Protective effects of N-acetylcysteine on 3, 4- methylenedioxymethamphetamine-induced neurotoxicity in male Sprague-Dawley rats

Metabolic Brain Disease

Volumn 28, Issue 4, 2013, Pages 677-686

  Soleimani Asl, Sara ^a,b   Mousavizedeh, Kazem ^c   Pourheydar, Bagher ^d,f   Soleimani, Mansoureh ^c   Rahbar, Elnaz ^e   Mehdizadeh, Mehdi ^c  

^a HAMADAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b HAMADAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d URMIA UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e SEMNAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^f URMIA UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

3, 4 methylendioxymethamphetamine (MDMA); Apoptosis; Body temperature; N acetyl L cysteine; Spatial memory

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; ACETYLCYSTEINE; CASPASE 3; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL COUNT; CELL DEATH; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG EXPOSURE; DRUG TARGETING; HIPPOCAMPUS; HYPERTHERMIA; LATENT PERIOD; MALE; MAZE TEST; MORRIS WATER MAZE; NEUROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; RAT; RECTUM TEMPERATURE; SPATIAL LEARNING; SPRAGUE DAWLEY RAT; TREATMENT DURATION; UPREGULATION;

ANIMALIA; RATTUS;

ACETYLCYSTEINE; ANIMALS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL DEATH; DOWN-REGULATION; HIPPOCAMPUS; MALE; MAZE LEARNING; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; NEUROTOXICITY SYNDROMES; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84887214610     PISSN: 08857490     EISSN: 15737365     Source Type: Journal    
DOI: 10.1007/s11011-013-9423-1     Document Type: Article

References (44)

