in developing dopamine cells. Cell Tissue Res 318:45–52
187. Pigino G, Morfini G, Pelsman A, Mattson MP, Brady ST, Busciglio J (2003) Alzheimer’s presenilin 1 mutations impair kinesin-based axonal transport. J Neurosci 23:4499–4508
188. Pilgrim JL, Gerostamoulos D, Drummer OH (2010) Deaths involving serotonergic drugs. Forensic Sci Int 198:110–117
189. Pilgrim JL, Gerostamoulos D, Woodford N, Drummer OH (2012) Serotonin toxicity involving MDMA (ecstasy) and moclobemide. Forensic Sci Int 215:184–188
190. Poole AC, Thomas RE, Andrews LA, McBride HM, Whitworth AJ, Pallanck LJ (2008) The PINK1/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci USA 105:1638–1643
191. Popov V, Medvedev NI, Davies HA, Stewart MG (2005) Mitochondria form a filamentous reticular network in hippocampal dendrites but are present as discrete bodies in axons: a three-dimensional ultrastructural study. J Comp Neurol 492:50–65
192. Prince JA, Yassin MS, Oreland L (1997) Normalization of cytochrome-c oxidase activity in the rat brain by neuroleptics after chronic treatment with PCP or methamphetamine. Neuropharmacology 36:1665–1678
193. Pubill D, Chipana C, Camins A, Pallàs M, Camarasa J, Escubedo E (2005) Free radical production induced by methamphetamine in rat striatal synaptosomes. Toxicol Appl Pharmacol 204:57–68
194. Puerta E, Hervias I, Goñi-Allo B et al (2010) Methylenedioxymethamphetamine inhibits mitochondrial complex I activity in mice: a possible mechanism underlying neurotoxicity. Br J Pharmacol 160:233–245
195. Qi X, Qvit N, Su Y, Mochly-Rosen D (2012) Novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J Cell Sci 126:789–802
196. Quinton MS, Yamamoto BK (2006) Causes and consequences of methamphetamine and MDMA toxicity. AAPS J 8:337–347
197. Raimundo N, Baysal BE, Shadel GS (2011) Revisiting the TCA cycle: signaling to tumor formation. Trends Mol Med 17:641–649
198. Ramkissoon A, Wells PG (2013) Developmental role of nuclear factor E2-related factor 2 in mitigating methamphetamine fetal toxicity and postnatal neurodevelopmental deficits. Free Radic Biol Med 65:620–631
199. Ramsay RR, Hunter DJB (2002) Inhibitors alter the spectrum and redox properties of monoamine oxidase A. Biochim Biophys Acta 1601:178–184
200. Ranieri M, Brajkovic S, Riboldi G et al (2013) Mitochondrial fusion proteins and human diseases. Neurol Res Int 2013:293893
201. Rasbach KA, Funk JA, Jayavelu T, Green PT, Schnellmann RG (2010) 5-Hydroxytryptamine receptor stimulation of mitochondrial biogenesis. J Pharmacol Exp Ther 332:632–639
202. Ricaurte GA, Guillery RW, Seiden LS, Schuster CR, Moore RY (1982) Dopamine nerve terminal degeneration produced by high doses of methylamphetamine in the rat brain. Brain Res 235:93–103
203. Ricaurte GA, Seiden LS, Schuster CR (1984) Further evidence that amphetamines produce long-lasting dopamine neurochemical deficits by destroying dopamine nerve fibers. Brain Res 303:359–364
204. Rintoul GL, Filiano AJ, Brocard JB, Kress GJ, Reynolds IJ (2003) Glutamate decreases mitochondrial size and movement in primary forebrain neurons. J Neurosci 23:7881–7888
205. Rojo M, Legros F, Chateau D, Lombès A (2002) Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo. J Cell Sci 115:1663–1674
206. Rothman RB, Partilla JS, Baumann MH, Dersch CM, Carroll FI, Rice KC (2000) Neurochemical neutralization of methamphetamine with high-affinity nonselective inhibitors of biogenic amine transporters: a pharmacological strategy for treating stimulant abuse. Synapse 35:222–227
