An insight into the hepatocellular death induced by amphetamines, individually and in combination: The involvement of necrosis and apoptosis

Archives of Toxicology

Volumn 87, Issue 12, 2013, Pages 2165-2185

  Dias Da Silva, Diana ^a,b,c   Carmo, Helena ^b   Lynch, Adam ^c   Silva, Elisabete ^c  

^a University of Porto   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c BRUNEL UNIVERSITY   (United Kingdom)

Author keywords

3,4 Methylenedioxymethamphetamine (ecstasy, MDMA); Amphetamine related toxicity; Apoptosis; Combination effects; Hepatocytes; Necrosis

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; 4 METHYLTHIOAMPHETAMINE; ADENOSINE TRIPHOSPHATE; AMPHETAMINE DERIVATIVE; BIM PROTEIN; CASPASE 3; CASPASE 7; DEXAMPHETAMINE; MESSENGER RNA; METHAMPHETAMINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAK; PROTEIN BAX; PROTEIN BID; PUMA PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BAX GENE; BCL 2 GENE; BCL XL GENE; BID GENE; BIM GENE; CELL DEATH; CELL STRAIN HEPG2; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE; HUMAN; HUMAN CELL; LIVER CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PUMA GENE; TEMPERATURE;

ADENOSINE TRIPHOSPHATE; AMPHETAMINES; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CASPASE 7; CELL DEATH; CELL LINE; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM STIMULANTS; DRUG-INDUCED LIVER INJURY; ENERGY METABOLISM; FLOW CYTOMETRY; HUMANS; MEMBRANES; MITOCHONDRIA; NECROSIS; NEUTRAL RED; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION; RNA; TETRAZOLIUM SALTS; THIAZOLES;

EID: 84890559573     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-013-1082-9     Document Type: Article

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