1. Alves E, Summavielle T, Alves CJ, Custódio J, Fernandes E, De Lourdes Bastos M (2009) Ecstasy-induced oxidative stress to adolescent rat brain mitochondria in vivo: influence of monoamine oxidase type. An Addict Biol 14:185-193
2. Bowyer JF, Thomas M, Schmued LC, Ali SF (2008) Brain region-specific neurodegenerative profiles showing the relative importance of amphetamine dose, hyperthermia, seizures, and the blood-brain barrier. Ann N Y Acad Sci 1139:127-139
3. Capela JP, Macedo C, Branco PS, Ferreira LM, Lobo AM et al (2007) Neurotoxicity mechanisms of thioether ecstasy metabolites. Neuroscience 8:1743-1757
4. Choy KH, Dean O, Berk M, Bush AI, Van Den Buuse M (2010) Effects of N-acetyl-cysteine treatment on glutathione depletion and a short-term spatial memory deficit in 2-cyclohexene-1-one-treated rats. Eur J Pharmacol 15:224-228
5. Cuzzocrea S, Mazzon E, Costantino G, Serraino I, Dugo L, Calabrò G et al (2000) Beneficial effects of n-acetylcysteine on ischaemic brain injury. Br J Pharmacol 130:1219-1226
6. De Flora S, Izzotti A, D'Agostini F, Balansky RM (2001) Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points. Carcinogenesis 22:999-1013
7. Fcology Arre M, Mathuna BO, Roset PN et al (2004) Repeated doses administration of MDMA in humans: pharmacological effects and pharmacokinetics. Psychopharmacology (Berlin) 173(3-4):364-375
8. Franco R, Cidlowski JA (2012) Glutathione efflux and cell death. Antioxid Redox Signal 15:1694-1713
9. Fu AL, Dong ZH, Sun MJ (2006) Protective effect of N-acetyl-L-cysteine on amyloid beta-peptide-induced learning and memory deficits in mice. Brain Res 13:201-206
10. Fukami G, Hashimoto K, Koike K, Okamura N, Shimizu E, Iyo M (2004) Effect of antioxidant N-acetyl-L-cysteine on behavioral changes and neurotoxicity in rats after administration of methamphetamine. Brain Res 30:90-95
11. Gabryel B, Toborek T, Małecki A (2005) Immunosuppressive immunophilin ligands attenuate damage in cultured rat astrocytes depleted of glutathione and exposed to simulated ischemia in vitro. Comparison with N-acetylcysteine. Neurotoxicology 26(3):373-384
12. Gonçalves J, Martins T, Ferreira R, Milhazes N, Borges F, Ribeiro CF et al (2008) Methamphetamine-induced early increase of IL-6 and TNF-alpha mRNA expression in the mouse brain. Ann N Y Acad Sci 1139:103-111
13. Hashimoto S, Gon Y, Matsumoto K, Takeshita I, Horie T (2001) N-acetylcysteine attenuates TNF-alpha-induced p38 MAP kinase activation and p38 MAP kinase-mediated IL-8 production by human pulmonary vascular endothelial cells. Br J Pharmacol 132:270-276
14. Jayanthi S, Deng X, Bordelon M, McCoy MT, Cadet JL (2001) Methamphetamine causes differential regulation of pro-death and anti-death Bcl-2 genes in the mouse neocortex. FASEB J 15:1745-1752
15. Jiménez A, Jordà Elvira G, Verdaguer E, Pubill D, Sureda F, Canudas AM et al (2004) Neurotoxicity of amphetamine derivatives is mediated by caspase pathway activation in rat cerebellar granule cells. Follow Toxicol Appl Pharmacol 196:223-234
16. Kamboj SS, Chopra K, Sandhir R (2008) Neuroprotective effect of N-acetylcysteine in the development of diabetic encephalopathy in streptozotocin-induced diabetes. Metab Brain Dis 23(4):427-443
17. Kermanian F, Mehdizadeh M, Soleimani M, Ebrahimzadeh Bideskan AR et al (2012) The role of adenosine receptor agonist and antagonist on Hippocampal MDMA detrimental effects; a structural and behavioral study. Metab Brain Dis 27:459-469
18. Kroemer G, Galluzzi L, Vandenabeele P, Abrams J, Alnemri ES, Baehrecke EH et al (2009) Classification of cell death: recommendations of the Nomenclature Committee on Cell Death Cell Death Differ. Cell Death Differ 16(1):3-11
19. Kuypers KP, Wingen M, Heinecke A, Formisano E, Ramaekers JG (2011) MDMA intoxication and verbal memory performance: a placebo-controlled pharmaco-MRI study. J Psychopharmacol 25(8):1053-1061
20. Lan A, Liao X, Mo L, Yang C, Yang Z, Wang X, Hu F et al (2011) Hydrogen sulfide protects against chemical hypoxia-induced injury by inhibiting ROS-activated ERK1/2 and p38MAPK signaling pathways in PC12 cells. PLoS One 6:e25921
21. Lee DH, Gold R, Linker RA (2012) Mechanisms of oxidative damage in multiple sclerosis and neurodegenerative diseases: therapeutic modulation via fumaric acid esters. Int J Mol Sci 13(9):11783-11803