207. Ryu NK, Yang MH, Jung MS, Jeon JO, Kim KW, Park JH (2007) Gene expression profiling of rewarding effect in methamphetamine treated Bax-deficient mouse. J Biochem Mol Biol 40:475–485
208. Sato M (1992) A lasting vulnerability to psychosis in patients with previous methamphetamine psychosis. Ann N Y Acad Sci 654:160–170
209. Sau D, Rusmini P, Crippa V et al (2011) Dysregulation of axonal transport and motorneuron diseases. Biol Cell 103:87–107
210. Saxton WM, Hollenbeck PJ (2012a) The axonal transport of mitochondria. J Cell Sci 125:2095–2104
211. Saxton WM, Hollenbeck PJ (2012b) The axonal transport of mitochondria. J Cell Sci 125:2095–2104
212. Schapira AHV (2010) Complex I: inhibitors, inhibition and neurodegeneration. Exp Neurol 224:331–335
213. Schwarz TL (2013) Mitochondrial trafficking in neurons. Cold Spring Harb Perspect Biol 5:a011304
214. Scorza MC, Carrau C, Silveira R, Zapata-Torres G, Cassels BK, Reyes-Parada M (1997) Monoamine oxidase inhibitory properties of some methoxylated and alkylthio amphetamine derivatives: structure–activity relationships. Biochem Pharmacol 54:1361–1369
215. Sekine Y, Ouchi Y, Takei N et al (2006) Brain serotonin transporter density and aggression in abstinent methamphetamine abusers. Arch Gen Psychiatry 63:90–100
216. Sevrioukova IF (2011) Apoptosis-inducing factor: structure, function, and redox regulation. Antioxid Redox Signal 14:2545–2579
217. Shankaran M, Yamamoto BK, Gudelsky GA (1999) Involvement of the serotonin transporter in the formation of hydroxyl radicals induced by 3,4-methylenedioxymethamphetamine. Eur J Pharmacol 385:103–110
218. Sheng Z, Cai Q (2012) Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration. Nat Rev Neurosci 13:77–93
219. Shiba T, Yamato M, Kudo W, Watanabe T, Utsumi H, Yamada KI (2011) In vivo imaging of mitochondrial function in methamphetamine-treated rats. Neuroimage 57:866–872
220. Shih JC, Grimsby J, Chen K (1999) Molecular biology of monoamine oxidase A and B: their role in the degradation of serotonin. In: Gothert HB (ed) Serotoninergic neurons and 5-HT receptors in the SNC. Springer, Berlin, pp 655–670
221. Shima N, Miyawaki I, Bando K et al (2011) Influences of methamphetamine-induced acute intoxication on urinary and plasma metabolic profiles in the rat. Toxicology 287:29–37
222. Shimizu S, Eguchi Y, Kamiike W et al (1996) Involvement of ICE family proteases in apoptosis induced by reoxygenation of hypoxic hepatocytes. Am J Physiol 271:G949–G958
223. Silva DD, Carmo H, Lynch A, Silva E (2013a) An insight into the hepatocellular death induced by amphetamines, individually and in combination: the involvement of necrosis and apoptosis. Arch Toxicol 87:2165–2185
224. Silva DD, Silva E, Carmo H (2013b) Combination effects of amphetamines under hyperthermia—the role played by oxidative stress. J Appl Toxicol 34:637–650
225. Sinha K, Das J, Pal PB, Sil PC (2013) Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis. Arch Toxicol 87:1157–1180
226. Sipos I, Tretter L, Adam-Vizi V (2003) Quantitative relationship between inhibition of respiratory complexes and formation of reactive oxygen species in isolated nerve terminals. J Neurochem 84:112–118
227. Smirnova E, Griparic L, Shurland DL, van der Bliek AM (2001) Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells. Mol Biol Cell 12:2245–2256
228. Soleimani M, Katebi M, Alizadeh A, Mohammadzadeh F, Mehdizadeh M (2012) The role of the A2A receptor in cell apoptosis caused by MDMA. Cell J 14:231–236
