The mixture of "ecstasy" and its metabolites is toxic to human SH-SY5Y differentiated cells at in vivo relevant concentrations

Archives of Toxicology

Volumn 88, Issue 2, 2014, Pages 455-473

  Barbosa, Daniel José ^a   Capela, João Paulo ^a,b   Silva, Renata ^a   Vilas Boas, Vânia ^a   Ferreira, Luísa Maria ^c   Branco, Paula Sério ^c   Fernandes, Eduarda ^a   Bastos, Maria De Lourdes ^a   Carvalho, Félix ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b Faculty of Health Sciences   (Portugal)

^c UNIVERSIDADE NOVA DE LISBOA   (Portugal)

Author keywords

3,4 Methylenedioxymethamphetamine (MDMA or "ecstasy"); MDMA metabolites; Neurotoxicity; Oxidative stress; SH SY5Y differentiated cells

Indexed keywords

ACETYLCYSTEINE; CALCIUM; CASPASE 3; CELL DIFFERENTIATION; CELL LINE; DEOXYEPINEPHRINE; DOPAMINE; DOPAMINERGIC NEURONS; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; HUMANS; MITOCHONDRIA; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; NEURONS; NEUROTOXICITY SYNDROMES; REACTIVE OXYGEN SPECIES;

EID: 84893949148     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-013-1120-7     Document Type: Article

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