22. Mehdizadeh M, Dabaghian F, Nejhadi A, Fallah-huseini H, Choopani S, Shekarriz N et al (2012) Zingiber officinale alters 3, 4-methylenedioxymetham- induced neurotoxicity in rat brain. Cell J 14(3):177-184
23. Mills EM, Rusyniak DE, Sprague JE (2004) The role of the sympathetic nervous system and uncoupling proteins in the thermogenesis induced by 3,4-methylenedioxymethamphetamine. J Mol Med (Berl) 82:787-799
24. Miura M (2012) Apoptotic and nonapoptotic caspase functions in animal development. Cold Spring Harb Perspect Biol 4(10):1
25. Montgomery T, Sitte H, McBean G (2010) 4-Methylthioamphetamine (4-MTA) induces mitochondrial-dependent apoptosis in SH-SY5Y cells independently of dopamine and noradrenaline transporters. BMC Pharmacology 10(supp 1):A22
26. Navarrete M, Núñez H, Ruiz S, Soto-Moyano R, Valladares L, White A et al (2007) Prenatal undernutrition decreases the sensitivity of the hypothalamo-pituitary-adrenal axis in rat, as revealed by subcutaneous and intra-paraventricular dexamethasone challenges. Neurosci Lett 29:99-103
27. O'Leary G, Nargiso J, Weiss RD (2001) 3, 4-methylenedioxymethamphetamine (MDMA): a review. Curr Psychiatr Rep 3(6):477-483
28. Oltvai ZN, Milliman CL, Korsmeyer SJ (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74(4):609-619, 27
29. Pedersen NP, Blessing WW (2001) Cutaneous vasoconstriction contributes to hyperthermia induced by 3, 4-methylenedioxymethamphetamine (ecstasy) in conscious rabbits. J Neurosci 1:8648-8654
30. Pinnen F, Sozio P, Cacciatore I, Cornacchia C, Mollica A, Iannitelli A et al (2011) Ibuprofen and glutathione conjugate as a potential therapeutic agent for treating Alzheimer's disease. Arch Pharm (Weinheim) 344:139-148
31. Sarkar S, Schmued L (2010) Neurotoxicity of ecstasy (MDMA): an overview. Curr Pharm Biotechnol 11(5):460-469
32. Schmued LC (2003) Demonstration and localization of neuronal degeneration in the rat forebrain following a single exposure to MDMA. Brain Res 974(1-2):127-133
33. Shankaran M, Yamamoto BK, Gudelsky GA (1999) Involvement of the serotonin transporter in the formation of hydroxyl radicals induced by 3, 4-methylenedioxymethamphetamine. Eur J Pharmacol 385:103-110
34. Simantov R, Tauber M (1997) The abused drug MDMA (Ecstasy) induces programmed death of human serotonergic cells. FASEB J 11(2):141-146
35. Slivka A, Mytilineou C, Cohen G (1987) Histochemical evaluation of glutathione in brain. Brain Res 21:275-284
36. Soleimani Asl S, Naghdi N, Choopani S, Farhadi MH, Samzadeh-Kermani A, Mehdizadeh M (2011) Non-acute effects of different doses of 3-4, methylenedioxymethamphetamine (MDMA) on spatial memory in the Morris water maze in Sprague Dawley male rats. NRR 6:1715-1719
37. Soleimani Asl S, Farhadi MH, Moosavizadeh K, Samadi Kuchak Saraei A, Soleimani M et al (2012) Evaluation of Bcl-2 family gene expression in hippocampus of 3-4 methylenedioxymethamphetamine treated rats. Cell J 13:275-280
38. Sprague JE, Nichols DE (1995) The monoamine oxidase-B inhibitor L-deprenyl protects against 3,4-methylenedioxymethamphetamine-induced lipid peroxidation and long-term serotonergic deficits. J Pharmacol Exp Ther 273(2):667-673
39. Sprague JE, Preston AS, Leifheit M, Woodside B (2003) Hippocampal serotonergic damage induced by MDMA (ecstasy): effects on spatial learning. Physiol Behav 79:281-287
40. Viegas CM, Tonin AM, Zanatta A, Seminotti B, Busanello EN, Fernandes CG et al (2012) Impairment of brain redox homeostasis caused by the major metabolites accumulating in hyperornithinemia-hyperammonemia-homocitrullinuria syndrome in vivo. Metab Brain Dis 27(4):521-530
41. Vorhees CV, Reed TM, Skelton MR, Williams MT (2004) Exposure to 3, 4-methylenedioxymethamphetamine (MDMA) on postnatal days 11-20 induces reference but not working memory deficits in the Morris water maze in rats: implications of prior learning. Int J Dev Neurosci 22:247-259
42. Xue C, Liu W, Wu J, Yang X, Xu H (2011) Chemoprotective effect of N-acetylcysteine (NAC) on cellular oxidative damages and apoptosis induced by nano titanium dioxide under UVA irradiation. Toxicol in Vitro 25:110-116
43. Yamamoto BK, Raudensky J (2008) The role of oxidative stress, metabolic compromise, and inflammation in neuronal injury produced by amphetamine-related drugs of abuse. J Neuroimmune Pharmacol 3:203-217
44. Zhang H, Spapen H, Nguyen DN, Benlabed M, Buurman WA, Vincent JL (1994) Protective effects of N-acetyl-L-cysteine in endotoxemia. Am J Physiol 266:1746-1754