229. Soleimani Asl S, Farhadi MH, Moosavizadeh K et al (2012) Evaluation of Bcl-2 family gene expression in hippocampus of 3,4-methylenedioxymethamphetamine treated rats. Cell J 13:275–280
230. Soleimani Asl S, Mousavizedeh K, Pourheydar B, Soleimani M, Rahbar E, Mehdizadeh M (2013) Protective effects of N-acetylcysteine on 3,4-methylenedioxymethamphetamine-induced neurotoxicity in male Sprague–Dawley rats. Metab Brain Dis 28:677–686
231. Soleimani Asl S, Saifi B, Sakhaie A, Zargooshnia S, Mehdizadeh M (2015) Attenuation of ecstasy-induced neurotoxicity by N-acetylcysteine. Metab Brain Dis 30:171–181
232. Song Z, Ghochani M, McCaffery JM, Frey TG, Chan DC (2009) Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion. Mol Biol Cell 20:3525–3532
233. Spencer JPE, Jenner P, Daniel SE, Lees AJ, Marsden DC, Halliwell B (1998) Conjugates of catecholamines with cysteine and GSH in Parkinson’s disease: possible mechanisms of formation involving reactive oxygen species. J Neurochem 71:2112–2122
234. Sprague JE, Nichols DE (1995a) Inhibition of MAO-B protects against MDMA-induced neurotoxicity in the striatum. Psychopharmacology 118:357–359
235. Sprague JE, Nichols DE (1995b) The monoamine oxidase-B inhibitor L-deprenyl protects against 3,4-methylenedioxymethamphetamine-induced lipid peroxidation and long-term serotonergic deficits. J Pharmacol Exp Ther 273:667–673
236. Srinivasula SM, Hegde R, Saleh A et al (2001) A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature 410:112–116
237. Stamer K, Vogel R, Thies E, Mandelkow E, Mandelkow E-M (2002) Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress. J Cell Biol 156:1051–1063
238. Stanley N, Salem A, Irvine RJ (2007) The effects of co-administration of 3,4-methylenedioxymethamphetamine (“ecstasy”) or para-methoxyamphetamine and moclobemide at elevated ambient temperatures on striatal 5-HT, body temperature and behavior in rats. Neuroscience 146:321–329
239. Stephans SE, Whittingham TS, Douglas AJ, Lust WD, Yamamoto BK (1998) Substrates of energy metabolism attenuate methamphetamine-induced neurotoxicity in striatum. J Neurochem 71:613–621
240. Stoothoff W, Jones PB, Spires-Jones TL et al (2009) Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport. J Neurochem 111:417–427
241. Stumm G, Schlegel J, Schäfer T et al (1999) Amphetamines induce apoptosis and regulation of bcl-x splice variants in neocortical neurons. FASEB J 13:1065–1072
242. Sulzer D, Chen TK, Lau YY, Kristensen H, Rayport S, Ewing A (1995) Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport. J Neurosci 15:4102–4108
243. Sulzer D, Sonders MS, Poulsen NW, Galli A (2005) Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol 75:406–433
244. Susin SA, Zamzami N, Castedo M et al (1996) Bcl-2 inhibits the mitochondrial release of an apoptogenic protease. J Exp Med 184:1331–1341
245. Taguchi N, Ishihara N, Jofuku A, Oka T, Mihara K (2007) Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission. J Biol Chem 282:11521–11529
246. Takamatsu Y, Shiotsuki H, Kasai S et al (2011) Enhanced hyperthermia induced by MDMA in parkin knockout mice. Curr Neuropharmacol 9:96–99
247. Tamburini I, Blandini F, Gesi M et al (2006) MDMA induces caspase-3 activation in the limbic system but not in striatum. Ann N Y Acad Sci 1074:377–381
248. Tatsuta T, Langer T (2008) Quality control of mitochondria: protection against neurodegeneration and ageing. EMBO J 27:306–314
249. Thrash B, Karuppagounder SS, Uthayathas S, Suppiramaniam V, Dhanasekaran M (2010) Neurotoxic effects of methamphetamine. Neurochem Res 35:171–179
250. Tian C, Murrin LC, Zheng JC (2009) Mitochondrial fragmentation is involved in methamphetaminei-induced cell death in rat hippocampal neural progenitor cells. PLoS ONE 4:e5546
251. Twig G, Shirihai OS (2011) The interplay between mitochondrial dynamics and mitophagy. Antioxid Redox Signal 14:1939–1951
252. Twig G, Elorza A, Molina AJ et al (2008a) Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J 27:433–446
253. Twig G, Hyde B, Shirihai OS (2008b) Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view. Biochim Biophys Acta 1777:1092–1097
254. Ulukaya E, Acilan C, Yilmaz Y (2011) Apoptosis: Why and how does it occur in biology? Cell Biochem Funct 29:468–480
255. Vafai SB, Mootha VK (2012) Mitochondrial disorders as windows into an ancient organelle. Nature 491:374–383
256. Vahsen N, Candé C, Brière JJ et al (2004) AIF deficiency compromises oxidative phosphorylation. EMBO J 23:4679–4689
257. Valenzuela A, Pla A, Villanueva E (1987) Effects of chronic administration of dextroamphetamine on enzymes of energy metabolism in regions of the rat brain. Neuropharmacology 26:627–631
258. Valvassori SS, Rezin GT, Ferreira CL et al (2010) Effects of mood stabilizers on mitochondrial respiratory chain activity in brain of rats treated with d-amphetamine. J Psychiatr Res 44:903–909
259. Valvassori SS, Calixto KV, Budni J et al (2013) Sodium butyrate reverses the inhibition of Krebs cycle enzymes induced by amphetamine in the rat brain. J Neural Transm 120:1737–1742
260. Van Laar VS, Berman SB (2013) The interplay of neuronal mitochondrial dynamics and bioenergetics: implications for Parkinson’s disease. Neurobiol Dis 51:43–55
261. Vilar S, Ferino G, Quezada E, Santana L, Friedman C (2012) Predicting monoamine oxidase inhibitory activity through ligand-based models. Curr Top Med Chem 12:2258–2274
262. Villemagne V, Yuan J, Wong DF et al (1998) Brain dopamine neurotoxicity in baboons treated with doses of methamphetamine comparable to those recreationally abused by humans: evidence from [11C]WIN-35,428 positron emission tomography studies and direct in vitro determinations. J Neurosci 18:419–427
263. Vincow ES, Merrihew G, Thomas RE et al (2013) The PINK1–Parkin pathway promotes both mitophagy and selective respiratory chain turnover In vivo. Proc Natl Acad Sci USA 110:6400–6405
264. Volkow ND, Chang L, Wang G et al (2001a) Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence. J Neurosci 21:9414–9418
265. Volkow ND, Chang L, Wang GJ et al (2001b) Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers. Am J Psychiatry 158:377–382
266. Vuori E, Henry JA, Ojanperä I et al (2003) Death following ingestion of MDMA (ecstasy) and moclobemide. Addiction 98:365–368
267. Wadley GD, Choate J, McConell GK (2007) NOS isoform-specific regulation of basal but not exercise-induced mitochondrial biogenesis in mouse skeletal muscle. J Physiol 585:253–262
268. Wagner GC, Ricaurte GA, Seiden LS, Schuster CR, Miller RJ, Westley J (1980) Long-lasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine. Brain Res 181:151–160
269. Wan FJ, Lin HC, Kang BH, Tseng CJ, Tung CS (1999) d-Amphetamine-induced depletion of energy and dopamine in the rat striatum is attenuated by nicotinamide pretreatment. Brain Res Bull 50:167–171
270. 2+-dependent regulation of kinesin-mediated mitochondrial motility. Cell 136:163–174
271. Wang X, Su B, Liu W et al (2011a) DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson’s disease. Aging Cell 10:807–823
272. Wang X, Winter D, Ashrafi G et al (2011b) PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell 147:893–906
273. Wang Z, Jiang H, Chen S, Du F, Wang X (2012) The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 148:228–243
274. Warren MW, Larner SF, Kobeissy FH et al (2007) Calpain and caspase proteolytic markers co-localize with rat cortical neurons after exposure to methamphetamine and MDMA. Acta Neuropathol 114:277–286
275. Weihofen A, Thomas KJ, Ostaszewski BL, Cookson MR, Selkoe DJ (2009) Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking. Biochemistry 48:2045–2052
276. Willson MC, Wilman AH, Bell EC, Asghar SJ, Silverstone PH (2004) Dextroamphetamine causes a change in regional brain activity in vivo during cognitive tasks: a functional magnetic resonance imaging study of blood oxygen level-dependent response. Biol Psychiatry 56:284–291
277. Wilson JM, Kalasinsky KS, Levey AI et al (1996) Striatal dopamine nerve terminal markers in human, chronic methamphetamine users. Nat Med 2:699–703
278. Wisessmith W, Phansuwan-Pujito P, Govitrapong P, Chetsawang B (2009) Melatonin reduces induction of Bax, caspase and cell death in methamphetamine-treated human neuroblastoma SH-SY5Y cultured cells. J Pineal Res 46:433–440
279. Wu Z, Puigserver P, Andersson U et al (1999) Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98:115–124
280. Wu G, Chai J, Suber TL et al (2000) Structural basis of IAP recognition by Smac/DIABLO. Nature 408:1008–1012
281. Wu CW, Ping YH, Yen JC et al (2007) Enhanced oxidative stress and aberrant mitochondrial biogenesis in human neuroblastoma SH-SY5Y cells during methamphetamine induced apoptosis. Toxicol Appl Pharmacol 220:243–251
282. Xie T, Tong L, Barrett T et al (2002) Changes in gene expression linked to methamphetamine-induced dopaminergic neurotoxicity. J Neurosci 22:274–283
283. Yamamoto BK, Moszczynska A, Gudelsky GA (2010) Amphetamine toxicities: classical and emerging mechanisms. Ann N Y Acad Sci 1187:101–121
284. Yang RF, Zhao GW, Liang ST et al (2012) Mitofilin regulates cytochrome c release during apoptosis by controlling mitochondrial cristae remodeling. Biochem Biophys Res Commun 428:93–98
285. Yoon Y, Krueger EW, Oswald BJ, McNiven MA (2003) The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1. Mol Cell Biol 23:5409–5420
286. Youdim MBH, Edmondson D, Tipton KF (2006) The therapeutic potential of monoamine oxidase inhibitors. Nat Rev Neurosci 7:295–309
287. Youle RJ, Narendra DP (2011) Mechanisms of mitophagy. Nat Rev Mol Cell Biol 12:9–14
288. Youle RJ, van der Bliek AM (2012) Mitochondrial fission, fusion, and stress. Science 337:1062–1065
289. Young R, Glennon RA (1986) Discriminative stimulus properties of amphetamine and structurally related phenalkylamines. Med Res Rev 6:99–130
290. Yuan S, Akey CW (2013) Apoptosome structure, assembly, and procaspase activation. Structure 21:501–515
291. Yuan H, Gerencser AA, Liot G et al (2007) Mitochondrial fission is an upstream and required event for bax foci formation in response to nitric oxide in cortical neurons. Cell Death Differ 14:462–471
292. Zhang X, Banerjee A, Banks WA, Ercal N (2009) N-Acetylcysteine amide protects against methamphetamine-induced oxidative stress and neurotoxicity in immortalized human brain endothelial cells. Brain Res 1275:87–95
293. Zhao J, Liu T, Jin S et al (2011) Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission. EMBO J 30:2762–2778
294. Zhou Z, Han V, Han J (2012) New components of the necroptotic pathway. Protein Cell 3:811–817
295. Zhu J, Wang KZ, Chu CT (2013) After the banquet: mitochondrial biogenesis, mitophagy, and cell survival. Autophagy 9:1663–1676